KEGG   Mustela lutreola (European mink): 131824847
Entry
131824847         CDS       T09578                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk00562  Inositol phosphate metabolism
mlk01100  Metabolic pathways
mlk01521  EGFR tyrosine kinase inhibitor resistance
mlk01522  Endocrine resistance
mlk01524  Platinum drug resistance
mlk04012  ErbB signaling pathway
mlk04014  Ras signaling pathway
mlk04015  Rap1 signaling pathway
mlk04024  cAMP signaling pathway
mlk04062  Chemokine signaling pathway
mlk04066  HIF-1 signaling pathway
mlk04068  FoxO signaling pathway
mlk04070  Phosphatidylinositol signaling system
mlk04071  Sphingolipid signaling pathway
mlk04072  Phospholipase D signaling pathway
mlk04081  Hormone signaling
mlk04140  Autophagy - animal
mlk04150  mTOR signaling pathway
mlk04151  PI3K-Akt signaling pathway
mlk04152  AMPK signaling pathway
mlk04210  Apoptosis
mlk04211  Longevity regulating pathway
mlk04213  Longevity regulating pathway - multiple species
mlk04218  Cellular senescence
mlk04360  Axon guidance
mlk04370  VEGF signaling pathway
mlk04380  Osteoclast differentiation
mlk04510  Focal adhesion
mlk04517  IgSF CAM signaling
mlk04518  Integrin signaling
mlk04550  Signaling pathways regulating pluripotency of stem cells
mlk04611  Platelet activation
mlk04613  Neutrophil extracellular trap formation
mlk04620  Toll-like receptor signaling pathway
mlk04625  C-type lectin receptor signaling pathway
mlk04630  JAK-STAT signaling pathway
mlk04650  Natural killer cell mediated cytotoxicity
mlk04660  T cell receptor signaling pathway
mlk04662  B cell receptor signaling pathway
mlk04664  Fc epsilon RI signaling pathway
mlk04666  Fc gamma R-mediated phagocytosis
mlk04668  TNF signaling pathway
mlk04670  Leukocyte transendothelial migration
mlk04722  Neurotrophin signaling pathway
mlk04725  Cholinergic synapse
mlk04750  Inflammatory mediator regulation of TRP channels
mlk04810  Regulation of actin cytoskeleton
mlk04910  Insulin signaling pathway
mlk04914  Progesterone-mediated oocyte maturation
mlk04915  Estrogen signaling pathway
mlk04917  Prolactin signaling pathway
mlk04919  Thyroid hormone signaling pathway
mlk04923  Regulation of lipolysis in adipocytes
mlk04926  Relaxin signaling pathway
mlk04929  GnRH secretion
mlk04930  Type II diabetes mellitus
mlk04931  Insulin resistance
mlk04932  Non-alcoholic fatty liver disease
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk04935  Growth hormone synthesis, secretion and action
mlk04960  Aldosterone-regulated sodium reabsorption
mlk04973  Carbohydrate digestion and absorption
mlk05010  Alzheimer disease
mlk05017  Spinocerebellar ataxia
mlk05020  Prion disease
mlk05100  Bacterial invasion of epithelial cells
mlk05132  Salmonella infection
mlk05135  Yersinia infection
mlk05142  Chagas disease
mlk05146  Amoebiasis
mlk05160  Hepatitis C
mlk05161  Hepatitis B
mlk05162  Measles
mlk05163  Human cytomegalovirus infection
mlk05164  Influenza A
mlk05165  Human papillomavirus infection
mlk05166  Human T-cell leukemia virus 1 infection
mlk05167  Kaposi sarcoma-associated herpesvirus infection
mlk05168  Herpes simplex virus 1 infection
mlk05169  Epstein-Barr virus infection
mlk05170  Human immunodeficiency virus 1 infection
mlk05171  Coronavirus disease - COVID-19
mlk05200  Pathways in cancer
mlk05203  Viral carcinogenesis
mlk05205  Proteoglycans in cancer
mlk05206  MicroRNAs in cancer
mlk05207  Chemical carcinogenesis - receptor activation
mlk05208  Chemical carcinogenesis - reactive oxygen species
mlk05210  Colorectal cancer
mlk05211  Renal cell carcinoma
mlk05212  Pancreatic cancer
mlk05213  Endometrial cancer
mlk05214  Glioma
mlk05215  Prostate cancer
mlk05218  Melanoma
mlk05220  Chronic myeloid leukemia
mlk05221  Acute myeloid leukemia
mlk05222  Small cell lung cancer
mlk05223  Non-small cell lung cancer
mlk05224  Breast cancer
mlk05225  Hepatocellular carcinoma
mlk05226  Gastric cancer
mlk05230  Central carbon metabolism in cancer
mlk05231  Choline metabolism in cancer
mlk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlk05415  Diabetic cardiomyopathy
mlk05417  Lipid and atherosclerosis
mlk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    131824847 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    131824847 (PIK3CA)
   04014 Ras signaling pathway
    131824847 (PIK3CA)
   04015 Rap1 signaling pathway
    131824847 (PIK3CA)
   04370 VEGF signaling pathway
    131824847 (PIK3CA)
   04630 JAK-STAT signaling pathway
    131824847 (PIK3CA)
   04668 TNF signaling pathway
    131824847 (PIK3CA)
   04066 HIF-1 signaling pathway
    131824847 (PIK3CA)
   04068 FoxO signaling pathway
    131824847 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    131824847 (PIK3CA)
   04072 Phospholipase D signaling pathway
    131824847 (PIK3CA)
   04071 Sphingolipid signaling pathway
    131824847 (PIK3CA)
   04024 cAMP signaling pathway
    131824847 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    131824847 (PIK3CA)
   04152 AMPK signaling pathway
    131824847 (PIK3CA)
   04150 mTOR signaling pathway
    131824847 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    131824847 (PIK3CA)
   04517 IgSF CAM signaling
    131824847 (PIK3CA)
   04518 Integrin signaling
    131824847 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    131824847 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    131824847 (PIK3CA)
   04218 Cellular senescence
    131824847 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    131824847 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    131824847 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    131824847 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    131824847 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    131824847 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    131824847 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    131824847 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    131824847 (PIK3CA)
   04660 T cell receptor signaling pathway
    131824847 (PIK3CA)
   04662 B cell receptor signaling pathway
    131824847 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    131824847 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    131824847 (PIK3CA)
   04670 Leukocyte transendothelial migration
    131824847 (PIK3CA)
   04062 Chemokine signaling pathway
