Marmota marmota marmota (Alpine marmot): 107137015 Help Entry 107137015         CDS       T09644                                  Symbol Sos1 Name (RefSeq) son of sevenless homolog 1   KO K03099   son of sevenless Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma01521   EGFR tyrosine kinase inhibitor resistance mmma01522   Endocrine resistance mmma04010   MAPK signaling pathway mmma04012   ErbB signaling pathway mmma04014   Ras signaling pathway mmma04062   Chemokine signaling pathway mmma04068   FoxO signaling pathway mmma04072   Phospholipase D signaling pathway mmma04150   mTOR signaling pathway mmma04151   PI3K-Akt signaling pathway mmma04510   Focal adhesion mmma04540   Gap junction mmma04630   JAK-STAT signaling pathway mmma04650   Natural killer cell mediated cytotoxicity mmma04660   T cell receptor signaling pathway mmma04662   B cell receptor signaling pathway mmma04664   Fc epsilon RI signaling pathway mmma04714   Thermogenesis mmma04722   Neurotrophin signaling pathway mmma04810   Regulation of actin cytoskeleton mmma04910   Insulin signaling pathway mmma04912   GnRH signaling pathway mmma04915   Estrogen signaling pathway mmma04917   Prolactin signaling pathway mmma04926   Relaxin signaling pathway mmma04935   Growth hormone synthesis, secretion and action mmma05034   Alcoholism mmma05160   Hepatitis C mmma05161   Hepatitis B mmma05163   Human cytomegalovirus infection mmma05165   Human papillomavirus infection mmma05200   Pathways in cancer mmma05205   Proteoglycans in cancer mmma05206   MicroRNAs in cancer mmma05207   Chemical carcinogenesis - receptor activation mmma05208   Chemical carcinogenesis - reactive oxygen species mmma05210   Colorectal cancer mmma05211   Renal cell carcinoma mmma05213   Endometrial cancer mmma05214   Glioma mmma05215   Prostate cancer mmma05220   Chronic myeloid leukemia mmma05221   Acute myeloid leukemia mmma05223   Non-small cell lung cancer mmma05224   Breast cancer mmma05225   Hepatocellular carcinoma mmma05226   Gastric cancer mmma05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     107137015 (Sos1)    04012 ErbB signaling pathway     107137015 (Sos1)    04014 Ras signaling pathway     107137015 (Sos1)    04630 JAK-STAT signaling pathway     107137015 (Sos1)    04068 FoxO signaling pathway     107137015 (Sos1)    04072 Phospholipase D signaling pathway     107137015 (Sos1)    04151 PI3K-Akt signaling pathway     107137015 (Sos1)    04150 mTOR signaling pathway     107137015 (Sos1)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     107137015 (Sos1)    04540 Gap junction     107137015 (Sos1)   09142 Cell motility    04810 Regulation of actin cytoskeleton     107137015 (Sos1)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     107137015 (Sos1)    04660 T cell receptor signaling pathway     107137015 (Sos1)    04662 B cell receptor signaling pathway     107137015 (Sos1)    04664 Fc epsilon RI signaling pathway     107137015 (Sos1)    04062 Chemokine signaling pathway     107137015 (Sos1)   09152 Endocrine system    04910 Insulin signaling pathway     107137015 (Sos1)    04912 GnRH signaling pathway     107137015 (Sos1)    04915 Estrogen signaling pathway     107137015 (Sos1)    04917 Prolactin signaling pathway     107137015 (Sos1)    04926 Relaxin signaling pathway     107137015 (Sos1)    04935 Growth hormone synthesis, secretion and action     107137015 (Sos1)   09156 Nervous system    04722 Neurotrophin signaling pathway     107137015 (Sos1)   09159 Environmental adaptation    04714 Thermogenesis     107137015 (Sos1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     107137015 (Sos1)    05206 MicroRNAs in cancer     107137015 (Sos1)    05205 Proteoglycans in cancer     107137015 (Sos1)    05207 Chemical carcinogenesis - receptor activation     107137015 (Sos1)    05208 Chemical carcinogenesis - reactive oxygen species     107137015 (Sos1)    05231 Choline metabolism in cancer     107137015 (Sos1)   09162 Cancer: specific types    05210 Colorectal cancer     107137015 (Sos1)    05225 Hepatocellular carcinoma     107137015 (Sos1)    05226 Gastric cancer     107137015 (Sos1)    05214 Glioma     107137015 (Sos1)    05221 Acute myeloid leukemia     107137015 (Sos1)    05220 Chronic myeloid leukemia     107137015 (Sos1)    05211 Renal cell carcinoma     107137015 (Sos1)    05215 Prostate cancer     107137015 (Sos1)    05213 Endometrial cancer     107137015 (Sos1)    05224 Breast cancer     107137015 (Sos1)    05223 Non-small cell lung cancer     107137015 (Sos1)   09172 Infectious disease: viral    05161 Hepatitis B     107137015 (Sos1)    05160 Hepatitis C     107137015 (Sos1)    05163 Human cytomegalovirus infection     107137015 (Sos1)    05165 Human papillomavirus infection     107137015 (Sos1)   09165 Substance dependence    05034 Alcoholism     107137015 (Sos1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     107137015 (Sos1)    01522 Endocrine resistance     107137015 (Sos1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH PH_10 PH_19 IQ_SEC7_PH RHG20_PH Takusan Motif Other DBs NCBI-GeneID:  107137015 NCBI-ProteinID:  XP_015334883 Ensembl:  ENSMMMG00000016674 LinkDB All DBs Position Unknown AA seq 1319 aa AA seqDB search MRGKDKGREDKHEKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQ KSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLE YISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINVLSLTDEEPST SGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHEL SVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQL SKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQ AITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGK DIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFF MRKVQINDKDDTSEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLD VTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTY HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELK RFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRMEEFIGTVRGKAMKKWVESITK IIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDL YRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRI IEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKY LAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQ NQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPL KSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASGA SSTTDVCSVFDSEHSSPFHSSSDTVFIQVTLPHGPRSASVSSISLTKGTDEVPIPPPVPP RRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSVSDPPESPPLLP PREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPPQTPSPHGTRRHLP SPPLTQDVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS NT seq 3960 nt NT seq  +upstreamnt  +downstreamnt atgagggggaaggacaaaggcagagaggacaagcatgagaaggtccagggacaagttcat ccgactcttgagtctaatgatgatgctctccagtatgttgaagaattaatcttgcagtta ttaaatatgctatgccaagctcagccccgaagtgcttcagatgtagaggaacgtgttcaa aaaagtttccctcatccaattgataaatgggcaatagctgatgctcaatcagctatagaa aagaggaagcgaagaaaccctttatctctcccagtagaaaaaattcatcctttattaaag gaggtcctaggttataaaattgaccatcaggtttctgtttacatagtagcagtattagaa tacatttctgcagacattttaaagctggtggggaattatgtaagaaacatacgccattat gaaattacaaaacaagatattaaagtggcaatgtgtgctgataaggtattgatggatatg