Mustela lutreola (European mink): 131833449 Help Entry 131833449         CDS       T09578                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism mlk  Mustela lutreola (European mink) Pathway mlk04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:mlk00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     131833449 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:mlk03036]     131833449 (SYNE1) Chromosome and associated proteins [BR:mlk03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     131833449 (SYNE1) SSDB OrthologParalogGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH Spectrin_SYNE1_2 SR_desmoplakin_3 SYNE3 PRR11_2nd Motif Other DBs NCBI-GeneID:  131833449 NCBI-ProteinID:  XP_059032715 LinkDB All DBs Position 6:14082377..14547895 Genome browser AA seq 8833 aa AA seqDB search MAASRTASRSPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPLAVDDLFEDMKDG VKLLALLEVLSGQKLPCEQGRRMKRIHAVANIGTALKFLEGRKSMYRGSPIKLVNINSTD IADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSGSTSSVDSTVSAETASPPSKRKVA TKIQGNAKRALLKWVQYTVAKQTGIEVKDFGRSWRSGLAFHSIIHAIRPELVDLERVKGR PNRENLAEAFTIAETELGIPRLLDPEDVDVDKPDEKSIMTYVAQFLKHYPDIHNTGTDGQ ETDEILPGFPCFANSIQIFKREDRLILKEAKVWIEQFERDLTRAQMTESNLQDKYQSFKH FRVQYELKRKQIEHLIQPVHRDGKLSLDQALVKQSWDRVSSRLFDWHIQLDKSLPAPLGT IGAWLYRAEVALREEITIQQVHEETANTIQRKREQHKDLLQNTDAHKRAFHEIYRTRSVN GIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR ESVELLLQNYISFIENTKFFEQYEVTYQILKQTAEMYVQADGSVEEAENVMKFMNETTAQ WRNLSVEVRSVRSMLEEVIANWDRYGNTVASLQAWLEDAEKMLNQSEHAKKDFFRNLPHW IQQHAAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYARADEMDRMKKEY TDCVTALSDFATEALKKMSEPLEVSFLNVKLLTQDLEDIEQRVPVMDAQYKMITKTAHLI AKESPQEEANEMFATMSRLKEQLTKVKECHSPLLYESQQLLIPLEELEKQMTFFYDSLGK INEILTVLEHEAQSSALFKQKQQELSACQESCKKTMTQIEKGSQNVQKFVTLSSVLKHFD QTKLHRQIADAHGAFQHMVKKIGDWKKHVETNSRLMKKFEESRAELEKVLRMAQEGLEEK GNPEDLLKRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQG EAPYHLLHLKIGVEKNRFLASVEECRTELDREIKLVAQEGSENIIKEHRIFFSDKGPHHL CEKRLQLIEELCLKLPVRDPVRNTPETCHATLRELRAAIDATYMKLVEDPDKWKDYSSRI SEFSSWISAKETQLKAFKSKPFDTANHGEVKRAVEEIRNGITTKGETLNWLKSRLKILIE VSSENEAQKQGDELAKLSGSFKALAALLSEVEKMLSNFGDCVQYKEIVQSSLEDLISGSK EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQVAQAQRGEGGLPDQAREE LRKLESTLDHMEHSREKQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSFSSLE SLSSELEQTKEFSKRTEGIAVQAENLVKEASEIPLGPKNKQLLQQQAKSIKEQVKKLEDT LEEDIKTMEMVKNKWDHFGNNFETLSDWITEKEKELNALETSSSAMDMQIHQIKVTIQEI ESKMSSITDLEEAAQSFAQFVTTGESARIKAKLTQIRRYWEELREHAQCLEATILGHLSQ QQKFEENLRKIQKSVSEFEDKLADPLKICSSATETYKVLQEHMDLCQALEALSSVVATTS ASAQKVANGGSSVQEAAALQQRYEETRTRAKERQTALETLLAHWQRLEKELSTFLTWLER CEEIASSPEMDISADRVKVESELQSIQALQNEVVSRASIYSSLLQLKESLFSVASKDDVK TMKVHLEQLDERWRDLPQIINKRITFLQSAVAEHQQFDELLLSFSVWIKLFLSELQTTSE ISITDHQAAFTRHKDHTAEVESKKGELHSLRDHLVKLGALGRAENLPVLQGKAEDCFQLF EEASQVVERRQLALSQLAEFLQSHASLSGVLHGLKHTVEATDRMSRKQTDLLEKDLNHAI QDAKALESAAISLDSVLAKAQYHLKSGNSEQRTSCRTTADHLCSELERIQNLLGMKQSEA DALAVLKKAFQDQKEELLRSIEDIEERTDKERLKELTRQALQQRLRVFNQLEDELNSHEH ELCWLKDKAKQIAQKDVAFASEVDKEVNRLEVTWADTKKLIHENQGQCCGLIDLMREYQN LKSAVSKVLENASNVIATRNTIKDQEDLRWALSKHETVKNEMCNKQKELDNFTSKGKQLL SELKKIHSSDFILVKTDMESTVDRWLDMSEKIEENMDRLRVSLTIWADVLSSKEEIDGWS