Entry |
|
Symbol |
PLCB2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
mlk Mustela lutreola (European mink)
|
Pathway |
mlk04070 | Phosphatidylinositol signaling system |
mlk04072 | Phospholipase D signaling pathway |
mlk04261 | Adrenergic signaling in cardiomyocytes |
mlk04270 | Vascular smooth muscle contraction |
mlk04613 | Neutrophil extracellular trap formation |
mlk04621 | NOD-like receptor signaling pathway |
mlk04723 | Retrograde endocannabinoid signaling |
mlk04750 | Inflammatory mediator regulation of TRP channels |
mlk04919 | Thyroid hormone signaling pathway |
mlk04925 | Aldosterone synthesis and secretion |
mlk04927 | Cortisol synthesis and secretion |
mlk04928 | Parathyroid hormone synthesis, secretion and action |
mlk04933 | AGE-RAGE signaling pathway in diabetic complications |
mlk04935 | Growth hormone synthesis, secretion and action |
mlk04961 | Endocrine and other factor-regulated calcium reabsorption |
mlk04973 | Carbohydrate digestion and absorption |
mlk05022 | Pathways of neurodegeneration - multiple diseases |
mlk05163 | Human cytomegalovirus infection |
|
Module |
mlk_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mlk00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
131836105 (PLCB2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
131836105 (PLCB2)
04310 Wnt signaling pathway
131836105 (PLCB2)
04371 Apelin signaling pathway
131836105 (PLCB2)
04020 Calcium signaling pathway
131836105 (PLCB2)
04070 Phosphatidylinositol signaling system
131836105 (PLCB2)
04072 Phospholipase D signaling pathway
131836105 (PLCB2)
04071 Sphingolipid signaling pathway
131836105 (PLCB2)
04022 cGMP-PKG signaling pathway
131836105 (PLCB2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
131836105 (PLCB2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
131836105 (PLCB2)
04613 Neutrophil extracellular trap formation
131836105 (PLCB2)
04621 NOD-like receptor signaling pathway
131836105 (PLCB2)
04062 Chemokine signaling pathway
131836105 (PLCB2)
09152 Endocrine system
04911 Insulin secretion
131836105 (PLCB2)
04922 Glucagon signaling pathway
131836105 (PLCB2)
04929 GnRH secretion
131836105 (PLCB2)
04912 GnRH signaling pathway
131836105 (PLCB2)
04915 Estrogen signaling pathway
131836105 (PLCB2)
04921 Oxytocin signaling pathway
131836105 (PLCB2)
04926 Relaxin signaling pathway
131836105 (PLCB2)
04935 Growth hormone synthesis, secretion and action
131836105 (PLCB2)
04918 Thyroid hormone synthesis
131836105 (PLCB2)
04919 Thyroid hormone signaling pathway
131836105 (PLCB2)
04928 Parathyroid hormone synthesis, secretion and action
131836105 (PLCB2)
04916 Melanogenesis
131836105 (PLCB2)
04924 Renin secretion
131836105 (PLCB2)
04925 Aldosterone synthesis and secretion
131836105 (PLCB2)
04927 Cortisol synthesis and secretion
131836105 (PLCB2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
131836105 (PLCB2)
04270 Vascular smooth muscle contraction
131836105 (PLCB2)
09154 Digestive system
04970 Salivary secretion
131836105 (PLCB2)
04971 Gastric acid secretion
131836105 (PLCB2)
04972 Pancreatic secretion
131836105 (PLCB2)
04973 Carbohydrate digestion and absorption
131836105 (PLCB2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
131836105 (PLCB2)
09156 Nervous system
04724 Glutamatergic synapse
131836105 (PLCB2)
04725 Cholinergic synapse
