Entry |
|
Symbol |
PLCB3
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
|
KO |
|
Organism |
mlk Mustela lutreola (European mink)
|
Pathway |
mlk04070 | Phosphatidylinositol signaling system |
mlk04072 | Phospholipase D signaling pathway |
mlk04261 | Adrenergic signaling in cardiomyocytes |
mlk04270 | Vascular smooth muscle contraction |
mlk04613 | Neutrophil extracellular trap formation |
mlk04621 | NOD-like receptor signaling pathway |
mlk04723 | Retrograde endocannabinoid signaling |
mlk04750 | Inflammatory mediator regulation of TRP channels |
mlk04919 | Thyroid hormone signaling pathway |
mlk04925 | Aldosterone synthesis and secretion |
mlk04927 | Cortisol synthesis and secretion |
mlk04928 | Parathyroid hormone synthesis, secretion and action |
mlk04933 | AGE-RAGE signaling pathway in diabetic complications |
mlk04935 | Growth hormone synthesis, secretion and action |
mlk04961 | Endocrine and other factor-regulated calcium reabsorption |
mlk04973 | Carbohydrate digestion and absorption |
mlk05022 | Pathways of neurodegeneration - multiple diseases |
mlk05163 | Human cytomegalovirus infection |
|
Module |
mlk_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mlk00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
131814631 (PLCB3)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
131814631 (PLCB3)
04310 Wnt signaling pathway
131814631 (PLCB3)
04371 Apelin signaling pathway
131814631 (PLCB3)
04020 Calcium signaling pathway
131814631 (PLCB3)
04070 Phosphatidylinositol signaling system
131814631 (PLCB3)
04072 Phospholipase D signaling pathway
131814631 (PLCB3)
04071 Sphingolipid signaling pathway
131814631 (PLCB3)
04022 cGMP-PKG signaling pathway
131814631 (PLCB3)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
131814631 (PLCB3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
131814631 (PLCB3)
04613 Neutrophil extracellular trap formation
131814631 (PLCB3)
04621 NOD-like receptor signaling pathway
131814631 (PLCB3)
04062 Chemokine signaling pathway
131814631 (PLCB3)
09152 Endocrine system
04911 Insulin secretion
131814631 (PLCB3)
04922 Glucagon signaling pathway
131814631 (PLCB3)
04929 GnRH secretion
131814631 (PLCB3)
04912 GnRH signaling pathway
131814631 (PLCB3)
04915 Estrogen signaling pathway
131814631 (PLCB3)
04921 Oxytocin signaling pathway
131814631 (PLCB3)
04926 Relaxin signaling pathway
131814631 (PLCB3)
04935 Growth hormone synthesis, secretion and action
131814631 (PLCB3)
04918 Thyroid hormone synthesis
131814631 (PLCB3)
04919 Thyroid hormone signaling pathway
131814631 (PLCB3)
04928 Parathyroid hormone synthesis, secretion and action
131814631 (PLCB3)
04916 Melanogenesis
131814631 (PLCB3)
04924 Renin secretion
131814631 (PLCB3)
04925 Aldosterone synthesis and secretion
131814631 (PLCB3)
04927 Cortisol synthesis and secretion
131814631 (PLCB3)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
131814631 (PLCB3)
04270 Vascular smooth muscle contraction
131814631 (PLCB3)
09154 Digestive system
04970 Salivary secretion
131814631 (PLCB3)
04971 Gastric acid secretion
131814631 (PLCB3)
04972 Pancreatic secretion
131814631 (PLCB3)
04973 Carbohydrate digestion and absorption
131814631 (PLCB3)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
