KEGG   Mustela lutreola (European mink): 131811851
Entry
131811851         CDS       T09578                                 
Symbol
ROCK1
Name
(RefSeq) rho-associated protein kinase 1 isoform X1
  KO
K04514  Rho-associated protein kinase 1 [EC:2.7.11.39]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk04022  cGMP-PKG signaling pathway
mlk04024  cAMP signaling pathway
mlk04062  Chemokine signaling pathway
mlk04071  Sphingolipid signaling pathway
mlk04270  Vascular smooth muscle contraction
mlk04350  TGF-beta signaling pathway
mlk04360  Axon guidance
mlk04510  Focal adhesion
mlk04520  Adherens junction
mlk04530  Tight junction
mlk04611  Platelet activation
mlk04670  Leukocyte transendothelial migration
mlk04810  Regulation of actin cytoskeleton
mlk04921  Oxytocin signaling pathway
mlk05135  Yersinia infection
mlk05163  Human cytomegalovirus infection
mlk05200  Pathways in cancer
mlk05205  Proteoglycans in cancer
mlk05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    131811851 (ROCK1)
   04071 Sphingolipid signaling pathway
    131811851 (ROCK1)
   04024 cAMP signaling pathway
    131811851 (ROCK1)
   04022 cGMP-PKG signaling pathway
    131811851 (ROCK1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    131811851 (ROCK1)
   04520 Adherens junction
    131811851 (ROCK1)
   04530 Tight junction
    131811851 (ROCK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    131811851 (ROCK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    131811851 (ROCK1)
   04670 Leukocyte transendothelial migration
    131811851 (ROCK1)
   04062 Chemokine signaling pathway
    131811851 (ROCK1)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    131811851 (ROCK1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    131811851 (ROCK1)
  09158 Development and regeneration
   04360 Axon guidance
    131811851 (ROCK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131811851 (ROCK1)
   05206 MicroRNAs in cancer
    131811851 (ROCK1)
   05205 Proteoglycans in cancer
    131811851 (ROCK1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    131811851 (ROCK1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    131811851 (ROCK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlk01001]
    131811851 (ROCK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mlk03036]
    131811851 (ROCK1)
Enzymes [BR:mlk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.39  ROCK-subfamily protein kinase
     131811851 (ROCK1)
Protein kinases [BR:mlk01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   131811851 (ROCK1)
Chromosome and associated proteins [BR:mlk03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    131811851 (ROCK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 Pkinase_C APH
Other DBs
NCBI-GeneID: 131811851
NCBI-ProteinID: XP_058996793
LinkDB
Position
11:49475618..49623763
AA seq 1355 aa
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRSSPNV
DKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSKIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKVEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
AQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSVSQLESLNRELQERNRILENSKTQTD
KDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLSLQLEQES
NKRLLLQNELKTQAFEADNLKGQEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRESLKKIQELQSEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETTSMLTKDIEVLRKENE
EITDKMRRAEEEYKLKKEEEISNLKAAFEKIINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHKNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALE
CRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
PSGFVRASPRTLSTRSTANQSFRKAVKNTSGKTSS
NT seq 4068 nt   +upstreamnt  +downstreamnt
atgtcgactggggacagttttgagactcgatttgaaaaaatcgacaacctgctgcgggat
cccaaatcggaagtgaattcggattgtttgctggatggattggatgctttggtatatgat
ttggattttcctgccttaagaaaaaacaaaaatattgacaactttttaagcagatataaa
gacacaataaataaaattagagatttacgaatgaaagctgaagactatgaagtagtgaag
