KEGG   Myotis lucifugus (little brown bat): 102433534
Entry
102433534         CDS       T07795                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mlf  Myotis lucifugus (little brown bat)
Pathway
mlf00562  Inositol phosphate metabolism
mlf01100  Metabolic pathways
mlf01521  EGFR tyrosine kinase inhibitor resistance
mlf01522  Endocrine resistance
mlf01524  Platinum drug resistance
mlf04012  ErbB signaling pathway
mlf04014  Ras signaling pathway
mlf04015  Rap1 signaling pathway
mlf04024  cAMP signaling pathway
mlf04062  Chemokine signaling pathway
mlf04066  HIF-1 signaling pathway
mlf04068  FoxO signaling pathway
mlf04070  Phosphatidylinositol signaling system
mlf04071  Sphingolipid signaling pathway
mlf04072  Phospholipase D signaling pathway
mlf04081  Hormone signaling
mlf04140  Autophagy - animal
mlf04145  Phagocytosis
mlf04150  mTOR signaling pathway
mlf04151  PI3K-Akt signaling pathway
mlf04152  AMPK signaling pathway
mlf04210  Apoptosis
mlf04211  Longevity regulating pathway
mlf04213  Longevity regulating pathway - multiple species
mlf04218  Cellular senescence
mlf04360  Axon guidance
mlf04370  VEGF signaling pathway
mlf04380  Osteoclast differentiation
mlf04510  Focal adhesion
mlf04517  IgSF CAM signaling
mlf04518  Integrin signaling
mlf04550  Signaling pathways regulating pluripotency of stem cells
mlf04611  Platelet activation
mlf04613  Neutrophil extracellular trap formation
mlf04620  Toll-like receptor signaling pathway
mlf04625  C-type lectin receptor signaling pathway
mlf04630  JAK-STAT signaling pathway
mlf04650  Natural killer cell mediated cytotoxicity
mlf04660  T cell receptor signaling pathway
mlf04662  B cell receptor signaling pathway
mlf04664  Fc epsilon RI signaling pathway
mlf04666  Fc gamma R-mediated phagosome formation
mlf04668  TNF signaling pathway
mlf04670  Leukocyte transendothelial migration
mlf04722  Neurotrophin signaling pathway
mlf04725  Cholinergic synapse
mlf04750  Inflammatory mediator regulation of TRP channels
mlf04810  Regulation of actin cytoskeleton
mlf04910  Insulin signaling pathway
mlf04914  Progesterone-mediated oocyte maturation
mlf04915  Estrogen signaling pathway
mlf04917  Prolactin signaling pathway
mlf04919  Thyroid hormone signaling pathway
mlf04923  Regulation of lipolysis in adipocytes
mlf04926  Relaxin signaling pathway
mlf04929  GnRH secretion
mlf04930  Type II diabetes mellitus
mlf04931  Insulin resistance
mlf04932  Non-alcoholic fatty liver disease
mlf04933  AGE-RAGE signaling pathway in diabetic complications
mlf04935  Growth hormone synthesis, secretion and action
mlf04960  Aldosterone-regulated sodium reabsorption
mlf04973  Carbohydrate digestion and absorption
mlf05010  Alzheimer disease
mlf05017  Spinocerebellar ataxia
mlf05020  Prion disease
mlf05100  Bacterial invasion of epithelial cells
mlf05132  Salmonella infection
mlf05135  Yersinia infection
mlf05142  Chagas disease
mlf05146  Amoebiasis
mlf05160  Hepatitis C
mlf05161  Hepatitis B
mlf05162  Measles
mlf05163  Human cytomegalovirus infection
mlf05164  Influenza A
mlf05165  Human papillomavirus infection
mlf05166  Human T-cell leukemia virus 1 infection
mlf05167  Kaposi sarcoma-associated herpesvirus infection
mlf05168  Herpes simplex virus 1 infection
mlf05169  Epstein-Barr virus infection
mlf05170  Human immunodeficiency virus 1 infection
mlf05171  Coronavirus disease
mlf05200  Pathways in cancer
mlf05203  Viral carcinogenesis
mlf05205  Proteoglycans in cancer
mlf05206  MicroRNAs in cancer
mlf05207  Chemical carcinogenesis - receptor activation
mlf05208  Chemical carcinogenesis - reactive oxygen species
mlf05210  Colorectal cancer
mlf05211  Renal cell carcinoma
mlf05212  Pancreatic cancer
mlf05213  Endometrial cancer
mlf05214  Glioma
mlf05215  Prostate cancer
mlf05218  Melanoma
mlf05220  Chronic myeloid leukemia
mlf05221  Acute myeloid leukemia
mlf05222  Small cell lung cancer
mlf05223  Non-small cell lung cancer
mlf05224  Breast cancer
mlf05225  Hepatocellular carcinoma
mlf05226  Gastric cancer
mlf05230  Central carbon metabolism in cancer
mlf05231  Choline metabolism in cancer
mlf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlf05415  Diabetic cardiomyopathy
mlf05417  Lipid and atherosclerosis
mlf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102433534 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    102433534 (PIK3CA)
   04014 Ras signaling pathway
    102433534 (PIK3CA)
   04015 Rap1 signaling pathway
    102433534 (PIK3CA)
   04370 VEGF signaling pathway
    102433534 (PIK3CA)
   04630 JAK-STAT signaling pathway
    102433534 (PIK3CA)
   04668 TNF signaling pathway
    102433534 (PIK3CA)
   04066 HIF-1 signaling pathway
    102433534 (PIK3CA)
   04068 FoxO signaling pathway
    102433534 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    102433534 (PIK3CA)
   04072 Phospholipase D signaling pathway
    102433534 (PIK3CA)
