KEGG   Mustela lutreola (European mink): 131835957
Entry
131835957         CDS       T09578                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mlk  Mustela lutreola (European mink)
Pathway
mlk01521  EGFR tyrosine kinase inhibitor resistance
mlk01522  Endocrine resistance
mlk04010  MAPK signaling pathway
mlk04012  ErbB signaling pathway
mlk04014  Ras signaling pathway
mlk04015  Rap1 signaling pathway
mlk04022  cGMP-PKG signaling pathway
mlk04024  cAMP signaling pathway
mlk04062  Chemokine signaling pathway
mlk04066  HIF-1 signaling pathway
mlk04068  FoxO signaling pathway
mlk04071  Sphingolipid signaling pathway
mlk04072  Phospholipase D signaling pathway
mlk04114  Oocyte meiosis
mlk04140  Autophagy - animal
mlk04148  Efferocytosis
mlk04150  mTOR signaling pathway
mlk04151  PI3K-Akt signaling pathway
mlk04210  Apoptosis
mlk04218  Cellular senescence
mlk04270  Vascular smooth muscle contraction
mlk04370  VEGF signaling pathway
mlk04371  Apelin signaling pathway
mlk04380  Osteoclast differentiation
mlk04510  Focal adhesion
mlk04540  Gap junction
mlk04550  Signaling pathways regulating pluripotency of stem cells
mlk04613  Neutrophil extracellular trap formation
mlk04620  Toll-like receptor signaling pathway
mlk04650  Natural killer cell mediated cytotoxicity
mlk04660  T cell receptor signaling pathway
mlk04662  B cell receptor signaling pathway
mlk04664  Fc epsilon RI signaling pathway
mlk04666  Fc gamma R-mediated phagocytosis
mlk04668  TNF signaling pathway
mlk04720  Long-term potentiation
mlk04722  Neurotrophin signaling pathway
mlk04725  Cholinergic synapse
mlk04726  Serotonergic synapse
mlk04730  Long-term depression
mlk04810  Regulation of actin cytoskeleton
mlk04910  Insulin signaling pathway
mlk04912  GnRH signaling pathway
mlk04914  Progesterone-mediated oocyte maturation
mlk04915  Estrogen signaling pathway
mlk04916  Melanogenesis
mlk04917  Prolactin signaling pathway
mlk04919  Thyroid hormone signaling pathway
mlk04921  Oxytocin signaling pathway
mlk04926  Relaxin signaling pathway
mlk04928  Parathyroid hormone synthesis, secretion and action
mlk04929  GnRH secretion
mlk04934  Cushing syndrome
mlk04935  Growth hormone synthesis, secretion and action
mlk05010  Alzheimer disease
mlk05022  Pathways of neurodegeneration - multiple diseases
mlk05034  Alcoholism
mlk05132  Salmonella infection
mlk05135  Yersinia infection
mlk05160  Hepatitis C
mlk05161  Hepatitis B
mlk05163  Human cytomegalovirus infection
mlk05164  Influenza A
mlk05165  Human papillomavirus infection
mlk05166  Human T-cell leukemia virus 1 infection
mlk05167  Kaposi sarcoma-associated herpesvirus infection
mlk05170  Human immunodeficiency virus 1 infection
mlk05200  Pathways in cancer
mlk05205  Proteoglycans in cancer
mlk05206  MicroRNAs in cancer
mlk05207  Chemical carcinogenesis - receptor activation
mlk05208  Chemical carcinogenesis - reactive oxygen species
mlk05210  Colorectal cancer
mlk05211  Renal cell carcinoma
mlk05212  Pancreatic cancer
mlk05213  Endometrial cancer
mlk05214  Glioma
mlk05215  Prostate cancer
mlk05216  Thyroid cancer
mlk05218  Melanoma
mlk05219  Bladder cancer
mlk05220  Chronic myeloid leukemia
mlk05221  Acute myeloid leukemia
mlk05223  Non-small cell lung cancer
mlk05224  Breast cancer
mlk05225  Hepatocellular carcinoma
mlk05226  Gastric cancer
mlk05230  Central carbon metabolism in cancer
mlk05231  Choline metabolism in cancer
mlk05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mlk00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    131835957 (MAP2K1)
   04012 ErbB signaling pathway
    131835957 (MAP2K1)
   04014 Ras signaling pathway
    131835957 (MAP2K1)
   04015 Rap1 signaling pathway
    131835957 (MAP2K1)
   04370 VEGF signaling pathway
    131835957 (MAP2K1)
   04371 Apelin signaling pathway
    131835957 (MAP2K1)
   04668 TNF signaling pathway
    131835957 (MAP2K1)
   04066 HIF-1 signaling pathway
    131835957 (MAP2K1)
   04068 FoxO signaling pathway
    131835957 (MAP2K1)
   04072 Phospholipase D signaling pathway
    131835957 (MAP2K1)
   04071 Sphingolipid signaling pathway
    131835957 (MAP2K1)
   04024 cAMP signaling pathway
    131835957 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    131835957 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    131835957 (MAP2K1)
   04150 mTOR signaling pathway
    131835957 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    131835957 (MAP2K1)
   04148 Efferocytosis
    131835957 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    131835957 (MAP2K1)
   04210 Apoptosis
    131835957 (MAP2K1)
   04218 Cellular senescence
    131835957 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    131835957 (MAP2K1)
   04540 Gap junction
    131835957 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    131835957 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    131835957 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    131835957 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    131835957 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    131835957 (MAP2K1)
   04660 T cell receptor signaling pathway
    131835957 (MAP2K1)
