KEGG   Molossus molossus (Pallas's mastiff bat): 118617106
Entry
118617106         CDS       T07221                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mmf  Molossus molossus (Pallas's mastiff bat)
Pathway
mmf00562  Inositol phosphate metabolism
mmf01100  Metabolic pathways
mmf01521  EGFR tyrosine kinase inhibitor resistance
mmf01522  Endocrine resistance
mmf01524  Platinum drug resistance
mmf04012  ErbB signaling pathway
mmf04014  Ras signaling pathway
mmf04015  Rap1 signaling pathway
mmf04024  cAMP signaling pathway
mmf04062  Chemokine signaling pathway
mmf04066  HIF-1 signaling pathway
mmf04068  FoxO signaling pathway
mmf04070  Phosphatidylinositol signaling system
mmf04071  Sphingolipid signaling pathway
mmf04072  Phospholipase D signaling pathway
mmf04081  Hormone signaling
mmf04140  Autophagy - animal
mmf04150  mTOR signaling pathway
mmf04151  PI3K-Akt signaling pathway
mmf04152  AMPK signaling pathway
mmf04210  Apoptosis
mmf04211  Longevity regulating pathway
mmf04213  Longevity regulating pathway - multiple species
mmf04218  Cellular senescence
mmf04360  Axon guidance
mmf04370  VEGF signaling pathway
mmf04380  Osteoclast differentiation
mmf04510  Focal adhesion
mmf04550  Signaling pathways regulating pluripotency of stem cells
mmf04611  Platelet activation
mmf04613  Neutrophil extracellular trap formation
mmf04620  Toll-like receptor signaling pathway
mmf04625  C-type lectin receptor signaling pathway
mmf04630  JAK-STAT signaling pathway
mmf04650  Natural killer cell mediated cytotoxicity
mmf04660  T cell receptor signaling pathway
mmf04662  B cell receptor signaling pathway
mmf04664  Fc epsilon RI signaling pathway
mmf04666  Fc gamma R-mediated phagocytosis
mmf04668  TNF signaling pathway
mmf04670  Leukocyte transendothelial migration
mmf04722  Neurotrophin signaling pathway
mmf04725  Cholinergic synapse
mmf04750  Inflammatory mediator regulation of TRP channels
mmf04810  Regulation of actin cytoskeleton
mmf04910  Insulin signaling pathway
mmf04914  Progesterone-mediated oocyte maturation
mmf04915  Estrogen signaling pathway
mmf04917  Prolactin signaling pathway
mmf04919  Thyroid hormone signaling pathway
mmf04923  Regulation of lipolysis in adipocytes
mmf04926  Relaxin signaling pathway
mmf04929  GnRH secretion
mmf04930  Type II diabetes mellitus
mmf04931  Insulin resistance
mmf04932  Non-alcoholic fatty liver disease
mmf04933  AGE-RAGE signaling pathway in diabetic complications
mmf04935  Growth hormone synthesis, secretion and action
mmf04960  Aldosterone-regulated sodium reabsorption
mmf04973  Carbohydrate digestion and absorption
mmf05010  Alzheimer disease
mmf05017  Spinocerebellar ataxia
mmf05020  Prion disease
mmf05100  Bacterial invasion of epithelial cells
mmf05132  Salmonella infection
mmf05135  Yersinia infection
mmf05142  Chagas disease
mmf05146  Amoebiasis
mmf05160  Hepatitis C
mmf05161  Hepatitis B
mmf05162  Measles
mmf05163  Human cytomegalovirus infection
mmf05164  Influenza A
mmf05165  Human papillomavirus infection
mmf05166  Human T-cell leukemia virus 1 infection
mmf05167  Kaposi sarcoma-associated herpesvirus infection
mmf05168  Herpes simplex virus 1 infection
mmf05169  Epstein-Barr virus infection
mmf05170  Human immunodeficiency virus 1 infection
mmf05171  Coronavirus disease - COVID-19
mmf05200  Pathways in cancer
mmf05203  Viral carcinogenesis
mmf05205  Proteoglycans in cancer
mmf05206  MicroRNAs in cancer
mmf05207  Chemical carcinogenesis - receptor activation
mmf05208  Chemical carcinogenesis - reactive oxygen species
mmf05210  Colorectal cancer
mmf05211  Renal cell carcinoma
mmf05212  Pancreatic cancer
mmf05213  Endometrial cancer
mmf05214  Glioma
mmf05215  Prostate cancer
mmf05218  Melanoma
mmf05220  Chronic myeloid leukemia
mmf05221  Acute myeloid leukemia
mmf05222  Small cell lung cancer
mmf05223  Non-small cell lung cancer
mmf05224  Breast cancer
mmf05225  Hepatocellular carcinoma
mmf05226  Gastric cancer
mmf05230  Central carbon metabolism in cancer
mmf05231  Choline metabolism in cancer
mmf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mmf05415  Diabetic cardiomyopathy
mmf05417  Lipid and atherosclerosis
mmf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    118617106 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    118617106 (PIK3CA)
   04014 Ras signaling pathway
    118617106 (PIK3CA)
   04015 Rap1 signaling pathway
    118617106 (PIK3CA)
   04370 VEGF signaling pathway
    118617106 (PIK3CA)
   04630 JAK-STAT signaling pathway
    118617106 (PIK3CA)