NSSVPQLAESISHLNNSVRAEEVLKEFETEVKNKALRLEELHCKVNDLKELTKNPETPPD LQFIEADLRQKLEHAKEITEEAKGTLKDFTAQSTQVEKCINDMTSWLAKVEELLMNCAQT KTWEGLRKVKEIQKELQSQQSNISSTQENLNSLCRKYHSVELESLGSALTGLIKNHEAVS QLCSKTQASLQDSLENHFSESMQEFQEWFSGIKAAAKASSDRTGDSKVLEAKLHDLQNIL DSISDGQSKLDAVTQEGQTLYAHVSKQIVSSIQEQITKANEEFQAFLKQCLRDKQALQDC ALELGSFEDQHRKLNLWIHEMNERLSTENLGESKQHIPEKKNEVHKVELFLGELLAARES LDKLSQRGQLLSEEGHGAGKEGRLCSQLLTNYQNLLRTTKERLRSCQMALQEHEALEEAL QSMWSWVKGIQDRLATAESTVGSKDTLEKRLLQIQDILLMKGEGEVKLNMAIGKGEQALR SSNKQGQKVIQTQLQTLKDVWADIISSSVHAQSTLEAVIGKWSDYLEWKHQLEQWLESVD QKVEQPLQLQPGLKEKFALLDHFQSVVSEAEEHAGALQSLASKSRELYQKTEDESFKEAA QEELKTQFNDIITVSKEKMRKVEEIVKDHLMYLDAVQEFTDWLHSAKEELHRWSDMSGDS SATQKKLSKIKELMDSREIGAGRLSRVELLAPAVKQNTSASGCELVDAEMQALRADWKQW EDSVLRTQTSLEDLVSQMALSEQEFSGQVAHLEQALGQFSALLSTWTQQLALLEGKNTDQ EIVECWQKGQEILDALQKSEPKTEDLKSQLNELCRFSRDLSTYSGRVSGLIKEYNCLCLQ ASKGCQNREQILQQRFRRAFKDFQQWLVNAKITTAKCFDIPQNISEVSASLQKIQEFLSE SENGQHKLNTMLSKGELLSTVLPKEKAEGIQAKVATAKEDWKNFHSNLHQKESALENLKI QMKDFEVSAEPVQDWLSKTEKLVQESSNRLYDLPAKRREQQKLQSVLEEINCYEPQLNRL REKAQQLWEGQAASKSFMHRVSQLSAQYLALSNLTKEKVSRLDRIVAEHSQFSLGIKELQ DWLTDAVHMLESYCHPTSDKSVLDSRMLKLEALLSVKQEKEIQMKMIVTRGESVLQNTSP EGIRALQQQLQSVKDMWASLSSAAIRCKSQLEGALSKWTSYQDDVRQFSSWMDSVEAGLN ESERQYAELREKTTALGKAKLLSEEVLSYSSLLETIELKGAGMTEHYVTQLEFQDLQERY RAIKERAKEAVTRSEKLVRLHQEYQRDLKAFEVWLGQEQDKLDRHSVLEGDADSHETTLR HLQELQVRCAEGQALLNSVLHAREEVIPSGIPQTEDRALESLRQDWQAYQQRLSETRTQF NNVVNKLRLMEQKYQQVDEWLKTLESKVSVRTGRQSSRAAKEMQLHQMKKWHEEVTAYKD EVEEVGARAQEMLDESHGSSQMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEESELS LSSYSEWYSSTYKNFKNVATKIDRVDKAMMGRKMKMLEGLLKDMEKGHGLLKSAREKGER ALKYLEDGEAETLRKEIQEHMEQLKELTSAVRKEHLTLEKGLLLAKEFSDKYKALTQWIS EYQEILHTPEEPKMELYEKKAQLSKYKSLQQVVLSHEPSVRSVREKGEALLELVQDVTLK DEIDKLQSDYKDLCGAGKEHVCSLEAKVRDHEDYNSELQEVEKGLLQMSGRLVAPDLMET SSLETITQQLAHHKAMMEEIAGFEDRLNNLKMKGDNLISQCADHLQVKLKQNVHGHLQGT RDSYSAICSTAQRVYQSLEHELQKHVSRQDTVQQCQAWLSAVQPDLQPSQHPPLSRAEAV KQVKHFRALQEQARTYLDLLCSMCDLSNPSVKATAKDIQQTEQMIEQRLAQAQNLTQGWG EIKHMKAELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQCKQASVTAIT ERVNKLTKNQESPEHKEISHVNDQWSDLCHQSNNLCLQREEDLQRTRDYHDRMDAVEVLL EKFTTEWDNLARSDAESTAVHLEALKKLALALQERKQAIEDLKDQKQKMIEHLNLDDKEL VKEQTSHLEQRWFQLEDLVKRKIQVSVTNLEELNVVRSRFQELMEWAEEQQPNIAEALKQ SPPPDTAQHLLLDHLSICSELEAKQMLLKSLIKDADRVMADLGLNERQIIQKALSEAQRH VNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQV KTCKSAQASLKTYQNEVTGLWAQGRELMKGVPEQEKSEVLGKLQELQSVYDTVLQKCSHR LQELEKNLVSRKHFKEDFDKACHWLKQADIVTFPEINLMNESPELHTQLAKYQHILEQSP EYETLLLNLQRTGQAMLPSLNEVDHSYLNEKLNALPLQFNVVVALAKDKFYKVQEAILAR KEYSSLIELMTQSLSELEDQFLKMSKVPTDLRAEEALSLQDGYRALLGEVAGLGEAVDEL NQKKETFRSTGQPWQPDKMLHLVTLYHRLKRQTEQRVTFLEDTTSAYQEHEKMCHQLEKQ LEAVKTEQSRVNEETLPAEEKLKKYHSLAGNLQDLGIVLKRVTMHLEDLVPHLDPLAHEK AKQQIQSWQEELKRLTSAIGATVTECESRMVQSIDFQTELSRSLDWLRSVKAELRGPVCL DLRLQDIQEEIRKIQIHQEEVQSSLRILNALSNKEKEKFTKAKELISADLQHTLAELSEL DGDVQEALRTRQAVLTQIYSQCQRYYQVSQAANDWLEDAHEMLQLAGNGLDVESAEENLK SHKEFFSTEDQFHSHLEELQGLVASLDPLIKPTGKEDLAQKMASLEEKSQRIIQDSHAQL DLLQRCSAQWQDYQKAREEVIELMNDAEKKLSEFSLSKTSSSHEAEGKLSEHKSLVSLVN SFHEKVVALEDKTSQLEKTGNDASKAAISRSMTTVWQRWTRLRAVAQDQEKILEDAVEEW KSFNSKVTKASEMIDQLQAKLPDSSAEKASKAELFALLDHHETLILELEQQHLALGLLRQ QALSMLQDGATPSPGEEPSIVQEITAMQDQCLNIQDKVKRNGKAVKQELEERDVVETQIN