KEGG   Marmota marmota marmota (Alpine marmot): 107138000
Entry
107138000         CDS       T09644                                 
Symbol
Map2k1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mmma  Marmota marmota marmota (Alpine marmot)
Pathway
mmma01521  EGFR tyrosine kinase inhibitor resistance
mmma01522  Endocrine resistance
mmma04010  MAPK signaling pathway
mmma04012  ErbB signaling pathway
mmma04014  Ras signaling pathway
mmma04015  Rap1 signaling pathway
mmma04022  cGMP-PKG signaling pathway
mmma04024  cAMP signaling pathway
mmma04062  Chemokine signaling pathway
mmma04066  HIF-1 signaling pathway
mmma04068  FoxO signaling pathway
mmma04071  Sphingolipid signaling pathway
mmma04072  Phospholipase D signaling pathway
mmma04114  Oocyte meiosis
mmma04140  Autophagy - animal
mmma04148  Efferocytosis
mmma04150  mTOR signaling pathway
mmma04151  PI3K-Akt signaling pathway
mmma04210  Apoptosis
mmma04218  Cellular senescence
mmma04270  Vascular smooth muscle contraction
mmma04370  VEGF signaling pathway
mmma04371  Apelin signaling pathway
mmma04380  Osteoclast differentiation
mmma04510  Focal adhesion
mmma04540  Gap junction
mmma04550  Signaling pathways regulating pluripotency of stem cells
mmma04613  Neutrophil extracellular trap formation
mmma04620  Toll-like receptor signaling pathway
mmma04650  Natural killer cell mediated cytotoxicity
mmma04660  T cell receptor signaling pathway
mmma04662  B cell receptor signaling pathway
mmma04664  Fc epsilon RI signaling pathway
mmma04666  Fc gamma R-mediated phagocytosis
mmma04668  TNF signaling pathway
mmma04720  Long-term potentiation
mmma04722  Neurotrophin signaling pathway
mmma04725  Cholinergic synapse
mmma04726  Serotonergic synapse
mmma04730  Long-term depression
mmma04810  Regulation of actin cytoskeleton
mmma04910  Insulin signaling pathway
mmma04912  GnRH signaling pathway
mmma04914  Progesterone-mediated oocyte maturation
mmma04915  Estrogen signaling pathway
mmma04916  Melanogenesis
mmma04917  Prolactin signaling pathway
mmma04919  Thyroid hormone signaling pathway
mmma04921  Oxytocin signaling pathway
mmma04926  Relaxin signaling pathway
mmma04928  Parathyroid hormone synthesis, secretion and action
mmma04929  GnRH secretion
mmma04934  Cushing syndrome
mmma04935  Growth hormone synthesis, secretion and action
mmma05010  Alzheimer disease
mmma05022  Pathways of neurodegeneration - multiple diseases
mmma05034  Alcoholism
mmma05132  Salmonella infection
mmma05135  Yersinia infection
mmma05160  Hepatitis C
mmma05161  Hepatitis B
mmma05163  Human cytomegalovirus infection
mmma05164  Influenza A
mmma05165  Human papillomavirus infection
mmma05166  Human T-cell leukemia virus 1 infection
mmma05167  Kaposi sarcoma-associated herpesvirus infection
mmma05170  Human immunodeficiency virus 1 infection
mmma05200  Pathways in cancer
mmma05205  Proteoglycans in cancer
mmma05206  MicroRNAs in cancer
mmma05207  Chemical carcinogenesis - receptor activation
mmma05208  Chemical carcinogenesis - reactive oxygen species
mmma05210  Colorectal cancer
mmma05211  Renal cell carcinoma
mmma05212  Pancreatic cancer
mmma05213  Endometrial cancer
mmma05214  Glioma
mmma05215  Prostate cancer
mmma05216  Thyroid cancer
mmma05218  Melanoma
mmma05219  Bladder cancer
mmma05220  Chronic myeloid leukemia
mmma05221  Acute myeloid leukemia
mmma05223  Non-small cell lung cancer
mmma05224  Breast cancer
mmma05225  Hepatocellular carcinoma
mmma05226  Gastric cancer
mmma05230  Central carbon metabolism in cancer
mmma05231  Choline metabolism in cancer
mmma05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmma00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    107138000 (Map2k1)
   04012 ErbB signaling pathway
    107138000 (Map2k1)
