Mirounga leonina (Southern elephant seal): 118026800
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Entry
118026800 CDS
T07472
Symbol
NOS3
Name
(RefSeq) nitric oxide synthase, endothelial isoform X1
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx00220
Arginine biosynthesis
mlx00330
Arginine and proline metabolism
mlx01100
Metabolic pathways
mlx04020
Calcium signaling pathway
mlx04022
cGMP-PKG signaling pathway
mlx04066
HIF-1 signaling pathway
mlx04071
Sphingolipid signaling pathway
mlx04151
PI3K-Akt signaling pathway
mlx04370
VEGF signaling pathway
mlx04371
Apelin signaling pathway
mlx04611
Platelet activation
mlx04915
Estrogen signaling pathway
mlx04921
Oxytocin signaling pathway
mlx04926
Relaxin signaling pathway
mlx04931
Insulin resistance
mlx04933
AGE-RAGE signaling pathway in diabetic complications
mlx05415
Diabetic cardiomyopathy
mlx05417
Lipid and atherosclerosis
mlx05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
118026800 (NOS3)
00330 Arginine and proline metabolism
118026800 (NOS3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
118026800 (NOS3)
04371 Apelin signaling pathway
118026800 (NOS3)
04066 HIF-1 signaling pathway
118026800 (NOS3)
04020 Calcium signaling pathway
118026800 (NOS3)
04071 Sphingolipid signaling pathway
118026800 (NOS3)
04022 cGMP-PKG signaling pathway
118026800 (NOS3)
04151 PI3K-Akt signaling pathway
118026800 (NOS3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
118026800 (NOS3)
09152 Endocrine system
04915 Estrogen signaling pathway
118026800 (NOS3)
04921 Oxytocin signaling pathway
118026800 (NOS3)
04926 Relaxin signaling pathway
118026800 (NOS3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
118026800 (NOS3)
05418 Fluid shear stress and atherosclerosis
118026800 (NOS3)
05415 Diabetic cardiomyopathy
118026800 (NOS3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
118026800 (NOS3)
04933 AGE-RAGE signaling pathway in diabetic complications
118026800 (NOS3)
Enzymes [BR:
mlx01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
118026800 (NOS3)
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Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
118026800
NCBI-ProteinID:
XP_034885695
LinkDB
All DBs
Position
Unknown
AA seq
1202 aa
AA seq
DB search
MGNLKSVGQEPRPPCGLGLGLGLGLCGKQGPASPTSSEPSRAPAPAPPPAPDLSSPPLTR
PPDGPKFPRVKNWEVGSITYDTLSAQSQQDGPCTPRRCLGSLVFPRKLQSRPSQDPPPPE
QLLSQARDFITQYYSSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDF
RIWNSQLVRYAGYRQQDSSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFALPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSTE
IGTRNLCDPHRYNVLEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYVLSPAFRYQPDPWK
GSASKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQASCETFCVGQDAKAAAR
DIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILV
RLDTGGQEALQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPGEPVAVEQLEKGSPGGPP
PSWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEESSEQQELESLSQDPRRYE
EWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLA
YRTQDGLGPLHYGVCSTWLSQLKAGDPVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPF
RGFWQERLHDIDSKGLQPAPMTLVFGCRCSQLDHLYRDEVRDAQQRGVFGRVLTAFSREP
DSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDTP
SP
NT seq
3609 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcccaggcccccatgtggcctggggctgggc
ctgggcctggggctgtgcggcaagcagggccctgcctccccgacctcctcagagcccagc
agggcaccagcacccgcgcccccaccagcaccagacctcagcagccccccgctcacccgg
ccaccggacgggcccaagttccctcgtgtgaagaactgggaggtggggagcatcacctac