SVKSWIQETKEYLGNPTIEIEAQLEELQILLTEATNHRQNIEKLTEEQKNKYLGLYSILP SELSLQLAEVALELGTIHDQIQDKVRDVEQSKAMSQEFGRQIQNIARDLTTILSKLRTKT DNIAQAKTDQKVLGEELDGCNLKLVELDAAVQKFSEQNGQLGKPLAKKIGKLIELHQQTL RQAENRLSKLGQAASHLEEYNEMLEFILKWIEKAKVLLHGKITWNSAHQLREQYILHQSM LEESEEIHSSLEAMIEKLQHLASVYSIENMSQQVAELGRESEELRQMIRIRMQNLHDAAK DMKKFETELKNLQVALEQAQTTLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVHAVQIC QSALRIPEDVVTNLPLCHAALHLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMQHLQE LIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHA TMLLTVTEVEGLAEGTEDLDRELLPATSAHPSVVMMTAGRCHTLLSPVTEESGEEGTSSE ISSPPACRSPSPVANTDASVNQDIAYYQALSPERLQTDAARIHPSSLPPQEFYEPGLEPS ATAKLDDLQRSWETLKNVISEKQRSLYEALERQQKYQDSLQSISTKMEAIEMKLSESLEP GRSPESQMAEHQSSPQALMDEILMLQEEISALQSSLAEELVSESPESDPAEQLALQSTLT VLAERMSTIKMKASGKRQLLEEKLSEQLEEQRQEQALQRYRCEADELDHWLLSTKATLDT ALGTATEPMDMETQLVDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKEEAEQLAVK LRTLKGSLLELQRALHDKQLNIQQGTAQEKEESHVDLTASQSPGVQDWLAQARTTWAHQR QSSLQQQKELEQELAEQKSLLRSVASRGEEILTQHSAAETSGGAGEKPDVLSQELGMEGE KSAAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDGQTQD RSAVTSLLDGLNQAFEEVSSQGVGTKRQNIHLEQKLYDGVSATSTWLDDVEERLFVATAL LPEETEACLFNQETLAKDIKEMSEEMDKNRNLFSQAFPENGDNRDVIEDTLGCLLGRLSL LDSVVNQRCHQMKERLQQILNFQNDLKVLCTSLADNKFIILQKLANVFEQPVAEQIEAIQ EAEDGLKELDAGIIELKKRGDKLQIEQPSMQELSKLQDMYDELMMTIGSRRSGLNQNLAL KSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETL FRKIISFAVPQETRFRTELMAQASAVLKQAHKRGVELEYILETWTHLDEAHQELSRQLEA VESSIPSVGLVEESEGRLIERITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLES QLNQLGEHWLNNTNKVSKELHRLETVLKHWTRYQSESAELTHWLQSAKDRLEFWTQQSVT VPQELEMVRDHLNAFLEFSKEVDAKSSLKSSVMSTGNQLLRLKKVDTAALRSELSHIESQ WTDLLTNIPTVQEKLHQLQMDKLPSRHAISEVMTWISLMENVIQKDEENIKNSIGYKAIH EYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNKSWQILQ GLVTEKIQMLEGLLESWSEYENDVQSLKAWYETQENRLKQQHRIGDQASVQNAMKDCQDL EDLIKAKEKEVEKIEQNGLALIQNKKEEVSGVVLNTLRELRQTWANLDRMVGQLKILLKS VFDQWNNHKVAFDEINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQEKNL QRFGSVTNQLLKECHPPVTETLTNTLKDVNMRWNNLLEEIAEQLHASKALLQLWQRYGDY SKQCASALQQQDDRTNELLKAATNKDIADDEVATWIEDCNDLLKELGVVKDSLFVLRELG EQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTMLQTGVLDYETFTKSLEVLEAW IVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSLAPDLDRLNELGYRLPLNDKEI KRMQSLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNY QHLLEQQRAHELFQAEMFSRQQILHSIIIDGQHLLEQGQVDDRDEFNLKLTLLSSQWQGV IRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYFPVSALGSVPIPLQQARTLFDEV QFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAALQAELSEIQEKWRSASTHLEEQKKK LAFLLKDWEKCENGIANSLEKLRTFKKKFSQPLPDHHEELHTEQMRCKELENAAGSWTDD LAQLTLLKDTLCAYISADDISILNERMELLQRQWEELCHQLSLRRQQVSERLNEWAVFSE KNKELCEWLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQENKIQLQQIGERLARAS HESKASEIEYKLGKVNDRWQHLLDLMAARVKKLKETLVAVQQLDKNMSNLRTWLAHIESE LAKPIVYNSCDSDEIQKKLTEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECD SIQQATRNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSS SGVLYTVAKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSSCSLKQMVHEGNQ RWDNLQKRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIK QLKAFQQEISLNHNKIEQIIAQGEQLIEKSEPLDAAVIEEELDELRRYCQEVFGRVERYH KKLIRLPLPDDEHDLSDRELELDDSAALSDLHWRDTSVDGVLSPQPSSNPSLSLAQPLRS