   04668 TNF signaling pathway
    118617106 (PIK3CA)
   04066 HIF-1 signaling pathway
    118617106 (PIK3CA)
   04068 FoxO signaling pathway
    118617106 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    118617106 (PIK3CA)
   04072 Phospholipase D signaling pathway
    118617106 (PIK3CA)
   04071 Sphingolipid signaling pathway
    118617106 (PIK3CA)
   04024 cAMP signaling pathway
    118617106 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    118617106 (PIK3CA)
   04152 AMPK signaling pathway
    118617106 (PIK3CA)
   04150 mTOR signaling pathway
    118617106 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    118617106 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    118617106 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    118617106 (PIK3CA)
   04218 Cellular senescence
    118617106 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    118617106 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    118617106 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    118617106 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    118617106 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    118617106 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    118617106 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    118617106 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    118617106 (PIK3CA)
   04660 T cell receptor signaling pathway
    118617106 (PIK3CA)
   04662 B cell receptor signaling pathway
    118617106 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    118617106 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    118617106 (PIK3CA)
   04670 Leukocyte transendothelial migration
    118617106 (PIK3CA)
   04062 Chemokine signaling pathway
    118617106 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    118617106 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    118617106 (PIK3CA)
   04929 GnRH secretion
    118617106 (PIK3CA)
   04915 Estrogen signaling pathway
    118617106 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    118617106 (PIK3CA)
   04917 Prolactin signaling pathway
    118617106 (PIK3CA)
   04926 Relaxin signaling pathway
    118617106 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    118617106 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    118617106 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    118617106 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    118617106 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    118617106 (PIK3CA)
   04722 Neurotrophin signaling pathway
    118617106 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    118617106 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    118617106 (PIK3CA)
   04380 Osteoclast differentiation
    118617106 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    118617106 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    118617106 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    118617106 (PIK3CA)
   05206 MicroRNAs in cancer
    118617106 (PIK3CA)
   05205 Proteoglycans in cancer
    118617106 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    118617106 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    118617106 (PIK3CA)
   05203 Viral carcinogenesis
    118617106 (PIK3CA)
   05230 Central carbon metabolism in cancer
    118617106 (PIK3CA)
   05231 Choline metabolism in cancer
    118617106 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    118617106 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    118617106 (PIK3CA)
   05212 Pancreatic cancer
    118617106 (PIK3CA)
   05225 Hepatocellular carcinoma
    118617106 (PIK3CA)
   05226 Gastric cancer
    118617106 (PIK3CA)
   05214 Glioma
    118617106 (PIK3CA)
   05221 Acute myeloid leukemia
    118617106 (PIK3CA)
   05220 Chronic myeloid leukemia
    118617106 (PIK3CA)
   05218 Melanoma
    118617106 (PIK3CA)
   05211 Renal cell carcinoma
    118617106 (PIK3CA)
   05215 Prostate cancer
    118617106 (PIK3CA)
   05213 Endometrial cancer
    118617106 (PIK3CA)
   05224 Breast cancer
    118617106 (PIK3CA)
   05222 Small cell lung cancer
    118617106 (PIK3CA)
   05223 Non-small cell lung cancer
    118617106 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    118617106 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    118617106 (PIK3CA)
   05161 Hepatitis B
    118617106 (PIK3CA)
   05160 Hepatitis C
    118617106 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    118617106 (PIK3CA)
   05164 Influenza A
