KEGG   Mirounga leonina (Southern elephant seal): 118025572
Entry
118025572         CDS       T07472                                 
Symbol
KRAS
Name
(RefSeq) GTPase KRas isoform X1
  KO
K07827  GTPase KRas
Organism
mlx  Mirounga leonina (Southern elephant seal)
Pathway
mlx01521  EGFR tyrosine kinase inhibitor resistance
mlx01522  Endocrine resistance
mlx04010  MAPK signaling pathway
mlx04012  ErbB signaling pathway
mlx04014  Ras signaling pathway
mlx04015  Rap1 signaling pathway
mlx04062  Chemokine signaling pathway
mlx04068  FoxO signaling pathway
mlx04071  Sphingolipid signaling pathway
mlx04072  Phospholipase D signaling pathway
mlx04137  Mitophagy - animal
mlx04140  Autophagy - animal
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04210  Apoptosis
mlx04211  Longevity regulating pathway
mlx04213  Longevity regulating pathway - multiple species
mlx04218  Cellular senescence
mlx04360  Axon guidance
mlx04370  VEGF signaling pathway
mlx04371  Apelin signaling pathway
mlx04519  Cadherin signaling
mlx04540  Gap junction
mlx04550  Signaling pathways regulating pluripotency of stem cells
mlx04625  C-type lectin receptor signaling pathway
mlx04650  Natural killer cell mediated cytotoxicity
mlx04660  T cell receptor signaling pathway
mlx04662  B cell receptor signaling pathway
mlx04664  Fc epsilon RI signaling pathway
mlx04714  Thermogenesis
mlx04720  Long-term potentiation
mlx04722  Neurotrophin signaling pathway
mlx04725  Cholinergic synapse
mlx04726  Serotonergic synapse
mlx04730  Long-term depression
mlx04810  Regulation of actin cytoskeleton
mlx04910  Insulin signaling pathway
mlx04912  GnRH signaling pathway
mlx04914  Progesterone-mediated oocyte maturation
mlx04915  Estrogen signaling pathway
mlx04916  Melanogenesis
mlx04917  Prolactin signaling pathway
mlx04919  Thyroid hormone signaling pathway
mlx04921  Oxytocin signaling pathway
mlx04926  Relaxin signaling pathway
mlx04929  GnRH secretion
mlx04933  AGE-RAGE signaling pathway in diabetic complications
mlx04935  Growth hormone synthesis, secretion and action
mlx04960  Aldosterone-regulated sodium reabsorption
mlx05010  Alzheimer disease
mlx05022  Pathways of neurodegeneration - multiple diseases
mlx05034  Alcoholism
mlx05160  Hepatitis C
mlx05161  Hepatitis B
mlx05163  Human cytomegalovirus infection
mlx05165  Human papillomavirus infection
mlx05166  Human T-cell leukemia virus 1 infection
mlx05167  Kaposi sarcoma-associated herpesvirus infection
mlx05170  Human immunodeficiency virus 1 infection
mlx05200  Pathways in cancer
mlx05203  Viral carcinogenesis
mlx05205  Proteoglycans in cancer
mlx05206  MicroRNAs in cancer
mlx05207  Chemical carcinogenesis - receptor activation
mlx05208  Chemical carcinogenesis - reactive oxygen species
mlx05210  Colorectal cancer
mlx05211  Renal cell carcinoma
mlx05212  Pancreatic cancer
mlx05213  Endometrial cancer
mlx05214  Glioma
mlx05215  Prostate cancer
mlx05216  Thyroid cancer
mlx05218  Melanoma
mlx05219  Bladder cancer
mlx05220  Chronic myeloid leukemia
mlx05221  Acute myeloid leukemia
mlx05223  Non-small cell lung cancer
mlx05224  Breast cancer
mlx05225  Hepatocellular carcinoma
mlx05226  Gastric cancer
mlx05230  Central carbon metabolism in cancer
mlx05231  Choline metabolism in cancer
mlx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mlx05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mlx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    118025572 (KRAS)
   04012 ErbB signaling pathway
    118025572 (KRAS)
   04014 Ras signaling pathway
    118025572 (KRAS)
   04015 Rap1 signaling pathway
    118025572 (KRAS)
   04370 VEGF signaling pathway
    118025572 (KRAS)
   04371 Apelin signaling pathway
    118025572 (KRAS)
   04068 FoxO signaling pathway
    118025572 (KRAS)
   04072 Phospholipase D signaling pathway
    118025572 (KRAS)
   04071 Sphingolipid signaling pathway
    118025572 (KRAS)
   04151 PI3K-Akt signaling pathway
    118025572 (KRAS)
   04150 mTOR signaling pathway
    118025572 (KRAS)
  09133 Signaling molecules and interaction
   04519 Cadherin signaling
    118025572 (KRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118025572 (KRAS)
   04137 Mitophagy - animal
    118025572 (KRAS)
  09143 Cell growth and death
   04210 Apoptosis
    118025572 (KRAS)
   04218 Cellular senescence
    118025572 (KRAS)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    118025572 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    118025572 (KRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118025572 (KRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    118025572 (KRAS)
   04650 Natural killer cell mediated cytotoxicity
    118025572 (KRAS)
   04660 T cell receptor signaling pathway
    118025572 (KRAS)
   04662 B cell receptor signaling pathway
    118025572 (KRAS)
