KEGG   Mirounga leonina (Southern elephant seal): 118003336
Entry
118003336         CDS       T07472                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx01521  EGFR tyrosine kinase inhibitor resistance
mlx01522  Endocrine resistance
mlx04010  MAPK signaling pathway
mlx04012  ErbB signaling pathway
mlx04014  Ras signaling pathway
mlx04015  Rap1 signaling pathway
mlx04022  cGMP-PKG signaling pathway
mlx04024  cAMP signaling pathway
mlx04062  Chemokine signaling pathway
mlx04066  HIF-1 signaling pathway
mlx04068  FoxO signaling pathway
mlx04071  Sphingolipid signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04114  Oocyte meiosis
mlx04140  Autophagy - animal
mlx04148  Efferocytosis
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04210  Apoptosis
mlx04218  Cellular senescence
mlx04270  Vascular smooth muscle contraction
mlx04370  VEGF signaling pathway
mlx04371  Apelin signaling pathway
mlx04380  Osteoclast differentiation
mlx04510  Focal adhesion
mlx04540  Gap junction
mlx04550  Signaling pathways regulating pluripotency of stem cells
mlx04613  Neutrophil extracellular trap formation
mlx04620  Toll-like receptor signaling pathway
mlx04650  Natural killer cell mediated cytotoxicity
mlx04660  T cell receptor signaling pathway
mlx04662  B cell receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04666  Fc gamma R-mediated phagocytosis
mlx04668  TNF signaling pathway
mlx04720  Long-term potentiation
mlx04722  Neurotrophin signaling pathway
mlx04725  Cholinergic synapse
mlx04726  Serotonergic synapse
mlx04730  Long-term depression
mlx04810  Regulation of actin cytoskeleton
mlx04910  Insulin signaling pathway
mlx04912  GnRH signaling pathway
mlx04914  Progesterone-mediated oocyte maturation
mlx04915  Estrogen signaling pathway
mlx04916  Melanogenesis
mlx04917  Prolactin signaling pathway
mlx04919  Thyroid hormone signaling pathway
mlx04921  Oxytocin signaling pathway
mlx04926  Relaxin signaling pathway
mlx04928  Parathyroid hormone synthesis, secretion and action
mlx04929  GnRH secretion
mlx04934  Cushing syndrome
mlx04935  Growth hormone synthesis, secretion and action
mlx05010  Alzheimer disease
mlx05022  Pathways of neurodegeneration - multiple diseases
mlx05034  Alcoholism
mlx05132  Salmonella infection
mlx05135  Yersinia infection
mlx05160  Hepatitis C
mlx05161  Hepatitis B
mlx05163  Human cytomegalovirus infection
mlx05164  Influenza A
mlx05165  Human papillomavirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05200  Pathways in cancer
mlx05205  Proteoglycans in cancer
mlx05206  MicroRNAs in cancer
mlx05207  Chemical carcinogenesis - receptor activation
mlx05208  Chemical carcinogenesis - reactive oxygen species
mlx05210  Colorectal cancer
mlx05211  Renal cell carcinoma
mlx05212  Pancreatic cancer
mlx05213  Endometrial cancer
mlx05214  Glioma
mlx05215  Prostate cancer
mlx05216  Thyroid cancer
mlx05218  Melanoma
mlx05219  Bladder cancer
mlx05220  Chronic myeloid leukemia
mlx05221  Acute myeloid leukemia
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
mlx05226  Gastric cancer
mlx05230  Central carbon metabolism in cancer
mlx05231  Choline metabolism in cancer
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    118003336 (MAP2K1)
   04015 Rap1 signaling pathway
    118003336 (MAP2K1)
   04668 TNF signaling pathway
    118003336 (MAP2K1)
   04066 HIF-1 signaling pathway
    118003336 (MAP2K1)
   04068 FoxO signaling pathway
    118003336 (MAP2K1)
   04072 Phospholipase D signaling pathway
    118003336 (MAP2K1)
   04071 Sphingolipid signaling pathway
    118003336 (MAP2K1)
   04024 cAMP signaling pathway
    118003336 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    118003336 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    118003336 (MAP2K1)
   04150 mTOR signaling pathway
    118003336 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118003336 (MAP2K1)
   04148 Efferocytosis
    118003336 (MAP2K1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    118003336 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    118003336 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    118003336 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    118003336 (MAP2K1)
   04660 T cell receptor signaling pathway
    118003336 (MAP2K1)
   04662 B cell receptor signaling pathway
    118003336 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    118003336 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    118003336 (MAP2K1)
   04062 Chemokine signaling pathway
