Mirounga leonina (Southern elephant seal): 118018835
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Entry
118018835 CDS
T07472
Symbol
GART
Name
(RefSeq) trifunctional purine biosynthetic protein adenosine-3 isoform X1
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx00230
Purine metabolism
mlx00670
One carbon pool by folate
mlx01100
Metabolic pathways
mlx01523
Antifolate resistance
Module
mlx_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
118018835 (GART)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
118018835 (GART)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
118018835 (GART)
Enzymes [BR:
mlx01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
118018835 (GART)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
118018835 (GART)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
118018835 (GART)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
ATP-grasp_2
ATP-grasp_3
CPSase_L_D2
ATP-grasp_4
Dala_Dala_lig_C
RimK
DUF3104
ATP-grasp_5
Motif
Other DBs
NCBI-GeneID:
118018835
NCBI-ProteinID:
XP_034873517
LinkDB
All DBs
Position
Unknown
AA seq
1010 aa
AA seq
DB search
MAAQVLVIGSGGREHTLAWKLAQSNHVKHVLVAPGNAGTACLEKISNTAISINDHTALAQ
FCKDEKIEFIVVGPEAPLAAGIVGNLTSAGVRCFGPTAEAAQLESSKRFAKEFMDRHGIP
TARWRAFTKPEEACSFIMSADFPALVVKASGLAAGKGVIVAKSTEEACRAVQEIMQDRAY
GAAGETIVIEELLEGEEVSCLCFTDGRTVAPMPPAQDHKRLLEGDHGPNTGGMGAYCPAP
QVSKDLFLKIKNTILQRTVDGMQQEGMPYTGVLYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWHEHVTAITVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKDGKVVTNGGRVLTVTAIQENLILALEEAKKGLAAIKFEGAIYRKD
IGYRAVAFLQQPRGLTYKESGVDIAAGNVLVKKIKPLAKATSRPGCDVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQQCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLNITETVVAGIARACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVIGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPEGCGDQTLGDLLLTPTR
IYSHSLLPVLRAGHVKAFAHITGGGLLENIPRVLPQKFGVDLDAQTWRVPRIFSWLQQEG
HLSEEEMARTFNCGIGAALVVSKDLTEQILRDIKQHKEEAWVIGKVVACPEGSPRVKVKN
LIETMQINGSVLKDGTLKNHFSVQPKKARVAVLISGTGSNLQALIDSTREPGSWAHIVVV
ISNKAAVAGLDKAERAGIPTRVINHKLYKSRVEFDTAIDQVLEEYSTDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQALEAGVTVTGCTVHFVAEDVDAGQIILQES
VPVKRDDTVATLSERVKLAEHKIFPAALQLVARGAVRLGENGKIRWVTEE
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccaagtacttgtaattggcagtggaggaagggaacacacactggcctggaaa
cttgcacagtctaatcatgtcaaacatgtgttggttgccccaggaaatgcaggcactgcc
tgcttggaaaagatttcaaatactgccatctcaatcaatgaccacactgcccttgctcag
ttctgcaaagatgagaaaattgaattcatagttgttggaccagaggcacctctggctgct
ggaattgttgggaacctgacatctgcaggagtccgatgctttggtcccactgcagaagca
gctcagttagagtccagcaagagatttgccaaagagtttatggaccgacatggaatccca
actgcacggtggagagctttcaccaaacctgaagaagcctgcagctttataatgagtgca
gacttccctgctttggttgtgaaggccagtggtcttgcggctggaaaaggggtgattgtt
gccaagagcacagaagaggcctgcagggctgtacaggagatcatgcaggatagagcttat
ggagcagctggagaaacaattgtcattgaagaacttcttgaaggagaagaggtgtcttgt
ctgtgcttcactgatggaaggaccgtggcacccatgcccccagcacaagaccataagcga
ttgctagagggagatcatggccccaacacagggggaatgggagcctattgtccagcacct
caggtttctaaggatttgttcctgaaaataaaaaataccattcttcagaggacagtggat
ggcatgcagcaggagggtatgccatacacaggtgttctctatgctggtataatgctgacc
aaggatggcccaaaagttctggagtttaattgccgtttcggtgatccagagtgccaagtg
atcctcccacttcttaaaagtgatctttatgaagtgatccagtctaccttggacggcctg
ctctgcacatctctgcctgtttggcatgaacacgtcactgccataactgtcgtgatggca
agtaaaggttatccaggagactacaccaagggtgtggagataacagggtttcctgaagct
caagctttaggactggaggtgttccacgcaggcactgccctgaaagatggcaaagtggtg
actaatgggggtagagtccttacggtaacagcaattcaggaaaatctcatcttggccctt
gaagaagccaagaaaggactagctgctataaaatttgagggagccatttacaggaaggac
attggctatcgtgccgtagcttttctccagcagcccaggggcctgacttacaaggaatct
ggggtagacattgcagctggaaatgtgctggtcaagaaaattaaacctttagcaaaagct
acctccagaccaggctgtgatgttgatcttggaggttttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcaagtggaacagatggtgttggaactaaactg
aagattgcccaacagtgtaataaacatgataccattggtcaagatttggttgcaatgtgt
gtcaatgacattctggcccaaggggcagagcctcttttcttcctcgattacttttcctgt
ggaaaacttgacctcaatataactgaaactgttgttgctggaatcgccagagcttgtgga
aaagctggatgtgctctccttggaggtgaaactgcagaaatgcctgacatgtatcctccg
ggagaatatgacctagctggttttgccgttggtgccatggagcgggatcagaaactccct
cacctggaaagaatcactgaaggggatgttgttattggaatagcttcatctggtctacac
agcaatggattcagccttgtaaggaaaattgtagcaaaatcttccctccagtactcgtct
ccagcacctgaaggctgtggtgaccagaccttaggggacttacttctcactccaaccaga
atctacagccattcactgctacctgtcctacgtgcaggacacgtcaaggcctttgcccat
attactggtggaggattgctagaaaacatccccagagtccttcctcagaagtttggggta
gatttagatgcccagacctggagggtccccaggatcttctcatggttacagcaggaagga
cacctctctgaggaagagatggccagaacatttaactgtgggattggggctgccctcgtg
gtatcaaaggatctgacagagcagattctgagggatattaagcagcacaaggaagaagcc
tgggtgattggcaaggtggttgcatgtcctgaaggttctcctcgtgtgaaagtcaagaat
ctgatagaaaccatgcaaataaatggctcagtattgaaggatggcactctgaaaaatcat
ttctctgtccaaccaaaaaaggcaagagtggctgtcctaatatctggaacaggatcaaac
ctgcaagctctcatagacagtacaagggagccaggtagctgggcacacattgttgttgtt
atctccaacaaagccgcagtggctggtttagataaagccgaaagagccggaattcccacc
agagtaattaatcataaattatataaaagtcgtgtagaatttgacacagcaattgaccaa
gtccttgaagagtactccacagacatagtgtgtcttgcaggattcatgagaattttatct
ggcccctttgtcaggaaatgggatgggaagatgctcaacattcacccatccttgctccct
tcttttaagggttcaaatgcccatgagcaagccctagaagctggggtcacagtcactggt
tgtactgtgcactttgtagctgaagatgtagatgctggacaaattattttacaagaatct
gttccagtgaagagagatgacactgttgcaactctgtctgaaagagtgaaattagcagag
cacaaaatatttcctgcagccctccagctggtagcccgtggagctgtacggcttggagaa
aatggcaagattcgttgggtcacagaagagtga
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