ERSGRDTPASVDSIPLEWDHDYDLSRDLESAVSRTLPSEDEEGQDDKDFYLRGAVGLSDV MIPESPEAYVKLTESAIRNTSGAPSALESQIRQLDRALDESRFQMQQTENIIRSKTPTGP ELDSTYRGYMKLLSECSGSIDSVRRLEHQLKEEEQNFPGFVNLNTTETQTAGVIDRWELI QAQALSKELRMKQSLQKWQQFQADLHSVWTWLGEAEQELEQLRRLELSTDIQAIELQIKK LKELQKAVDHRKAIILSINLCSSEFTQTGSEKSQDLQDRLCQMNGRWDRVCSLLEEWRGL LQDALMQCQDFHEMSHGLLLMLENIDRRKNEIVPIDSNLDADTLQDHHRQLLQIRHELLE SQLRVASLQDMSCQLLVNAEGTDCLEAKEKVHVIGNRLKLLLKEVSRHIKELEKLLDMSS SQQDLSSWSSADELDTSGSVSPTSGRSTPNRQRTPRGKCSLSQPGPSVSSPHSRSIKGGS DSSLSEPRPARSGRAFWFRVLRAALPLQLLLLLLIGLACLVPMSEEDYSCALSNNFARSF HPMLRYTNGPPPL NT seq 26502 nt NT seq  +upstreamnt  +downstreamnt atggcggcttctaggacggcctcacggtctcctcgggacattgccaacgtgatgcaaaga ctgcaagatgagcaagagatagtacaaaaacgtactttcacaaaatggatcaattctcat ctggccaagcggaaacccccactggcggtagatgatctttttgaagacatgaaagatggt gtaaagctgcttgctcttctggaggttctctctgggcagaaactgccttgtgaacaagga cgccgtatgaagcgaatccatgctgtggccaatattggcacggcactcaagttccttgaa ggaaggaagtccatgtacagaggatcaccgattaaattagtcaacattaactccactgat atagctgacggccgaccatcaatagttctcggattgatgtggaccattattctatatttc cagattgaggagttgaccagcaacctgccacagctgcagtctttgtccggaagcacatcc tctgtggacagcacggttagtgctgagaccgccagccccccaagtaaacggaaagtggcc accaagatccaaggaaatgccaagagggctcttttaaagtgggttcagtacacagtagcc aagcagaccggaatcgaagtaaaagattttgggcggagctggaggagtgggcttgccttt cattccatcatccacgccattcgaccagaattagtggacttggagcgagtgaaagggaga cctaaccgggaaaacctggcggaggctttcactattgctgaaacagaactaggaatcccg agactgctggatcctgaagatgttgatgtggataaaccagatgagaagtctattatgaca tatgtagcccagtttctgaaacattaccctgacatccacaatactggcactgatgggcaa gagactgatgaaatacttccaggttttccatgttttgcaaattctatccaaatttttaag agagaagacaggctaattctgaaggaagcaaaagtttggatagaacagtttgaaagagat ttgacaagggcacagatgacggaatcaaatttgcaagataaatatcagtcatttaagcac ttcagagttcaatatgaattaaaaaggaaacagattgaacatttaatacaacctgtacat agagacggtaaactgtcacttgaccaagcattggtaaaacaatcctgggacagagtgtcc tccaggctctttgattggcatatacagcttgataaatctctccccgcacctctgggcacc ataggtgcttggttatacagagcagaggtggccttgagagaggaaattaccattcagcag gtccacgaggaaacagccaacacaatacagcggaaacgtgagcaacacaaggatctgctt caaaacacagatgcccacaaaagagcattccatgaaatctaccggaccaggtctgttaac gggatcccagtgccacctgatcagttagaggacatggccgagaggtttcattttgtttcc tccacatcagagctgcacttaatgaaaatggaatttctagaattaaagtaccgtctgctc tcactgctggttcttgcagagtcaaagctgaaatcttggatcatcaagtatgggaggaga gagtcagtggagctgcttctgcaaaactacatctcttttatagaaaataccaagttcttt gagcagtatgaagtgacataccagatcttgaaacagacagcagagatgtacgtccaagct gacgggtcagtggaagaagccgagaatgtgatgaaattcatgaacgaaaccactgcccag tggcggaacctctcagtagaagtccgaagcgttcggagcatgctggaggaagtaattgct aactgggatcgatatggcaacactgtggccagtcttcaggcctggctagaggatgcagag aaaatgctaaatcagtcagagcatgccaaaaaggattttttccgaaacttgcctcactgg atacagcagcatgctgccatgaatgatgcgggcaatttcctaattgaaacgtgcgatgag atggtctcccgggaccttaaacagcagttactactgttgaatgggcgatggagggagctc ttcatggaagtcaaacaatatgctcgggctgatgagatggacagaatgaaaaaggagtac acagactgtgtgaccgccctgtccgattttgcaactgaagcccttaagaaaatgtctgaa cccttagaagtctcttttcttaatgtcaagttattaactcaagacttggaggacattgag cagagggtacctgtaatggacgcccagtacaagatgattaccaagactgcacacctcatt gccaaagagagcccccaagaagaagctaatgaaatgtttgcaaccatgtctaggctcaag gaacagctaaccaaggtcaaagaatgtcactctccactcctttatgagtctcaacagctg ttgatcccactggaagaactagaaaagcagatgacattcttttatgactcacttgggaaa