   04014 Ras signaling pathway
    107138000 (Map2k1)
   04015 Rap1 signaling pathway
    107138000 (Map2k1)
   04370 VEGF signaling pathway
    107138000 (Map2k1)
   04371 Apelin signaling pathway
    107138000 (Map2k1)
   04668 TNF signaling pathway
    107138000 (Map2k1)
   04066 HIF-1 signaling pathway
    107138000 (Map2k1)
   04068 FoxO signaling pathway
    107138000 (Map2k1)
   04072 Phospholipase D signaling pathway
    107138000 (Map2k1)
   04071 Sphingolipid signaling pathway
    107138000 (Map2k1)
   04024 cAMP signaling pathway
    107138000 (Map2k1)
   04022 cGMP-PKG signaling pathway
    107138000 (Map2k1)
   04151 PI3K-Akt signaling pathway
    107138000 (Map2k1)
   04150 mTOR signaling pathway
    107138000 (Map2k1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    107138000 (Map2k1)
   04148 Efferocytosis
    107138000 (Map2k1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    107138000 (Map2k1)
   04210 Apoptosis
    107138000 (Map2k1)
   04218 Cellular senescence
    107138000 (Map2k1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107138000 (Map2k1)
   04540 Gap junction
    107138000 (Map2k1)
   04550 Signaling pathways regulating pluripotency of stem cells
    107138000 (Map2k1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107138000 (Map2k1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    107138000 (Map2k1)
   04620 Toll-like receptor signaling pathway
    107138000 (Map2k1)
   04650 Natural killer cell mediated cytotoxicity
    107138000 (Map2k1)
   04660 T cell receptor signaling pathway
    107138000 (Map2k1)
   04662 B cell receptor signaling pathway
    107138000 (Map2k1)
   04664 Fc epsilon RI signaling pathway
    107138000 (Map2k1)
   04666 Fc gamma R-mediated phagocytosis
    107138000 (Map2k1)
   04062 Chemokine signaling pathway
    107138000 (Map2k1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    107138000 (Map2k1)
   04929 GnRH secretion
    107138000 (Map2k1)
   04912 GnRH signaling pathway
    107138000 (Map2k1)
   04915 Estrogen signaling pathway
    107138000 (Map2k1)
   04914 Progesterone-mediated oocyte maturation
    107138000 (Map2k1)
   04917 Prolactin signaling pathway
    107138000 (Map2k1)
   04921 Oxytocin signaling pathway
    107138000 (Map2k1)
   04926 Relaxin signaling pathway
    107138000 (Map2k1)
   04935 Growth hormone synthesis, secretion and action
    107138000 (Map2k1)
   04919 Thyroid hormone signaling pathway
    107138000 (Map2k1)
   04928 Parathyroid hormone synthesis, secretion and action
    107138000 (Map2k1)
   04916 Melanogenesis
    107138000 (Map2k1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    107138000 (Map2k1)
  09156 Nervous system
   04725 Cholinergic synapse
    107138000 (Map2k1)
   04726 Serotonergic synapse
    107138000 (Map2k1)
   04720 Long-term potentiation
    107138000 (Map2k1)
   04730 Long-term depression
    107138000 (Map2k1)
   04722 Neurotrophin signaling pathway
    107138000 (Map2k1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    107138000 (Map2k1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107138000 (Map2k1)
   05206 MicroRNAs in cancer
    107138000 (Map2k1)
   05205 Proteoglycans in cancer
    107138000 (Map2k1)
   05207 Chemical carcinogenesis - receptor activation
    107138000 (Map2k1)
   05208 Chemical carcinogenesis - reactive oxygen species
    107138000 (Map2k1)
   05230 Central carbon metabolism in cancer
    107138000 (Map2k1)
   05231 Choline metabolism in cancer
    107138000 (Map2k1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107138000 (Map2k1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107138000 (Map2k1)
   05212 Pancreatic cancer
    107138000 (Map2k1)
