KEGG   Mustela lutreola (European mink): 131829935
Entry
131829935         CDS       T09578                                 
Symbol
NOS3
Name
(RefSeq) LOW QUALITY PROTEIN: nitric oxide synthase 3
  KO
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk00220  Arginine biosynthesis
mlk00330  Arginine and proline metabolism
mlk01100  Metabolic pathways
mlk04020  Calcium signaling pathway
mlk04022  cGMP-PKG signaling pathway
mlk04066  HIF-1 signaling pathway
mlk04071  Sphingolipid signaling pathway
mlk04151  PI3K-Akt signaling pathway
mlk04370  VEGF signaling pathway
mlk04371  Apelin signaling pathway
mlk04611  Platelet activation
mlk04915  Estrogen signaling pathway
mlk04921  Oxytocin signaling pathway
mlk04926  Relaxin signaling pathway
mlk04931  Insulin resistance
mlk04933  AGE-RAGE signaling pathway in diabetic complications
mlk05415  Diabetic cardiomyopathy
mlk05417  Lipid and atherosclerosis
mlk05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    131829935 (NOS3)
   00330 Arginine and proline metabolism
    131829935 (NOS3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    131829935 (NOS3)
   04371 Apelin signaling pathway
    131829935 (NOS3)
   04066 HIF-1 signaling pathway
    131829935 (NOS3)
   04020 Calcium signaling pathway
    131829935 (NOS3)
   04071 Sphingolipid signaling pathway
    131829935 (NOS3)
   04022 cGMP-PKG signaling pathway
    131829935 (NOS3)
   04151 PI3K-Akt signaling pathway
    131829935 (NOS3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    131829935 (NOS3)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    131829935 (NOS3)
   04921 Oxytocin signaling pathway
    131829935 (NOS3)
   04926 Relaxin signaling pathway
    131829935 (NOS3)
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    131829935 (NOS3)
   05418 Fluid shear stress and atherosclerosis
    131829935 (NOS3)
   05415 Diabetic cardiomyopathy
    131829935 (NOS3)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    131829935 (NOS3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    131829935 (NOS3)
Enzymes [BR:mlk01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     131829935 (NOS3)
SSDB
Motif
Pfam: NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1
Other DBs
NCBI-GeneID: 131829935
NCBI-ProteinID: XP_059028224
LinkDB
Position
4:196791580..196809267
AA seq 1203 aa
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPTSSEPSRAPAPTPAPPPAPDRSPPLT
RPPDGPKFPRVKNWEVGSITYDTLSAQSQQDGPCTPRRCLGSLVFPRKLQSRPSRDPQPT
EQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRN
APRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGD
FRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPP
ELFALPPELVLEVPLEHPTLEWFGALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMST
EIGARNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDH
HAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPDPW
KGSGSKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGR
LFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSS
PRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHF
CAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGEDAKAAA
RDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATIL
VRLDTGGQEALQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGP
PPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESSEQQELESLSQDPRRY
EEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVL
AYRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPTLPCILVGPGTGIXP
FRGFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFGRVLTAFSRE
PDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELD
EAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDT
PSP
NT seq 3612 nt   +upstreamnt  +downstreamnt
atgggcaacttgaagagtgtgggccaggagcccgggcccccctgtggcctggggctgggc