131814631 (PLCB3)
09156 Nervous system
04724 Glutamatergic synapse
131814631 (PLCB3)
04725 Cholinergic synapse
131814631 (PLCB3)
04728 Dopaminergic synapse
131814631 (PLCB3)
04726 Serotonergic synapse
131814631 (PLCB3)
04720 Long-term potentiation
131814631 (PLCB3)
04730 Long-term depression
131814631 (PLCB3)
04723 Retrograde endocannabinoid signaling
131814631 (PLCB3)
09157 Sensory system
04742 Taste transduction
131814631 (PLCB3)
04750 Inflammatory mediator regulation of TRP channels
131814631 (PLCB3)
09159 Environmental adaptation
04713 Circadian entrainment
131814631 (PLCB3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
131814631 (PLCB3)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
131814631 (PLCB3)
09174 Infectious disease: parasitic
05146 Amoebiasis
131814631 (PLCB3)
05142 Chagas disease
131814631 (PLCB3)
05143 African trypanosomiasis
131814631 (PLCB3)
09164 Neurodegenerative disease
05010 Alzheimer disease
131814631 (PLCB3)
05016 Huntington disease
131814631 (PLCB3)
05017 Spinocerebellar ataxia
131814631 (PLCB3)
05022 Pathways of neurodegeneration - multiple diseases
131814631 (PLCB3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
131814631 (PLCB3)
05415 Diabetic cardiomyopathy
131814631 (PLCB3)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
131814631 (PLCB3)
04934 Cushing syndrome
131814631 (PLCB3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mlk04131]
131814631 (PLCB3)
Enzymes [BR:mlk01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
131814631 (PLCB3)
Membrane trafficking [BR:mlk04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
131814631 (PLCB3)
Endocytosis
Macropinocytosis
Phospholipase C
131814631 (PLCB3)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
1:282368042..282383632
|
AA seq |
1231 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPNS
SVRKRPLEQSNSALSESSAATTEPSSPQLGSPSSDSCPGLSNGEEVALEKPSLEPRKSLG
EDGLQRGTDALGSADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEP
VKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNY
MPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEAI
VDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEE
PFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALL
IYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQASPETCQETPSQQ
LGSQLTPNPTPSPLDTSPRRAPGPATSSSSTSLSSPGQRDDLIASLLSEVAPASLDELRG
HKVLVKLRGRQERELRELHKKHQRKAVALTRRLLSGLAQARTEGRCRPRPGVPGGENEEE
EEEEAKQYQEFQKRQVQSLLELREAQADTEAERRLEHLRQAQLRLREIVLEAHTTQIKRL
KEVNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQ
KQRHERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGETPEGLGDGH
LVACASNGHAPGSSGHLSGADSESQEENTKL |
NT seq |
3696 nt +upstreamnt +downstreamnt
atggccggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgtgtggactccaatggcttctttctgtattggaccggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacgggtcgctacgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccctgatgcccggctggag
gagaagttgatgacggtggtagctgggccagacccggtgaatacgacgttcttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgtttaagctggctatg
aacatcctggctcagaacgcctcccggaacacgttcctgcgaaaagcatacacaaagctg
aagctgcaggtgaaccaggacggacggattccggtgaagaatatcctgaagatgttttca
gcagataagaagcgggtagagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcccgacgagttttccttggagatcttcgagcggttcctgaataagttg
tgtctgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccttac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaac
gaggtgctgtacccacccctgcggccgtcccaggcccggctgctcatcgagaagtatgag
cccaaccagcagttcctagagcgagaccagatgtccatggagggcttcagccgctacctg
ggcggtgaggagaacggcatcctgcccctggaggccctggatctcagtgcggacatgacc
cagccgctgagcgcctacttcatcaactcctcacacaacacctatctcacagcggggcag
ctggccgggacctcgtcggtggagatgtaccggcaggcgctgctgtggggctgccgctgc
gtggagctggacgtgtggaaaggccggccgcccgaggaggagcccttcatcacccatggc
ttcaccatgaccacggaggtgccgctgcgggacgtgctcgaggccattgcggagactgcc
ttcaagacctcaccttaccctgtcatcctctcttttgagaaccacgtggactcggcaaag
caacaggccaagatggccgagtactgccggtccatctttggggacgcactgctcatcgac
ccactggacaagtacccgctggccccaggcgtccccctgcccagcccgcaggatctgatg
ggccgcatcctggtgaagaacaagaagcgacaccagcccagcaccggtgtccccaacagc
tctgtgcgcaagcggcccctggaacagagcaactcggccctgagcgagagctcggccgcc
accactgagccctcctcccctcagctcgggtcccccagctctgacagctgcccaggcctg
agcaacggggaagaagtggccctggagaagcccagcctggagcctcgcaagtctctgggc
gaggacgggctacagcggggcactgatgctcttggatctgcagaccgtgaggatgaggag
gaggatgaggaagaagaggaacagacagatcctaaaaagccaaccacagatgagggcact
gccagcagtgaggtcaatgccaccgaggaaatgtccacactcgtcaactacatcgagcct
gtcaagttcaagtcctttgaggctgctcgaaaaaggaacaaatgcttcgagatgtcatcc
ttcgtggagaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatac
aacaagcagcagctcagccgcatctaccccaagggcacccgcgtggactcatccaactat
atgccccagctcttctggaatgtcggctgccagcttgtcgcgctcaacttccagaccctg
gacgtggcgatgcagctgaacgcaggcgtgttcgagtacaacgggcgcagcggctacctg
ctcaagcccgagttcatgcggcggccagacaagtccttcgatcccttcaccgaagccatc
gtggacggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtcg
gacaggaaggtgggcatctatgtggaagtggacatgttcggcctccccgtggatacgcgg
cgcaaataccgcactcggacttctcaggggaattccttcaatcccgtatgggacgaggag
ccctttgacttccccaaggtggtgctgcccacgctggcttccctgcgcatcgcggccttt
gaggagggcggcaagtttgtggggcatcgaatcttgcccgtctcggccatccgctcaggg
taccactacatctgtctgcggaacgaggccaaccagccgctctgcctgccggccctgctc
atctacactgaagcctctgactacattcctgacgaccaccaggactacgcggaggccctt
atcaaccccatcaagcatgtcagcctgatggaccagagggccaagcagctggctgccctc
attggggagagcgaggctcaggccagcccagagacctgccaagagactccgtctcagcag
ctggggtcccagctgaccccaaaccccacacccagcccactggacacttccccgcgccgg
gccccaggcccggccacgtcctctagcagcacctccctcagcagcccaggccagcgggat
gacctcatcgccagcctcctctcagaggtggccccggcctcgctggacgagctccgaggc
cacaaggtgctggtgaagctccggggccggcaggagcgagagcttcgagagctgcacaag
aagcaccagcgcaaggccgttgccctcacgcgccggctgctcagcggcctggcccaggcc
cggacggagggcaggtgccgcccacggccgggtgtcccaggtggggagaacgaggaggag
gaggaggaagaggcgaagcagtatcaggaattccagaagagacaggtgcagagtctcctg
gagctgagggaggcccaggctgatactgaggctgagcggcggctggagcacctgagacag
gctcagctgcggctcagggagattgtcctggaggctcacacaactcagatcaagaggctg
aaggaggtgaacgagagggagaagaaggaactgcagaagattctggacaggaagcgtcat
aacagtatctcagaggccaagacaagggagaaacataagaaggaggcggaactgacagag
attaaccgccggcacatcaccgagtcggtcaactctatccgtcggctggaggaggcccag
aagcagcggcacgagcgccttgtggctgggcagcagcaggtcctacagcagctggcagag
gaggagcccaagctgctagcccagctggcccaggagtgccaggaacagcgggcaaggctg
ccccaggagatccgccggagcctgctgggcgagacgccggaggggctgggggacgggcat
ctggtggcctgtgccagtaacggtcacgcacctggaagcagcgggcacctgtccggcgct
gactcggagagccaagaggagaatacgaagctctga |