Mustela lutreola (European mink): 131813128
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Entry
131813128 CDS
T09578
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X1
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
mlk
Mustela lutreola (European mink)
Pathway
mlk00790
Folate biosynthesis
mlk01100
Metabolic pathways
mlk01240
Biosynthesis of cofactors
mlk01523
Antifolate resistance
mlk04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
mlk00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
131813128 (FPGS)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
131813128 (FPGS)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
131813128 (FPGS)
Enzymes [BR:
mlk01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
131813128 (FPGS)
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
131813128
NCBI-ProteinID:
XP_058999297
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Position
12:complement(7510269..7529478)
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AA seq
589 aa
AA seq
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MSQARCHLRAALFLAAVSSRGATTGVTARRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQMQLDAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWHLYHRLEETKDSSSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGIDHTSLLGDTVEAI
AWQKGGIFKCGVPAFTVLQPDGPLAVLRDRAQQISCPLYLCPSLEALEEGGPPLTLGLEG
EHQRSNAALALQLARCWLQQKGHQGLGELKMSRPSVLRQMPLAPVFQPTSHMRHGLRDTE
WLGRTQTLRRGPLTWYLDGAHTVSSVQACVRWFRQALYRSQRPSRGREVRVLLFNSTGNR
DSEALLKLLQPCQFDYAVFCPNLTEVSSASNADQQNFMVTLDQVLLRCLAHQQHWSHLDE
ELASPDLWSPTSPEQGDEPTSLLLASRPRHPHSTGSLVFSCISHALQWISQGRDPVFQPP
SPPPSLLAHPVAGSGAGVLREAAAVHVLVTGSLHLVGGVLKLLDPSLSQ
NT seq
1770 nt
NT seq
+upstream
nt +downstream
nt
atgtcgcaggcacgctgccacctgcgcgccgctctcttcctggcagcagtttcttcgcgc
ggtgccacgaccggggtcacggcgcggcgagggttgagcgcgtggcccgcgccgcaggag
cccggcatggagtatcaggatgctgtgcgcacactgaacaccctgcagaccaatgctggc
tacctggagcaggtgaagcgccagcggggtgaccctcagatgcaactggacgcgatgaag
ctgtacttggcccggagtgggctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggttccacttgtgccttcactgaacgtattctccgcagc
tatggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaacgggcagcccataagccccgagctcttcaccaagcacttttggcacctctac
catcggctggaggagaccaaggacagcagcagctgtgtctccatgcccgcctacttccgc
ttcctcacactcatggccttccacatcttcctccaagagaaggtggacctagcagtggtg
gaagtgggcattggtggcgcttacgactgtaccaacatcatcaggaagcctgtggtgtgt
ggcatctcctctcttggcatcgaccacaccagccttctgggggacacagtggaggcgatc
gcatggcagaaagggggcatcttcaagtgtggtgtccctgccttcacggtgctccagcct
gacggtcccctggcagtgctgcgggaccgtgcccagcagatctcctgtcctctctacctg
tgcccatcactcgaagccctggaggaaggtgggccaccgctgaccctgggcctggaggga
gagcaccagcggtccaacgccgccttggccttgcagctggctcgctgctggctgcagcaa
aagggccaccagggcctcggagagctaaagatgtctcggcccagcgtcttgcggcagatg
cccctggcacccgtgttccagcccacgtcccacatgcgacatgggcttcgggacaccgag
tggctgggccggacgcagacactgcggcgcgggcccctcacctggtacctggacggcgcg
cacaccgtgagcagcgtgcaggcctgtgtgcgctggttccgccaggcgctgtaccgcagc
cagaggccgagccgcggccgtgaggtgcgcgtcttgcttttcaactcaactgggaaccgg
gattcggaggccctgctgaagctgctgcagccctgtcagtttgactatgccgttttctgc
cctaacctgacggaggtgtcatctgctagcaacgcagaccagcagaacttcatggtgacc
ctggaccaggtgttgctccgctgtcttgcacatcaacagcactggagccacctggatgag
gagctggccagcccagacctctggagccccaccagcccggagcagggtgatgagcccacg
tccttgctgctggcttcccgcccacgccacccccatagcaccggctccctcgtcttcagc
tgcatctcccatgccctgcagtggatcagccaaggccgggaccctgtctttcagccaccc
agtccccctccaagcctccttgcccaccctgtggctggcagtggggcgggcgtgctccgc
gaggctgccgccgtccatgtactggtcacaggcagcctgcacctggtgggtggcgtcctg
aagctgctggacccttccctgtcccagtag
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