atcaatgaaatcttaacagttcttgagcatgaggcacaatctagtgctctttttaaacag aaacaacaggagctgtcagcttgtcaagaaagctgtaagaaaaccatgacacaaattgag aaaggcagtcaaaatgttcaaaaattcgtgaccttgagcagtgtgctaaagcattttgat cagacaaagctgcacagacagattgccgatgcccatggtgctttccagcatatggtgaag aaaattggagactggaagaaacatgtggaaaccaatagtcgcttgatgaagaaattcgag gagtctcgagcagagctggagaaggtgctgcggatggcacaggagggtctggaggaaaag ggaaacccggaggacctcctgaagagacacaccgagtttttcagtcagctggatcagaga gtgctcaatgctttcctgaaagcttgcgacgagctcaccgacattctccctgagcaggag cagcagggtctgcaggaagccgttcgaaagctccataaacagtggaaggatcttcaagga gaagccccatatcacttgcttcatctgaagattggtgtggagaagaataggttcttagct tctgtagaagaatgcagaactgagctggatcgggagatcaaactggtggcccaggaaggc agtgaaaatatcattaaagaacacaggattttcttcagtgacaaaggtcctcatcatctt tgtgagaaaaggctacagcttattgaagaactgtgtctgaaactcccagtccgggacccg gtaaggaacacaccggaaacctgtcatgccactctgagagagctcagagctgccatcgat gccacctacatgaagctcgtggaagacccagacaagtggaaggactactctagcagaatt tccgagttctcatcttggatatctgcaaaggagacacagctgaaagcgtttaagagtaaa ccctttgatactgccaaccacggagaggttaaacgtgctgtagaggagatcaggaatggc attaccacaaagggcgagactctcaactggctgaaatccaggcttaaaattttaattgaa gtttcttctgagaatgaagcccaaaagcaaggagacgagctggcaaaattatctggttct ttcaaggctcttgcagctttgttgtcagaggtggaaaagatgttaagcaactttggggac tgtgtccagtacaaagaaatagtgcaaagttcccttgaagacttaatttctggctctaaa gaagtccaggagcaggcggagaagatcctggacacggaaaacctgtttgaagcacagcag ttacttctccatcaccagcaaaagacaaagaggatttctgccaagaagagagacgtgcag cagcaggtagcgcaggctcagcggggagaaggcgggctgcccgaccaggcccgggaggag ctgcggaagctggagagcaccctggaccacatggagcacagcagggagaagcaggagcgc cgcatccaggtcacattaagaaaatgggagcgatttgaaacaaacaaagagacagtggtc agatacctttttcaaacaggttccagccatgagcgctttttgagttttagcagtttggaa agtttatcttcagaactggaacagacaaaggagttttctaaacgaacagaaggtattgca gtccaggctgaaaatcttgtgaaggaagcttctgagataccccttgggcccaagaataag cagctgcttcagcagcaggctaagtcaatcaaagagcaagtcaaaaaattagaagacaca cttgaagaagatattaaaaccatggaaatggtgaaaaacaagtgggatcattttggcaat aattttgagaccctgtccgactggataactgagaaagaaaaagaactcaatgccttggaa acttcgtcatctgccatggacatgcaaatccaccagatcaaggtcacaattcaggaaata gaaagcaagatgagcagcattacagacttagaagaagcagctcagtcttttgctcagttt 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gaggctcaacttgaagaacttcagattctcctaacggaagccacaaatcaccgacagaac attgagaaattgactgaagagcagaagaataagtacctgggtctctactccatcttacct tctgaactgtccctccagttagccgaggtggcactggaattgggaactatccatgatcag atccaggacaaagtaagagacgttgaacagagcaaagccatgagccaggaattcggccga caaattcagaacatagccagagatctcacaactattctaagtaagctgagaacgaagaca gataatatagcacaagctaaaaccgaccaaaaggtgctaggagaagaactggatggctgt aatttaaaattagtggaactagatgcagcagtacagaaattctcggaacagaatggccaa ctgggtaaaccgctggctaagaagataggaaaactgattgaacttcatcagcagaccctt aggcaggctgagaaccggctctccaagctcggtcaggcagcatctcacttagaagaatac aatgaaatgcttgaattcattctgaagtggattgaaaaagctaaagtgttgctacatgga aagattacatggaactcagcacatcaacttcgagaacaatacattttacatcagagcatg ctagaagaatctgaagagatccacagcagtctggaagcaatgattgagaaattacagcac ctcgctagcgtgtactccatagaaaacatgtctcagcaagtggcagaactgggacgggag tctgaggagctgcgacagatgatccgaattcgtatgcagaatctccacgatgctgccaag gatatgaaaaaatttgaaaccgagctaaaaaatttacaagttgctttggagcaagcccag acaaccttgacttctccagaagtcggacgtcttagtctcaaggagcaactttctcatcga cagcatttgttatctgagatggagtcactcaagccaaaggtccacgcagtgcagatctgc cagagcgccctccggatccccgaggatgtggtcaccaacttgccactctgccacgcggcc