   04071 Sphingolipid signaling pathway
    102433534 (PIK3CA)
   04024 cAMP signaling pathway
    102433534 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    102433534 (PIK3CA)
   04152 AMPK signaling pathway
    102433534 (PIK3CA)
   04150 mTOR signaling pathway
    102433534 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102433534 (PIK3CA)
   04517 IgSF CAM signaling
    102433534 (PIK3CA)
   04518 Integrin signaling
    102433534 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    102433534 (PIK3CA)
   04140 Autophagy - animal
    102433534 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    102433534 (PIK3CA)
   04218 Cellular senescence
    102433534 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102433534 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    102433534 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102433534 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102433534 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    102433534 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    102433534 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    102433534 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    102433534 (PIK3CA)
   04660 T cell receptor signaling pathway
    102433534 (PIK3CA)
   04662 B cell receptor signaling pathway
    102433534 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    102433534 (PIK3CA)
   04666 Fc gamma R-mediated phagosome formation
    102433534 (PIK3CA)
   04670 Leukocyte transendothelial migration
    102433534 (PIK3CA)
   04062 Chemokine signaling pathway
    102433534 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102433534 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    102433534 (PIK3CA)
   04929 GnRH secretion
    102433534 (PIK3CA)
   04915 Estrogen signaling pathway
    102433534 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    102433534 (PIK3CA)
   04917 Prolactin signaling pathway
    102433534 (PIK3CA)
   04926 Relaxin signaling pathway
    102433534 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    102433534 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    102433534 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102433534 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    102433534 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    102433534 (PIK3CA)
   04722 Neurotrophin signaling pathway
    102433534 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102433534 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    102433534 (PIK3CA)
   04380 Osteoclast differentiation
    102433534 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    102433534 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    102433534 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102433534 (PIK3CA)
   05206 MicroRNAs in cancer
    102433534 (PIK3CA)
   05205 Proteoglycans in cancer
    102433534 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    102433534 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    102433534 (PIK3CA)
   05203 Viral carcinogenesis
    102433534 (PIK3CA)
   05230 Central carbon metabolism in cancer
    102433534 (PIK3CA)
   05231 Choline metabolism in cancer
    102433534 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102433534 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102433534 (PIK3CA)
   05212 Pancreatic cancer
    102433534 (PIK3CA)
   05225 Hepatocellular carcinoma
    102433534 (PIK3CA)
   05226 Gastric cancer
    102433534 (PIK3CA)
   05214 Glioma
    102433534 (PIK3CA)
   05221 Acute myeloid leukemia
    102433534 (PIK3CA)
   05220 Chronic myeloid leukemia
    102433534 (PIK3CA)
   05218 Melanoma
    102433534 (PIK3CA)
   05211 Renal cell carcinoma
    102433534 (PIK3CA)
   05215 Prostate cancer
    102433534 (PIK3CA)
   05213 Endometrial cancer
    102433534 (PIK3CA)
   05224 Breast cancer
    102433534 (PIK3CA)
   05222 Small cell lung cancer
    102433534 (PIK3CA)
   05223 Non-small cell lung cancer
    102433534 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102433534 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    102433534 (PIK3CA)
   05161 Hepatitis B
    102433534 (PIK3CA)
   05160 Hepatitis C
    102433534 (PIK3CA)
   05171 Coronavirus disease
    102433534 (PIK3CA)
   05164 Influenza A
    102433534 (PIK3CA)
   05162 Measles
    102433534 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    102433534 (PIK3CA)
   05163 Human cytomegalovirus infection
    102433534 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102433534 (PIK3CA)
   05169 Epstein-Barr virus infection
    102433534 (PIK3CA)
   05165 Human papillomavirus infection
    102433534 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102433534 (PIK3CA)
   05135 Yersinia infection
