Myotis lucifugus (little brown bat): 102417411
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Entry
102417411 CDS
T07795
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X2
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
mlf
Myotis lucifugus (little brown bat)
Pathway
mlf01521
EGFR tyrosine kinase inhibitor resistance
mlf01522
Endocrine resistance
mlf04010
MAPK signaling pathway
mlf04012
ErbB signaling pathway
mlf04014
Ras signaling pathway
mlf04015
Rap1 signaling pathway
mlf04022
cGMP-PKG signaling pathway
mlf04024
cAMP signaling pathway
mlf04062
Chemokine signaling pathway
mlf04066
HIF-1 signaling pathway
mlf04068
FoxO signaling pathway
mlf04071
Sphingolipid signaling pathway
mlf04072
Phospholipase D signaling pathway
mlf04114
Oocyte meiosis
mlf04140
Autophagy - animal
mlf04148
Efferocytosis
mlf04150
mTOR signaling pathway
mlf04151
PI3K-Akt signaling pathway
mlf04210
Apoptosis
mlf04218
Cellular senescence
mlf04270
Vascular smooth muscle contraction
mlf04370
VEGF signaling pathway
mlf04371
Apelin signaling pathway
mlf04380
Osteoclast differentiation
mlf04510
Focal adhesion
mlf04540
Gap junction
mlf04550
Signaling pathways regulating pluripotency of stem cells
mlf04613
Neutrophil extracellular trap formation
mlf04620
Toll-like receptor signaling pathway
mlf04650
Natural killer cell mediated cytotoxicity
mlf04660
T cell receptor signaling pathway
mlf04662
B cell receptor signaling pathway
mlf04664
Fc epsilon RI signaling pathway
mlf04666
Fc gamma R-mediated phagocytosis
mlf04668
TNF signaling pathway
mlf04720
Long-term potentiation
mlf04722
Neurotrophin signaling pathway
mlf04725
Cholinergic synapse
mlf04726
Serotonergic synapse
mlf04730
Long-term depression
mlf04810
Regulation of actin cytoskeleton
mlf04910
Insulin signaling pathway
mlf04912
GnRH signaling pathway
mlf04914
Progesterone-mediated oocyte maturation
mlf04915
Estrogen signaling pathway
mlf04916
Melanogenesis
mlf04917
Prolactin signaling pathway
mlf04919
Thyroid hormone signaling pathway
mlf04921
Oxytocin signaling pathway
mlf04926
Relaxin signaling pathway
mlf04928
Parathyroid hormone synthesis, secretion and action
mlf04929
GnRH secretion
mlf04934
Cushing syndrome
mlf04935
Growth hormone synthesis, secretion and action
mlf05010
Alzheimer disease
mlf05022
Pathways of neurodegeneration - multiple diseases
mlf05034
Alcoholism
mlf05132
Salmonella infection
mlf05135
Yersinia infection
mlf05160
Hepatitis C
mlf05161
Hepatitis B
mlf05163
Human cytomegalovirus infection
mlf05164
Influenza A
mlf05165
Human papillomavirus infection
mlf05166
Human T-cell leukemia virus 1 infection
mlf05167
Kaposi sarcoma-associated herpesvirus infection
mlf05170
Human immunodeficiency virus 1 infection
mlf05200
Pathways in cancer
mlf05205
Proteoglycans in cancer
mlf05206
MicroRNAs in cancer
mlf05207
Chemical carcinogenesis - receptor activation
mlf05208
Chemical carcinogenesis - reactive oxygen species
mlf05210
Colorectal cancer
mlf05211
Renal cell carcinoma
mlf05212
Pancreatic cancer
mlf05213
Endometrial cancer
mlf05214
Glioma
mlf05215
Prostate cancer
mlf05216
Thyroid cancer
mlf05218
Melanoma
mlf05219
Bladder cancer
mlf05220
Chronic myeloid leukemia
mlf05221
Acute myeloid leukemia
mlf05223
Non-small cell lung cancer
mlf05224
Breast cancer
mlf05225
Hepatocellular carcinoma
mlf05226
Gastric cancer
mlf05230
Central carbon metabolism in cancer
mlf05231
Choline metabolism in cancer
mlf05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mlf00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102417411 (MAP2K1)
04012 ErbB signaling pathway
102417411 (MAP2K1)
04014 Ras signaling pathway
102417411 (MAP2K1)
04015 Rap1 signaling pathway
102417411 (MAP2K1)
04370 VEGF signaling pathway
102417411 (MAP2K1)
04371 Apelin signaling pathway
102417411 (MAP2K1)
04668 TNF signaling pathway
102417411 (MAP2K1)
04066 HIF-1 signaling pathway
102417411 (MAP2K1)
04068 FoxO signaling pathway
102417411 (MAP2K1)
04072 Phospholipase D signaling pathway
102417411 (MAP2K1)
04071 Sphingolipid signaling pathway
102417411 (MAP2K1)
04024 cAMP signaling pathway
102417411 (MAP2K1)
04022 cGMP-PKG signaling pathway
102417411 (MAP2K1)
04151 PI3K-Akt signaling pathway
102417411 (MAP2K1)
04150 mTOR signaling pathway
102417411 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
102417411 (MAP2K1)
04148 Efferocytosis
102417411 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
102417411 (MAP2K1)
04210 Apoptosis
102417411 (MAP2K1)
04218 Cellular senescence
102417411 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
102417411 (MAP2K1)
04540 Gap junction
102417411 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
102417411 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
102417411 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
102417411 (MAP2K1)
04620 Toll-like receptor signaling pathway
102417411 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
102417411 (MAP2K1)
04660 T cell receptor signaling pathway
102417411 (MAP2K1)
04662 B cell receptor signaling pathway