131836105 (PLCB2)
04728 Dopaminergic synapse
131836105 (PLCB2)
04726 Serotonergic synapse
131836105 (PLCB2)
04720 Long-term potentiation
131836105 (PLCB2)
04730 Long-term depression
131836105 (PLCB2)
04723 Retrograde endocannabinoid signaling
131836105 (PLCB2)
09157 Sensory system
04742 Taste transduction
131836105 (PLCB2)
04750 Inflammatory mediator regulation of TRP channels
131836105 (PLCB2)
09159 Environmental adaptation
04713 Circadian entrainment
131836105 (PLCB2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
131836105 (PLCB2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
131836105 (PLCB2)
09174 Infectious disease: parasitic
05146 Amoebiasis
131836105 (PLCB2)
05142 Chagas disease
131836105 (PLCB2)
05143 African trypanosomiasis
131836105 (PLCB2)
09164 Neurodegenerative disease
05010 Alzheimer disease
131836105 (PLCB2)
05016 Huntington disease
131836105 (PLCB2)
05017 Spinocerebellar ataxia
131836105 (PLCB2)
05022 Pathways of neurodegeneration - multiple diseases
131836105 (PLCB2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
131836105 (PLCB2)
05415 Diabetic cardiomyopathy
131836105 (PLCB2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
131836105 (PLCB2)
04934 Cushing syndrome
131836105 (PLCB2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mlk04131]
131836105 (PLCB2)
Enzymes [BR:mlk01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
131836105 (PLCB2)
Membrane trafficking [BR:mlk04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
131836105 (PLCB2)
Endocytosis
Macropinocytosis
Phospholipase C
131836105 (PLCB2)
|
SSDB |
|
Motif |
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Other DBs |
|
LinkDB |
|
Position |
7:complement(66729529..66749500)
|
AA seq |
1187 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQNKEMEFLD
ITNIRDTRFGKFAKIPKSQKLRDVFNMDFPDNNFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKSWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPLARPDQVRGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLAGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIYFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRMTFGEMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSVPATPSKEPGGG
AENNCPPRASVGEDPVWAGEDGAEPEEEEVEEEEEESGNLDEEELKKMQSDEGTAGLEVT
AYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMS
RIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFM
RRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSDRSVRTYVEVELFGLPGDPKRRYRTK
LSPTANSINPVWKEEPFVFEKILMPELASLRVAVLEEGNKFLGHRIIPINALNSGYHHLC
LHSESNLPLTMPALFVFLELKDYVPDTWADLTVALANPIKFFSAHDKKSVKLKEAMEGLP
EKPFPLGSPIVRPVNGALAPTSNGSAAAGARAKEEAMKEATEPQTASPEELRELKGVLKL
QRRHEKELRDLERRGARRWEELLQRGAAELAGLGQPSAGGCGGRRLGPGKGSRKKRTLQC
EEAAGPAPGEGREGSEGADARARELQDRLELELLQQGEEQYECILKRKEQHVAEQIAKMM
ELAREKQAAELKTLKETLEIDTKEMKKKLEAKRLERIQAMVKVTPDKMAQERLKREINNS
HIQEVVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQQEVLAEYEVRMKGLEAEV
KESVKACLRNCLPSEAKDKPERPYEAFRELCDQDPLTAKAGAEESRL |
NT seq |
3564 nt +upstreamnt +downstreamnt
atgtctctcctcaaccccgtcctgctgccccccaaggtgaaggcttatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaaccacaatagcctccccagttatcctccgtgtg
gatcccaagggttactacttatattggacatatcagaataaggagatggagtttctggat
atcaccaacatcagggatacccgctttgggaagtttgccaagatacccaagagccagaag
ctccgggacgtcttcaacatggacttccccgacaacaacttcctcctcaagacactcact