   04664 Fc epsilon RI signaling pathway
    118025572 (KRAS)
   04062 Chemokine signaling pathway
    118025572 (KRAS)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118025572 (KRAS)
   04929 GnRH secretion
    118025572 (KRAS)
   04912 GnRH signaling pathway
    118025572 (KRAS)
   04915 Estrogen signaling pathway
    118025572 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    118025572 (KRAS)
   04917 Prolactin signaling pathway
    118025572 (KRAS)
   04921 Oxytocin signaling pathway
    118025572 (KRAS)
   04926 Relaxin signaling pathway
    118025572 (KRAS)
   04935 Growth hormone synthesis, secretion and action
    118025572 (KRAS)
   04919 Thyroid hormone signaling pathway
    118025572 (KRAS)
   04916 Melanogenesis
    118025572 (KRAS)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118025572 (KRAS)
  09156 Nervous system
   04725 Cholinergic synapse
    118025572 (KRAS)
   04726 Serotonergic synapse
    118025572 (KRAS)
   04720 Long-term potentiation
    118025572 (KRAS)
   04730 Long-term depression
    118025572 (KRAS)
   04722 Neurotrophin signaling pathway
    118025572 (KRAS)
  09158 Development and regeneration
   04360 Axon guidance
    118025572 (KRAS)
  09149 Aging
   04211 Longevity regulating pathway
    118025572 (KRAS)
   04213 Longevity regulating pathway - multiple species
    118025572 (KRAS)
  09159 Environmental adaptation
   04714 Thermogenesis
    118025572 (KRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118025572 (KRAS)
   05206 MicroRNAs in cancer
    118025572 (KRAS)
   05205 Proteoglycans in cancer
    118025572 (KRAS)
   05207 Chemical carcinogenesis - receptor activation
    118025572 (KRAS)
   05208 Chemical carcinogenesis - reactive oxygen species
    118025572 (KRAS)
   05203 Viral carcinogenesis
    118025572 (KRAS)
   05230 Central carbon metabolism in cancer
    118025572 (KRAS)
   05231 Choline metabolism in cancer
    118025572 (KRAS)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118025572 (KRAS)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118025572 (KRAS)
   05212 Pancreatic cancer
    118025572 (KRAS)
   05225 Hepatocellular carcinoma
    118025572 (KRAS)
   05226 Gastric cancer
    118025572 (KRAS)
   05214 Glioma
    118025572 (KRAS)
   05216 Thyroid cancer
    118025572 (KRAS)
   05221 Acute myeloid leukemia
    118025572 (KRAS)
   05220 Chronic myeloid leukemia
    118025572 (KRAS)
   05218 Melanoma
    118025572 (KRAS)
   05211 Renal cell carcinoma
    118025572 (KRAS)
   05219 Bladder cancer
    118025572 (KRAS)
   05215 Prostate cancer
    118025572 (KRAS)
   05213 Endometrial cancer
    118025572 (KRAS)
   05224 Breast cancer
    118025572 (KRAS)
   05223 Non-small cell lung cancer
    118025572 (KRAS)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118025572 (KRAS)
   05170 Human immunodeficiency virus 1 infection
    118025572 (KRAS)
   05161 Hepatitis B
    118025572 (KRAS)
   05160 Hepatitis C
    118025572 (KRAS)
   05163 Human cytomegalovirus infection
    118025572 (KRAS)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118025572 (KRAS)
   05165 Human papillomavirus infection
    118025572 (KRAS)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118025572 (KRAS)
   05022 Pathways of neurodegeneration - multiple diseases
    118025572 (KRAS)
  09165 Substance dependence
   05034 Alcoholism
    118025572 (KRAS)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118025572 (KRAS)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    118025572 (KRAS)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118025572 (KRAS)
   01522 Endocrine resistance
    118025572 (KRAS)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mlx04131]
    118025572 (KRAS)
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:mlx04031]
    118025572 (KRAS)
Membrane trafficking [BR:mlx04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    118025572 (KRAS)
GTP-binding proteins [BR:mlx04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    118025572 (KRAS)
SSDB
Motif
Pfam: Ras Roc Arf GTP_EFTU MMR_HSR1 RsgA_GTPase ATP_bind_1 FeoB_N Septin DUF6974
Other DBs
NCBI-GeneID: 118025572
NCBI-ProteinID: XP_034883951
LinkDB
Position
Unknown
AA seq 189 aa
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKINKEEKTPGC
VKIKKCIVM
NT seq 570 nt   +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcactttgtggatgaatatgatcctacaatagaggattcctac
aggaaacaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcttttgaagatattcaccattatagagaacaaata
aaaagagttaaagactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagatacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagagagtggaggatgctttttatacattggtg
agagagatccgacaatacagattgaaaaaaatcaacaaagaagaaaagactcctggctgt
gtgaaaattaaaaaatgcattgtaatgtaa

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