Entry |
|
Symbol |
PLCB4
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
|
KO |
|
Organism |
mlk Mustela lutreola (European mink)
|
Pathway |
mlk04070 | Phosphatidylinositol signaling system |
mlk04072 | Phospholipase D signaling pathway |
mlk04261 | Adrenergic signaling in cardiomyocytes |
mlk04270 | Vascular smooth muscle contraction |
mlk04613 | Neutrophil extracellular trap formation |
mlk04621 | NOD-like receptor signaling pathway |
mlk04723 | Retrograde endocannabinoid signaling |
mlk04750 | Inflammatory mediator regulation of TRP channels |
mlk04919 | Thyroid hormone signaling pathway |
mlk04925 | Aldosterone synthesis and secretion |
mlk04927 | Cortisol synthesis and secretion |
mlk04928 | Parathyroid hormone synthesis, secretion and action |
mlk04933 | AGE-RAGE signaling pathway in diabetic complications |
mlk04935 | Growth hormone synthesis, secretion and action |
mlk04961 | Endocrine and other factor-regulated calcium reabsorption |
mlk04973 | Carbohydrate digestion and absorption |
mlk05022 | Pathways of neurodegeneration - multiple diseases |
mlk05163 | Human cytomegalovirus infection |
|
Module |
mlk_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mlk00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
131808080 (PLCB4)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
131808080 (PLCB4)
04310 Wnt signaling pathway
131808080 (PLCB4)
04371 Apelin signaling pathway
131808080 (PLCB4)
04020 Calcium signaling pathway
131808080 (PLCB4)
04070 Phosphatidylinositol signaling system
131808080 (PLCB4)
04072 Phospholipase D signaling pathway
131808080 (PLCB4)
04071 Sphingolipid signaling pathway
131808080 (PLCB4)
04022 cGMP-PKG signaling pathway
131808080 (PLCB4)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
131808080 (PLCB4)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
131808080 (PLCB4)
04613 Neutrophil extracellular trap formation
131808080 (PLCB4)
04621 NOD-like receptor signaling pathway
131808080 (PLCB4)
04062 Chemokine signaling pathway
131808080 (PLCB4)
09152 Endocrine system
04911 Insulin secretion
131808080 (PLCB4)
04922 Glucagon signaling pathway
131808080 (PLCB4)
04929 GnRH secretion
131808080 (PLCB4)
04912 GnRH signaling pathway
131808080 (PLCB4)
04915 Estrogen signaling pathway
131808080 (PLCB4)
04921 Oxytocin signaling pathway
131808080 (PLCB4)
04926 Relaxin signaling pathway
131808080 (PLCB4)
04935 Growth hormone synthesis, secretion and action
131808080 (PLCB4)
04918 Thyroid hormone synthesis
131808080 (PLCB4)
04919 Thyroid hormone signaling pathway
131808080 (PLCB4)
04928 Parathyroid hormone synthesis, secretion and action
131808080 (PLCB4)
04916 Melanogenesis
131808080 (PLCB4)
04924 Renin secretion
131808080 (PLCB4)
04925 Aldosterone synthesis and secretion
131808080 (PLCB4)
04927 Cortisol synthesis and secretion
131808080 (PLCB4)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
131808080 (PLCB4)
04270 Vascular smooth muscle contraction
131808080 (PLCB4)
09154 Digestive system
04970 Salivary secretion
131808080 (PLCB4)
04971 Gastric acid secretion
131808080 (PLCB4)
04972 Pancreatic secretion
131808080 (PLCB4)
04973 Carbohydrate digestion and absorption
131808080 (PLCB4)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
131808080 (PLCB4)
09156 Nervous system
04724 Glutamatergic synapse
131808080 (PLCB4)
04725 Cholinergic synapse
131808080 (PLCB4)
04728 Dopaminergic synapse
131808080 (PLCB4)
04726 Serotonergic synapse
131808080 (PLCB4)
04720 Long-term potentiation
131808080 (PLCB4)
04730 Long-term depression
131808080 (PLCB4)
04723 Retrograde endocannabinoid signaling
131808080 (PLCB4)
09157 Sensory system
04742 Taste transduction
131808080 (PLCB4)
04750 Inflammatory mediator regulation of TRP channels
131808080 (PLCB4)
09159 Environmental adaptation
04713 Circadian entrainment
131808080 (PLCB4)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
131808080 (PLCB4)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
131808080 (PLCB4)
09174 Infectious disease: parasitic
05146 Amoebiasis
131808080 (PLCB4)
05142 Chagas disease
131808080 (PLCB4)
05143 African trypanosomiasis
131808080 (PLCB4)
09164 Neurodegenerative disease
05010 Alzheimer disease
131808080 (PLCB4)
05016 Huntington disease
131808080 (PLCB4)
05017 Spinocerebellar ataxia
131808080 (PLCB4)
05022 Pathways of neurodegeneration - multiple diseases
131808080 (PLCB4)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
131808080 (PLCB4)
05415 Diabetic cardiomyopathy
131808080 (PLCB4)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
131808080 (PLCB4)
04934 Cushing syndrome
131808080 (PLCB4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mlk04131]
131808080 (PLCB4)
Enzymes [BR:mlk01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
