KEGG   Mirounga leonina (Southern elephant seal): 118015997
Entry
118015997         CDS       T07472                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx00562  Inositol phosphate metabolism
mlx01100  Metabolic pathways
mlx04015  Rap1 signaling pathway
mlx04020  Calcium signaling pathway
mlx04022  cGMP-PKG signaling pathway
mlx04062  Chemokine signaling pathway
mlx04070  Phosphatidylinositol signaling system
mlx04071  Sphingolipid signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04081  Hormone signaling
mlx04082  Neuroactive ligand signaling
mlx04261  Adrenergic signaling in cardiomyocytes
mlx04270  Vascular smooth muscle contraction
mlx04310  Wnt signaling pathway
mlx04371  Apelin signaling pathway
mlx04540  Gap junction
mlx04611  Platelet activation
mlx04613  Neutrophil extracellular trap formation
mlx04621  NOD-like receptor signaling pathway
mlx04713  Circadian entrainment
mlx04720  Long-term potentiation
mlx04723  Retrograde endocannabinoid signaling
mlx04724  Glutamatergic synapse
mlx04725  Cholinergic synapse
mlx04726  Serotonergic synapse
mlx04728  Dopaminergic synapse
mlx04730  Long-term depression
mlx04742  Taste transduction
mlx04750  Inflammatory mediator regulation of TRP channels
mlx04911  Insulin secretion
mlx04912  GnRH signaling pathway
mlx04915  Estrogen signaling pathway
mlx04916  Melanogenesis
mlx04918  Thyroid hormone synthesis
mlx04919  Thyroid hormone signaling pathway
mlx04921  Oxytocin signaling pathway
mlx04922  Glucagon signaling pathway
mlx04924  Renin secretion
mlx04925  Aldosterone synthesis and secretion
mlx04926  Relaxin signaling pathway
mlx04927  Cortisol synthesis and secretion
mlx04928  Parathyroid hormone synthesis, secretion and action
mlx04929  GnRH secretion
mlx04933  AGE-RAGE signaling pathway in diabetic complications
mlx04934  Cushing syndrome
mlx04935  Growth hormone synthesis, secretion and action
mlx04961  Endocrine and other factor-regulated calcium reabsorption
mlx04970  Salivary secretion
mlx04971  Gastric acid secretion
mlx04972  Pancreatic secretion
mlx04973  Carbohydrate digestion and absorption
mlx05010  Alzheimer disease
mlx05016  Huntington disease
mlx05017  Spinocerebellar ataxia
mlx05022  Pathways of neurodegeneration - multiple diseases
mlx05142  Chagas disease
mlx05143  African trypanosomiasis
mlx05146  Amoebiasis
mlx05163  Human cytomegalovirus infection
mlx05200  Pathways in cancer
mlx05415  Diabetic cardiomyopathy
mlx05417  Lipid and atherosclerosis
Module
mlx_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118015997 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    118015997 (PLCB3)
   04310 Wnt signaling pathway
    118015997 (PLCB3)
   04371 Apelin signaling pathway
    118015997 (PLCB3)
   04020 Calcium signaling pathway
    118015997 (PLCB3)
   04070 Phosphatidylinositol signaling system
    118015997 (PLCB3)
   04072 Phospholipase D signaling pathway
    118015997 (PLCB3)
   04071 Sphingolipid signaling pathway
    118015997 (PLCB3)
   04022 cGMP-PKG signaling pathway
    118015997 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    118015997 (PLCB3)
   04081 Hormone signaling
    118015997 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    118015997 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118015997 (PLCB3)
   04613 Neutrophil extracellular trap formation
    118015997 (PLCB3)
   04621 NOD-like receptor signaling pathway
    118015997 (PLCB3)
   04062 Chemokine signaling pathway
    118015997 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    118015997 (PLCB3)
   04922 Glucagon signaling pathway
    118015997 (PLCB3)
   04929 GnRH secretion
    118015997 (PLCB3)
   04912 GnRH signaling pathway
    118015997 (PLCB3)
   04915 Estrogen signaling pathway