    118003336 (MAP2K1)
  09152 Endocrine system
   04929 GnRH secretion
    118003336 (MAP2K1)
   04915 Estrogen signaling pathway
    118003336 (MAP2K1)
   04917 Prolactin signaling pathway
    118003336 (MAP2K1)
   04921 Oxytocin signaling pathway
    118003336 (MAP2K1)
   04926 Relaxin signaling pathway
    118003336 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    118003336 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    118003336 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    118003336 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    118003336 (MAP2K1)
   04726 Serotonergic synapse
    118003336 (MAP2K1)
   04720 Long-term potentiation
    118003336 (MAP2K1)
   04730 Long-term depression
    118003336 (MAP2K1)
   04722 Neurotrophin signaling pathway
    118003336 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    118003336 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118003336 (MAP2K1)
   05206 MicroRNAs in cancer
    118003336 (MAP2K1)
   05205 Proteoglycans in cancer
    118003336 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    118003336 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    118003336 (MAP2K1)
   05230 Central carbon metabolism in cancer
    118003336 (MAP2K1)
   05231 Choline metabolism in cancer
    118003336 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118003336 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118003336 (MAP2K1)
   05212 Pancreatic cancer
    118003336 (MAP2K1)
   05225 Hepatocellular carcinoma
    118003336 (MAP2K1)
   05226 Gastric cancer
    118003336 (MAP2K1)
   05214 Glioma
    118003336 (MAP2K1)
   05216 Thyroid cancer
    118003336 (MAP2K1)
   05221 Acute myeloid leukemia
    118003336 (MAP2K1)
   05220 Chronic myeloid leukemia
    118003336 (MAP2K1)
   05218 Melanoma
    118003336 (MAP2K1)
   05211 Renal cell carcinoma
    118003336 (MAP2K1)
   05219 Bladder cancer
    118003336 (MAP2K1)
   05215 Prostate cancer
    118003336 (MAP2K1)
   05213 Endometrial cancer
    118003336 (MAP2K1)
   05224 Breast cancer
    118003336 (MAP2K1)
   05223 Non-small cell lung cancer
    118003336 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118003336 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    118003336 (MAP2K1)
   05161 Hepatitis B
    118003336 (MAP2K1)
   05160 Hepatitis C
    118003336 (MAP2K1)
   05164 Influenza A
    118003336 (MAP2K1)
   05163 Human cytomegalovirus infection
    118003336 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118003336 (MAP2K1)
   05165 Human papillomavirus infection
    118003336 (MAP2K1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    118003336 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118003336 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    118003336 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    118003336 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    118003336 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118003336 (MAP2K1)
   01522 Endocrine resistance
    118003336 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlx01001]
    118003336 (MAP2K1)
Enzymes [BR:mlx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     118003336 (MAP2K1)
Protein kinases [BR:mlx01001]
 Serine/threonine kinases: STE group
  STE7 family
   118003336 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 118003336
NCBI-ProteinID: XP_034850125
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSAY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggctcccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagttg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaattgaaggatgacgacttcgagaagatcagtgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcgcacaagccctccggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctacatgag
tgcaactccccctacattgtgggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcacatggatggtggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagataatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacacggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggttgggagg
tatcccatccctcctccagatgctaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccagaccaaggacccctggaaggcccctcagcgcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccgaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataag
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttt
atcaagagatcggacggggaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagccggcgtctaa

DBGET integrated database retrieval system