KEGG   Mirounga leonina (Southern elephant seal): 118014553
Entry
118014553         CDS       T07472                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx01521  EGFR tyrosine kinase inhibitor resistance
mlx01522  Endocrine resistance
mlx01524  Platinum drug resistance
mlx04010  MAPK signaling pathway
mlx04012  ErbB signaling pathway
mlx04014  Ras signaling pathway
mlx04015  Rap1 signaling pathway
mlx04022  cGMP-PKG signaling pathway
mlx04024  cAMP signaling pathway
mlx04062  Chemokine signaling pathway
mlx04066  HIF-1 signaling pathway
mlx04068  FoxO signaling pathway
mlx04071  Sphingolipid signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04140  Autophagy - animal
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04152  AMPK signaling pathway
mlx04210  Apoptosis
mlx04211  Longevity regulating pathway
mlx04213  Longevity regulating pathway - multiple species
mlx04218  Cellular senescence
mlx04261  Adrenergic signaling in cardiomyocytes
mlx04370  VEGF signaling pathway
mlx04371  Apelin signaling pathway
mlx04380  Osteoclast differentiation
mlx04510  Focal adhesion
mlx04550  Signaling pathways regulating pluripotency of stem cells
mlx04611  Platelet activation
mlx04613  Neutrophil extracellular trap formation
mlx04620  Toll-like receptor signaling pathway
mlx04625  C-type lectin receptor signaling pathway
mlx04630  JAK-STAT signaling pathway
mlx04660  T cell receptor signaling pathway
mlx04662  B cell receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04666  Fc gamma R-mediated phagocytosis
mlx04668  TNF signaling pathway
mlx04722  Neurotrophin signaling pathway
mlx04725  Cholinergic synapse
mlx04728  Dopaminergic synapse
mlx04810  Regulation of actin cytoskeleton
mlx04910  Insulin signaling pathway
mlx04914  Progesterone-mediated oocyte maturation
mlx04915  Estrogen signaling pathway
mlx04917  Prolactin signaling pathway
mlx04919  Thyroid hormone signaling pathway
mlx04920  Adipocytokine signaling pathway
mlx04922  Glucagon signaling pathway
mlx04923  Regulation of lipolysis in adipocytes
mlx04926  Relaxin signaling pathway
mlx04929  GnRH secretion
mlx04931  Insulin resistance
mlx04932  Non-alcoholic fatty liver disease
mlx04933  AGE-RAGE signaling pathway in diabetic complications
mlx04935  Growth hormone synthesis, secretion and action
mlx04936  Alcoholic liver disease
mlx04973  Carbohydrate digestion and absorption
mlx05010  Alzheimer disease
mlx05017  Spinocerebellar ataxia
mlx05132  Salmonella infection
mlx05135  Yersinia infection
mlx05142  Chagas disease
mlx05145  Toxoplasmosis
mlx05152  Tuberculosis
mlx05160  Hepatitis C
mlx05161  Hepatitis B
mlx05162  Measles
mlx05163  Human cytomegalovirus infection
mlx05164  Influenza A
mlx05165  Human papillomavirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05168  Herpes simplex virus 1 infection
mlx05169  Epstein-Barr virus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05200  Pathways in cancer
mlx05205  Proteoglycans in cancer
mlx05207  Chemical carcinogenesis - receptor activation
mlx05208  Chemical carcinogenesis - reactive oxygen species
mlx05210  Colorectal cancer
mlx05211  Renal cell carcinoma
mlx05212  Pancreatic cancer
mlx05213  Endometrial cancer
mlx05214  Glioma
mlx05215  Prostate cancer
mlx05218  Melanoma
mlx05220  Chronic myeloid leukemia
mlx05221  Acute myeloid leukemia
mlx05222  Small cell lung cancer
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
mlx05226  Gastric cancer
mlx05230  Central carbon metabolism in cancer
mlx05231  Choline metabolism in cancer
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlx05415  Diabetic cardiomyopathy
mlx05417  Lipid and atherosclerosis
mlx05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    118014553 (AKT3)
   04015 Rap1 signaling pathway
    118014553 (AKT3)
   04630 JAK-STAT signaling pathway
    118014553 (AKT3)
   04668 TNF signaling pathway
    118014553 (AKT3)
   04066 HIF-1 signaling pathway
    118014553 (AKT3)
   04068 FoxO signaling pathway
    118014553 (AKT3)
   04072 Phospholipase D signaling pathway
    118014553 (AKT3)
   04071 Sphingolipid signaling pathway
    118014553 (AKT3)
   04024 cAMP signaling pathway
    118014553 (AKT3)
   04022 cGMP-PKG signaling pathway
    118014553 (AKT3)
   04151 PI3K-Akt signaling pathway
    118014553 (AKT3)
   04152 AMPK signaling pathway
    118014553 (AKT3)
   04150 mTOR signaling pathway
    118014553 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118014553 (AKT3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    118014553 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118014553 (AKT3)
   04613 Neutrophil extracellular trap formation
    118014553 (AKT3)
   04620 Toll-like receptor signaling pathway
    118014553 (AKT3)
   04660 T cell receptor signaling pathway
    118014553 (AKT3)
   04662 B cell receptor signaling pathway
    118014553 (AKT3)
   04664 Fc epsilon RI signaling pathway
    118014553 (AKT3)
   04666 Fc gamma R-mediated phagocytosis
    118014553 (AKT3)
   04062 Chemokine signaling pathway
    118014553 (AKT3)
  09152 Endocrine system
   04922 Glucagon signaling pathway
    118014553 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    118014553 (AKT3)
   04929 GnRH secretion
    118014553 (AKT3)
   04915 Estrogen signaling pathway
    118014553 (AKT3)
   04917 Prolactin signaling pathway
    118014553 (AKT3)
   04926 Relaxin signaling pathway
    118014553 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    118014553 (AKT3)
   04919 Thyroid hormone signaling pathway
