KEGG   Mirounga leonina (Southern elephant seal): 118024329
Entry
118024329         CDS       T07472                                 
Symbol
MAP2K6
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 6 isoform X1
  KO
K04433  mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx04010  MAPK signaling pathway
mlx04015  Rap1 signaling pathway
mlx04218  Cellular senescence
mlx04380  Osteoclast differentiation
mlx04620  Toll-like receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04668  TNF signaling pathway
mlx04750  Inflammatory mediator regulation of TRP channels
mlx04912  GnRH signaling pathway
mlx04935  Growth hormone synthesis, secretion and action
mlx04936  Alcoholic liver disease
mlx05014  Amyotrophic lateral sclerosis
mlx05022  Pathways of neurodegeneration - multiple diseases
mlx05132  Salmonella infection
mlx05135  Yersinia infection
mlx05145  Toxoplasmosis
mlx05161  Hepatitis B
mlx05163  Human cytomegalovirus infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05169  Epstein-Barr virus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlx05417  Lipid and atherosclerosis
mlx05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118024329 (MAP2K6)
   04015 Rap1 signaling pathway
    118024329 (MAP2K6)
   04668 TNF signaling pathway
    118024329 (MAP2K6)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    118024329 (MAP2K6)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    118024329 (MAP2K6)
   04664 Fc epsilon RI signaling pathway
    118024329 (MAP2K6)
  09152 Endocrine system
   04912 GnRH signaling pathway
    118024329 (MAP2K6)
   04935 Growth hormone synthesis, secretion and action
    118024329 (MAP2K6)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118024329 (MAP2K6)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    118024329 (MAP2K6)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118024329 (MAP2K6)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    118024329 (MAP2K6)
   05161 Hepatitis B
    118024329 (MAP2K6)
   05163 Human cytomegalovirus infection
    118024329 (MAP2K6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118024329 (MAP2K6)
   05169 Epstein-Barr virus infection
    118024329 (MAP2K6)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118024329 (MAP2K6)
   05135 Yersinia infection
    118024329 (MAP2K6)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    118024329 (MAP2K6)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    118024329 (MAP2K6)
   05022 Pathways of neurodegeneration - multiple diseases
    118024329 (MAP2K6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118024329 (MAP2K6)
   05418 Fluid shear stress and atherosclerosis
    118024329 (MAP2K6)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    118024329 (MAP2K6)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mlx01001]
    118024329 (MAP2K6)
Enzymes [BR:mlx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     118024329 (MAP2K6)
Protein kinases [BR:mlx01001]
 Serine/threonine kinases: STE group
  STE7 family
   118024329 (MAP2K6)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Pkinase_fungal Seadorna_VP7 Choline_kinase Haspin_kinase CLP1_P DUF4344 APH
Other DBs
NCBI-GeneID: 118024329
NCBI-ProteinID: XP_034882052
LinkDB
Position
Unknown
AA seq 359 aa
MPGVCCSASLACSLENLIRVTPGLLFQGWASRKRNPGLKIPKEAFEQPQPSSTPPRDLDS
KACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKR
LLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDIL
GKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAG
CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS
PQLPADKFSEEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKATDVASFVKLILGD
NT seq 1080 nt   +upstreamnt  +downstreamnt
atgcctggtgtgtgctgttctgcgagccttgcttgcagccttgaaaacctcatcagagtc
acccctggcctcctctttcagggatgggcaagcaggaagcgaaaccctggccttaaaatt
ccaaaagaagcatttgaacaacctcagcccagttccacgccacctcgagacttagactct
aaagcttgcatttctattggaaatcagaactttgaggtgaaggcagatgacctggagcct
ataatggaactggggcgaggtgcgtacggggtggtggagaagatgcgacacgtgcccagc
gggcagatcatggcggtgaagcggatccgggccacagtaaatagccaggagcagaaaagg
ctactgatggatttggatatttccatgaggacagtggactgtccttttaccgtcaccttt
tatggtgcactcttccgggagggtgatgtttggatctgcatggagctcatggatacgtcg
ctagataaattctacaaacaagtgatcgataaaggccaaacaattccagaggacatctta
gggaaaatagcagtttctattgtaaaagcgttagaacacttacacagtaagctctctgtc
attcatcgagacgtcaagccttccaacgtgctgatcaacactctgggccaagtaaagatg
tgcgattttggaatcagtggctaccttgtagactctgttgctaaaactattgatgcagga
tgcaaaccgtacatggcccctgaaagaataaacccagagctcaatcagaagggatacagt
gtgaagtctgacatttggagtctgggcatcacaatgattgagttggcgatccttcggttt
ccctacgactcttggggaacccccttccagcagctcaaacaggtggtcgaggaaccctcg
ccacaactcccggcggataaattctccgaagagtttgttgactttacctcacagtgcttg
aagaagaattccaaagaacggccaacatatccagaacttatgcaacatccatttttcacc
ctacatgaatccaaagcaacagacgtggcatcttttgtaaaactgattcttggagactaa

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