Mustela lutreola (European mink): 131837162 Help Entry 131837162         CDS       T09578                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism mlk  Mustela lutreola (European mink) Pathway mlk04020   Calcium signaling pathway mlk04371   Apelin signaling pathway mlk04713   Circadian entrainment mlk04921   Oxytocin signaling pathway mlk04970   Salivary secretion mlk05010   Alzheimer disease mlk05012   Parkinson disease mlk05020   Prion disease mlk05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mlk00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     131837162 (RYR3)    04020 Calcium signaling pathway     131837162 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     131837162 (RYR3)   09154 Digestive system    04970 Salivary secretion     131837162 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     131837162 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     131837162 (RYR3)    05012 Parkinson disease     131837162 (RYR3)    05020 Prion disease     131837162 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     131837162 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mlk04040]     131837162 (RYR3) Ion channels [BR:mlk04040]  Voltage-gated cation channels   Ryanodine receptor    131837162 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  131837162 NCBI-ProteinID:  XP_059039390 LinkDB All DBs Position 7:complement(60272164..60624478) Genome browser AA seq 4862 aa AA seqDB search MVRKILSSVSGRAVQEEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLT CLTTSRSQTDKLAFDVGLRENATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSVSNGNVQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRLFHGHDECLTIPSTDQ NDAQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHITTGHYLALTEDQ GLLLQDRTKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIASG LWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQF VSGNNRAAAPVTLPIQEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEGM LALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNN LDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDVL CSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPSIFLGVAEGSAQYKKWY FELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWS GRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVSF SAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGIRDLLGTT QSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQ HPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSN GYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVP YALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSYA VRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGRT WQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGRM NLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRIDG TMDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEIL SHTTTCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESV KRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPNTK VFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSR MPSSFLKVETERVSERHGWAVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYHTL RLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKERK LMMKNEYIIPITSATRKIRLYPDESKRHGLPGVGLRTCLKPRFRFSTPCFVVTGEEHQKQ SPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDD IRQILLLIDPSVFGEHSVETEDGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPES VKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKSRYNELMQALNMSAALTARK TREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEEDTS WAGKLHALVYKIKGPPKPEKEQPTEEEEKCPITLKELISQTMIRWAQEDQIQDAELVRMM FSLLQRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLIIN GLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYFCR ISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKV VTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLI RRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDGEDEEIVHMGNA IMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNK DGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSL STTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLVDSTLQTIYRLSKGRSLTKAQRD TIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGW GSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRISA TLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYGISL DENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEAVVQQRENEQL RSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHP LLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGVKDMELDASSMEKRFAYKFLKKI LKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLSSPLK PLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKS GSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSI FEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAIPV AFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESGARY TEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIINNNL GIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTKGDT QEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPSADSDQLFRMVAEVFILWCK SHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLYSIQTSLIVA ALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHLQEKSDDPAVKWQL NLYKDVLKSEEPFNAEKTIERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVA CFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEEMEKQ PDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEKTFEEKEM EKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAGVQQKMLD YLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQND EFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTINVIISTVDYLLRLQESISDFYWYYS GKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFAN MQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMI LKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFLLSCAEAD ENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAGSVLNYFEPYL GRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFC EDTIFEMQLASQISESDSAERPDEEEEEDEDSSYVLEIEGEEEDDKSFESASAFAMACAS VKRNIANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFRLFFTILGGIFQ ILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALDAERAEVTEPGVPPELIHFV KGEKGDTDIMSDLFGLHPKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVRKKRKAQAA EMKAAHEAEGKVEPEKTDLEDGEKEDTAKEEEQAEALWADVTKKKKRRRGQKVEKPEAFM ANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPVEEETEDVANL WNSFTDEEEEEAMVFFVLQESTGYMAPALRALAIIHTVISLVCVVGYYCLKVPLVVFKRE KEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGA ERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHVWKLGVVFTDNSFLYLAWY TTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVA FNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIV FDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGF ETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQ LG NT seq 14589 nt NT seq  +upstreamnt  +downstreamnt atggtaaggaaaattctttcctcggtctcaggcagggctgtgcaggaggaagatgaggtg gttctccagtgcatcgcgaacattcacaaggagcaaaggaagttctgcctggcagccgag ggcctcgggaaccgcctgtgcttcttggagcccacttccgaagccaagtatgttcctcca gatctctgtgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcaggaa atgcttgccaacacaggtgaaaatggcggtgaaggggcagcacaagggggtggccacagg accctgctatatggccacgcgattctcctgcggcactccttcagcggaatgtatctaaca tgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgggaa aatgccacaggagaagcctgttggtggaccatacatccggcatccaaacagagatctgag ggagagaaagttcgaattggtgatgacctcattctcgtcagcgtgtcctctgaaagatac