tttcatcaagatgtagaagatataaatgtattatctttaactgatgaagagccttccact tcaggagaacaaacttactatgatttggtaaaagcatttatggcagaaattcgacaatat ataagggaactaaatctaattataaaagtttttagagagccctttgtctccaattccaaa ttgttttcagctaatgatgtagaaaatatatttagccgtatagtagatatacatgaactt agtgtaaagttactgggccatatagaagacactgtagaaatgacagatgaaggcagtccc catcctttagtaggaagctgctttgaagacttggcagaggaactggcatttgatccatac gaatcatatgctcgagatattttacggcctggttttcatgatcgtttccttagtcagtta tcaaagcctggggcagcactttatttgcagtcaataggcgaaggtttcaaagaagctgtt caatatgttttacccaggctacttctagcccctgtttaccactgtctacattactttgaa cttctgaagcagttagaagaaaagagtgaagatcaagaagacaaagaatgtttgaaacaa gcaataacagctttgcttaatgttcaaagtggtatggaaaaaatatgttctaaaagtctt gcaaaacgaaggctgagtgaatctgcatgtcggttttatagtcagcaaatgaagggaaaa caactagcaatcaagaaaatgaacgagattcagaagaatattgatggttgggagggaaaa gacatcggacagtgttgcaatgagtttataatggaaggaactcttacacgtgtaggagcc aaacatgagagacacatatttctctttgatggtttaatgatttgctgtaaatcaaatcat gggcagccaagacttcctggtgctagcaatgcagaatatcgtctgaaagaaaagtttttt atgcgaaaggtacaaattaatgataaagatgacaccagtgaatacaagcatgcttttgaa ataattctaaaagatgaaaatagtgttatattttctgccaagtcagctgaagagaaaaac aattggatggcagcattgatatctttgcagtaccggagtacactggaaaggatgcttgat gtaacaatgctacaagaagagaaggaagagcagatgaggctgcctagcgctgatgtgtat agatttgcagagcctgactctgaagagaatattatatttgaagagaacatgcaacctaag gctggaattccaattattaaagcaggaactgttattaaacttatagagagacttacatac catatgtatgcagatcccaattttgttcggacatttcttacaacatacagatctttttgc aaacctcaagaactactgagtcttataatagaaaggtttgaaattccagagcctgagcca acagaagctgatcgtatagctatagagaatggagatcaacccttgagtgcagaactaaaa agatttagaaaagaatatatacagcctgtacaactacgagtattaaatgtatgtcggcac tgggtagagcaccacttttatgattttgaaagagatgcagatcttttacaacgaatggag gaatttattggaacagtaagaggtaaagcaatgaaaaaatgggttgaatccatcactaaa ataatccaaaggaaaaaaattgcaagagacaatgggccaggtcacaatattacatttcag agttcacctcccacagttgagtggcatataagcagacccgggcacatagagacttttgac ctgctcaccttacacccaatagaaattgctcgacaactcactttacttgaatcagattta taccgagctgtacagccatcagaattagttggaagtgtgtggacaaaagaagacaaagaa attaattctcccaatcttttgaaaatgatccgacataccactaatctcactctatggttt gagaaatgtattgtagaaactgaaaatttagaagaaagagtagctgtggtgagtcgaata attgagattctccaagtctttcaagaactgaataacttcaatggtgtccttgaggttgtc agtgctatgaactcatcacctgtttacagactagaccacacatttgagcaaataccaagt cgccaaaagaaaattttagaagaagctcatgaattgagtgaagatcactataagaaatat ttggcaaaactcaggtctattaatccaccatgtgtgcctttctttggaatttatctcact aatatcttgaaaacagaagaaggcaaccctgaggtcctaaaaagacatggaaaagaactt ataaactttagcaaaagaaggaaagtagcagaaataacaggagagatccagcagtaccaa aatcagccttattgtttacgagtagaatcagatatcaaaagattctttgaaaacttgaat ccaatgggaaatagcatggagaaagaatttactgattatctcttcaacaaatccctagag atagaaccacggaaccctaagcctcttccaagatttccaaaaaaatacagctacccccta aaatctcctggtgttcgtccatcaaacccaagaccaggtaccatgaggcatcccacacct ctacagcaggagccaagaaaaatcagttatagcaggatccctgaaagtgaaacagaaagt acagcatctgcaccaaattctccaagaacaccactaacacctcctcctgcttctggtgct tccagtaccacagatgtttgcagcgtgtttgattctgaacattcgagcccttttcattca agcagcgataccgtctttatccaagttacactgccccatggcccaagatctgcttcagta tcatctataagtttaaccaagggcactgatgaagtgcccatcccccctcctgttcctcca cgaagacgaccagaatctgccccagcagaatcttcgccatctaagattatgtctaagcac ttggacagtcccccagccattcctcctaggcaacccacatcaaaagcctattcacctcga tattcaatatcagaccgtacctctgtgtcagaccctccagaaagccctcctttattacca ccacgagaacctgtgaggacacctgatgttttctcaagctcaccactacatcttcagcct ccccctttgggcaaaaagagtgaccatggcaatgccttcttcccaaacagcccttctcct tttacaccaccacctcctcctcaaaccccttctcctcacggcacaagaaggcatctgcca tcaccaccattgacacaagatgtggacctccattccattgctgggccacctgttcctcca cgacaaagcacttctcaacatatccctaaactccctccaaaaacttataaaagggagcat acacacccatccatgcacagagatggaccaccactgttggagaatgcccattcttcctga

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