KEGG   Mirounga leonina (Southern elephant seal): 118003693
Entry
118003693         CDS       T07472                                 
Symbol
ADCY4
Name
(RefSeq) adenylate cyclase type 4 isoform X1
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx00230  Purine metabolism
mlx01100  Metabolic pathways
mlx01522  Endocrine resistance
mlx04015  Rap1 signaling pathway
mlx04020  Calcium signaling pathway
mlx04022  cGMP-PKG signaling pathway
mlx04024  cAMP signaling pathway
mlx04062  Chemokine signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04081  Hormone signaling
mlx04082  Neuroactive ligand signaling
mlx04114  Oocyte meiosis
mlx04211  Longevity regulating pathway
mlx04213  Longevity regulating pathway - multiple species
mlx04261  Adrenergic signaling in cardiomyocytes
mlx04270  Vascular smooth muscle contraction
mlx04371  Apelin signaling pathway
mlx04540  Gap junction
mlx04611  Platelet activation
mlx04713  Circadian entrainment
mlx04714  Thermogenesis
mlx04723  Retrograde endocannabinoid signaling
mlx04724  Glutamatergic synapse
mlx04725  Cholinergic synapse
mlx04727  GABAergic synapse
mlx04742  Taste transduction
mlx04750  Inflammatory mediator regulation of TRP channels
mlx04911  Insulin secretion
mlx04912  GnRH signaling pathway
mlx04913  Ovarian steroidogenesis
mlx04914  Progesterone-mediated oocyte maturation
mlx04915  Estrogen signaling pathway
mlx04916  Melanogenesis
mlx04918  Thyroid hormone synthesis
mlx04921  Oxytocin signaling pathway
mlx04923  Regulation of lipolysis in adipocytes
mlx04925  Aldosterone synthesis and secretion
mlx04926  Relaxin signaling pathway
mlx04927  Cortisol synthesis and secretion
mlx04928  Parathyroid hormone synthesis, secretion and action
mlx04934  Cushing syndrome
mlx04935  Growth hormone synthesis, secretion and action
mlx04970  Salivary secretion
mlx04971  Gastric acid secretion
mlx04972  Pancreatic secretion
mlx04976  Bile secretion
mlx05032  Morphine addiction
mlx05163  Human cytomegalovirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05200  Pathways in cancer
mlx05207  Chemical carcinogenesis - receptor activation
mlx05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    118003693 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    118003693 (ADCY4)
   04371 Apelin signaling pathway
    118003693 (ADCY4)
   04020 Calcium signaling pathway
    118003693 (ADCY4)
   04072 Phospholipase D signaling pathway
    118003693 (ADCY4)
   04024 cAMP signaling pathway
    118003693 (ADCY4)
   04022 cGMP-PKG signaling pathway
    118003693 (ADCY4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    118003693 (ADCY4)
   04081 Hormone signaling
    118003693 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    118003693 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    118003693 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118003693 (ADCY4)
   04062 Chemokine signaling pathway
    118003693 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    118003693 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    118003693 (ADCY4)
   04912 GnRH signaling pathway
    118003693 (ADCY4)
   04913 Ovarian steroidogenesis
    118003693 (ADCY4)
   04915 Estrogen signaling pathway
    118003693 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    118003693 (ADCY4)
   04921 Oxytocin signaling pathway
    118003693 (ADCY4)
   04926 Relaxin signaling pathway
    118003693 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    118003693 (ADCY4)
   04918 Thyroid hormone synthesis
    118003693 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    118003693 (ADCY4)
   04916 Melanogenesis
    118003693 (ADCY4)
   04925 Aldosterone synthesis and secretion
    118003693 (ADCY4)
   04927 Cortisol synthesis and secretion
    118003693 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    118003693 (ADCY4)
   04270 Vascular smooth muscle contraction
    118003693 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    118003693 (ADCY4)
   04971 Gastric acid secretion
    118003693 (ADCY4)
   04972 Pancreatic secretion
    118003693 (ADCY4)
   04976 Bile secretion
    118003693 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    118003693 (ADCY4)
   04727 GABAergic synapse
    118003693 (ADCY4)
   04725 Cholinergic synapse
    118003693 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    118003693 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    118003693 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    118003693 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    118003693 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    118003693 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    118003693 (ADCY4)
   04714 Thermogenesis
    118003693 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118003693 (ADCY4)
   05207 Chemical carcinogenesis - receptor activation
    118003693 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118003693 (ADCY4)
   05163 Human cytomegalovirus infection
