Mirounga leonina (Southern elephant seal): 118023942
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Entry
118023942 CDS
T07472
Symbol
PLCE1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
KO
K05860
phosphatidylinositol phospholipase C, epsilon [EC:
3.1.4.11
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx00562
Inositol phosphate metabolism
mlx01100
Metabolic pathways
mlx04014
Ras signaling pathway
mlx04015
Rap1 signaling pathway
mlx04020
Calcium signaling pathway
mlx04024
cAMP signaling pathway
mlx04070
Phosphatidylinositol signaling system
mlx04919
Thyroid hormone signaling pathway
mlx04933
AGE-RAGE signaling pathway in diabetic complications
mlx05205
Proteoglycans in cancer
Module
mlx_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
118023942 (PLCE1)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
118023942 (PLCE1)
04015 Rap1 signaling pathway
118023942 (PLCE1)
04020 Calcium signaling pathway
118023942 (PLCE1)
04070 Phosphatidylinositol signaling system
118023942 (PLCE1)
04024 cAMP signaling pathway
118023942 (PLCE1)
09150 Organismal Systems
09152 Endocrine system
04919 Thyroid hormone signaling pathway
118023942 (PLCE1)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
118023942 (PLCE1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
118023942 (PLCE1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mlx04131
]
118023942 (PLCE1)
Enzymes [BR:
mlx01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
118023942 (PLCE1)
Membrane trafficking [BR:
mlx04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
118023942 (PLCE1)
Endocytosis
Macropinocytosis
Phospholipase C
118023942 (PLCE1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
PI-PLC-Y
RasGEF
RA
C2
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
118023942
NCBI-ProteinID:
XP_034881249
LinkDB
All DBs
Position
Unknown
AA seq
2299 aa
AA seq
DB search
MTSEEMAASVLTPVTQRKVTSTPSAVDESSEKVSDISVPKVHSVRQSGQTSTIPWMNKLK
EESSGSNLPKILSIAREKTVSDENSNEKCWAESTPVSVKNLNINHNNILTNRQGILPQSQ
CYDMCTSVMEEDPCLETGIPSSLERKAFPGIQLEIDRPRMDISPLGSQSAVVETGQADPD
SNTAAFHFHYEVERRVSDAFCTLSGNLILDDCGNCVPLPGVGGEQKKNYVAYTCKLMELA
ENCDNKNGQLQCDHCDTLDDLCFEGSCQRASVVCSSDSFCREDLTNSPPAKTFLSHFEDF
PDNCEDVEEDFFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLPSGHIGLGAYSY
IDQKRSGLLLPSGRILERLSAVAIRQDGSQCLSEAQWYRIYNAVRRGEEIENTIGSLLHV
FTKLPASETAHERISVSPCLKQCVRDTLCEYRATLQRTSVSQYITGSLLEATTSLGARSG
LLSTFGGSTGRTMLKERQPGTSMANSSALPSSSAGISKELIDLQPLIQFPEEVASILMEQ
EQNIYRRVLPVDYLCFLTRDLGTPECQTSLPCLKASISASILTSQNREHNALEDLVMRFN
EVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQF
MDQSDLETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASG
LMKLCPRYNSQEETLEFVADYSGQDNFLQRVGHNGLKNSEKESTVNSIFQIIRSCSRSLE
AEDEDSPSEGNSSRKNSLRDKARWQFIIGDLLDSENDIFEQSKEWDSHGSEEPQKAFDHG
TELIPWYVLSIRADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWIKPTTASPA
SAKAKLGVLSSTSEPGKFPLLGNAGLSGLAEGVLDLFSAKAVYMGHPSIDIHTVCVQNKL
GSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQRQQW
LRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSLGISTKSAEKPSVQRNNTLGIS
TTKKKKKTLIRGESGEAADDEMATRKAKMHRESRSRSGSDPQDMNEQEESEANAIMSLHN
TLPSRRAHSLTTAGSPNLSAGTSSPIRPVSSPVLSSSNKSPSSARSSCSGHGRIKGGMKG
FQSFMVSDSTMSFVEFVELFKSFSVRSRKDLKDLFDIYAVPCNRAGSEPAPLYTNLTIEE
NSSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGVESTSLGIF
GVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSVSMCHQGLLSFEGFARFLMDKDNFAS
KNDESQENIKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWD
GDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFK
TVFGEKLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASM
QAQAYNGGNANPPPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEE
IPKRIKKADNSACNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLST
LNASGSSRGKERKSRKSIFGNNPGRMSPGETASFNKASGKSSCEGMRQAWEESSSPLNPT
TSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPL
MFWLHGIQFVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERD
LDNMEPAVYSLTIVSGQNVCPSSGTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNE
QFLFRVHFEDLIFLRFAVVENNSSAVTAQRIIPLKALKRGYRHLQLRNLHNEVLEISSLF
INSRRMEENSSSSAVPASLMFNTEERKCLQTHRVTVHGVPGPEPFTVFSINGGTKAKQLL
QQILTTEQDTKPIVTDYFLMEEKYFISKEKNECRKQPFQRAIGPEEEIMQILSSWFPEEG
YVGRIVLKTQQENQEERSIVQDDKEIILNSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQ
DVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDATKKSATPKSSQRVLLDQECVFQAQS
KWKGAGKFILKLKEQVQASREDKRKGISFASEFKKFTKSTKQPRGLTSPSQVLASESVQS
KEEKLVGSLPSSDTTEYRQ
NT seq
6900 nt
NT seq
+upstream
nt +downstream
nt
atgacgtctgaagaaatggcagcttctgttctcacacctgtgactcagagaaaagtgacg
tctactccatcggctgtagatgaaagtagtgaaaaggtctcggacatcagtgttccaaag
gtacatagtgtcaggcagagcgggcagacttctaccatcccatggatgaacaagcttaaa
gaagaatcttctggaagcaacttgcccaagattctctccatagcaagggagaaaacagtg
agcgatgagaacagcaatgaaaagtgctgggcagaaagcacaccagtttctgtgaaaaac
cttaacattaaccacaacaacatactgacaaaccgccagggcatccttcctcagagccag
tgttatgacatgtgcacttctgtcatggaggaagacccatgtttggaaactggaatccca
tcctcactggaaagaaaggcatttcctggaattcaactggaaatcgatcgacctcgcatg
gacattagccccttaggaagtcagtcagctgttgtagagactggccaggcagaccctgac
agtaacacggcagcatttcactttcattatgaagttgagagaagagtgtcagatgctttc
tgtaccctgtcaggtaacttgattttggatgattgtggaaactgtgtaccactgcctggt
gttggtggggagcaaaagaaaaattatgtggcatatacttgtaaactcatggaattggcc
gaaaactgtgataataagaatgggcagcttcagtgtgatcattgtgacaccttggatgac
ttgtgctttgaaggttcttgccaaagggccagtgtggtatgttcaagtgacagcttttgc
agggaggacttgactaacagtccacctgccaagacctttctgagccattttgaggacttc
cctgataattgtgaagatgtagaagaagatttttttaagagcaaaaaggagaggtccact
ttgttagtgaggagattttgtaaaaatgacagggaagtaaagaaatctgtgtataccggg
acaagggcaatcatgagaactctgccttctggtcacattgggctgggagcttacagttac
atcgatcagaagagaagtggtctcttattgcccagtgggagaattctggaaaggctgtca
gcggtggcgattaggcaggacgggagccagtgcctatcagaagcccagtggtatcggatc
tacaatgcagtgagaaggggagaagaaatagaaaatacaattggatctcttctccatgtc