    131824847 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    131824847 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    131824847 (PIK3CA)
   04929 GnRH secretion
    131824847 (PIK3CA)
   04915 Estrogen signaling pathway
    131824847 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    131824847 (PIK3CA)
   04917 Prolactin signaling pathway
    131824847 (PIK3CA)
   04926 Relaxin signaling pathway
    131824847 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    131824847 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    131824847 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    131824847 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    131824847 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    131824847 (PIK3CA)
   04722 Neurotrophin signaling pathway
    131824847 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    131824847 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    131824847 (PIK3CA)
   04380 Osteoclast differentiation
    131824847 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    131824847 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    131824847 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131824847 (PIK3CA)
   05206 MicroRNAs in cancer
    131824847 (PIK3CA)
   05205 Proteoglycans in cancer
    131824847 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    131824847 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    131824847 (PIK3CA)
   05203 Viral carcinogenesis
    131824847 (PIK3CA)
   05230 Central carbon metabolism in cancer
    131824847 (PIK3CA)
   05231 Choline metabolism in cancer
    131824847 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    131824847 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    131824847 (PIK3CA)
   05212 Pancreatic cancer
    131824847 (PIK3CA)
   05225 Hepatocellular carcinoma
    131824847 (PIK3CA)
   05226 Gastric cancer
    131824847 (PIK3CA)
   05214 Glioma
    131824847 (PIK3CA)
   05221 Acute myeloid leukemia
    131824847 (PIK3CA)
   05220 Chronic myeloid leukemia
    131824847 (PIK3CA)
   05218 Melanoma
    131824847 (PIK3CA)
   05211 Renal cell carcinoma
    131824847 (PIK3CA)
   05215 Prostate cancer
    131824847 (PIK3CA)
   05213 Endometrial cancer
    131824847 (PIK3CA)
   05224 Breast cancer
    131824847 (PIK3CA)
   05222 Small cell lung cancer
    131824847 (PIK3CA)
   05223 Non-small cell lung cancer
    131824847 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    131824847 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    131824847 (PIK3CA)
   05161 Hepatitis B
    131824847 (PIK3CA)
   05160 Hepatitis C
    131824847 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    131824847 (PIK3CA)
   05164 Influenza A
    131824847 (PIK3CA)
   05162 Measles
    131824847 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    131824847 (PIK3CA)
   05163 Human cytomegalovirus infection
    131824847 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131824847 (PIK3CA)
   05169 Epstein-Barr virus infection
    131824847 (PIK3CA)
   05165 Human papillomavirus infection
    131824847 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    131824847 (PIK3CA)
   05135 Yersinia infection
    131824847 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    131824847 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    131824847 (PIK3CA)
   05142 Chagas disease
    131824847 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    131824847 (PIK3CA)
   05017 Spinocerebellar ataxia
    131824847 (PIK3CA)
   05020 Prion disease
    131824847 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131824847 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    131824847 (PIK3CA)
   05415 Diabetic cardiomyopathy
    131824847 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    131824847 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    131824847 (PIK3CA)
   04931 Insulin resistance
    131824847 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    131824847 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    131824847 (PIK3CA)
   01524 Platinum drug resistance
    131824847 (PIK3CA)
   01522 Endocrine resistance
    131824847 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlk04131]
    131824847 (PIK3CA)
Enzymes [BR:mlk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     131824847 (PIK3CA)
Membrane trafficking [BR:mlk04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    131824847 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 131824847
NCBI-ProteinID: XP_059019401
LinkDB
Position
2:complement(122237348..122322137)
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acgttaataactataaagcatgaattatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgagaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataagttagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactagaagtatgttgctatcatctgaacaactcaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgagaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttattcccaactgccaatggac
tgtttcacaatgccttcatattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgcgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattatacagatactctagtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaacaccatgcttagagttggagtttgattggttc
agcagtgtggtcaagttcccagatatgtcagtgattgaagagcatgccaactggtcggtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaacgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctatggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtgaaagattggcctccaatcaaacctgaacaggctatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatacttaacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacggtt
agtcagaggtttggccttcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgatatcctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcagatgcgg
cgaccagatttcatggatgctctccaaggttttctatctcctcttaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctcacacttcaaataattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatctccgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgcgaaattctcacacgattatgcagatt
cagtgcaaaggtggcctgaaaggcgctctgcagtttaacagccacacactccaccagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgttca
tgtgctggatactgtgttgctaccttcattctgggcattggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgggaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcgttgaactga

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