    118003693 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    118003693 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    118003693 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    118003693 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    118003693 (ADCY4)
Enzymes [BR:mlx01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     118003693 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc Adcy_cons_dom AC_N CD52 DUF4231
Other DBs
NCBI-GeneID: 118003693
NCBI-ProteinID: XP_034850680
LinkDB
Position
Unknown
AA seq 1077 aa
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALLAMLAVASASGRDLASDRG
FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSVLVWAALLGLGHGFQFTGGLVSAWDQV
SFFLFIIFTVYAMLPLGMRDAAAAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNVAGAYHKALMERALRATFREALRSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVEDASMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSLLMTR
YLESWGAAKPFAHLSHLESPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDEDLDTGDAK
FFQVIEQLNSQKQWKQSKDFNPLTLYFREKELEKEYRLSALPAFKYYAACTFLVFLSNFI
IQMLVTNRPPALAITYSVTFLLFFLLLFVCFSEHLTKCVLKGPKMLHWLPALSSLVATRP
GLRVALGTATILLVFVMAITSLFFLPAASNCTSRAANVPSVASNLSWELPGSLPLISVPY
SMHCCVLGFLSCSLFLHMSFELKLLLLLLWLGTSCSLFLHSHAWLSDCVLARLYPTPSDS
RPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWQKKLRQEQEETETMENLTRL
LLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLR
LLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDTQQDAERSCSHLGTMV
EFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMEST
GVLGKIQVTEETARVLQALGYTCYSRGIIKVKGKGQLCTYFLNTDLTRTGPPSATLG
NT seq 3234 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagtccccggccgccccccagcgaagacctcttctacgagacctac
tacagcctgagccagcagtacccactgctgcttctgctgctggtgatcgtgctctgcgcg
ctcctggcgatgctagctgtcgcctccgccagcggcagggatctagcttcagaccggggc
ttcctgaccactgtgctgtgcgcgttgggtggcttctcgctgctcctgggcctggcttcc
cgcgagcaacgactgcagcgctggacacgccccctgtcggtcctggtgtgggccgcgcta
ctcgggctaggccacggcttccagttcactgggggcctggtgagcgcctgggaccaggtg
tcctttttcctcttcatcatcttcaccgtgtatgccatgttgcccttgggcatgcgggat
gccgccgctgcgggtcttgcctcatcactctcccacctgctggtccttgggctgtacctg
gggcctcagccggactcccggccagcgctgctgccgcagctggcagcaaacgccgtgttg
ttcctgtgcgggaacgtggcgggggcgtaccacaaggcgctgatggagcgcgcgctgcgc
gccacgttccgggaggctcttcgctccctgcactcgcgccgccggctggacaccgagaag
aagcaccaggaacaccttctcttgtccatccttcctgcctacttggcccgagagatgaag
gcagagatcatggcacggctgcaggctggacaggggtcacggccagagagcaccaacaac
ttccacagcctctatgtcaagaggcaccagggagtcagcgtgctatatgctgacatcgtg
ggcttcacgaggctggccagtgagtgctcccctaaggagttggtgctcatgctcaacgag
ctctttggcaagttcgaccagattgccaaggagcatgaatgcatgcggatcaagatcctg
ggagactgttactactgtgtctctgggcttccgctctccctgccagaccacgccatcaac
tgcgtgcgcatggggctggacatgtgccgggccatcaggaaactccgggcagccactggt
gtggacatcaacatgcgtgtgggtgtgcattcgggcagtgtgctctgcggggtcatcggc
ctacagaagtggcagtatgacgtctggtcccatgatgtcacactagccaaccacatggag
gcgggcggcgtgccaggacgagtacatattacaggggctaccctggccctgctggcaggg
gcttatgctgtggaggatgcatccatggaacaccgggacccataccttcgggagctaggg
gagcccacctacctagtcatcgatccccgggctgaggaggaggatgagaagggcactgcg
ggagggctgctgtcctctctcgagggtcccaagatgcggccgtcgctgctgatgacccgc
tacctggagtcctggggcgcagccaagccttttgcccacctgagccacctagagagccct
gtgtccacctccacccctctcccggagaaggccctggcctccttcagcccccagtggagc
ctggaccggagccgtactcccaggggactagatgaggacctggacactggggacgccaag
ttcttccaggtcatcgaacagctcaactctcagaaacagtggaagcagtcaaaggacttc
aacccactgacactgtacttcagagagaaggagctggagaaagagtatcgactctctgcc
ctccccgccttcaaatactatgcagcctgcaccttcctggtcttcctctccaatttcatc
atccagatgctggtgaccaacaggcccccagctctggccatcacttatagcgtcaccttc
ctcctcttcttcctcctcctcttcgtctgcttctcagagcacctgacgaagtgtgtcttg
aaaggccccaagatgctgcactggctgcccgcactgtctagcctggtggccacacggccc
ggcctgcgagttgccctgggcacggccaccatcctcctcgtttttgtcatggctattacc
agcctgttcttcttgccggcagcatcaaactgcacttcccgggctgccaatgtgccctcc
gtggcttccaacctctcctgggagctcccggggtccctgcctctcatcagcgtcccatac
tctatgcattgctgcgtgctggggttcctgtcctgctccctctttctgcatatgagcttc
gagctgaagttactgctgctcctgctctggctggggacctcctgctccctcttcctgcac
tcccatgcctggctgtccgactgtgtcctcgcccgcctctatccgactccctcggactcc
aggccaggggtgctgaaggagcccaaactgatgggagcgatctccttcttcatcttcttc
ttcaccctccttgtcctggctcggcagaatgagtattactgccgcctggacttcctgtgg
cagaagaagctgcggcaggagcaggaggagacagagacaatggagaacctgacgcggctc
ctgctggagaatgtgctccctgcgcacgtggccccccagttcattggccagaaccggcgc
aacgaggacctctaccaccagtcctacgagtgtgtctgtgtcctcttcgcctcagttcca
gactttaaggagttttactctgaatccaacatcaaccacgagggtctagagtgtctgcgg
ctgcttaatgagatcattgctgattttgacgagctgctctcaaagcccaagtttagtggg
gtggagaagatcaaaaccatcggcagcacctacatggcagccacaggcttaaatgccacc
tccggacaggacacacagcaggatgctgagcgaagctgcagccacctgggcaccatggtg
gagtttgcagtggcccttggatcgaagctggatgtcatcaataagcactctttcaacaat
ttccgcctgcgtgtggggttgaaccatggacctgtagtggctggagtgattggggcccag
aagcctcagtacgacatctggggcaacacggtgaacgtggccagccgcatggagagcact
ggagtcctgggcaagatccaagtgactgaagagacagcccgggtgctgcaggccttaggc
tatacctgctacagccggggcatcatcaaggtcaaaggcaaagggcagctctgcacctac
ttcctgaacacagatttgacacgaactggccctccttcggccaccctaggctga

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