cttcatctctcagtgtcaaacgggaacgtacaagtggacgcctcttttatgcagacactc tggaatgtacatcctacatgctcaggaagtagcgttgaagaaggatacctacttggtggg cacgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagaccag aatgatgcccagcacaggaggatattctatgaagctgggggagctgggacacgagcccga tctctgtggagagtggaaccccttcggataagttggagtggcagtaacatccgatggggc caggctttccggctccggcatatcaccacaggccactacctggccctgacggaggaccaa ggccttctactgcaggaccggacgaagtcagacaccaagtccaccgccttctctttcagg gcttccaaggaaatcaaggagaaattggattccagtcacaagcgagatatagaaggcatg ggcgttccagaaatcaagtatggagattctgtctgctttgtgcagcatatagccagcggt ctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaaaga aaggtcatactccaccaggaaggccacatggacgacgggttaacactgcagagatgccag cgcgaggagtcgcaggctgctcgcatcatccggaacacaaccgccttattcagccagttt gtgagcgggaacaaccgcgcagcggcccctgtcaccctgccgatccaagaggtcctgcag accttgcaggacttgattgcctactttcagcccccagaggaggagatgcagcacgaggac aaacagaacaaactccgctcgctcaagaacagacagaatctcttcaaggaggagggaatg ttggcccttgtgttaaactgcattgaccgcttaaatatctacaacagtgttgcacacttt gcggggatcgcaagggaggagagtggcatggcttggaaggaaatactgaacctcctctac aaactgctcgctgctctcattcgtggaaacagaaacaactgcgctcagttctccaacaac ctcgattggctaatcagcaaactggacagactagaatcttcctcaggtatcttggaagtt ttgcactgcatcttgattgaaagcccagaagccttaaatctgatagccgagggccacatc aagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggacgtgctg tgttccctctgtctctgcaatggggttgctgtcagagccaaccagaatctgatttgtgac aacttgctgccccggaggaacttgctcctgcagacacggctaattaatgatgtgaccagc attcggcccagcatcttcctgggagttgccgagggctcggcgcagtacaagaagtggtac ttcgagctgattatcgaccaggtggatcccttcctaacagctgagcccacacacctgcgg gtgggctgggcctcctcctccggctatgctccataccctggcgggggagaaggatgggga ggcaatggtgtcggtgatgacctctactcctatggctttgatggactccacctttggtca ggccgcatacccagagccgtagcctccatcaaccagcacctcctgagatcagatgacgtg gtgagctgttgcctcgaccttggagtgcccagcatctccttccgcatcaacgggcagccc gtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagcttc tcagcaggtgtcaaggtgcgtttcctgatgggtggacgtcatggagaatttaagttcctg cctccctctggctatgccccttgctatgaagccttacttccaaaagaaaagatgagattg gagcctgtgaaagaatataaacgtgacgcagaaggcattagagatctgctgggtaccacc cagtccctctcccaagcctccttcatcccatgccccatcgacaccagtcaggttgttttg ccccctcacctagaaaagatccgagatagactggctgaaaacatccacgagctttgggga atgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaagacaa cacccctgtcttgtggagttttcaaagctgcctgaaaccgagaagaattataacctacag atgtcaactgaaaccttaaagaccctcctggccctagggtgccatattgctcatgtgaat ccagctgctgaggaagatctcaagaaggtcaaattgcccaaaaactatatgatgtccaat ggctataagccagcccctttggatctgtctgatgtgaagctattacctcctcaagaagtt ttagtggataagcttgcagaaaatgcacacaacgtttgggccaaagacagaataaaacaa ggatggacctatggcatccaacaggatttaaagaataaaagaaatccccggctggtgcca tatgctttactggatgagcgtaccaagaagtccaatagggacagccttcgtgaagctgtt cgcacatttgttggttatggctataacattgagccttcggaccaagaactggctgaccca gctgtggagaaagtcagcattgacaagattcgatttttccgggttgagcggtcttatgca gtgagatctggaaaatggtattttgagtttgaggtggtaactggaggagacatgcgcgtt ggctgggccaggccaggttgtcggcctgacattgagctgggggccgatgaccaagccttt gtgtttgaaggcagcaggggccagcggtggcatcaaggcagtgggtattttggacgtacg tggcagccaggagacgtggttggatgtatgattaacttggatgatgcttcgatgatcttc acactgaatggcgagctgctgatcaccaacaaaggctctgaactcgccttcgctgattac gaaattgagaatggctttgtgcccatctgctctctgggactgtctcagatcggccgcatg aatctcgggatggatgccagcaccttcaagttttataccatgtgtggcctccaagagggc tttgagccttttgctgtcaacatgaaccgggacgttgcgatgtggttcagcaagcgcctc ccgacgtttgtcaacgtgccaaaggatcatccccatatagaggttgtgaggatcgatggc accatggacagtcctccatgcctcaaggtgacccacaagacatttggcacacagaatagc aatgccagcatgatctactgccgcctgagcatgcctgttgagtgccactcctccttcagc cacagcccctgcctggacagtgaagctttccagaaaaggaaacagatgcaagaaatactc tctcataccacaacatgctactatgcaatccgcatctttgctggacaggacccctcctgc