KEGG   Mustela lutreola (European mink): 131828723
Entry
131828723         CDS       T09578                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk01522  Endocrine resistance
mlk04010  MAPK signaling pathway
mlk04012  ErbB signaling pathway
mlk04014  Ras signaling pathway
mlk04024  cAMP signaling pathway
mlk04068  FoxO signaling pathway
mlk04071  Sphingolipid signaling pathway
mlk04137  Mitophagy - animal
mlk04140  Autophagy - animal
mlk04141  Protein processing in endoplasmic reticulum
mlk04210  Apoptosis
mlk04215  Apoptosis - multiple species
mlk04217  Necroptosis
mlk04310  Wnt signaling pathway
mlk04380  Osteoclast differentiation
mlk04510  Focal adhesion
mlk04530  Tight junction
mlk04620  Toll-like receptor signaling pathway
mlk04621  NOD-like receptor signaling pathway
mlk04622  RIG-I-like receptor signaling pathway
mlk04625  C-type lectin receptor signaling pathway
mlk04657  IL-17 signaling pathway
mlk04658  Th1 and Th2 cell differentiation
mlk04659  Th17 cell differentiation
mlk04660  T cell receptor signaling pathway
mlk04664  Fc epsilon RI signaling pathway
mlk04668  TNF signaling pathway
mlk04722  Neurotrophin signaling pathway
mlk04723  Retrograde endocannabinoid signaling
mlk04728  Dopaminergic synapse
mlk04750  Inflammatory mediator regulation of TRP channels
mlk04910  Insulin signaling pathway
mlk04912  GnRH signaling pathway
mlk04914  Progesterone-mediated oocyte maturation
mlk04917  Prolactin signaling pathway
mlk04920  Adipocytokine signaling pathway
mlk04926  Relaxin signaling pathway
mlk04930  Type II diabetes mellitus
mlk04931  Insulin resistance
mlk04932  Non-alcoholic fatty liver disease
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk04935  Growth hormone synthesis, secretion and action
mlk04936  Alcoholic liver disease
mlk05010  Alzheimer disease
mlk05012  Parkinson disease
mlk05016  Huntington disease
mlk05017  Spinocerebellar ataxia
mlk05020  Prion disease
mlk05022  Pathways of neurodegeneration - multiple diseases
mlk05132  Salmonella infection
mlk05133  Pertussis
mlk05135  Yersinia infection
mlk05142  Chagas disease
mlk05145  Toxoplasmosis
mlk05152  Tuberculosis
mlk05161  Hepatitis B
mlk05162  Measles
mlk05166  Human T-cell leukemia virus 1 infection
mlk05167  Kaposi sarcoma-associated herpesvirus infection
mlk05169  Epstein-Barr virus infection
mlk05170  Human immunodeficiency virus 1 infection
mlk05171  Coronavirus disease - COVID-19
mlk05200  Pathways in cancer
mlk05208  Chemical carcinogenesis - reactive oxygen species
mlk05210  Colorectal cancer
mlk05212  Pancreatic cancer
mlk05231  Choline metabolism in cancer
mlk05415  Diabetic cardiomyopathy
mlk05417  Lipid and atherosclerosis
mlk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    131828723 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    131828723 (MAPK8)
   04012 ErbB signaling pathway
    131828723 (MAPK8)
   04014 Ras signaling pathway
    131828723 (MAPK8)
   04310 Wnt signaling pathway
    131828723 (MAPK8)
   04668 TNF signaling pathway
    131828723 (MAPK8)
   04068 FoxO signaling pathway
    131828723 (MAPK8)
   04071 Sphingolipid signaling pathway
    131828723 (MAPK8)
   04024 cAMP signaling pathway
    131828723 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    131828723 (MAPK8)
   04137 Mitophagy - animal
    131828723 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    131828723 (MAPK8)
   04215 Apoptosis - multiple species
    131828723 (MAPK8)
   04217 Necroptosis
    131828723 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    131828723 (MAPK8)
   04530 Tight junction
    131828723 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    131828723 (MAPK8)
   04621 NOD-like receptor signaling pathway
    131828723 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    131828723 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    131828723 (MAPK8)
   04660 T cell receptor signaling pathway
    131828723 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    131828723 (MAPK8)
   04659 Th17 cell differentiation
    131828723 (MAPK8)
   04657 IL-17 signaling pathway
    131828723 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    131828723 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    131828723 (MAPK8)
   04920 Adipocytokine signaling pathway
    131828723 (MAPK8)
   04912 GnRH signaling pathway
    131828723 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    131828723 (MAPK8)
   04917 Prolactin signaling pathway
    131828723 (MAPK8)
   04926 Relaxin signaling pathway
    131828723 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    131828723 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    131828723 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    131828723 (MAPK8)
   04722 Neurotrophin signaling pathway
    131828723 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    131828723 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    131828723 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131828723 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    131828723 (MAPK8)
   05231 Choline metabolism in cancer
    131828723 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    131828723 (MAPK8)
   05212 Pancreatic cancer
    131828723 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    131828723 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    131828723 (MAPK8)
   05161 Hepatitis B
    131828723 (MAPK8)
   05171 Coronavirus disease - COVID-19
    131828723 (MAPK8)
   05162 Measles
    131828723 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131828723 (MAPK8)
   05169 Epstein-Barr virus infection
    131828723 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    131828723 (MAPK8)
   05135 Yersinia infection
    131828723 (MAPK8)
   05133 Pertussis
    131828723 (MAPK8)
   05152 Tuberculosis
    131828723 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    131828723 (MAPK8)
   05142 Chagas disease
    131828723 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    131828723 (MAPK8)
   05012 Parkinson disease
    131828723 (MAPK8)
   05016 Huntington disease
    131828723 (MAPK8)
   05017 Spinocerebellar ataxia
    131828723 (MAPK8)
   05020 Prion disease
    131828723 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    131828723 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131828723 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    131828723 (MAPK8)
   05415 Diabetic cardiomyopathy
    131828723 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    131828723 (MAPK8)
   04936 Alcoholic liver disease
    131828723 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    131828723 (MAPK8)
   04931 Insulin resistance
    131828723 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    131828723 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    131828723 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlk01001]
    131828723 (MAPK8)
Enzymes [BR:mlk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     131828723 (MAPK8)
Protein kinases [BR:mlk01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   131828723 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 131828723
NCBI-ProteinID: XP_059025640
LinkDB
Position
4:complement(40982352..41084665)
AA seq 427 aa
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattt
acagtcttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattcttgaaagaaatgttgcaatcaagaagctaagccggcca
tttcagaaccagactcatgctaaacgggcttacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgagagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatcgtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacaccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccatgccctgaattcatgaagaaactacagccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcagaacacaacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctggtaattgatgcatctaaaaggatttctgtagatgaagctctccagcacccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacatacaatagaagaatggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttataaggggacagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga

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