KEGG   Myotis lucifugus (little brown bat): 102422649
Entry
102422649         CDS       T07795                                 
Symbol
PIK3CD
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mlf  Myotis lucifugus (little brown bat)
Pathway
mlf00562  Inositol phosphate metabolism
mlf01100  Metabolic pathways
mlf01521  EGFR tyrosine kinase inhibitor resistance
mlf01522  Endocrine resistance
mlf01524  Platinum drug resistance
mlf04012  ErbB signaling pathway
mlf04014  Ras signaling pathway
mlf04015  Rap1 signaling pathway
mlf04024  cAMP signaling pathway
mlf04062  Chemokine signaling pathway
mlf04066  HIF-1 signaling pathway
mlf04068  FoxO signaling pathway
mlf04070  Phosphatidylinositol signaling system
mlf04071  Sphingolipid signaling pathway
mlf04072  Phospholipase D signaling pathway
mlf04081  Hormone signaling
mlf04140  Autophagy - animal
mlf04150  mTOR signaling pathway
mlf04151  PI3K-Akt signaling pathway
mlf04152  AMPK signaling pathway
mlf04210  Apoptosis
mlf04211  Longevity regulating pathway
mlf04213  Longevity regulating pathway - multiple species
mlf04218  Cellular senescence
mlf04360  Axon guidance
mlf04370  VEGF signaling pathway
mlf04380  Osteoclast differentiation
mlf04510  Focal adhesion
mlf04550  Signaling pathways regulating pluripotency of stem cells
mlf04611  Platelet activation
mlf04613  Neutrophil extracellular trap formation
mlf04620  Toll-like receptor signaling pathway
mlf04625  C-type lectin receptor signaling pathway
mlf04630  JAK-STAT signaling pathway
mlf04650  Natural killer cell mediated cytotoxicity
mlf04660  T cell receptor signaling pathway
mlf04662  B cell receptor signaling pathway
mlf04664  Fc epsilon RI signaling pathway
mlf04666  Fc gamma R-mediated phagocytosis
mlf04668  TNF signaling pathway
mlf04670  Leukocyte transendothelial migration
mlf04722  Neurotrophin signaling pathway
mlf04725  Cholinergic synapse
mlf04750  Inflammatory mediator regulation of TRP channels
mlf04810  Regulation of actin cytoskeleton
mlf04910  Insulin signaling pathway
mlf04914  Progesterone-mediated oocyte maturation
mlf04915  Estrogen signaling pathway
mlf04917  Prolactin signaling pathway
mlf04919  Thyroid hormone signaling pathway
mlf04923  Regulation of lipolysis in adipocytes
mlf04926  Relaxin signaling pathway
mlf04929  GnRH secretion
mlf04930  Type II diabetes mellitus
mlf04931  Insulin resistance
mlf04932  Non-alcoholic fatty liver disease
mlf04933  AGE-RAGE signaling pathway in diabetic complications
mlf04935  Growth hormone synthesis, secretion and action
mlf04960  Aldosterone-regulated sodium reabsorption
mlf04973  Carbohydrate digestion and absorption
mlf05010  Alzheimer disease
mlf05017  Spinocerebellar ataxia
mlf05020  Prion disease
mlf05100  Bacterial invasion of epithelial cells
mlf05132  Salmonella infection
mlf05135  Yersinia infection
mlf05142  Chagas disease
mlf05146  Amoebiasis
mlf05160  Hepatitis C
mlf05161  Hepatitis B
mlf05162  Measles
mlf05163  Human cytomegalovirus infection
mlf05164  Influenza A
mlf05165  Human papillomavirus infection
mlf05166  Human T-cell leukemia virus 1 infection
mlf05167  Kaposi sarcoma-associated herpesvirus infection
mlf05168  Herpes simplex virus 1 infection
mlf05169  Epstein-Barr virus infection
mlf05170  Human immunodeficiency virus 1 infection
mlf05171  Coronavirus disease - COVID-19
mlf05200  Pathways in cancer
mlf05203  Viral carcinogenesis
mlf05205  Proteoglycans in cancer
mlf05206  MicroRNAs in cancer
mlf05207  Chemical carcinogenesis - receptor activation
mlf05208  Chemical carcinogenesis - reactive oxygen species
mlf05210  Colorectal cancer
mlf05211  Renal cell carcinoma
mlf05212  Pancreatic cancer
mlf05213  Endometrial cancer
mlf05214  Glioma
mlf05215  Prostate cancer
mlf05218  Melanoma
mlf05220  Chronic myeloid leukemia
mlf05221  Acute myeloid leukemia
mlf05222  Small cell lung cancer
mlf05223  Non-small cell lung cancer
mlf05224  Breast cancer