gtggtgtctggccctgacatggtagacctcaccttccacaacttcgtctcctataaggag
aatgtgggcaagagctgggccgaagatgtgctggccctcgtcaagcacccactgacagcc
aatgcctcccgtagcaccttcttggacaaaatcctggtgaagctcaagatgcagctcaac
cccgaagggaagattcctgtgaaaaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgccctcagcgcttgccacctcccaaaaggcaagaacgatgccatcaatcct
gaggacttcccagaatccgtctacaagagtttcctcatgagcctctgtcctcggccagaa
atagacgagatcttcacttcctaccacgccaaggccaaaccctacatgaccaaagaacac
ctgaccaagttcatcaaccagaaacagagggacccccgtctcaactctctgctgtttcca
ctggcacggcctgaccaggtgcggggcctcatcgacaagtatgagcccagtggcatcaac
gtgcagaggggccagctctcccccgagggcatggtgtggtttctctgcgggcctgagaac
agcgtgctggcccaggacaagctgcttctccaccaggacatgacgcagcccctcaaccat
tacttcatcaactcctcacacaacacttacctgacagccggccagttctctggcctgtcg
tcggccgagatgtaccgccaggtgctgctggccggctgccgctgcgtggagctggactgc
tggaagggcaagccccctgacgaggagcccattatcacccatggcttcaccatgaccaca
gacatctacttcaaggaagcaattgaagccattgcagaaagtgcctttaagacctccccc
tatcctgtcattctgtcatttgaaaaccatgtggactcaccccgccaacaggccaagatg
gctgaatactgccggatgacgtttggggagatgctgctcacagagcccttggaaaagttc
ccattgaaaccaggcatccccctgcccagccctgaggatctccgaggcaagatcctcatc
aagaacaaaaagaaccagttttctgtcccagcaacccccagcaaggagccgggtgggggt
gctgagaacaactgcccacccagagcctcggtgggagaggacccagtgtgggctggtgag
gacggggcagagccggaggaggaagaggtggaagaggaggaggaggagtcgggaaacttg
gatgaggaggagctcaagaagatgcagtcggatgagggcacagcaggcctagaggtgaca
gcttacgaggagatgtccagcctagtgaattacatccagcccaccaagttcatctccttt
gagttctctgcccagaaaaacagaagttacgtcatctcgtccttcacagagctcaaggcc
tatgacctgctctccaaggcctcagtgcagttcgtggactacaacaagcgccagatgagt
cgcatttacccgaagggcacacgcatggactcctccaactacatgccccagatgttctgg
aacgccggttgccagatggtggccctcaacttccagaccatggacctgcccatgcagcag
aacatggcattgtttgagttcaacgggcagagtggctacctcctcaagcatgagttcatg
cggcggccggacaagcagttcaaccccttctcagtggaccgcatcgacgtggtggtggct
accaccctttccatcacggtcatctctggacagttcctgtcagatcgcagtgtgcgcaca
tatgtggaagtggaactctttggccttcccggggaccccaagaggcgctatcgcacgaag
ctgtcacccaccgccaactccatcaatcctgtctggaaggaggagccttttgtctttgag
aagatcttgatgcctgagctggcatccctcagggtggctgtactggaggaaggcaacaaa
tttcttggacaccgcatcatccccattaatgccctgaattctggctaccaccatctgtgc
ctgcatagcgagagcaacttgccccttaccatgcccgccctttttgtcttcctggagttg
aaggactatgtacctgacacctgggcagatctcaccgtggctctggccaatcccatcaag
ttcttcagtgcccatgacaagaagtctgtgaagctcaaggaagccatggaaggtctgcct
gagaaacccttcccacttgggagtccaattgtccgcccggtcaacggggccttggcccca
acgagcaatgggtctgcagcagctggggccagggccaaggaggaggctatgaaagaagct
acggagccccagaccgccagcccggaggagctgcgggagctgaagggcgtcctgaagctg
cagcggcggcacgagaaggagctgcgggacctggagcggcgcggcgcgcggcgctgggag
gagctgctgcagaggggcgcggcggagctggccgggctggggcagcccagcgcggggggc
tgcgggggccgccggctcggccctggcaagggctctcgaaagaagaggaccctgcagtgc
gaggaggccgccgggcccgcgccgggcgagggccgcgagggctccgagggcgcggacgcg
cgtgcgcgtgagctgcaggaccggctagagctggagctgctgcagcagggtgaggagcag
tacgagtgcatcctgaagcgcaaagagcagcacgtggctgagcaaatcgccaagatgatg
gagctggccagagagaagcaggcggcagagctgaagaccctcaaggagaccctggagatt
gacaccaaagagatgaagaaaaagctggaggccaagaggctggagcggattcaggccatg
gtcaaagtcacccctgacaagatggctcaggaaagactgaagagagagattaacaactct
cacatccaggaggtggtgcaagtcattaagcagatgacagaaaacctggagaagcaccag
gagaagctggaggagaagcaggcagcctgcctggaacagatccgggagatggaaaagcag
ttccagcaggaggtgctagcagagtacgaagtccggatgaagggcctggaggctgaggtg
aaggagtcagtgaaggcctgcctcaggaactgcttaccctctgaggccaaggacaagcct
gagaggccctatgaggccttcagggagctgtgtgaccaggacccactcacagcaaaggca
ggcgccgaggagagccgcctctga |