   05225 Hepatocellular carcinoma
    107138000 (Map2k1)
   05226 Gastric cancer
    107138000 (Map2k1)
   05214 Glioma
    107138000 (Map2k1)
   05216 Thyroid cancer
    107138000 (Map2k1)
   05221 Acute myeloid leukemia
    107138000 (Map2k1)
   05220 Chronic myeloid leukemia
    107138000 (Map2k1)
   05218 Melanoma
    107138000 (Map2k1)
   05211 Renal cell carcinoma
    107138000 (Map2k1)
   05219 Bladder cancer
    107138000 (Map2k1)
   05215 Prostate cancer
    107138000 (Map2k1)
   05213 Endometrial cancer
    107138000 (Map2k1)
   05224 Breast cancer
    107138000 (Map2k1)
   05223 Non-small cell lung cancer
    107138000 (Map2k1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    107138000 (Map2k1)
   05170 Human immunodeficiency virus 1 infection
    107138000 (Map2k1)
   05161 Hepatitis B
    107138000 (Map2k1)
   05160 Hepatitis C
    107138000 (Map2k1)
   05164 Influenza A
    107138000 (Map2k1)
   05163 Human cytomegalovirus infection
    107138000 (Map2k1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    107138000 (Map2k1)
   05165 Human papillomavirus infection
    107138000 (Map2k1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    107138000 (Map2k1)
   05135 Yersinia infection
    107138000 (Map2k1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107138000 (Map2k1)
   05022 Pathways of neurodegeneration - multiple diseases
    107138000 (Map2k1)
  09165 Substance dependence
   05034 Alcoholism
    107138000 (Map2k1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    107138000 (Map2k1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107138000 (Map2k1)
   01522 Endocrine resistance
    107138000 (Map2k1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmma01001]
    107138000 (Map2k1)
Enzymes [BR:mmma01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     107138000 (Map2k1)
Protein kinases [BR:mmma01001]
 Serine/threonine kinases: STE group
  STE7 family
   107138000 (Map2k1)
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Seadorna_VP7 Kinase-like Haspin_kinase
Other DBs
NCBI-GeneID: 107138000
NCBI-ProteinID: XP_015335998
Ensembl: ENSMMMG00000006173
LinkDB
Position
Unknown
AA seq 371 aa
MKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISIC
MEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRG
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYP
IPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPP
PKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
QPSTPTHAAGV
NT seq 1116 nt   +upstreamnt  +downstreamnt
atgaagctggagaggaccaatctggaggccttgcagaagaagctggaagagctggagctt
gatgagcagcagcggaagcgccttgaagcctttctgacccagaagcagaaggtgggagaa
ctgaaagatgatgactttgagaagatcagcgagctgggtgcaggcaatggcggtgtggta
ttcaaggtctcccacaagccgtctggcctggtcatggccagaaagctaattcacctggag
atcaaacctgcaatccggaaccagatcatcagggagctgcaggttctgcatgaatgcaac
tccccatacatcgtgggcttttatggcgcattctatagtgacggggagatcagcatctgc
atggagcacatggatgggggttctttggatcaagtcctgaagaaagccggaagaattcct
gaacaaattttaggaaaagttagcattgcagtaataaaaggcctgacgtatctgagggag
aagcacaagattatgcacagagatgtcaagccatccaacatcctagtcaactcccgtggg
gagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggccaactcc
ttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattactcagtg
cagtcggacatctggagcatggggctctctctggtggaaatggcagtggggaggtacccc
atccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggagggagat
gcagctgagacaccccccaggcccaggacacccgggaggccccttagctcatatggaatg
gacagtcgacctcccatggcaatttttgagttgttggattacatagtcaatgagccgcct
ccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaatgctta
ataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgcttttatcaag
agatctgatgccgaggaagtggattttgcaggttggctctgctccaccataggccttaac
cagcccagcacaccaacccatgcagctggtgtctaa

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