mlf05225  Hepatocellular carcinoma
mlf05226  Gastric cancer
mlf05230  Central carbon metabolism in cancer
mlf05231  Choline metabolism in cancer
mlf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlf05415  Diabetic cardiomyopathy
mlf05417  Lipid and atherosclerosis
mlf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102422649 (PIK3CD)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102422649 (PIK3CD)
   04014 Ras signaling pathway
    102422649 (PIK3CD)
   04015 Rap1 signaling pathway
    102422649 (PIK3CD)
   04370 VEGF signaling pathway
    102422649 (PIK3CD)
   04630 JAK-STAT signaling pathway
    102422649 (PIK3CD)
   04668 TNF signaling pathway
    102422649 (PIK3CD)
   04066 HIF-1 signaling pathway
    102422649 (PIK3CD)
   04068 FoxO signaling pathway
    102422649 (PIK3CD)
   04070 Phosphatidylinositol signaling system
    102422649 (PIK3CD)
   04072 Phospholipase D signaling pathway
    102422649 (PIK3CD)
   04071 Sphingolipid signaling pathway
    102422649 (PIK3CD)
   04024 cAMP signaling pathway
    102422649 (PIK3CD)
   04151 PI3K-Akt signaling pathway
    102422649 (PIK3CD)
   04152 AMPK signaling pathway
    102422649 (PIK3CD)
   04150 mTOR signaling pathway
    102422649 (PIK3CD)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102422649 (PIK3CD)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102422649 (PIK3CD)
  09143 Cell growth and death
   04210 Apoptosis
    102422649 (PIK3CD)
   04218 Cellular senescence
    102422649 (PIK3CD)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102422649 (PIK3CD)
   04550 Signaling pathways regulating pluripotency of stem cells
    102422649 (PIK3CD)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102422649 (PIK3CD)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102422649 (PIK3CD)
   04613 Neutrophil extracellular trap formation
    102422649 (PIK3CD)
   04620 Toll-like receptor signaling pathway
    102422649 (PIK3CD)
   04625 C-type lectin receptor signaling pathway
    102422649 (PIK3CD)
   04650 Natural killer cell mediated cytotoxicity
    102422649 (PIK3CD)
   04660 T cell receptor signaling pathway
    102422649 (PIK3CD)
   04662 B cell receptor signaling pathway
    102422649 (PIK3CD)
   04664 Fc epsilon RI signaling pathway
    102422649 (PIK3CD)
   04666 Fc gamma R-mediated phagocytosis
    102422649 (PIK3CD)
   04670 Leukocyte transendothelial migration
    102422649 (PIK3CD)
   04062 Chemokine signaling pathway
    102422649 (PIK3CD)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102422649 (PIK3CD)
   04923 Regulation of lipolysis in adipocytes
    102422649 (PIK3CD)
   04929 GnRH secretion
    102422649 (PIK3CD)
   04915 Estrogen signaling pathway
    102422649 (PIK3CD)
   04914 Progesterone-mediated oocyte maturation
    102422649 (PIK3CD)
   04917 Prolactin signaling pathway
    102422649 (PIK3CD)
   04926 Relaxin signaling pathway
    102422649 (PIK3CD)
   04935 Growth hormone synthesis, secretion and action
    102422649 (PIK3CD)
   04919 Thyroid hormone signaling pathway
    102422649 (PIK3CD)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102422649 (PIK3CD)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102422649 (PIK3CD)
  09156 Nervous system
   04725 Cholinergic synapse
    102422649 (PIK3CD)
   04722 Neurotrophin signaling pathway
    102422649 (PIK3CD)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102422649 (PIK3CD)
  09158 Development and regeneration
   04360 Axon guidance
    102422649 (PIK3CD)
   04380 Osteoclast differentiation
    102422649 (PIK3CD)
  09149 Aging
   04211 Longevity regulating pathway
    102422649 (PIK3CD)
   04213 Longevity regulating pathway - multiple species
    102422649 (PIK3CD)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102422649 (PIK3CD)
   05206 MicroRNAs in cancer
    102422649 (PIK3CD)
   05205 Proteoglycans in cancer
    102422649 (PIK3CD)
   05207 Chemical carcinogenesis - receptor activation