ctgggcctggggctgtgcggcaagcagggtccggcctcccccacctcctctgagcccagc
agggcacccgcgcccacgcccgcgcccccacccgcaccagaccgcagccccccactcacc
cggcccccggacgggcccaagttccctcgagtgaagaactgggaggtggggagcatcacc
tacgataccctgagtgcccagtcacagcaggatgggccctgcaccccccgacgctgcctg
ggctcgctggtgttcccgcggaaactgcagagtcggccatctcgggacccccaacccacg
gagcagctgctgagtcaggccagggactttatcaaccagtactacagctccatcaagagg
agcggctcccaggcccatgagcagaggcttcaggaggtggaagccgaggtggcagccacg
ggcacctaccagctccgggagagtgagctggtgttcggggccaagcaggcctggcgcaac
gcaccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgatgcccgggac
tgcagctcagcccaggagatgttcacctacatctgcaaccacatcaagtatgccaccaac
cggggcaacctccgctcagccatcacagtgttcccccagcgcgccccaggccggggagac
ttccgaatctggaacagccagctggtacgctatgcgggctacaggcagcaggatggctca
gtgcggggggacccagccaacgtggagatcaccgagctctgcatccagcatggctggacc
ccaggaaacggccgctttgacgtgctgccactcctgctccaggccccggatgagccccca
gagctctttgctctgccccccgagctggtcctcgaggtgcccctggagcaccccacgctg
gagtggtttggggccctgggcctgcgctggtacgccctcccggcggtgagtaacatgctg
ctggagatcgggggcctggagttccccgcagcccctttcagcggctggtacatgagcacg
gagatcggcgcgcggaacctgtgtgaccctcaccgatataacatcctggaggatgtggca
gtctgcatggacttggacaccaggacaacctcatccctgtggaaagacaaggcagcggtg
gaaatcaacttggccgtgctgcacagttaccagctggccaaagtgaccattgtggaccac
cacgctgccaccgcctccttcatgaagcacctggagaacgagcagaaggctagggggggc
tgccctgccgattgggcctggattgtgccccccatctctggcagcctcacccctgtcttc
catcaggagatggtcaactacgtcctgtcccctgccttccgctatcagccagacccatgg
aaggggagtggatccaagggtaccggcatcaccaggaagaagacctttaaggaagtggcc
aatgcagtgaagatctcagcctcgctcatgggcaccgtgatggcaaagcgagtgaaggcg
accatcctgtatggctccgagaccggccgggcccagagctatgcacagcagctggggaga
ctcttccggaaggctttcgacccccgggtcttgtgcatggatgagtatgatgtggtgtcc
cttgagcatgagacgctggtgttggtggtgaccagtacgtttgggaatggtgacccccca
gagaatggagagagttttgcggcggccctgatggagatgtcgggcccctacaacagctcc
cctcggccagaacagcacaagagttacaaaatccgcttcaacagcgtctcttgctcagac
ccgctggtgtcctcttggaggcggaagagaaaggagtccagtaacacagacagcgcaggg
gccctggggaccctcaggttctgtgtgttcgggctgggctcccgggcatacccccacttc
tgcgcctttgctcgtgcggtggacacacggctggaagagctgggcggggagcggctactg
cagctgggccagggagatgagctgtgcggccaggaggaggccttccgtggctgggcccag
gctgccttccaggcctcctgtgagactttctgcgtgggagaggatgccaaggccgctgcc
cgggacatattcagccccaaacggagctggaagcgccagcggtaccggctgagcacccag
gccgagggcctccagctgctgccaggcctgatccacgtgcacaggagaaagatgttccag
gctacggtcctctcagtggaaaacctgcaaagcagcaagtccacccgggccaccatcctg
gtgcgcctagacaccggaggccaggaggcgctacagtaccagcccggggatcacataggc
atctgcccgcccaaccggccaggcctcgtggaggcactgctgagccgcgttgaggatcct
cctccacccggcgagcctgtggctgtggagcagctggagaagggcagccctggtggcccg
ccccctggctgggttcgggacccccggctgcccccatgcacactgcgccaggctctcacc
ttcttcctggacatcacttccccgcccagtcctcaactccttcgactgctcagcaccctg
gccgaagagtccagcgaacagcaggagcttgagagcctcagccaggacccgcggcggtac
gaggagtggaagtggttccgctgccccacgctgctggaggtgctggagcagtttccatcg
gtggccctgcccgcgccgctgctcctcacccagctgcccctgctccagccccggtactac
tcagtcagctcggcgcccagcgcccacccaggagagatccacctcacagtagctgtgcta
gcatacaggacacaggacggactgggcccccttcattatggagtctgctccacgtggctg
agccagctgaaggccggggatcctgtaccctgcttcatcaggggggctccctccttccgg
ctgccacctgaccccaccttgccctgcatcctagtgggccctggcacaggtattngcccc
ttccggggattctggcaggagcggctgcatgacattgacagcaaaggcctgcagcccgcc
cccatgactttggtgttcggctgccgatgctcccagctcgaccacctttaccgcgacgag
gtgcaggatgcccagcagcgcggagtttttgggcgcgtcctcaccgccttctcccgggag
cccgacagccctaagacctacgtgcaggacatcctgcggacggagctggctgctgaggtg
caccgcgtgctgtgcctcgagcggggccacatgtttgtgtgcggcgacgtcaccatggca
accagcgttctgcagacggtgcagcgcatcctagcgacggagggcgacatggagctggac
gaggccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttc
gggctcacactgcgtacccaggaggtgacaagccgcatacgcacccagagcttttccttg
caggagcgacatctgcggggcgcagtgccctgggcgttcgacccgcccgggccagacacc
cccagcccctga

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