102417411 (MAP2K1)
04664 Fc epsilon RI signaling pathway
102417411 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
102417411 (MAP2K1)
04062 Chemokine signaling pathway
102417411 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
102417411 (MAP2K1)
04929 GnRH secretion
102417411 (MAP2K1)
04912 GnRH signaling pathway
102417411 (MAP2K1)
04915 Estrogen signaling pathway
102417411 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
102417411 (MAP2K1)
04917 Prolactin signaling pathway
102417411 (MAP2K1)
04921 Oxytocin signaling pathway
102417411 (MAP2K1)
04926 Relaxin signaling pathway
102417411 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
102417411 (MAP2K1)
04919 Thyroid hormone signaling pathway
102417411 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
102417411 (MAP2K1)
04916 Melanogenesis
102417411 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
102417411 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
102417411 (MAP2K1)
04726 Serotonergic synapse
102417411 (MAP2K1)
04720 Long-term potentiation
102417411 (MAP2K1)
04730 Long-term depression
102417411 (MAP2K1)
04722 Neurotrophin signaling pathway
102417411 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
102417411 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102417411 (MAP2K1)
05206 MicroRNAs in cancer
102417411 (MAP2K1)
05205 Proteoglycans in cancer
102417411 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
102417411 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
102417411 (MAP2K1)
05230 Central carbon metabolism in cancer
102417411 (MAP2K1)
05231 Choline metabolism in cancer
102417411 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
102417411 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
102417411 (MAP2K1)
05212 Pancreatic cancer
102417411 (MAP2K1)
05225 Hepatocellular carcinoma
102417411 (MAP2K1)
05226 Gastric cancer
102417411 (MAP2K1)
05214 Glioma
102417411 (MAP2K1)
05216 Thyroid cancer
102417411 (MAP2K1)
05221 Acute myeloid leukemia
102417411 (MAP2K1)
05220 Chronic myeloid leukemia
102417411 (MAP2K1)
05218 Melanoma
102417411 (MAP2K1)
05211 Renal cell carcinoma
102417411 (MAP2K1)
05219 Bladder cancer
102417411 (MAP2K1)
05215 Prostate cancer
102417411 (MAP2K1)
05213 Endometrial cancer
102417411 (MAP2K1)
05224 Breast cancer
102417411 (MAP2K1)
05223 Non-small cell lung cancer
102417411 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
102417411 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
102417411 (MAP2K1)
05161 Hepatitis B
102417411 (MAP2K1)
05160 Hepatitis C
102417411 (MAP2K1)
05164 Influenza A
102417411 (MAP2K1)
05163 Human cytomegalovirus infection
102417411 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
102417411 (MAP2K1)
05165 Human papillomavirus infection
102417411 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
102417411 (MAP2K1)
05135 Yersinia infection
102417411 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
102417411 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
102417411 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
102417411 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102417411 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102417411 (MAP2K1)
01522 Endocrine resistance
102417411 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mlf01001
]
102417411 (MAP2K1)
Enzymes [BR:
mlf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
102417411 (MAP2K1)
Protein kinases [BR:
mlf01001
]
Serine/threonine kinases: STE group
STE7 family
102417411 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
Motif
Other DBs
NCBI-GeneID:
102417411
NCBI-ProteinID:
XP_014315236
LinkDB
All DBs
Position
Unknown
AA seq
300 aa
AA seq
DB search
MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ
VLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSG
QLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELEL
LFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLE
FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
903 nt
NT seq
+upstream
nt +downstream
nt
atggccagaaagctaattcacctggagatcaaacctgcgatccggaaccagataataagg
gagctgcaggttctccatgagtgtaactccccatacattgtgggcttctatggtgcattc
tacagcgatggagagatcagcatctgcatggagcatatggatgggggttccttggatcaa
gtcctgaagaaagctggaagaattcctgaacaaattttaggaaaagttagcattgctgta
ataaaaggcctgacatatctgagggagaaacacaagattatgcatagagatgtcaagcct
tctaacatcctagtgaactcccgtggggagatcaagctctgtgactttggagtcagcggg
cagctcatcgactccatggccaactccttcgtgggcacaaggtcctacatgtcgccagag
agactccaggggactcattactcggtgcagtcggacatctggagcatggggctctctctg
gttgagatggcggttgggaggtatcccatccctcctccagatgccaaggagctggagctg
ctgtttgggtgccaggtggagggagatgcggctgagacaccaccccggccaaggacccct
gggaggccccttagctcttatggaatggacagccgaccgcccatggcaatttttgagtta
ttggattacatagtcaacgagcctcctccaaaactgcccagtggagtattcagtctggaa
tttcaagattttgtgaataaatgcttaataaaaaaccctgcagagagagcagatttgaag
caactcatggttcatgcttttatcaagagatctgatgctgaggaagtggattttgcaggt
tggctctgctccaccatcggccttaaccagcccagcacaccaacccatgcggctggtgtc
taa
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