Molossus molossus (Pallas's mastiff bat): 118635666
Help
Entry
118635666 CDS
T07221
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
KO
K08845
A-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
mmf
Molossus molossus (Pallas's mastiff bat)
Pathway
mmf01521
EGFR tyrosine kinase inhibitor resistance
mmf01522
Endocrine resistance
mmf04010
MAPK signaling pathway
mmf04012
ErbB signaling pathway
mmf04068
FoxO signaling pathway
mmf04270
Vascular smooth muscle contraction
mmf04650
Natural killer cell mediated cytotoxicity
mmf04720
Long-term potentiation
mmf04726
Serotonergic synapse
mmf04730
Long-term depression
mmf04810
Regulation of actin cytoskeleton
mmf04910
Insulin signaling pathway
mmf04914
Progesterone-mediated oocyte maturation
mmf04928
Parathyroid hormone synthesis, secretion and action
mmf05010
Alzheimer disease
mmf05022
Pathways of neurodegeneration - multiple diseases
mmf05034
Alcoholism
mmf05160
Hepatitis C
mmf05161
Hepatitis B
mmf05200
Pathways in cancer
mmf05205
Proteoglycans in cancer
mmf05208
Chemical carcinogenesis - reactive oxygen species
mmf05210
Colorectal cancer
mmf05211
Renal cell carcinoma
mmf05212
Pancreatic cancer
mmf05213
Endometrial cancer
mmf05214
Glioma
mmf05215
Prostate cancer
mmf05218
Melanoma
mmf05219
Bladder cancer
mmf05220
Chronic myeloid leukemia
mmf05221
Acute myeloid leukemia
mmf05223
Non-small cell lung cancer
mmf05224
Breast cancer
mmf05225
Hepatocellular carcinoma
mmf05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
mmf00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
118635666 (ARAF)
04012 ErbB signaling pathway
118635666 (ARAF)
04068 FoxO signaling pathway
118635666 (ARAF)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
118635666 (ARAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
118635666 (ARAF)
09152 Endocrine system
04910 Insulin signaling pathway
118635666 (ARAF)
04914 Progesterone-mediated oocyte maturation
118635666 (ARAF)
04928 Parathyroid hormone synthesis, secretion and action
118635666 (ARAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
118635666 (ARAF)
09156 Nervous system
04726 Serotonergic synapse
118635666 (ARAF)
04720 Long-term potentiation
118635666 (ARAF)
04730 Long-term depression
118635666 (ARAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
118635666 (ARAF)
05205 Proteoglycans in cancer
118635666 (ARAF)
05208 Chemical carcinogenesis - reactive oxygen species
118635666 (ARAF)
09162 Cancer: specific types
05210 Colorectal cancer
118635666 (ARAF)
05212 Pancreatic cancer
118635666 (ARAF)
05225 Hepatocellular carcinoma
118635666 (ARAF)
05226 Gastric cancer
118635666 (ARAF)
05214 Glioma
118635666 (ARAF)
05221 Acute myeloid leukemia
118635666 (ARAF)
05220 Chronic myeloid leukemia
118635666 (ARAF)
05218 Melanoma
118635666 (ARAF)
05211 Renal cell carcinoma
118635666 (ARAF)
05219 Bladder cancer
118635666 (ARAF)
05215 Prostate cancer
118635666 (ARAF)
05213 Endometrial cancer
118635666 (ARAF)
05224 Breast cancer
118635666 (ARAF)
05223 Non-small cell lung cancer
118635666 (ARAF)
09172 Infectious disease: viral
05161 Hepatitis B
118635666 (ARAF)
05160 Hepatitis C
118635666 (ARAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
118635666 (ARAF)
05022 Pathways of neurodegeneration - multiple diseases
118635666 (ARAF)
09165 Substance dependence
05034 Alcoholism
118635666 (ARAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
118635666 (ARAF)
01522 Endocrine resistance
118635666 (ARAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmf01001
]
118635666 (ARAF)
Enzymes [BR:
mmf01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
118635666 (ARAF)
Protein kinases [BR:
mmf01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
118635666 (ARAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
ABC1
Pkinase_fungal
zf-RING-like
TUG-UBL1
Kdo
Motif
Other DBs
NCBI-GeneID:
118635666
NCBI-ProteinID:
XP_036126287
LinkDB
All DBs
Position
Unknown
AA seq
611 aa
AA seq
DB search
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEASLNRPLNEPL
TPQGPSFSPGSSCTQHRDPEHFPFPASANAPLQRIRSTSTPNVHMVSTTAPMDSSLIQLS
AQSFSTDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFEMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARPVP
NT seq
1836 nt
NT seq
+upstream
nt +downstream
nt
atggagccaccacggggcccccctgccaacggggccgagccgtcccgggcagtgggcact
gtcaaagtgtacctgcccaacaagcaacgcacagtggtgactgttcgggatggcatgagt
gtctatgactctctagacaaggctctcaaggtgcggggtctcaatcaggattgctgcgtg
gtctacaggctcatcaaagggcgaaagacagtcactgcctgggatacagccattgccccc
ctggatggtgaggagctcattgttgaggtccttgaagatgttccactgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctctaaggtc
cccacagtctgtgttgacatgagtaccaactgccgacagttctaccacagtgtccaagat
ttgtccggaggctccagacagcatgaggcttccttgaaccgtcctctgaatgagccgcta
acccctcagggtcccagcttttcccctggcagctcttgcactcagcaccgagaccctgag
cacttcccctttcctgcctcggccaatgccccgctccagcgcatccgctccacgtctact
cccaacgtccatatggtcagcaccacagcccccatggactccagcctcatccagctctct
gcccagagtttcagcactgatgctgctggtagtagaggtggtggtgatggagccccccgg
gggagccccagcccggcaagtgtgtcctctgggaggaagtccccacactccaagtcccca
tcagaacagcgggagaggaagtccttggctgatgacaagaagaaagtgaagaatctgggg
taccgggactcgggctattactgggaggtgccacccagtgaggtgcagctgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggcgatgtggctgtg
aaggtgctcaaggtggctcaacccacagctgagcaggcccaggccttcaagaacgagatg
caggtgctcaggaagacacgtcatgtcaacatcttgctgttcatgggcttcatgacccgg
ccagggtttgccatcatcacacagtggtgcgagggctccagcctctaccaccacctgcat
gtggccgacacacgctttgagatggtccagctcattgacgtggcccggcagactgcccag
ggcatggactacctccatgccaagaacatcatccaccgggatctcaagtctaacaacatc
ttcctacatgaggggctcacagtgaagattggtgacttcggcctggccacggtgaaaacg
cggtggagcggggctcagcccttggagcagccctcaggctctgtgctgtggatggcagct
gaggtgatccgtatgcaggacccgaacccctacagcttccagtcggatgtctacgcctat
ggggttgtgctttacgagctcatgaccggctccttgccttatagccacattggcagccgt
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaactgccccaaggccatgcggcgcctgctgtctgactgcctcaagttccagcgagag
gagcggcccctcttcccccagatcctggccacgattgagctgctgcagcggtcactcccc
aagattgagcggagtgcctctgaaccctccttgcaccgtacccaggctgatgaattgccc
gcctgcctactcagcgcagcccgccctgtgccttag
DBGET
integrated database retrieval system