    102422649 (PIK3CD)
   05208 Chemical carcinogenesis - reactive oxygen species
    102422649 (PIK3CD)
   05203 Viral carcinogenesis
    102422649 (PIK3CD)
   05230 Central carbon metabolism in cancer
    102422649 (PIK3CD)
   05231 Choline metabolism in cancer
    102422649 (PIK3CD)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102422649 (PIK3CD)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102422649 (PIK3CD)
   05212 Pancreatic cancer
    102422649 (PIK3CD)
   05225 Hepatocellular carcinoma
    102422649 (PIK3CD)
   05226 Gastric cancer
    102422649 (PIK3CD)
   05214 Glioma
    102422649 (PIK3CD)
   05221 Acute myeloid leukemia
    102422649 (PIK3CD)
   05220 Chronic myeloid leukemia
    102422649 (PIK3CD)
   05218 Melanoma
    102422649 (PIK3CD)
   05211 Renal cell carcinoma
    102422649 (PIK3CD)
   05215 Prostate cancer
    102422649 (PIK3CD)
   05213 Endometrial cancer
    102422649 (PIK3CD)
   05224 Breast cancer
    102422649 (PIK3CD)
   05222 Small cell lung cancer
    102422649 (PIK3CD)
   05223 Non-small cell lung cancer
    102422649 (PIK3CD)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102422649 (PIK3CD)
   05170 Human immunodeficiency virus 1 infection
    102422649 (PIK3CD)
   05161 Hepatitis B
    102422649 (PIK3CD)
   05160 Hepatitis C
    102422649 (PIK3CD)
   05171 Coronavirus disease - COVID-19
    102422649 (PIK3CD)
   05164 Influenza A
    102422649 (PIK3CD)
   05162 Measles
    102422649 (PIK3CD)
   05168 Herpes simplex virus 1 infection
    102422649 (PIK3CD)
   05163 Human cytomegalovirus infection
    102422649 (PIK3CD)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102422649 (PIK3CD)
   05169 Epstein-Barr virus infection
    102422649 (PIK3CD)
   05165 Human papillomavirus infection
    102422649 (PIK3CD)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102422649 (PIK3CD)
   05135 Yersinia infection
    102422649 (PIK3CD)
   05100 Bacterial invasion of epithelial cells
    102422649 (PIK3CD)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102422649 (PIK3CD)
   05142 Chagas disease
    102422649 (PIK3CD)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102422649 (PIK3CD)
   05017 Spinocerebellar ataxia
    102422649 (PIK3CD)
   05020 Prion disease
    102422649 (PIK3CD)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102422649 (PIK3CD)
   05418 Fluid shear stress and atherosclerosis
    102422649 (PIK3CD)
   05415 Diabetic cardiomyopathy
    102422649 (PIK3CD)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102422649 (PIK3CD)
   04932 Non-alcoholic fatty liver disease
    102422649 (PIK3CD)
   04931 Insulin resistance
    102422649 (PIK3CD)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102422649 (PIK3CD)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102422649 (PIK3CD)
   01524 Platinum drug resistance
    102422649 (PIK3CD)
   01522 Endocrine resistance
    102422649 (PIK3CD)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlf04131]
    102422649 (PIK3CD)
Enzymes [BR:mlf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102422649 (PIK3CD)
Membrane trafficking [BR:mlf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102422649 (PIK3CD)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2
Other DBs
NCBI-GeneID: 102422649
NCBI-ProteinID: XP_023602126
Ensembl: ENSMLUG00000008026
LinkDB
Position
Unknown
AA seq 1048 aa
MPPGVDCPMEFWANEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKALWHRAQYEPLFH
MLSDPEAYVFTCVNQTAEQQELEDEQRKVCDIQPFLPVLPLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEENDFRVKMRQFCEEAAARRQQLGWEAWLQYSFPLQLEPSARTWGA
GTLRVPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGKQEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKSR
TKPPPIPMKKVSSLSLGSQQDPVPAVLTQGIKMIAVGRIKLVVQAGLFHGNETLCKTVSS
SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLTLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVCSNPNTESAAALVICLPEVAP
HPVYYPALDKILELGRHGEHGRATEEEQLQLREILERRGSGSGSGELYEHEKDLVWKMRH
EVQERFPEALARLLLVTKWNRHEDVAQMLYLLCSWPELPVLSALELLDSSFPDRHVGSFA
IKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMH
VPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKSPKPQTKELMH
LCMRQETYLEALSHLQSPLDPRILLAEVCVEQCTFMDSKMKPLWVMYSNEEAGGDGSVGI
IFKNGDDLRQDMLTLQMIQLMDILWKQEGLDLRMTPYGCLSTGDRTGLIEVVLRSDTIAN
IQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS
DNIMIRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERF
RGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFR
VKFNEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3147 nt   +upstreamnt  +downstreamnt
atgcccccgggggtggactgccccatggaattctgggccaacgaggagaaccagagcgtg
gcggtggacttcctgctgcccacgggggtctatctgaacttccccgtgtcccgcaatgcc
aacctcagcaccatcaagaaggcgctgtggcaccgagcccagtatgagccgctcttccac
atgctcagcgaccccgaggcctacgtgttcacctgcgtcaaccagacggcggagcagcag
gagctggaggacgagcagcggaaggtgtgcgacatccagcccttcctgcccgtcctgccc
ctagtggcccgcgagggcgaccgggtcaagaagctcatcaactcgcagatcagcctcctc
attggcaaaggcctgcacgagtttgattctttgcgggacccggaggagaatgactttcga
gtcaagatgcgccagttctgtgaggaggcggccgcccggcggcagcagctgggctgggag
gcctggctgcagtacagcttccccctgcagctggaaccctcggcgcggacctggggcgcc
ggcaccctgcgggtccccaaccgggccctcctggtcaacgtcaagttcgagggcagtgag
gagagcttcaccttccaggtgtccaccaaggacgtgcccctggcgctgatggcctgcgcc
ctgcggaagaaggccacggtgttccggcagcccctggtggagcagcccgaggactacacg
ctgcaggtgaacgggaagcaggagtacctgtacggcagctacccgctctgccagttccag
tacatctgcagctgcctgcacagcgggctgaccccccacctgaccatggtccactcctcc
tccatcctcgccatgcgggacgagcagagcaacccggccccccaggtccaaaaatcgcgc
accaagccgccccccattcccatgaagaaggtgagctctctgagcttgggcagccaacaa
gaccctgtgccggctgtcttgactcagggcattaaaatgattgcggtcgggcgtataaag
ctggtggtgcaggccgggctcttccacggcaacgagacgctgtgcaagacggtgtccagc
tcggaggtgagcgtgtgctcggagcccgtgtggaagcagcgcctggagttcgacatcaac
gtgtgcgacctgccccgcatggcccggctctgcttcgcgctgtacgccgtcatcgagaag
gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gctaacctcaccctgttcgactacaaggaccagctcaagaccggcgagcgctgcctctac
atgtggccctcggtcccagacgagaaaggggagctgctgaaccccacaggaaccgtgtgc
agcaaccccaacaccgagagtgctgccgccctggtcatctgtctccccgaggtggcgccc
caccccgtgtactaccccgccctggacaagatcctggagctggggcggcacggggagcac
gggcgcgccacggaggaggagcagctgcagctccgggaaatcctggagcggcgcgggtcc
gggtccgggtccggggagctgtacgagcacgagaaggacttggtgtggaagatgcgccac
gaggtgcaggagcgcttccccgaggcgctggcccggctgctgctggtcaccaagtggaac
aggcacgaggacgtggcccagatgctctacctgctctgctcctggccggagctgcccgtc
ctgagcgccctggagctgctggactccagcttccccgaccgccacgtgggctccttcgcc
atcaagtccctgcgaaagctgacggacgacgagctgttccagtacctgctgcagctggtg
caggtgctcaagtacgagtcctacctggactgcgagctgacgaaattcctgctggaccgg
gcgctggccaaccgcaagatcggccacttcctcttctggcacctccgctccgagatgcac
gtgccctcggtggccctacgcttcggcctcatcatggaggcctactgcaggggcagcacc
caccacatgaaggtgctgatgaagcagggggaggcgctgagcaagctgaaggccctgaac
gacttcgtcaaagtgagctcccagaagagccccaagccgcagaccaaggagctgatgcac
ctgtgcatgcgccaggagacctacctggaggccctgtcccacctgcagtccccgctggac
cccaggatcctgctggcggaagtctgtgtggagcagtgcaccttcatggactccaagatg
aagccgctgtgggtcatgtacagcaacgaggaggcgggcggcgacggcagcgtgggcatc
atctttaagaacggggacgacctccgccaggacatgctgacgctgcagatgatccagctc
atggacatcctgtggaagcaggaggggctggacctgaggatgaccccctacggctgcctc
tccaccggggaccgcacgggcctcatcgaggtggtgcttcgctcagacaccatcgccaac
atccagctcaacaagagcaacatggcagccacggccgctttcaacaaggacgccctactc
aactggctcaagtccaagaaccctggggaggccctggacagggccatcgaggagttcacc
ctctcctgcgctggctactgtgtggccacgtacgtgctgggcatcggcgaccggcacagc
gacaacatcatgatccgcgagaacgggcagctgttccacattgattttggccactttctg
gggaatttcaagaccaagtttggaatcaaccgtgagcgagtcccattcatcctcacctat
gactttgtccatgtgattcagcaggggaagactaacaacagtgagaagtttgaaaggttc
cgtggctactgcgagagagcctacaccatcctgaggcgccatgggctgctcttcctccac
ctcttcgccctgatgcgggcggcaggcctgccagagctcagctgctccaaagacatccag
tatctcaaggactcgctggcgctggggaaaacggaggaggaggcgctgaagcacttccgc
gtgaagttcaacgaggcgctgcgggagagctggaagaccaaagtgaactggctggcccac
aacgtgtccaaagacaaccggcaatag

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