gtctgggtcggatgggtgacaccagactatcacttatatagtgaaaagttcgacctgaat aaaaactgcacagttactgtcactctaggggatgaaagaggccgggtccatgaaagtgtg aaacgcagcaactgctacatggtctggggcggggatattgtggccacttcccaaagatca agtcgaagcaacgtggacctggagattggctgcctcgtggatctggcgatgggcatgttg tctttttctgccaatgggagagaactcggcacctgctaccaggtggagcccaataccaaa gtgtttccagcggttttcctacagcccacgagcacttccttgtttcagtttgaacttggg aagctgaagaacgcgatgcccctgtcggcggccatctttaagagcgaagagaagaaccca gttccacagtgtccgcctcggctggatgtccagaccatccagcccgtgctctggagccgc atgcccagcagcttcctgaaggtggagacggagcgcgtgagcgagcgccacggctgggcg gtgcagtgcctggagcccctgcagatgatggcgctccacatccccgaggagaacaggtgt gtggacatcctggagctgtgtgagcaggaggacctgatgcagttccattaccacacgctc cgactctacagcgccgtgtgcgccctgggaaacagcagggtggcctacgccctgtgcggc catgtggacctctcccagctcttctacgccattgataacaagtacctccctggcctcctt cgctccgggttctacgacctcctcatcagcatccacctggccaacgctaaggagaggaag ctaatgatgaagaacgagtacatcattcccatcaccagtgccaccaggaaaatccgcctg tacccagacgaatccaagaggcacgggctgccaggggtgggcctgagaacgtgccttaag cccaggttcaggttctccaccccttgctttgttgtgactggcgaggagcaccagaagcag agccctgagatccccttggagattctcaagacgaaggcgctgagcatgctgacggaggcg gtgcagcacagcggggctcacatccgcgaccctgtgggtgggtctgtggagttccagttc gtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgttcgatgacgatgac atccggcagatcctcctcctgattgatccctctgtgttcggggagcacagtgtggagacg gaggacggagcagagaaggaggaagtgactcaggtggaggagaaggcagtggaggccggg gagaaggctggcaaggaggctcccgtcaaaggcttgctgcagacccgactgcctgaatct gtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcagcatcga gtggaggccattgtggcatttggcgacatttatgtctccaaactccaggcaaatcagaag tcccgctacaatgagctcatgcaggccttgaacatgtctgcagccctgactgcccggaag accagggagttccgctccccgccgcaggagcagatcaacatgcttcttaacttccaactg ggagaaaattgcccctgcccagaggagatccgggaggagctatatgacttccatgaggac cttctcattcactgtggcgttccactggaggaggaggaagaggaagaggaggacacgtcc tgggctggaaaactccatgccttggtgtataaaatcaaaggccctcccaagcctgagaag gaacagccaacagaagaggaagagaaatgccctatcaccttgaaggagctcatctcacag accatgatccgctgggcccaggaggaccagatccaggatgcggagttggtccgaatgatg ttcagcctccttcagagacagtacgacagcatcggggagctgctgcaggccctgcggaag acctacaccatcagccaggcctccgtgagtgacaccatcaacctgctggctgcgctgggc cagatccgctgcctgctcagtgtcaggatgggcaaggaggaggagctgctcatcatcaac gggctgggagacattatgaacaacaaggtgttttaccagcatcccaacctcatgcgagtc cttggcatgcacgagacggtgatggaggtgatggtgaacgtgctgggcgcagagaagtct cagattgcttttcccaagatggttgctagctgttgccgcttcctctgctatttctgtcga attagcaggcaaaatcagaaggccatgtttgagcatctgagttacctgctggagaatagc agtgttggcctagcctccccttccatgaggggatctaccccactggacgtggcagcttcc tctgtaatggacaacaatgagttagctctgggcttagaggaaccggacctcgagaaggtg gtgacctacttggcaggctgtggcctgcagagctgtcccatgcttctagccaaaggatac cctgatgtcggctggaaccccattgaaggggaacgttacctgtccttcctgaggtttgcc gtctttgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctgctcatc agacgcccggagtgcttcggcccagccctgcgaggtgaaggaggaaacggtctgttggcg gccatgcagggcgccattaagatctctgagaacccagccctcgaccttccctctcaggga tacaagagagaagtcatggaggacggtgaagatgaagagattgtacacatgggcaatgcc attatgtctttttattcagctcttatagatctcctgggccgctgtgcgcctgaaatgcac cttatccagacaggaaagggagaagccatccggatcaggtcaatcctgcgctccctggtc cccactgaggacctggttggcatcatcagcatccccttgaagctgccgtccctaaacaaa gatgggtccatcagcgagccagatatggcagctaacttctgccctgaccacaaggcaccc atggtgcttttcttggatcgtgtttatggcatcaaggaccaaacatttctgctccacttg ctggaggttggatttttacccgacttaagagcctctgcctctctagacacagtttccctg agcaccacagaggctgcgcttgccctaaataggtacttatgttctgccgtgctcccactc ctcacaagatgcgccccgctctttgccggaacggagcactacacatctctcgtcgattct acgctgcagaccatataccggctttccaaaggacgttccctcaccaaagctcagagggac accatagaagaatgtttgctcgccatttgcaatcatttgaggccttccatgttacagcag ctcctgcgacgtttggtttttgatgtgccacagctcaacgagtactgcaaaatgcccctt aagcttctgacgaatcactatgaacagtgctggaagtattactgtctgccttcaggatgg