ttcacaaagctcccagcctccgagacagcccatgaaaggataagcgttagtccatgctta
aagcagtgtgtccgagacaccctatgtgagtaccgtgccaccctgcagaggacgtccgta
tctcaatacatcacgggttctctcctagaagcgaccacatctttgggagctagaagtggc
ctactcagtacttttggaggatccactggacgaacgatgctaaaagaacgccagccaggc
acctccatggccaattccagtgccctcccttcaagttcagctgggatcagcaaggagctg
attgacctgcagcccctcattcagttcccagaggaagtcgccagcatcctgatggagcag
gaacagaacatttaccgaagggtcttgccagttgactacctttgcttcttgacccgggac
ttgggcactccggaatgccagacatccctgccctgcctcaaagcatccatctcagcttcg
attcttacctcccagaacagagagcacaatgccctggaagatctggtgatgagatttaat
gaggtgagctcctgggtgacgtggctgatcctcacggcgggctccatggaggagaagcga
gaagtcttctcctatttggtgcacgtggccaagtgctgctggaacatgggcaactacaat
gctgtcatggagttcttggctggcctcaggtcaagaaaagttttaaaaatgtggcagttt
atggaccagtctgacctggagaccatgaggagcctgaaggacgccatggctcagcacgaa
tcttcctgcgagtacaggaaggtggtcacgcgggccctgcacatacccggctgtaaggtg
gttcccttctgtggggtgtttctgaaggagctctgtgaagtactggatggagcctctggc
ctcatgaagctttgcccgaggtacaattcccaagaagaaactctagagttcgtagctgat
tacagtggacaagataatttcttacaacgagtgggacataatggcctaaagaattcagag
aaggagtccaccgtcaacagcatctttcagatcatcaggagctgcagccgaagtctggag
gccgaggatgaggacagccccagtgaaggcaacagctctaggaaaaattccttaagggat
aaagcacggtggcagtttataattggagatttgttggactccgaaaacgacatctttgag
cagtcgaaggaatgggactctcatggatcagaagagccacagaaggcctttgaccacggg
acagagctgatcccatggtacgtgctgtccatccgagctgatgtgcaccagttcctgctg
cagggggccactgtcatccactatgaccaggacacgcacctgtcagcccgctgcttcctc
cagcttcagcctgacaacagcaccttgacctggataaagcctaccactgcttccccagcc
agtgctaaagcaaaacttggtgtgcttagtagcacgtctgagcccggcaaattcccgtta
ctgggcaatgctggattaagtggcctggcagagggggtcttggatctgttttcagcaaag
gctgtgtacatgggacaccctagcattgatatacacactgtgtgtgttcagaacaaactg
ggtagcatgtttctctcagagactggcgtgactctgctctatgggctccagaccacggac
aatagattattgcactttgtggcacccaagcacacagctaagatgctcttcagtggattg
ctagaactcacgagggccgtgaggaagatgaggaagttccccgaccagagacagcagtgg
ctgcggaaacagtacgtcagcctctatcaggaggacggacggtatgaaggcccaactttg
gctcacgctgtggaactctttggtggccggcgatggagtacacgcaaccccagccttggg
atatccacaaagagtgctgagaagcccagtgtgcagagaaacaacaccttgggcataagc
accaccaagaaaaagaagaaaacccttataaggggtgagagtggagaggcggccgacgat
gagatggccacgcggaaggccaaaatgcacagggagagccgcagccggagtggttccgac
cctcaagacatgaatgagcaagaagaatccgaggcgaatgccatcatgagccttcataac
actctgccttccagaagagcccattctttgaccacggctgggtctcctaacttgtctgct
gggacatcatctcccatcaggccagtgtcctcccctgtgctgtcttcttcaaacaagagc
ccgtccagtgctcggagcagctgcagcgggcacgggaggatcaaaggaggaatgaagggt
tttcagagcttcatggtttcagacagtaccatgagttttgttgaattcgttgagctgttc
aaatcattcagcgtgaggagccgcaaggacctgaaggatctctttgacatctacgccgtg
ccctgcaaccgagccggctccgagccggcccccctctacaccaacctaacaatcgaggaa
aactccagcgaccttcagcctgatctagatttgttgaccagaaatgtctcggacttgggg
ttgttcattaagagtaaacagcagctgtccgacaaccagaggcagatatctgatgccatt
gcggctgcaagtattgtgacaaatggcactggggttgagagcacgtctctgggcatcttt
ggggttggcatcctccagctcaatgacttcctcgtcaactgccagggagaacactgcacg
tacgatgaaatcctcagcatcatccagaagttcgagcctagcgttagtatgtgtcatcag
gggttactgtcatttgagggatttgcaaggtttctgatggataaagataattttgcctcc
