KEGG   Mustela lutreola (European mink): 131812295
Entry
131812295         CDS       T09578                                 
Symbol
HSPA5
Name
(RefSeq) endoplasmic reticulum chaperone BiP
  KO
K09490  endoplasmic reticulum chaperone BiP [EC:5.6.1.10]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk03060  Protein export
mlk04141  Protein processing in endoplasmic reticulum
mlk04612  Antigen processing and presentation
mlk04918  Thyroid hormone synthesis
mlk05012  Parkinson disease
mlk05014  Amyotrophic lateral sclerosis
mlk05020  Prion disease
mlk05022  Pathways of neurodegeneration - multiple diseases
mlk05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03060 Protein export
    131812295 (HSPA5)
   04141 Protein processing in endoplasmic reticulum
    131812295 (HSPA5)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    131812295 (HSPA5)
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    131812295 (HSPA5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    131812295 (HSPA5)
   05014 Amyotrophic lateral sclerosis
    131812295 (HSPA5)
   05020 Prion disease
    131812295 (HSPA5)
   05022 Pathways of neurodegeneration - multiple diseases
    131812295 (HSPA5)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131812295 (HSPA5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:mlk03110]
    131812295 (HSPA5)
   04131 Membrane trafficking [BR:mlk04131]
    131812295 (HSPA5)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mlk04147]
    131812295 (HSPA5)
Enzymes [BR:mlk01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.10  non-chaperonin molecular chaperone ATPase
     131812295 (HSPA5)
Chaperones and folding catalysts [BR:mlk03110]
 Heat shock proteins
  HSP70 / DNAK
   131812295 (HSPA5)
Membrane trafficking [BR:mlk04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    131812295 (HSPA5)
 Autophagy
  ER-phagy
   ER stress-related proteins
    131812295 (HSPA5)
Exosome [BR:mlk04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   131812295 (HSPA5)
  Exosomal proteins of other body fluids (saliva and urine)
   131812295 (HSPA5)
  Exosomal proteins of colorectal cancer cells
   131812295 (HSPA5)
SSDB
Motif
Pfam: HSP70 MreB_Mbl FtsA Hydantoinase_A FGGY_C DDR CC_BshC
Other DBs
NCBI-GeneID: 131812295
NCBI-ProteinID: XP_058997611
LinkDB
Position
12:9703454..9708176
AA seq 669 aa
MSCQPADRLAYGAGKMKLSLVAAVLLLLGAARAEEEDKKEDVGTVVGIDLGTTYSCVGVF
KNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWND
PSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKV
THAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDL
GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAV
QKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKV
LEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVL
SGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKV
YEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKIT
ITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGK
LSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGD
EEPADKDEL
NT seq 2010 nt   +upstreamnt  +downstreamnt
atgtcctgccagcctgccgaccgactggcctacggcgccggcaagatgaagctgtccctg
gtggctgcggtgctgctgctgctcggcgcggcgcgggccgaggaggaggacaagaaggag
gacgtgggcacggtggtggggatcgacctggggaccacctactcctgcgtcggggtgttc
aagaacggccgcgtggagatcatcgccaacgatcagggcaaccgcatcacgccgtcttat
gtggccttcactccggaaggggagcgtctgatcggcgacgcggccaagaaccagctcacc
tccaaccctgagaacacggtcttcgacgccaagcggctcatcggccgcacgtggaacgac
ccgtccgtgcagcaggacatcaagttcctgccgttcaaggtggttgagaagaagactaaa
ccatacattcaagtggatattggaggtgggcaaacaaagacatttgctcctgaagaaatt
tctgccatggttctcaccaaaatgaaggaaactgcagaggcttacttgggaaagaaggtt
acccatgcagttgttactgtaccagcctatttcaatgatgcccaacgacaggcaaccaaa
gatgctgggactattgctggattgaatgtcatgaggatcattaatgagcctacagcagct
gctattgcttatggcttggataagagggaaggggagaagaatattctggtgtttgacctg
ggtggtggaactttcgatgtatctcttctcaccattgacaatggtgtcttcgaagtcgta
gctactaacggagatactcatctgggtggagaagactttgaccaacgtgtcatggaacac
tttatcaaactctacaaaaagaagactggcaaagatgttagaaaagataacagagctgtg
cagaaactccggcgggaggtagaaaaggccaaacgggcactgtcttctcaacatcaagca
agaattgaaattgagtctttctatgaaggagaagacttctctgagactctgacacgggcc
aaatttgaagagctaaatatggacctgttccgttctaccatgaagcctgtccagaaggtg
ctggaggattctgacttaaagaagtctgatattgatgaaattgttcttgttggtggctct
actcgaatcccaaagattcaacaactggttaaagagttcttcaatggcaaggagccatcc
cgtggcatcaacccagatgaggctgtagcatatggtgctgctgtccaggctggtgtactt
tctggtgatcaagatacaggtgatctggtactgcttgatgtatgtccccttacacttggt
attgaaactgtgggaggcgtcatgaccaaactgattcccaggaacaccgtggtgcccacc
aagaagtctcagatcttttctacagcttctgataaccaaccaactgttacaatcaaggtc
tatgaaggtgaacgaccccttacaaaagacaatcaccttctgggaacttttgatctgact
ggaattcctcctgctccccgtggggtcccacagattgaagttacctttgagatagatgtg
aatggcattcttcgagtgacagccgaagacaagggtacaggcaacaaaaacaagattaca
attaccaatgaccaaaatcgtctgacacctgaagaaattgaaaggatggttaatgatgct
gagaagtttgccgaggaagacaaaaagctcaaggagcgcattgacaccagaaatgaattg
gaaagctatgcctattctctaaagaatcagattggagataaggaaaagctgggaggtaaa
ctctcctctgaagataaggagaccatggaaaaagctgtagaggaaaagattgaatggcta
gaaagtcaccaagatgctgacattgaagatttcaaagctaaaaagaaggaactagaagaa
attgttcagccaattatcagcaaactctatggaagtgcaggccctcccccaactggtgat
gaggaaccagcagacaaggatgagttgtag

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