    118015997 (PLCB3)
   04921 Oxytocin signaling pathway
    118015997 (PLCB3)
   04926 Relaxin signaling pathway
    118015997 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    118015997 (PLCB3)
   04918 Thyroid hormone synthesis
    118015997 (PLCB3)
   04919 Thyroid hormone signaling pathway
    118015997 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    118015997 (PLCB3)
   04916 Melanogenesis
    118015997 (PLCB3)
   04924 Renin secretion
    118015997 (PLCB3)
   04925 Aldosterone synthesis and secretion
    118015997 (PLCB3)
   04927 Cortisol synthesis and secretion
    118015997 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    118015997 (PLCB3)
   04270 Vascular smooth muscle contraction
    118015997 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    118015997 (PLCB3)
   04971 Gastric acid secretion
    118015997 (PLCB3)
   04972 Pancreatic secretion
    118015997 (PLCB3)
   04973 Carbohydrate digestion and absorption
    118015997 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    118015997 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    118015997 (PLCB3)
   04725 Cholinergic synapse
    118015997 (PLCB3)
   04728 Dopaminergic synapse
    118015997 (PLCB3)
   04726 Serotonergic synapse
    118015997 (PLCB3)
   04720 Long-term potentiation
    118015997 (PLCB3)
   04730 Long-term depression
    118015997 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    118015997 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    118015997 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    118015997 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    118015997 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118015997 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    118015997 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118015997 (PLCB3)
   05142 Chagas disease
    118015997 (PLCB3)
   05143 African trypanosomiasis
    118015997 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118015997 (PLCB3)
   05016 Huntington disease
    118015997 (PLCB3)
   05017 Spinocerebellar ataxia
    118015997 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    118015997 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118015997 (PLCB3)
   05415 Diabetic cardiomyopathy
    118015997 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    118015997 (PLCB3)
   04934 Cushing syndrome
    118015997 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlx04131]
    118015997 (PLCB3)
Enzymes [BR:mlx01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     118015997 (PLCB3)
Membrane trafficking [BR:mlx04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    118015997 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    118015997 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 118015997
NCBI-ProteinID: XP_034869024
LinkDB
Position
Unknown
AA seq 1230 aa
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDSNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTYLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAAGVPLPSPQDLMGRILVKNKKRHRPSTVVPNS
SVRKRPLEQSNSALSEGSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPNLEPRKSLGE
DGLQRGPDALGSADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRVAAFEEGGKFVGHRILPVSAVRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETCQETQPQQL
GSQLTPNPTPSPLDTSPRRPPGPATSPTSSSLSSPGQRDDLIASLLSEVAPVPLDELRGH
KALVKLRSRQERELRELHKKHQRKAVALTRRLLDGLAQARAESKCHQRPGVLGGENEEEE
EEEVKRYQEFQKRQVQSLLELREAQADTEAERRLEHLRQAQQRLREIVLDAHTTQLKRLK
EMNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRRERLAAGQQQALQQLVEEEPKLLAQLARECQEQRARLPQEIRRSLLGETPEALGDGHL
VACASNGHAPGSGGHLSGADSESQEENTKL
