Mustela lutreola (European mink): 131813137 Help Entry 131813137         CDS       T09578                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism mlk  Mustela lutreola (European mink) Pathway mlk01521   EGFR tyrosine kinase inhibitor resistance mlk04062   Chemokine signaling pathway mlk04081   Hormone signaling mlk04148   Efferocytosis mlk04151   PI3K-Akt signaling pathway mlk04217   Necroptosis mlk04550   Signaling pathways regulating pluripotency of stem cells mlk04630   JAK-STAT signaling pathway mlk04658   Th1 and Th2 cell differentiation mlk04659   Th17 cell differentiation mlk04725   Cholinergic synapse mlk04917   Prolactin signaling pathway mlk04920   Adipocytokine signaling pathway mlk04933   AGE-RAGE signaling pathway in diabetic complications mlk04935   Growth hormone synthesis, secretion and action mlk05140   Leishmaniasis mlk05145   Toxoplasmosis mlk05152   Tuberculosis mlk05161   Hepatitis B mlk05164   Influenza A mlk05167   Kaposi sarcoma-associated herpesvirus infection mlk05168   Herpes simplex virus 1 infection mlk05200   Pathways in cancer mlk05207   Chemical carcinogenesis - receptor activation mlk05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mlk05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mlk00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     131813137 (JAK2)    04151 PI3K-Akt signaling pathway     131813137 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     131813137 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     131813137 (JAK2)   09143 Cell growth and death    04217 Necroptosis     131813137 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     131813137 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     131813137 (JAK2)    04659 Th17 cell differentiation     131813137 (JAK2)    04062 Chemokine signaling pathway     131813137 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     131813137 (JAK2)    04917 Prolactin signaling pathway     131813137 (JAK2)    04935 Growth hormone synthesis, secretion and action     131813137 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     131813137 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     131813137 (JAK2)    05207 Chemical carcinogenesis - receptor activation     131813137 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     131813137 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     131813137 (JAK2)    05164 Influenza A     131813137 (JAK2)    05168 Herpes simplex virus 1 infection     131813137 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     131813137 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     131813137 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     131813137 (JAK2)    05140 Leishmaniasis     131813137 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     131813137 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     131813137 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     131813137 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mlk01001]     131813137 (JAK2) Enzymes [BR:mlk01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      131813137 (JAK2) Protein kinases [BR:mlk01001]  Non-receptor tyrosine kinases   JAK family [OT]    131813137 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  131813137 NCBI-ProteinID:  XP_058999307 LinkDB All DBs Position 12:94849590..94989665 Genome browser AA seq 1130 aa AA seqDB search MACLTMTEMEGTSVSPVHQNGDVPGNANPVKQIDPLLQVYLYHSLEKAEGEYLKFPTGEY VAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPY WYCNGSNRTYRYGISRGAETPLLDDFVMAYLFAQWRHDFLHGWIKIPVTHETQEECLGMA VLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSH CKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK HKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLKEA LSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQTGL YVLRCSPKDFNKYFLTFAVERENAIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNCYQ METVRSDSIIFQFTKCCPPKLKDKSNLLVFRTSGISDVPTSPTLQRHNNVNQMVFHKIRN EDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWAMH FLEEKALVHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPE CTENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTELAN LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPT QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICK GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL KNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG NT seq 3393 nt NT seq  +upstreamnt  +downstreamnt atggcttgccttacaatgacagaaatggaaggaacgtccgtatcccctgtacatcagaac ggtgatgttcctggaaatgctaatccggtgaagcaaatagatccactcctacaggtgtat ctttaccattctcttgagaaagctgaaggagagtatctgaagtttccaactggggagtat gttgcagaagaaatctgtgttgctgcttctaaagcttgtggaatcacacctgtgtatcat agtatgtttgctttaatgagtgaaacagaaaggatttggtatccgcccaaccatgtcttc catatagatgaatcaaccaggcacaatgtactctacagaataagattttactttccttac tggtattgtaacggcagcaacagaacctatcggtatgggatatctcgaggtgctgaaact cctcttcttgacgactttgtcatggcctacctttttgctcagtggcggcatgatttttta catggatggataaaaatacctgtgactcatgaaacacaagaagaatgtcttggaatggct gtgttagatatgatgagactagccaaagagaaagatcagaccccattggacatctatagc tctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagactatcat attttgacaaggaaacgaataaggtacagatttcgcagatttattgagcagttcagccat tgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag tcagccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttcaggtgag gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa cataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttccctgat attattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtagaattgta actatacataagcaagatggtaaaaatctggaaattgaacttagctcattaaaagaagct ttgtcctttgtgtcattaattgatggctattatagattaactgcagatgcacatcattac ctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgtcatggc ccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagactggactc tacgtacttcgatgcagtcctaaggattttaataagtattttctgacttttgctgttgag cgagaaaatgccattgaatataagcactgtttgattacaaagaatgaaaatggagaatac aacctcagtgggaccaagaagaacttcagtaaccttaaagatcttttgaattgctaccag atggaaactgttcgctcagacagtataattttccagtttactaaatgttgtcccccaaag ttgaaagataaatcaaaccttctagtcttcagaaccagtggcatttctgatgttcccaca tcaccaacattacagaggcacaataatgtgaaccaaatggtgtttcacaaaatcagaaat gaagatttgatgtttaatgaaagccttggccaaggcacttttacaaaaatttttaaaggt ataaggagagaagtaggagattatggtcaactacatgaaacagaagttcttttaaaagtt ctggataaagctcacagaaactattccgagtctttctttgaagcagcaagcatgatgagc cagctttctcacaagcatctagttttaaattatggagtgtgtgtctgtggggaggagaat attctggttcaagagtttgtaaaatttggatcattagatacatatctgaaaaagaataaa aattctataaatatattatggaaacttgaagtggctaaacagttggcatgggccatgcat tttctagaagaaaaagcacttgttcatgggaatgtgtgtgccaaaaatattctgcttatc agagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcctggcatt agtattacagttttgccaaaggacattcttcaggagagaataccatgggtaccacctgaa tgcactgaaaatcctaaaaatctaaatttggcgacagacaaatggagttttggtaccact ttgtgggaaatctgcagtggaggagataaacctctgagtgctttggattctcaaagaaag ctacagttttacgaagataggcaccagcttcctgcaccaaagtggacagaattagcaaat cttattaataattgtatggattatgaaccagatttcagaccttctttcagagccatcata cgagatcttaatagtttgtttactccagattatgaactactaacagaaaatgacatgtta ccaaatatgagaataggtgccctggggttttctggtgcttttgaagaccgagaccctaca caatttgaagagagacacttgaaatttctacagcaacttggcaagggtaattttggcagc gtggagatgtgccggtatgaccccctgcaggacaacactggggaggtggtggctgtgaag aagctccagcacagtactgaggagcacctgagagactttgagagggagattgaaatcctg aaatccctgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgctggtcgg cgtaatctaagattaattatggaatatttaccatatggaagtttacgagactatctccaa aaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagatatgcaag ggcatggagtatcttggtacaaaaagatatatccacagggatctggcaacaaggaatata ttggtggaaaatgaaaacagggtaaaaattggagattttgggttaaccaaagtcttgcca caagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctggtatgct ccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagctttggagtg gttctctatgaacttttcacatatattgagaagagtaaaagtcccccagcggaatttatg cgcatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactcctg aagaataatggaagattaccaagaccagatggatgcccagatgagatttatttgatcatg acagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagctcttcga gttgatcaaataagggacaacatggctggatga

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