    118617106 (PIK3CA)
   05162 Measles
    118617106 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    118617106 (PIK3CA)
   05163 Human cytomegalovirus infection
    118617106 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    118617106 (PIK3CA)
   05169 Epstein-Barr virus infection
    118617106 (PIK3CA)
   05165 Human papillomavirus infection
    118617106 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    118617106 (PIK3CA)
   05135 Yersinia infection
    118617106 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    118617106 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    118617106 (PIK3CA)
   05142 Chagas disease
    118617106 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    118617106 (PIK3CA)
   05017 Spinocerebellar ataxia
    118617106 (PIK3CA)
   05020 Prion disease
    118617106 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    118617106 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    118617106 (PIK3CA)
   05415 Diabetic cardiomyopathy
    118617106 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    118617106 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    118617106 (PIK3CA)
   04931 Insulin resistance
    118617106 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    118617106 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    118617106 (PIK3CA)
   01524 Platinum drug resistance
    118617106 (PIK3CA)
   01522 Endocrine resistance
    118617106 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmf04131]
    118617106 (PIK3CA)
Enzymes [BR:mmf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     118617106 (PIK3CA)
Membrane trafficking [BR:mmf04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    118617106 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 118617106
NCBI-ProteinID: XP_036098608
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTAAPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatccggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acgttaataactataaagcatgaactatttaaagaagcaagaaagtaccctctccatcaa
cttcttcaggatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gagttttttgatgaaacaagacgactttgtgacctccggctctttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgacatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaattatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaatcatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttactatcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaaatatattttaaaagtgtgtggatgtgatgaatac
tttctagaaaaatatcctctgagtcaatataagtatataagaagctgtatcatgcttggg
aggatgcccaatttaatgctgatggctaaggaaagcctttattcacagctgccaatggac
tgttttacaatgccatcttattccagacgcatctccacagctgcaccatatatgaatgga
gaaacttctacaaaatccctttgggttataaatagtgcgctcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgacaagatctatgttcgaacaggcatc
taccatggaggagagcccttgtgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattacgatatatacattcctgatcttcctcgtgctgct
cggctttgcctttccatttgttctgttaaaggtcgaaaaggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaatcctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtcaagtttccagatatgtcagtgattgaagagcatgccaactggtctgtg
tcccgagaagcaggatttagttattcccatgcaggactgagtaacagattagctagagac
aacgaattaagggaaaatgacaaagaacagctccgagcaatttgtacccgagatcctctg
tctgaaatcacagagcaagagaaagattttctgtggagccacagacactattgtgtaact
attcctgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccgatcaaacccgaacaggctatggag
cttctggactgcaactacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatatttaacagatgacaagctttctcagtacctaattcagctagtacaggtactaaaa
tacgaacagtatttggataacctacttgtgagatttttactcaaaaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaagtctgagatgcacaataaaacagtc
agtcagagatttggcctgcttttggagtcctactgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtggaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaactcaaaaggtacaaatgaagtttttagttgagcaaatgcgg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaatcctgctcatcag
ttaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacaccattatgcagatt
cagtgcaaaggtggtctgaagggtgcactgcagttcaacagccacacactacaccagtgg
ctcaaagacaagaacaaaggagaaatatacgatgcagccattgatctgttcacacgttca
tgtgctggatattgtgtcgctaccttcattttggggattggagatcgtcacaatagcaac
atcatggttaaagatgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaagtttggttataaacgagaacgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaagcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgcc
tacattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccat
acaattaagcagcatgctttgaactga

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