gtgattggtagaggtgcatttggagaagtacaattggtaagacataaatccaccaggaag
gtatatgctatgaagcttctcagtaaatttgaaatgattaagagatccgattctgctttt
ttctgggaagaaagggacatcatggcttttgctaacagcccttgggtcgtccagcttttt
tatgcattccaagatgatcgttatctctacatggtgatggagtacatgcctggtggagat
cttgtaaacttaatgagcaactatgatgtgcctgaaaaatgggcacgattctatactgca
gaagtagttcttgcattggatgcaatccattccatgggtttcattcatagagatgtgaaa
cctgataacatgctgctggataaatctggacatttgaagttagcagattttggtacttgt
atgaagatgaataaggaaggtatggtacgatgtgatacagcagttggaacacctgattac
atttcccctgaagtattaaaatctcaaggtggtgatggctattatggacgagaatgtgac
tggtggtcagttggggtatttttatatgaaatgcttgtaggtgatacacctttttatgca
gattctctggttggaacttacagtaagattatgaatcataaaaattcacttacctttcct
gatgataatgatatatcaaaagaagcaaaaaatcttatttgtgccttccttactgacaga
gaggtgagattagggcgaaatggtgttgaagaaatcaaacgacatctcttcttcaaaaat
gatcaatgggcttgggagacactcagagacactgtagcaccagttgtacctgatttaagt
agtgacattgatacaagtaattttgatgacttggaagaagataaaggagatgaagaaaca
ttccccatacctaaagcttttgttggcaatcaattaccttttgtaggatttacatattat
agcaatcgtagatacttatcttcagcaaatcctaatgataaccgaagtagccccaatgtg
gataaaagcttgcaggaaaatttgcaaaaaacaatttataagctggaagaacagctgcat
aatgaaatgcaattaaaagatgaaatggagcagaagtgcagaacttcaaagataaagcta
gacaagataatgaaagaattggatgaagaggggaatcaaagaagaaacctagaatctaca
gtttctcagattgagaaggagaaaatgttgctacagcatagaattaatgagtaccagaga
aaagtggaacaggaaaatgagaaaaggaggaatgtagaaaatgaagtttctacattaaag
gatcagttggaagacttaaagaaagtcagtcaaaattcacagcttgctaatgagaagctg
gcacaattacaaaagcagctagaagaagccaatgacttacttagaacagaatcagacaca
gctgtcagattaaggaagagtcacacagagatgagtaagtcagttagtcagctagagtcc
ctaaacagagaattgcaggagagaaatagaattttagagaattccaagacacagacggac
aaggactattaccagctgcaagctgtattagaagctgaacgaagagacagaggtcatgat
tctgagatgattggagaccttcaagctcgaattacatctttacaagaggaggtgaagcat
ctcaaacataatcttgaaaaagtggaaggagaaagaaaagaagctcaagacatgcttaat
cactcagaaaaggaaaaaaataatttagagatagatttaaactataagcttaaatcatta
caacaacgtttagaacaagaggtaaatgaacacaaagtaactaaagctcgtttaactgac
aaacatcaatctattgaagaggcaaagtctgttgcaatgtgtgaaatggaaaaaaagctg
aaggaagagagagaagctcgagagaaggctgaaaatagagttgttcagattgagaaacag
tgttcaatgctagatgttgatctgaaacaatctcagcagaagcttgagcatttgactgaa
aataaagaaaggatggaggatgaagttaagaatctgtcccttcaactggagcaggaatca
aacaagcggttgttattacagaatgaattgaagactcaagcatttgaagcagacaattta
aaaggtcaagaaaagcaaatgaaacaggaaataaatactttattggaagcaaagagatta
ttagaatttgaattagctcagcttacaaaacagtatagaggaaatgaaggacagatgcgg
gagctacaagatcagcttgaagctgagcaatatttctcgacactttataaaacccaggta
aaggaacttaaagaagaaattgaagaaaaaaacagagaaagtttaaagaaaatacaagaa
ctacaaagtgaaaaggaaactcttgctactcagctggatctagcagaaacaaaagctgag
tctgagcagttggctcgagggcttctagaagaacagtattttgaattaacccaagaaagc
aagaaagctgcttccagaaatagacaagagattacagataaagatcatactgttagtcgg
cttgaagaaacaaccagcatgttaaccaaagatattgaagtattaagaaaagaaaatgaa
gagataaccgataaaatgaggagggcagaggaggaatataaattgaagaaggaggaggag
atcagtaatcttaaggctgcctttgaaaagattatcaatacagaaagaacccttaaaacg
caggctgttaacaagttggcagaaataatgaatcggaaagattttaaaattgatagaaag
aaagctaatacacaggatttgagaaagaaggagaaggaaaatcgaaagctacaactggaa
ctcaaccaagaaagagagaaattcaaccagatggtagtgaaacatcagaaggaactgaat
gacatgcaggcgcaattggtagaagaatgtgcacataagaatgagcttcagatgcaattg
gctagcaaagagagtgatatagagcaattgcgtgctaaacttttggacctttcggattct
acaagtgttgctagttttcctagtgctgatgaaactgatggaaaccttccagagtcaaga
attgaaggttggctttcaataccaaatcgaggaaatatcaaacgatatggctggaagaag
cagtatgttgtggtgagcagcaaaaaaattttgttctataatgatgaacaagataaggaa
caatccagtccatccatggtattggacatagataaattgtttcacgttcgacctgtaacc
caaggagatgtttacagggctgaaactgaagaaattcctaaaatattccagatcctatat
gcaaatgaaggtgaatgtagaaaagatgtagagatggaaccagtacagcaagctgaaaag
actaattttcaaaaccacaaaggccatgagttcattcctacactctaccactttcctgcc
aactgtgaggcctgtgccaaacctctctggcatgtttttaagccacctcctgccctagaa
tgtcgaagatgccatgttaagtgccacagagatcacttagataagaaagaggacttaatt
tctccctgtaaagtaagttatgatgtaacatcagcaagagatatgctgctgttagcatgt
tctcaggatgaacaaaaaaaatgggtgacacatttggtaaagaaaatccctaagaatcca
ccatctggttttgttcgtgcatcccctcgaacactttctacaagatctactgcaaatcag
tctttccgaaaagcggtcaaaaatacatccggaaaaactagcagttaa

DBGET integrated database retrieval system