    118014553 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118014553 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    118014553 (AKT3)
   04728 Dopaminergic synapse
    118014553 (AKT3)
   04722 Neurotrophin signaling pathway
    118014553 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    118014553 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    118014553 (AKT3)
   04213 Longevity regulating pathway - multiple species
    118014553 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118014553 (AKT3)
   05205 Proteoglycans in cancer
    118014553 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    118014553 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    118014553 (AKT3)
   05230 Central carbon metabolism in cancer
    118014553 (AKT3)
   05231 Choline metabolism in cancer
    118014553 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118014553 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118014553 (AKT3)
   05212 Pancreatic cancer
    118014553 (AKT3)
   05225 Hepatocellular carcinoma
    118014553 (AKT3)
   05226 Gastric cancer
    118014553 (AKT3)
   05214 Glioma
    118014553 (AKT3)
   05221 Acute myeloid leukemia
    118014553 (AKT3)
   05220 Chronic myeloid leukemia
    118014553 (AKT3)
   05218 Melanoma
    118014553 (AKT3)
   05211 Renal cell carcinoma
    118014553 (AKT3)
   05215 Prostate cancer
    118014553 (AKT3)
   05213 Endometrial cancer
    118014553 (AKT3)
   05224 Breast cancer
    118014553 (AKT3)
   05222 Small cell lung cancer
    118014553 (AKT3)
   05223 Non-small cell lung cancer
    118014553 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118014553 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    118014553 (AKT3)
   05161 Hepatitis B
    118014553 (AKT3)
   05160 Hepatitis C
    118014553 (AKT3)
   05164 Influenza A
    118014553 (AKT3)
   05162 Measles
    118014553 (AKT3)
   05163 Human cytomegalovirus infection
    118014553 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118014553 (AKT3)
   05169 Epstein-Barr virus infection
    118014553 (AKT3)
   05165 Human papillomavirus infection
    118014553 (AKT3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    118014553 (AKT3)
   05152 Tuberculosis
    118014553 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    118014553 (AKT3)
   05142 Chagas disease
    118014553 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118014553 (AKT3)
   05017 Spinocerebellar ataxia
    118014553 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118014553 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    118014553 (AKT3)
   05415 Diabetic cardiomyopathy
    118014553 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    118014553 (AKT3)
   04932 Non-alcoholic fatty liver disease
    118014553 (AKT3)
   04931 Insulin resistance
    118014553 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    118014553 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118014553 (AKT3)
   01524 Platinum drug resistance
    118014553 (AKT3)
   01522 Endocrine resistance
    118014553 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlx01001]
    118014553 (AKT3)
Enzymes [BR:mlx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     118014553 (AKT3)
Protein kinases [BR:mlx01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   118014553 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like ABC1 DUF6932 PH_20
Other DBs
NCBI-GeneID: 118014553
NCBI-ProteinID: XP_034866847
LinkDB
Position
Unknown
AA seq 496 aa
MVTMVTGCSGILVPFGGAHRRRGSTGFVRWRAGEYIKNWRPRYFLLKTDGSFIGYKEKPQ
DVDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQ
AVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVI
LVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCF
VMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDG
HIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGR
LPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHS
FFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCVDNE
RRPHFPQFSYSASGRE
NT seq 1491 nt   +upstreamnt  +downstreamnt
atggtaactatggtcaccggttgcagtggtattttagtcccctttggtggagcccacagg
cggagaggaagcacaggattcgtaagatggagggcgggagaatatataaaaaactggagg
ccaagatatttccttttgaagacagatggctcattcataggatataaagagaaacctcaa
gatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccagttaatgaaa
acagaacgaccaaagccaaacacatttattatcagatgtctccagtggaccactgttata
gagagaacatttcatgtagatactccagaggaaagggaagagtggacagaagctattcag
gctgtagcagacagacttcagagacaagaagaggagagaatgaattgtagtccaacttca
caaattgataatataggggaggaggagatggatgcttccacaacccatcataaaagaaag
acaatgaatgattttgactatttgaaactactaggtaaaggcacttttgggaaagttatt
ttggttcgagagaaggcaagtgggaaatactatgctatgaagattctgaagaaagaagtt
attattgcaaaggatgaagtggcgcatactctgactgagagcagagtattaaagaacacc
agacacccctttttaacatccttgaaatattccttccagacaaaagaccgtttgtgtttt
gtgatggaatatgtaaatgggggagagctgtttttccatttgtcgagagagcgggtgttc
tccgaggaccgcacacgtttctatggtgcagaaattgtctctgctttggactatctacat
tccggaaagattgtgtaccgtgatctcaagttggagaatttaatgctggataaagatggc
cacataaaaattacagattttggactttgcaaagaagggatcacagatgcagccaccatg
aagacattctgtggcacaccagaatatctggcaccagaggtgttagaagacaatgactat
ggccgagctgtggattggtggggcctgggggtcgtcatgtatgagatgatgtgtgggagg
ctacctttctacaaccaggatcatgagaaactttttgaactaatactaatggaagacatt
aaatttcctcgaacactctcttcagatgcaaaatcactgctttcagggctcttgataaag
gatccaaataaacgccttggcgggggcccagatgatgcaaaagaaattatgaggcacagt
ttcttctctggagtcaactggcaagatgtttatgataaaaagcttgtacctccttttaag
cctcaagttacatctgagacagataccagatattttgatgaagaattcacagctcagact
attacaataactccacctgaaaaatatgacgaggacggcatggactgcgtggacaacgag
cggcggccgcacttccctcagttctcctactccgccagcggccgcgagtaa

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