gggagctacgggctagctgtggaagaagaattgcacctgacggagaagctcttctggggg attttcgactccctttcccataagaagtatgacccagaccttttccgaatggcccttcct tgtctcagtgctatagcgggggccctgccaccagattatttagacaccagaatctcagcc acgttggagaagcagatttcagtggatgcggatggcaactttgaccccaaacccatcaac accatgaatttctccttgcctgaaaaatgggaatacatcgtcaccaagtatgcagagcat tcacatgataaatgggcctgtgacaagagtcagaatggatggaaatacggaatttccctg gacgaaaatgtgaagacccatccactgatcaggcctttcaagacattaacggaaaaggag aaggaaatttaccgctggcccgcccgggagtccctgaaaaccatgctggctgtgggctgg tctgtggagaggaccaaagagggagaggccgtggttcaacagcgggaaaacgagcaactt cggagcgtgtctcaggccagccagggcaacagctacagccctgctcccctggacctctct aacgtggtgctctccagggagcttcagggaatggtggaggtcgtggctgaaaactatcac aacatctgggccaagaagaagaagctggaactggagagcaaaggtggtggcagtcaccct ctgttggtaccatatgataccctgacagccaaggagaagttcagggaccgagagaaggca caggacctgtttaaattcctccaagtgaacggcatcgtggtttctagaggtgtgaaggat atggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaagaagatc ctgaaatatgttgattccgcccaagagtttattgcccatttggaggccattgtcagcagt ggaaaaacagaaaagtctccccacgaccaggagatcaaattctttgccaaagttctcctc ccactggttgaccagtacttcaccaatcaccacctctacttcctgtcatcccctctgaag ccccttagcagcagcggctatgcctctcataaggagaaagaaatggtggccagcctcttc tgcaaactcgctgctcttgttcgacacaggatttccctctttgggagcgattctactaca atggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatgaagtca ggctcagagctggtcaaggccgggttacgagcattctttgaaaatgctgcagaagactta gagaagacttcggaaaacctgaagctggggaagtttacccattccagaacacagattaaa ggcgtgtctcagaatattaactataccacggtggctctgctccccatcctgacgtccatc tttgagcacgttgctcagcatcagttcggggtggatttactcttaggcgatgtgcagatt tcatgctaccacatactgtgcagcctctactcccttgggactggaaagaatatctacgtt gaaaggcaacgtcctgcccttggagaatgtctggcctcactagcagctgccatcccagtg gcgttcctggagcccacgcttaatcgctacaatccactctcggtcttcaacaccaaaacc cccagggagaggtctattctgggcatgccggacacagtggaagagatgtgtcctgacatc ccgcagctggaaggcctgatgaaggagatcagcgacctggctgagtcaggggcccggtac acagagatgccccacgtcatcgaggtgatcttgcccatgctctgcaactacctgtcctac tggtgggagcgggggcctgagcacctgccccccagcacagggccctggtgcaccaaggtc acatctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaacaacaacctg ggcatcgatgaggcgtcctggatgaaacgtattgcagtgtatgcccagccgatcatcagc aaagcccggccagacctgctgaaaagccacttcatcccaactctggagaagctgaagaaa aaggcggtaaagactgtgcaggaggaggagcagctgaaagccgacaccaagggagacact caggaggcggagctcctcatcctggatgagtttgcggtcctctgcagagacctctatgcc ttctaccccatgctgatccgttatgtggacaacaacagatctaactggcttaaaagtccc agtgctgactctgaccagctcttccgcatggtggcagaggtcttcatcctgtggtgtaaa tctcacaacttcaagagggaagagcagaattttgtgattcagaatgaaattaataatttg gcatttttaactggagacagcaaaagcaagatgtcgaaatctggaggacaggaccaggaa cggaagaagacaaagcggaggggagacttgtattccatccagacctctctcatcgtggcc gcactcaagaaaatgctgcccattggtttgaatatgtgcacgccaggcgatcaggagctc atctccctggccaaatctcggtacagctatagggacacagatgaagaggtgaaggaacat ctgcggaataacttgcacctgcaggagaagtctgatgacccagcagtaaagtggcaactg aacctctacaaagatgttctaaagagtgaagaacctttcaatgcagaaaagaccatagag cgtgtacagagaatttcagcagcggtgttccacctggagcaggtggaacagcctttgagg tccaagaaggcggtctggcacaaactgttgtcaaagcagcggaaacgggcagtggtggcc tgtttcaggatggcccctctctacaacctgcccaggcaccgctccattaacctcttcctc catggctatcagagattttggatagaaacagaggagtattcttttgaagagaaactagta caggatttggctaaatcccccaaggtggaagaggaggaggaggaggagatggaaaagcaa ccagacccacttcatcagatcattctccattttagccgcaatgctctcacggagaggagc aaactggaagatgaccctttgtacacgtcctattccagcatgatggccaagagttgtcag agtggggaggacgaagaagaagaggaagacaaggagaaaacattcgaagagaaagagatg gaaaagcagaaaaccctctaccaacaagcacggctgcatgagcggggagctgcagagatg gtccttcagatgataagtgccagcaaaggtgagatgagccccatggtggttgagactctg aagctgggcatcgccattctgaatgggggcaacgccggcgtgcagcagaaaatgctagat tacctaaaggagaaaaaggatgctggattctttcaaagcctttctggtcttatgcagtct tgcagtgtccttgatttgaatgcgtttgaaaggcagaataaagcagaaggcctgggtatg