KEGG   Myotis lucifugus (little brown bat): 102420799
Entry
102420799         CDS       T07795                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mlf  Myotis lucifugus (little brown bat)
Pathway
mlf01521  EGFR tyrosine kinase inhibitor resistance
mlf01522  Endocrine resistance
mlf04010  MAPK signaling pathway
mlf04012  ErbB signaling pathway
mlf04068  FoxO signaling pathway
mlf04270  Vascular smooth muscle contraction
mlf04650  Natural killer cell mediated cytotoxicity
mlf04720  Long-term potentiation
mlf04726  Serotonergic synapse
mlf04730  Long-term depression
mlf04810  Regulation of actin cytoskeleton
mlf04910  Insulin signaling pathway
mlf04914  Progesterone-mediated oocyte maturation
mlf04928  Parathyroid hormone synthesis, secretion and action
mlf05010  Alzheimer disease
mlf05022  Pathways of neurodegeneration - multiple diseases
mlf05034  Alcoholism
mlf05160  Hepatitis C
mlf05161  Hepatitis B
mlf05200  Pathways in cancer
mlf05205  Proteoglycans in cancer
mlf05208  Chemical carcinogenesis - reactive oxygen species
mlf05210  Colorectal cancer
mlf05211  Renal cell carcinoma
mlf05212  Pancreatic cancer
mlf05213  Endometrial cancer
mlf05214  Glioma
mlf05215  Prostate cancer
mlf05218  Melanoma
mlf05219  Bladder cancer
mlf05220  Chronic myeloid leukemia
mlf05221  Acute myeloid leukemia
mlf05223  Non-small cell lung cancer
mlf05224  Breast cancer
mlf05225  Hepatocellular carcinoma
mlf05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mlf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102420799 (ARAF)
   04012 ErbB signaling pathway
    102420799 (ARAF)
   04068 FoxO signaling pathway
    102420799 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102420799 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102420799 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102420799 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    102420799 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    102420799 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102420799 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    102420799 (ARAF)
   04720 Long-term potentiation
    102420799 (ARAF)
   04730 Long-term depression
    102420799 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102420799 (ARAF)
   05205 Proteoglycans in cancer
    102420799 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    102420799 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102420799 (ARAF)
   05212 Pancreatic cancer
    102420799 (ARAF)
   05225 Hepatocellular carcinoma
    102420799 (ARAF)
   05226 Gastric cancer
    102420799 (ARAF)
   05214 Glioma
    102420799 (ARAF)
   05221 Acute myeloid leukemia
    102420799 (ARAF)
   05220 Chronic myeloid leukemia
    102420799 (ARAF)
   05218 Melanoma
    102420799 (ARAF)
   05211 Renal cell carcinoma
    102420799 (ARAF)
   05219 Bladder cancer
    102420799 (ARAF)
   05215 Prostate cancer
    102420799 (ARAF)
   05213 Endometrial cancer
    102420799 (ARAF)
   05224 Breast cancer
    102420799 (ARAF)
   05223 Non-small cell lung cancer
    102420799 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102420799 (ARAF)
   05160 Hepatitis C
    102420799 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102420799 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    102420799 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    102420799 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102420799 (ARAF)
   01522 Endocrine resistance
    102420799 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlf01001]
    102420799 (ARAF)
Enzymes [BR:mlf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102420799 (ARAF)
Protein kinases [BR:mlf01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102420799 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 102420799
NCBI-ProteinID: XP_014318471
Ensembl: ENSMLUG00000014746
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQYYHSIQDLSGGYRQHEAPSNRSLNEPL
TPQGSSSSSQHRDPEHFPFPATANAPLQRIRSTSTPNVHMVSTTTPLDSSLIQLAAQSFN
AEAAGSRGGSDGVPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggctctcaaggtgcggggtctcaatcaggattgttgcgtg
gtctaccggctcatcgaagggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggcgaggagctcattgttgaggtccttgaagatgtcccactgactatgcacaat
tttgtacggaaaacgttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaggtc
cccacagtctgtgttgacatgagtaccaactgccgacagtactaccacagtatccaggat
ttgtccggaggctacagacagcatgaggctccctccaaccgttctctgaatgagccacta
acccctcagggttccagctccagctcccagcaccgagaccctgaacacttcccctttcct
gccacggccaacgcccccctgcagcgcatccgctccacgtctactcccaacgtccatatg
gtcagcaccacaacccccctggactccagtctcatccagctcgccgcccagagtttcaac
gctgaagctgctggtagtagaggtggcagtgatggagtgccccgggggagccccagcccg
gctagtgtgtcctcggggaggaagtccccacattccaagtccccctcagaacagcgggag
aggaagtccttggctgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacgtcatgtcaacatcttgctgttcatgggcttcatgacccggccggggtttgccatc
atcacacagtggtgcgagggctccagcctctaccaccacctgcatgtggccgacacacgc
ttcgacatggtccagctcattgatgtggcccggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgggatctcaagtctaacaacatcttcctacatgagggg
ctcacagtgaagatcggtgacttcggcctggccacggtgaagacaagatggagcggggct
cagcccttggagcagccctcaggctctgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcggatgtctacgcctatggggttgtgctctac
gagctcatgaccggctccttgccttatagccacattggcagccgtgaccagattatcttt
atggtaggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgattgcctcaagtttcagcgagaggagcggcccctcttc
ccccagatcctggccaccattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcatcgcacccaggctgatgagttgcccgcctgcctactcagc
gcagcccgccttgtgccttag

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