    102433534 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    102433534 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    102433534 (PIK3CA)
   05142 Chagas disease
    102433534 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102433534 (PIK3CA)
   05017 Spinocerebellar ataxia
    102433534 (PIK3CA)
   05020 Prion disease
    102433534 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102433534 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    102433534 (PIK3CA)
   05415 Diabetic cardiomyopathy
    102433534 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102433534 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    102433534 (PIK3CA)
   04931 Insulin resistance
    102433534 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102433534 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102433534 (PIK3CA)
   01524 Platinum drug resistance
    102433534 (PIK3CA)
   01522 Endocrine resistance
    102433534 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlf04131]
    102433534 (PIK3CA)
Enzymes [BR:mlf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     102433534 (PIK3CA)
Membrane trafficking [BR:mlf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    102433534 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 102433534
NCBI-ProteinID: XP_014307826
Ensembl: ENSMLUG00000009229
LinkDB
Position
Unknown
AA seq 1069 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDYVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWGINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLEMEFDWF
SSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGPSNRLARDNELRENDKEQLRAICTRDP
LSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAM
ELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALT
NQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDIL
KQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPL
WLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCL
SIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTR
SCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQD
FLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDI
AYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3210 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattagtaactataaagcatgaactatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgatcttcggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcac
agtagagcaatgtatgtttatcctccaaatgtagaatcttcaccagaattgccaaaacac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgattatgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctttgtgttctagagtatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcaatataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaggaaagcctttactcgcagctgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacctctacaaaatccctttggggtataaatagtgcactcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgacatatacattcctgatcttcctcgtgctgct
cggctttgcctttccatttgttctgttaaaggtcgaaaaggtgctaaagaggaacactgt
ccattggcgtggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagatggagtttgactggttc
agcagtagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaactggtct
gtgtcccgagaagcaggatttagttattcccatgcaggaccgagtaacagactagctaga
gacaacgaattaagggaaaatgataaagaacagctccgagcaatttgtacccgagatcct
ctctctgaaatcactgagcaggagaaagattttctttggagccacagacactattgtgta
actatccctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaa
gtagctcagatgtactgcttggtaaaagactggcctccaatcaaacccgaacaagctatg
gagcttctggactgcaactacccagaccctatggttcgaagttttgctgttcgatgctta
gaaaaatatttaacagatgacaaactttctcagtatctaattcagctagtacaggtccta
aaatatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcgttgact
aatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaaca
gttagtcagaggtttggcctgcttttggaatcctactgccgtgcatgtgggatgtatttg
aagcacctgaacaggcaagtcgaggctatggaaaagctcatcaacttaactgacattctc
aaacaagagaagaaggatgagactcaaaaggtacagatgaaatttttagttgagcagatg
cggcgaccagatttcatggatgctctacagggctttctatctcctctaaatcctgctcat
caattagggaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg
tggttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatc
atctttaaaaatggggatgatttgcggcaagatatgctaacacttcaaattattcgcatt
atggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttgccttatggctgcctg
tccattggggactgtgtggggctcattgaggtggtgagaaactctcacaccatcatgcag
atccagtgcaaagggggcctgaaaggggccctgcagttcaacagccacacgctgcaccag
tggctcaaggacaagaacaaaggggaaatatatgatgcagccattgatctgtttacacgt
tcatgtgctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagc
aacatcatggttaaagatgatggacaactgttccatatagattttggacactttttggat
cacaagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaagat
ttcttaatagtgattagtaaaggagcccaggaatgcaccaagacaagagaatttgagagg
tttcaggagatgtgttacaaagcttatctagctatccggcagcatgccaatctcttcata
aatcttttctcaatgatgcttggctctgggatgccagaactacaatcttttgatgatatt
gcatacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttc
atgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttc
cacacaattaagcagcatgctttgaactga

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