ctgcacctgcaggaggaggccagccggctgcagcacacggccatccagcagtgcaacatc atgcaggaggctgtggtacaatatgaacagtatgagcaagaaatgcagcacctccaggag ctcatagaaggagcccacagagaaattgaggacaaacctgtggccaccagtaacatccag gagctgcaggcccagatttctcgacacgaggagctggctcagaaaatcaagggctaccag gagcagatcgcctctttgaactccaagtgcaagatgctgacgatgaaagccaagcacgcc accatgctgctgacggtgacggaggtggaggggctggcggaggggacggaggacctggac cgggagctcctccccgcgacctcggcccacccctcggtggtcatgatgactgcaggtcgc tgtcacactttgctgtcacctgtcactgaggagtctggggaggagggaaccagcagtgaa atttcctctccacctgcctgtcgctccccttcacctgtggctaatacagatgcttccgtt aaccaggacattgcttattaccaagcgctgtcccctgagaggttgcagaccgatgccgca aggatacaccccagctcgctgccccctcaagagttctacgaaccagggctggagccctct gctactgctaaactagatgatttgcagcgttcttgggaaaccttaaaaaatgtgatcagt gaaaagcagcgcagtctctatgaggccttggaacgtcagcagaagtaccaggactccctc cagtccatctccacgaagatggaggccatcgagatgaaactcagtgagagtctggagccc ggcaggagcccggagagccagatggctgaacatcagtcttctccacaggccttgatggac gagatcctcatgcttcaagaggagatcagcgcgctccagtcatcgctcgcggaggagctg gtgtccgagtcccccgagtccgaccccgcagaacagctggccctgcagtccacgctcacc gtcctggccgagcgcatgtccaccatcaagatgaaggcctcagggaagcgacagcttttg gaggagaagttaagtgagcagcttgaggaacagagacaggaacaggctctgcagaggtac cgctgtgaggccgacgagctggaccactggctcttgagcacgaaggctactctggacacg gcactgggcacagccacggagcctatggacatggagacccagctggtggactgccagaac atgctggtggagatcgagcagaaggtggtggccttatcggaactctcagtccacaatgag aacctgctcctggagggcaaggctcacacgaaggaggaggctgagcagctggctgtaaag ctgaggaccctcaagggaagcctcctggagctgcagagagcgctgcacgacaaacagctc aacatccagcagggcacagcgcaagagaaggaggagagccatgtggacttaactgccagc cagagccctggggtccaggactggctggcccaagctcgaaccacgtgggcccaccagcga cagagcagcctccagcaacaaaaggagttggaacaggaattagccgagcagaagagcctc ctgcggtcagtagccagtcgtggagaggaaattctcacccaacactcagctgcagagacc tctggcggtgctggcgaaaaacctgatgtgttatcccaggagttggggatggaaggggag aaatcagctgctgaagaccagatgagaatgaaatgggaaagcctacatcaagaatttagt accaagcagaagctactacagaatgttctggaacaggaacaggagcaagtgctctacagc aggccgaatcgactcttgtctggtgtgccactatacaaaggagatggacagacccaagac agatctgcagtgacatctttgctggatggattgaaccaggcctttgaggaggtttcatct cagggtgtggggacaaaaaggcagaacattcacttggaacagaagttgtatgatggggtc tcagctacgtctacatggttggatgatgttgaggaacgtttatttgttgccacagcactt ttaccagaagaaacggaagcttgcctcttcaaccaagagactcttgccaaagatattaaa gaaatgtctgaagaaatggataagaacaggaacttgttttctcaagcatttccagagaat ggtgataaccgggatgtcattgaagacactttgggttgtcttttgggcaggttgtccttg ctagactcagtagtaaatcagcgctgtcatcagatgaaggaaagacttcagcaaatactg aatttccagaatgatctgaaggtgctgtgcacgtcgctggctgacaacaagttcatcatt ctgcagaaactggcaaatgtgtttgaacagcctgtggcagagcaaatagaggcgatacaa gaggctgaagatgggctaaaggaattggatgcaggaatcattgaattaaaaaagcgtggg gacaagttgcagattgagcagccgtccatgcaggaactatccaaacttcaggacatgtat gatgaactgatgatgaccattggctcccggcggagtgggctgaaccagaatctcgcactt aagagtcagtatgaaagggcccttcaagatctggctgacctgctggagactggacaggag aagatggcaggtgaccagaaaatcatcgtgtcctccaaagaggaaattcaacaactactt gataaacataaggaatactttcagggcctggaatctcatatgatcttgactgaaacgctc ttcagaaagatcatcagctttgcagtcccacaggaaacacggttccgcacggaactgatg gcacaggcttccgcggtactgaagcaggctcacaagaggggcgtggagttggagtacatt ctggagacatggactcatttggatgaagcccaccaggagctcagcagacagctggaggcg gtggaaagcagcatcccgagcgtggggctggtggaagagagcgagggcaggctcatcgag cgcataacgctctaccagcatttgaaatccagccttaatgaataccagcccaaattatat