aaaaatgatgagtcacaggaaaacattaaagacttgcagctgcccctctcctactattac
attgaatcttctcacaatacctacctcacaggccaccagctcaaaggagagtcctcagtg
gaactctacagtcaggtcctcctgcaaggctgcaggagcgtggagttggactgctgggac
ggagatgatgggatgcccatcatctaccatggacacacactgacaaccaagatccccttc
aaggaagtggtagaagccatcgaccgcagtgccttcatcaactctgacctgcccatcatc
atatcaattgagaaccactgctcattgcctcagcaacgaaaaatggcagaaattttcaag
actgtgtttggagaaaaactggtggctaaattcctgtttgagagcgatttctcagatgat
ccaatgcttccctcacctgaccaacttaggaggaaagtgcttcttaaaaataagaagcta
aaagcccaccagacaccagtggatatcctaaagcaaaaggctcatcagttagcatccatg
caagctcaggcttataatggagggaatgccaaccccccacctgctaataacgaggaagag
gaggatgaagaggatgaatatgattatgactatgaatccctgtctgatgacaacattcta
gaagacagacctgaaaataaatcatgtaatgacaagcttcagttcgagtataatgaagaa
attcccaagaggataaagaaagccgataactctgcttgcaacaaaggaaaggtttatgac
atggaactgggagaagaattttatcttcctcagaataaaaaggaaagcagacagattgca
ccagagctttctgaccttgtcatctattgccaagcagtaaaatttccaggcctgtcaact
ctaaatgcatctggctctagcagaggaaaagaaaggaaaagcaggaagtccatttttggc
aacaatccgggcagaatgagccctggggagacagcatcgtttaacaaagcatctggaaaa
agttcctgtgaaggaatgcgacaggcctgggaggaatcttcttcccccctcaacccaacc
acatccctcagcgctatcattaggactcccaaatgttaccatatctcatcgctgaatgaa
aatgccgccaaacgtctgtgtcgcaggtattctcagaaactgatccagcacaccgcctgt
cagctgctgaggacttacccggctgccacccgcatcgactcctccaaccccaaccccctc
atgttctggctccatgggatacagttcgtggcgctcaactaccagacagatgatctcccc
ttgcatttaaatgctgccatgtttgaggccaacggtggctgtggttatgttctgaaaccc
ccagttctgtgggacaagaactgtcccatgtatcagaagttttcgcccttggaaagagac
ctggacaacatggagcctgccgtctattccttaactattgtctctggtcaaaacgtgtgt
ccgagcagtggcacggggagcccgtgtatcgaagtcgacgtgctgggcatgcccctagac
agctgccacttccgcacaaagcccatccaccggaacactctgaaccccatgtggaatgaa
cagtttctcttccgggttcactttgaagacctcatatttcttcgttttgcagttgtggaa
aacaacagctcagccgtaaccgctcagagaatcatcccactcaaggctttaaaacgagga
tatcggcatcttcagctacgaaacctccacaatgaagtcttggaaatctctagtttattc
ataaacagcagaaggatggaagaaaattcctccagcagtgccgtgccagcctctttgatg
tttaatacagaagaaagaaaatgtttgcagactcacagagtcacagtgcatggggtcccg
ggtccagagccctttactgttttctccataaatggaggcaccaaggcaaagcagcttctc
caacaaattctgactactgaacaagacaccaaacctattgtcacagactattttttgatg
gaagaaaaatattttatatctaaagaaaaaaatgaatgcaggaaacaaccattccagaga
gccattggtccagaagaagagatcatgcagattttaagcagctggtttccagaggaagga
tatgttggccggattgtcttaaaaacccagcaggaaaaccaagaagagagaagcattgtt
caagatgacaaggagataatcttgaactccgaggaggagagtttctttgtccaagtgcat
gacgtttctccagagcaacctcgaacagtcatcaaagcaccccgtgtcagcaccgcgcag
gatgtcattcagcagaccttatgcaaggccaaatattcctacagcattctgagcaacccc
aacccgagtgactatgtgcttttggaagaggtggtgaaagacgctaccaagaagtctgcc
accccgaagtcctcccagcgggttcttttggaccaggagtgtgtgtttcaagcccaaagc
aagtggaaaggtgcaggaaaattcatccttaagctaaaggagcaggtgcaggcatcccga
gaagacaaaagaaaaggcatttcttttgcaagtgaattcaagaagttcaccaagtcaact
aaacagccccgaggactcacatcaccttctcaggtcttggcctcagaaagtgtccaaagc
aaggaggagaaactggtgggcagcttgccctccagtgacaccacagagtaccgacaataa
DBGET
integrated database retrieval system