gacaccctgagtgcccagtcacagcaggatgggccctgcacccccagacgctgcctgggc
tccctggtatttccacggaaactgcagagccggccctctcaggaccctccgccccctgag
cagctgctgagccaggccagggacttcatcacccagtactatagctccatcaagaggagc
ggctcccaggcccatgagcagaggcttcaggaagtggaagcagaggtagcagccacgggc
acctaccagcttcgggagagcgagctggtgttcggggccaagcaggcctggcgaaatgct
ccccgctgtgtaggccggatccagtgggggaagctgcaggtgttcgatgcccgggattgc
agctctgcccaagagatgttcacctacatctgcaaccacatcaagtatgccacgaaccgg
ggcaacctccgctcggccatcacagtgttcccccagcgcgccccaggccgcggagacttc
cgaatctggaacagccaactggtgcgctatgcgggctacaggcagcaggacagctcggtg
cggggggacccagccaacgtggagatcactgagctctgcatccagcacggctggacccca
ggaaacggccgctttgacgtgctgcccctactgctccaggccccagatgagcccccagaa
ctctttgctctgccccctgagctggtcctcgaggtgcccctggaacaccccacgctggag
tggtttgcagccctgggcctgcgctggtatgccctcccggcagtgagcaacatgctgctg
gaaatcgggggactggagttccctgcggcccctttcagcggctggtacatgagcactgag
attggcacgcggaacctgtgtgaccctcacagatataacgtcctggaggatgtggcggtc
tgcatggacttggataccaggacaacctcatcgctgtggaaagacaaggcagcggtggaa
atcaacttggccgtgctgcacagttaccagctggccaaagtgaccatcgtggaccaccat
gctgccaccgcctccttcatgaagcacctggagaatgagcagaaggctagggggggctgc
cctgccgactgggcctggatcgtgccccccatctctggcagcctcacccctgtcttccat
caggagatggtcaactatgtcctgtccccggccttccgctatcagccagacccgtggaag
gggagtgcatccaagggtgccggcatcaccaggaagaagacctttaaggaagtggccaat
gcggtgaagatctctgcctcactcatgggcaccgtgatggcaaagcgagtgaaggcgacc
atcctgtatggctccgagaccggccgggcccagagctacgcccagcagctggggagactc
ttccggaaggctttcgaccccagggtcctgtgcatggatgagtacgatgtggtgtccctt
gagcatgagacgctggtgttggtggtgaccagcacatttgggaatggtgatcccccggag
aatggagagagttttgcggcagccctgatggagatgtccggcccctacaacagttcccct
cggccagaacagcacaagagttacaaaatccgcttcaacagcgtctcctgctcagacccg
ctggtgtcctcctggagacggaagagaaaggagtccagtaatacagatagcgcaggggcc
ctgggtaccctcaggttctgtgtgttcggcctgggctcccgggcatacccccacttctgc
gccttcgctcgtgcggtggacacacggctagaagagctgggcggggagcggctactgcag
ctgggccagggagatgagttgtgtggccaggaggaggccttccgtggctgggcccaggcc
gccttccaggcctcctgtgagactttctgtgtgggacaggatgccaaggccgccgcccgg
gacatattcagccccaaacggagctggaagcgccagaggtaccggctgagtgcccaggcc
gagggcctccagctactgccaggcctgatccacgtgcacaggaggaagatgttccaggct
acggtcctttcagtggaaaacctgcaaagcagcaagtccacccgggccacgatcctggtg
cgtctggacactggaggccaggaggcgctgcagtaccagccaggggaccacataggcatc
tgcccacccaaccggcccggcctcgtggaggcactgctgagccgcgtggaggacccgcct
ccaccaggagagccggtggccgtggagcagctggagaagggcagccctggtggaccaccc
cccagctgggttcgggacccccggctgcccccatgcacgctgcgccaggctctcaccttc
ttcctggacatcacttccccgcccagccctcaactccttcgactgctcagcaccctggcc
gaagagtccagcgaacagcaggagctcgagagcctcagccaggacccacggcgctacgag
gagtggaagtggttccgctgccccacgctgctggaggtgctggagcagttcccatcggtg
gcactgcccgcccccctgatcctcacccagctgcccctgctccagccccggtactactcg
gtcagctcagcacccagcgcccacccaggagagatccacctcacagtagccgtgctggca
tacaggacgcaggatggactgggcccccttcattatggagtctgctccacatggctgagc
caactgaaggccggagatcccgtaccctgcttcatcaggggggctccctctttccgacta
ccgcctgatcccagcttgccctgcatcctagtgggccctggcacaggtattgcccccttc
cggggattttggcaggagcggctgcacgacattgacagcaaagggctgcagcccgccccc
atgactttggtgttcggctgccgatgctcccagctcgaccacctttaccgcgacgaggtg
cgggatgcccagcagcgcggagtttttgggcgcgtcctcaccgccttctcccgggagccc
gacagccctaagacctacgtgcaggacatcctgcggaccgagctggctgctgaggtgcac
cgcgtgctgtgcctcgagcggggccacatgtttgtgtgcggcgacgtcaccatggcaacc
agcgtcctgcagacggtgcagcgaatcctagcgacggagggcgacatggagctggacgag
gccggcgacgtcatcggcgtgctgcgggatcagcaacgctatcacgaggacattttcggg
ctcacactgcgcactcaggaggtgacaagccgcatacgcacccagagcttttccttgcag
gagcgacatctgcggggcgcagtgccctgggcgttcgacccgcctggcccagacaccccc
agcccctga
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