caggtattagatgacgggaaacgactgctcatatccattagctgctcagatctagaaagc cagctaaatcaacttggagaacactggttaaataataccaacaaagtgtcaaaggagctt cacagattggaaacagtgttgaaacactggaccagatatcaaagtgaatctgcagaactt actcactggttacaatctgcaaaagacaggctagaattttggactcaacaatctgtgaca gtcccacaagaactggaaatggtccgtgatcatctaaatgctttcctggagttttccaaa gaagtggatgccaaatcttccctgaaatcatctgttatgagcactggaaatcagcttctt cgattaaagaaagtggacacagctgccctacgttcagagctgtcacacattgagagccag tggactgacctgctgacaaatattcccactgtacaggagaagctccaccagctccaaatg gataagctgccttcccgccatgccatttctgaagttatgacttggatttctctcatggaa aatgttattcaaaaggatgaagagaatataaaaaattcaataggttacaaggcaattcat gaataccttcagaaatataagggttttaagatagatattaactgtaaacagttgacagtt gattttgtgaatcagtccgtgctacagatcagtagtcaggatgtggaaagtaaacgcagt gataagactgattttgctgagcaactgggagccatgaacaaaagttggcaaatccttcag ggtcttgtaactgagaagatccagatgttggaaggcttattggaatcttggtcagaatat gaaaatgatgtacaaagtctgaaagcttggtatgaaacccaggaaaacagactaaagcaa cagcatcgcattggagatcaggcttcagttcagaatgcaatgaaagactgtcaggatcta gaagatttgattaaagcaaaagaaaaagaggtggagaaaattgagcagaatggacttgct ttgattcagaacaagaaagaagaagtctctggtgttgtcctgaacacactgagggagctc aggcaaacgtgggctaatttagaccgcatggttggacaattaaagatactgctgaagtcc gtgttcgaccaatggaataatcacaaggtagcctttgacgagatcaacagctacctcatg gaggcgagatactctctgtcccgcttccgtctgctgactggttctttagaagcagtacaa gttcaggtagacaatcttcagaatcttcaagatgatctggaaaaacaggaaaagaactta cagaggtttggctctgtcaccaaccaactgttaaaagagtgtcacccgcctgtgacagaa actcttaccaatacattaaaagatgtcaatatgagatggaataacttgctggaagagatc gctgagcagctgcacgccagcaaagccctacttcagctttggcagaggtacggggactac tcgaagcagtgtgcctctgcgctgcagcagcaggacgaccgaaccaacgagctcctgaag gcggccaccaacaaggacattgctgatgacgaggttgcgacgtggatcgaagattgcaat gatctcctcaaagaactgggggtagtgaaggattccctatttgttctgcgtgagctggga gagcagctcaagcagcaagtggacgcttcagcggcatcagccattcaatccgatcagctg tctttgagtcaacatctgtgtgccctagagcaggctctttgcaagcagcagaccatgtta cagactggagttcttgactatgaaacctttaccaagagcttagaagtgttggaggcctgg atagtagaagctgaagaaatattacaagggcaggacccaagccactcatctgacctctca accatccaggaaaggatggaagaacttaaggggcagatgctaaaattcagcagcctggcc cctgacctagaccgtctgaatgagcttggatacaggctaccgctgaatgataaagaaatc aaaaggatgcagagtctgaaccgacactggtctctgatctcctcacagaccacagagaga ttcagtaagttgcagtcatttttgctgcaacaccagactttcttggaaaaatgtgaaaca tggatggaattcctggttcaaacggaacaaaagttagcggtggagatttcaggcaactat cagcatcttttggagcagcagagagcgcatgagttgtttcaagcagagatgttcagtcgc cagcagattttgcactcaatcattattgacgggcagcatcttctagaacaaggtcaagtt gatgacagggatgaattcaacctgaaattgacacttctcagcagtcagtggcagggagtg atccgcagggcccagcagaggaggggtatcatcgacagccagattcgccagtggcagcgc tacagggagatggccgagaagctgcgtaaatggttggttgaagtgtcctattttcccgtg agtgctctcggaagcgtccccataccactgcaacaggcaaggaccctctttgatgaagtg cagtttaaagaaaaagtgttcctgcgacagcaaggcagctacatccttacagtggaggcg ggcaagcagctcctgctctcggccgacagtggggctgaggccgctttgcaggcagagctc agtgagatccaggagaagtggagatcagccagcacgcatttggaggaacagaagaaaaaa ctggccttcttgctgaaagactgggaaaaatgtgagaacggaatagctaattctctggag aagctacgaacgttcaaaaagaagttttctcagcctctgccggatcaccatgaagagcta cacacagaacaaatgcgctgcaaggagttggaaaatgcagctgggagctggacagatgac ttggctcagctgaccctcttgaaggacaccctctgtgcctacattagtgctgacgatatc tccatcctgaacgagcgcatggagcttctgcaaaggcagtgggaagaactatgccaccag ctctccctaaggcggcagcaagtaagtgagagattgaatgaatgggcggtcttcagtgaa