gttactgaggaaggaacactcattgtgcgtgagcgtggtgaaaaagtactccagaatgac gagtttactcgtgatctctttcggttcctgcagttactttgtgaaggacataacagtgac tttcagaacttcctgcggactcagatgggcaataccaccaccataaacgtcatcatcagt accgtggactacctcttgcgtctgcaggagtcaatcagtgatttctactggtattattca gggaaggacatcattgacgaatctggacagcacaatttttccaaagctctggcagtcacg aagcagattttcaattctcttacagaatatatccagggcccttgcattgggaaccagcag agcctggctcacagcaggctgtgggacgcggtggtcggcttcctccatgtgtttgctaac atgcagatgaaactctctcaggattccagtcagatcgagctgctgaaggaactcttggat ctccttcaggacatggtggtgatgcttctgtccctcctggaagggaatgtggtaaatgga actattggcaagcagatggttgacacactggtagaatcatctaccaatgtagaaatgatc ttgaaattctttgacatgttcttgaaacttaaagacctaaccagctcagacaccttcaaa gaatatgacccagatggtaaagggattatctctaaaaaagagttccaaaaggccatggaa gggcagaaacagtacacacagtcagagattgactttctcctttcgtgcgcagaagctgat gagaatgatatgtttaattacattgattttgtagaccggttccatgagccggccaaggac atagggtttaatgtggcagtgttactgaccaatctctccgaacacatgccaaatgattct cgccttaagtgtctgttggacccagcaggaagtgtactaaattactttgaaccgtacctg ggacgaattgagatcatgggcggggccaagaaaattgagcgtgtttatttcgagatcagt gaatccagtcgaactcagtgggagaagccccaagtgaaggagtcaaagcggcagttcatc tttgatgtggtcaatgaagggggagagcaagaaaagatggaactgtttgtgaacttctgt gaggataccatctttgaaatgcagttagcctctcagatctccgaatctgactcagctgag aggcccgacgaggaggaggaagaagatgaagattcatcttatgtgttagaaattgagggt gaagaggaagacgacaagtctttcgagtcagcctctgcatttgccatggcctgtgcctca gtgaagagaaacattgccaactttctgaagaaggcaaccctgaagaacctccggaaacag tacaggaaggtgaaaaagatgactgtgaaggagctggtaaaagtgttcttctctttcttc tggatgttgtttgtggggctcttccggttgttcttcaccatattgggaggaatcttccag atcctctggaacacagtgtttggaggtggcctcgtggaaggggcaaagaacatcagagtg accaagatcctgggtgacatgcctgaccccacccagtttggtatccatgacgatgctctg gatgctgagcgggcagaggtgactgagccaggggttccacccgaactaattcacttcgtg aagggtgagaagggagatacagatattatgtcagatctctttggattacacccgaagaaa gaaggtggcttaaagcatgggcctgaagtgggtttgggtgacctttctgagattattggc aaggatgaaccccctacactagagagtactgtccggaagaaaaggaaagcacaggcagct gagatgaaagcagcacatgaagccgaagggaaagtggagcctgagaagacagacctagaa gacggggagaaggaggatacggccaaagaggaagagcaggccgaggccctgtgggcagat gtgacaaagaagaagaagcgacggcggggccagaaagtcgagaagcctgaagccttcatg gctaatttcttcaaagggctggaaatctatcagaccaagttactgcattacctggccagg aatttctacaacctgaggttcctcgctctgttcgtagccttcgcgatcaacttcatccta ctcttttataaggtcaccgaggaacctgtagaagaagagacagaagacgttgcaaatctg tggaattcctttaccgatgaggaagaagaagaagcgatggtgttctttgtcctgcaggag agcactgggtacatggcacccgcattgcgggccttggccattatccacaccgtcatctct ttggtctgtgtggtgggctattactgcctgaaggtccctctggtggtattcaaaagggaa aaagaaatcgccaggaagctggagtttgatggcctatatatcactgaacagccatctgaa gatgacatcaaggggcagtgggaccgcctggtaatcaacacaccatcttttcctaataac tactgggacaagtttgttaagagaaaggtgatcaacaagtacggcgacctctatggagca gaacgcattgcggaactcctgggtttggacaaaaatgccctggatttcagcccagtggaa gagagcaaagcagaggcggcctctctggtgtcatggctgagttccatcgacatgaagtac cacgtctggaagctgggagttgtttttaccgacaactcctttctctacctggcctggtat accaccatgtcagtcctgggccactacaacaacttcttctttgctgctcatctgctggac atcgcgatgggcttcaagacgctgaggactattctgtcatctgtaactcacaatggcaag cagctggttctgactgtcggtctcctggccgtggtggtttacctctacaccgtggtggcc ttcaacttcttccgcaagttctacaacaaaagtgaagatgacgatgagcccgatatgaag tgtgatgacatgatgacgtgttacctgttccacatgtatgtgggagtgagagctggaggg ggcattggcgacgaaattgaagaccctgctggtgacccttatgagatgtaccgcattgtc tttgacattaccttcttcttcttcgtcattgtcatcttgctggccatcattcaaggtctt attattgatgcttttggagagctaagagaccagcaggaacaagtgcgagaagatatggag actaaatgtttcatctgtgggattggcaatgactattttgacacgactcctcatggcttt gaaacacataccttacaggagcacaacttagccaactatttgttcttcctgatgtacctg attaataaagatgagacagaacacacgggtcaggaatcttacgtctggaagatgtaccaa gaaagatgttgggatttcttcccggctggtgactgctttcggaaacaatatgaagatcag cttgggtaa

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