NT seq 3693 nt   +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgaggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtaaccctgcgtgtggactccaatggcttctttctgtactggaccggacccaacatggag
gtggacacactggacatcagttccatcagggacacgcggacggggcgttatgcccgcctg
cccaaggaccccaagatccgggaggtgctgggctttgggggccctgacgcccggctggag
gagaagttaatgacggtggtggctgggccagacccggtgaatacgacatacttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgttcaagctggccatg
aacatcctggctcagaacgcctcccggaacaccttcctgcgaaaagcatacacgaagctg
aagctgcaggtgaaccaggatggacggatcccggtgaagaatatcctcaagatgttttca
gcagataaaaagcgagtagagactgcactggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcccgacgagttttccttggaaatcttcgagcggttcctgaataagttg
tgtctgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccatac
ctgacgctggagcagctcatggacttcattaaccagaagcaacgggacccgaggctcaac
gaagtgctgtacccacccttgcgcccctcccaggcccggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagccgctacctg
ggaggtgaggagaatggcatcctgcccctggaggccctggatctgagcgcagacatgacc
cagccgctgagcgcctacttcatcaactcctcacacaacacctatctcacagcggggcag
ctggccgggacctcgtcggtggagatgtaccggcaggcactgctgtggggctgtcgctgc
gtggagctggacgtgtggaaagggcggccgcctgaggaggagcccttcatcacccacggc
ttcaccatgaccacggaggtgccgctgcgggatgtgctcgaggccatcgccgagaccgcc
ttcaagacctcgccctaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggccgagtactgccgttccatctttggggacgcgctgctcatcgac
ccgctggacaagtatccgctggccgcaggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccggcccagcaccgttgtccccaacagc
tctgtgcgcaagcggccgctggagcagagcaactcggccctgagcgagggctctgccgcc
actgagccctcctcacctcagctcgggtcccccagctctgacagctgcccaggcctgagc
aatggggaagaggtgggtctggagaagcccaacctagagcctcggaagtctctgggcgag
gacgggctacagcggggccctgatgctcttggatctgctgaccgtgaggatgaggaggaa
gatgaggaagaggaagaacagacagatcctaaaaagccgaccacggatgagggcactgcc
agcagtgaggtcaacgccaccgaggaaatgtcaacactcgtcaactacatcgagcccgtc
aagttcaagtcatttgaggctgctcgaaaaaggaacaaatgcttcgagatgtcatccttc
gtggaaaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaac
aaacagcagctcagccgcatctaccccaagggcacccgcgtggactcgtccaactacatg
ccccagctcttctggaacgtcggctgccagcttgttgcgctcaacttccagaccctggac
gtggcgatgcagctcaacgcaggcgtgttcgagtacaacgggcgcagtggctacctgctc
aagcccgagttcatgcggcggccagacaagtccttcgatcccttcactgaggtcatcgtg
gatggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctttccgac
aggaaggtgggcatctacgtggaggtggacatgttcggcctccctgtggacacgcggcgc
aagtaccgcactcggacctctcaagggaactccttcaatcccgtgtgggacgaggagccc
tttgacttccccaaggtggtgctgcccacactagcttcgctgcgcgtcgcggccttcgag
gagggcggcaagttcgtggggcatcggattctgcccgtctcggctgtccgctcagggtac
cactacatctgtctgcggaacgaggccaaccagccgctttgcctgccagccctgctcatc
tacaccgaggcctccgactacattcccgacgaccaccaggactacgctgaggccctgatc
aaccccatcaagcacgttagcctgatggaccagagggccaagcagttggccgccctcatt
ggggagagcgaggctcaggctggcccagagacctgccaggagactcagcctcagcagctt
gggtcccagctgaccccaaatcccacacccagcccgctggacacctccccacgccggccc
ccaggccctgccacgtcccctaccagctcttccctcagtagcccagggcagcgggacgac
ctcatcgccagtctcctctcagaggtggccccggtcccgctggacgagctccgaggccac
aaggcgctggtgaagctccggagccggcaggagcgagagctgcgggagctgcacaagaag
caccagcggaaggccgtggccctcacgcgccggctgctcgacggcctggcccaggcccgg
gcggagagcaaatgccaccagcggccgggcgtcctaggcggggagaacgaggaggaggag
gaggaagaggtgaagcggtatcaagaattccagaagagacaggtgcagagtctgctggag
ctgagggaggcccaggcggatacagaggctgagcggaggctggagcacctgcgacaggct
cagcagcggcttagggagattgtcctggatgctcacacaactcagctcaagaggctgaag
gagatgaacgagagggagaagaaggaactgcagaagattctggacaggaagcgccacaac
agtatctcagaggccaagacaagggagaaacataagaaggaggcggaactgacagagatt
aaccgccggcacatcaccgagtcggtcaactccatccggcggctggaggaggcccagaag
cagcggcgagagcgcctcgcggctgggcagcagcaggccctacagcagctggtagaagag
gagcccaagctgctggcccagctggcccgggagtgtcaggagcagcgggcgaggctgccc
caggagatccgccgcagcctgctgggcgagacgccggaggcgctgggggatgggcatctg
gtggcctgtgccagcaacgggcacgcacctgggagcggtgggcacctgtctggcgctgac
tcggagagccaagaggagaacaccaagctctga

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