aagaacaaggagctttgtgaatggctgacccagatggaaagcaaagtttctcaaaatgga gacatcctcattgaagaaatgatagagaagctcaagaaggattatcaagaggaaattgct gtggcccaagagaacaaaatacagctccagcagataggagaacgactggctcgagccagc catgaaagcaaagcctctgagattgaatacaagctcggcaaggtcaatgaccggtggcag catcttctggatcttatggcagccagggtgaagaagctgaaggagaccctggtggctgtg cagcagctagacaagaacatgagcaacctgaggacgtggttggctcatatcgagtcagag ctggccaagcccatagtctacaattcctgtgactcggatgaaatacagaagaagctcact gagcagcaggagcttcagagagacatcgagaaacacagcacaggcgtggcctccgtgctc aacctgtgtgaggtcctgctgcatgactgtgacgcctgtgccacagacgcagagtgtgac tccatccagcaggcgacgcgaaacctggaccggcggtggaggaacatctgtgccatgtcc atggaaagaaggctcaaaatcgaagagacgtggcgactgtggcagaagtttctggatgat tattctcgttttgaagattggctcaagatttcagagaggacagctgccttccccagctct tccggggtgctctatacagttgccaaggaggaactaaagaaatttgaggctttccagcga caggtgcacgagagcctgacccagctggagctgatcaacaagcagtaccgtcgcctggct agagagaaccgcaccgattcctcctgcagcctaaagcagatggttcacgaaggcaaccag cgatgggacaacctgcaaaaacgtgtcacctccatcttgcgcagactcaagcatttcatt ggccagcgtgaggagtttgagaccgcgcgggacagcattctggtgtggctgacggagatg gatctacagctcacgaatatcgagcatttttcggagtgtgacgttcaagctaaaataaag caactcaaggcctttcagcaggaaatttcactgaaccacaataagatcgagcagataatt gcccaaggagagcagctcatagagaagagcgagccgttggatgccgcagtcattgaggag gagctggacgaactccgacgttattgtcaggaggtcttcgggcgcgtggagagataccat aagaaactgattcgcctacctctcccagatgatgagcatgacctctctgaccgggagctg gagctggatgactccgcagctctctccgacctccactggcgtgacacctctgtggacggc gtgctttccccccagccttcctccaacccctccctctcactcgcccagcccctgcggagc gagcggtcgggacgagacacccctgccagtgtggactccatccccctggagtgggaccat gactatgatctcagtcgtgacctggagtctgctgtgtccagaacgctgccctctgaggac gaagagggtcaggatgataaggatttctacctcaggggagctgttggcttatcagatgta atgatccccgaaagtcctgaggcctatgtaaaactcacagaaagtgcaatcagaaatacc tctggagctcccagtgccttagagtcacagatccgacaactggacagagccttggatgag agccgttttcagatgcagcaaactgaaaatattatccgcagcaaaactcccacaggacca gagctagactccacctacaggggctacatgaagctgctgagtgagtgcagcggcagtatc gactccgtgaggagactagaacaccaactgaaggaggaagaacagaatttccccggcttc gttaacctgaatactacggaaacccaaacggctggtgtgatcgaccggtgggagctcatc caggcccaggccctgagcaaggagctgagaatgaaacagagtctccagaagtggcagcag ttccaggcggacctgcacagcgtctggacgtggctgggggaggcggagcaggagctggag cagctgcggcgcctggagctcagcaccgacatccaggctatcgagctccaaatcaaaaag ctcaaggagctccagaaagccgtggaccaccgcaaagccatcatcctctccatcaacctg tgcagctctgagttcacccagaccggcagtgagaagagccaggatctgcaagaccgcttg tgccagatgaacgggcgctgggaccgggtgtgctcgctgctggaggagtggcggggccta ctccaggacgcgctgatgcagtgtcaggatttccatgaaatgagtcatggtttgcttctt atgctggagaacatagacagaaggaaaaatgaaattgtccctattgattctaacctggat gcagacacacttcaagaccatcacaggcagctcttgcaaataaggcatgagctcttggaa tcccagctcagagtggcctcactgcaagacatgtcttgccaactcctggtgaacgctgaa ggcacagactgtttggaagccaaagaaaaagtccacgtaattggaaatcggctcaaactt ctcttgaaggaggtcagtcgtcacatcaaggagctggagaagctattagacatgtcaagc agtcagcaggatttgtcttcctggtcttcggctgatgagctggacacttcgggatctgtg agtcctacttccggaagaagcaccccaaacagacaaagaacgccacgaggcaaatgtagt ctctcacagcctggaccctctgtcagcagtccacatagcaggtccataaagggtggctcc gattcctccctttctgagcctcggcccgctcggtccggccgagccttctggttcagagtc ctccgagcggctcttccgcttcagcttctcctgctgctcctcatcgggctcgcctgcctc gtgccgatgtcagaggaggactacagctgtgccctctccaacaactttgcccgatcattc caccccatgctcagatacacaaacggccctcctccgctctga

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