   04662 B cell receptor signaling pathway
    131835957 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    131835957 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    131835957 (MAP2K1)
   04062 Chemokine signaling pathway
    131835957 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    131835957 (MAP2K1)
   04929 GnRH secretion
    131835957 (MAP2K1)
   04912 GnRH signaling pathway
    131835957 (MAP2K1)
   04915 Estrogen signaling pathway
    131835957 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    131835957 (MAP2K1)
   04917 Prolactin signaling pathway
    131835957 (MAP2K1)
   04921 Oxytocin signaling pathway
    131835957 (MAP2K1)
   04926 Relaxin signaling pathway
    131835957 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    131835957 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    131835957 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    131835957 (MAP2K1)
   04916 Melanogenesis
    131835957 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    131835957 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    131835957 (MAP2K1)
   04726 Serotonergic synapse
    131835957 (MAP2K1)
   04720 Long-term potentiation
    131835957 (MAP2K1)
   04730 Long-term depression
    131835957 (MAP2K1)
   04722 Neurotrophin signaling pathway
    131835957 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    131835957 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    131835957 (MAP2K1)
   05206 MicroRNAs in cancer
    131835957 (MAP2K1)
   05205 Proteoglycans in cancer
    131835957 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    131835957 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    131835957 (MAP2K1)
   05230 Central carbon metabolism in cancer
    131835957 (MAP2K1)
   05231 Choline metabolism in cancer
    131835957 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    131835957 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    131835957 (MAP2K1)
   05212 Pancreatic cancer
    131835957 (MAP2K1)
   05225 Hepatocellular carcinoma
    131835957 (MAP2K1)
   05226 Gastric cancer
    131835957 (MAP2K1)
   05214 Glioma
    131835957 (MAP2K1)
   05216 Thyroid cancer
    131835957 (MAP2K1)
   05221 Acute myeloid leukemia
    131835957 (MAP2K1)
   05220 Chronic myeloid leukemia
    131835957 (MAP2K1)
   05218 Melanoma
    131835957 (MAP2K1)
   05211 Renal cell carcinoma
    131835957 (MAP2K1)
   05219 Bladder cancer
    131835957 (MAP2K1)
   05215 Prostate cancer
    131835957 (MAP2K1)
   05213 Endometrial cancer
    131835957 (MAP2K1)
   05224 Breast cancer
    131835957 (MAP2K1)
   05223 Non-small cell lung cancer
    131835957 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    131835957 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    131835957 (MAP2K1)
   05161 Hepatitis B
    131835957 (MAP2K1)
   05160 Hepatitis C
    131835957 (MAP2K1)
   05164 Influenza A
    131835957 (MAP2K1)
   05163 Human cytomegalovirus infection
    131835957 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    131835957 (MAP2K1)
   05165 Human papillomavirus infection
    131835957 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    131835957 (MAP2K1)
   05135 Yersinia infection
    131835957 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    131835957 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    131835957 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    131835957 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    131835957 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    131835957 (MAP2K1)
   01522 Endocrine resistance
    131835957 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlk01001]
    131835957 (MAP2K1)
Enzymes [BR:mlk01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     131835957 (MAP2K1)
Protein kinases [BR:mlk01001]
 Serine/threonine kinases: STE group
  STE7 family
   131835957 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Seadorna_VP7 Kinase-like Haspin_kinase Arabinose_bd
Other DBs
NCBI-GeneID: 131835957
NCBI-ProteinID: XP_059036868
LinkDB
Position
7:53349390..53430426
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELVFGCPVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagcttgaggagctg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaattgaaggatgatgactttgagaagatcagtgagcttggcgcaggcaacggtggt
gtggtgttcaaggtctcccacaagccatcaggcctggtcatggccagaaagctcattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagcttcaggtcctacacgag
tgcaactccccctacatcgtgggcttctacggtgcattctacagcgatggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgagcaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagtgggcaactcatcgactccatggcc
aactcctttgtgggcacaaggtcctacatgtcgccggaaagactccaggggacccactac
tcagtgcagtcggacatctggagcatggggctgtctctggttgagatggcggtggggagg
tatcccatccctcccccagacgccaaggagctggagctggtgtttgggtgcccagtggag
ggagatgcggcggagacaccacccagacccaggactcctggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagctgctggattacatagtcaatgag
ccccctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttt
atcaagagatctgatggggaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagctggcgtctaa

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