131808080 (PLCB4)
Membrane trafficking [BR:mlk04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
131808080 (PLCB4)
Endocytosis
Macropinocytosis
Phospholipase C
131808080 (PLCB4)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
9:34470666..34881964
|
AA seq |
1206 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSIRLGATPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVSILEDDNEEEIESADQEEEAHPEYKFGNELSADDLGHKEAVANSVKKASD
DLEHEINKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNI
HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS
LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI
SGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLA
VLRIAVYDDNNRLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGF
GDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQ
SSSELRPTTTAALGSGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAK
EHSTMQKLHCTQVDKMVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSD
HKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKMS
HDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMK
QSKEMDQLKKVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEVGSRDGPQASNSSV
KLQNSN |
NT seq |
3621 nt +upstreamnt +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gccgtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgaatttggcttctttctgacctggaggagtgaaggcaaggaaggacaagtgcta
gaatgttccctcatcaacagtattcgattgggagccacacccaaggatcccaaaatcctg
gccgctctcgaagctgttggaaagtcagagaatgatctggaagggcggatagtttgtgtt
tgcagcggcacagatctggtgaacatcagtttcacatacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggactgagatcgatcatacacaacttcagggccaacaat
gtcagtccaatgacctgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaaa
gtgatctttcaagcactcaaggaattaggtcttcccagtggaaagaatgacgaaattgag
cctgcggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcagcgagaccctcgactgaatgaaattttattc
ccattttacgatgctaaaagggcaatgcagatcatcgagatgtatgagcccgatgaagat
ttgaagaaaaaaggcctcatatcaagcgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctggatcgtttagaactttaccaagaaatggaccatcctctggcc
cactacttcatcagttcttcccataacacctatctcacgggccgacagtttggcgggaaa
tcttcagtagaaatgtacagacaggttctcctggctggttgcagatgcgttgaacttgac
tgttgggatggaaaaggtgaagatcaagaaccgataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgttattcaagccatcaaggaaaccgcatttgtcacatcc
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcagcagtacaagatg
tccaaatattgcgaagatctatttggggatctcctgttgaaacaagcacttgaatcacat
ccacttgaaccaggcagacccttaccatcccccaatgacctcaaaagaaaaatactcatc
aaaaataagcggctgaaacctgaggttgaaaaaaaacagctcgaggctttgaaaagcatg
atggaagctggagaatctgctgccccggttagcatcctagaggatgataatgaagaggaa
atagaaagtgctgaccaagaggaggaagctcaccccgaatacaaatttggaaacgaactt
tctgctgatgacttgggccacaaggaggctgttgcaaatagtgtcaagaaggcttcagat
gaccttgaacatgaaatcaacaaaaagggcctggtgaccgtggaagacgaacaggcatgg
atggcgtcttataaatatgtaggtgctaccactaacatccatccgtatttgtctacaatg
atcaactatgcacaacccgtaaagtttcaaggtttccatgtggctgaagagcgcaatatt
cattataacatgtcttcttttaatgagtccgtcggcctgggctacttgaagacgcacgcc
attgaatttgtgaattataacaaacggcaaatgagccgcatttaccccaagggaggccgg
gtcgattccagtaattacatgcctcagattttctggaatgctggctgccagatggtttcg
ctcaactatcaaaccccagatttagcgatgcaattgaatcagggaaaatttgagtataat
ggatcatgcgggtacctcctcaaaccagatttcatgagacggcccgatcgaacattcgat
cccttctctgaaactcctgtcgatggggttattgcggccacttgctcagtccaggtcata
tcaggtcagtttttatcagataagaaaattggtacatacgtagaagtggatatgtatggg
ttgcccaccgacaccatacgtaaggaattccgaactcgcatggtgatgaacaacggactc
aatccagtttacaatgaagaatcatttgtgttccggaaggtaatcctccctgacctggca
gtcttgagaatagcagtgtatgacgacaacaacaggctcataggccagaggatccttcct
ctggatggcctccaagcaggctatcgacacatttcccttcgaaacgagggaaataaacca
ttatcactgccaaccattttctgcaatattgttcttaaaacatatgtgcctgatggattt
ggagatatcgtagatgctttatcagatccaaagaaatttctttccattacggaaaagaga
gcagaccaaatgagagctatgggcattgaaactagtgacatagcagatgtgcccagtgat
acttctaagaatgacaagaaaggaaaagccaacactgccaaagcaaacgtgaccccacag
agcagctctgagctcagaccaaccaccacagcggccctggggtctggcgtggaagcgaag
aaaggtatcgaacttatccctcaagtgaggatagaagatttgaagcagatgaaggcttac
ctgaagcacttaaagaaacagcagaaggagctaaattctttaaagaagaaacacgcaaag
gagcacagcacaatgcagaagttgcactgcacacaagttgacaagatggtggcacagtac
gacaaagagaagtcgacgcatgagaaaatcctagagaaagcgatgaagaagaaaggggga
agtaattgtctcgaaatgaaaaaagaaactgaaattaaaattcagacactgacatcagat
cacaaatctaaggtcaaagagatagtggcccagcacacaaaggagtggtcagaaatgatc
aacacccacagtgctgaggagcaagaaatccgggacctacacctcagccagcagtgtgag
ctcctgagaaaactactgatcaatgcccatgagcagcaaacccagcagctgaaaatgtcc
catgacagggaaagcaaggaaatgcgagcacaccaggctaagatttctatggaaaacagc
aaagccatcagccaagataaatctatcaagaacaaagctgaacgggaaaggcgagtcagg
gagttaaatagcagcaacaccaaaaagtttctggaagaaagaaagagacttgcaatgaaa
cagtccaaagaaatggatcagttgaaaaaagtccagcttgaacacctcgagttcctagag
aaacagaatgagcagctattgaaatcctgccatgcagtgtcccaaacacaaggcgaagga
gatgcagcagatggtgaagttggaagccgagatggaccgcaggccagcaacagtagtgtg
aaactccaaaattcaaactga |