Entry |
|
Symbol |
Plcb2
|
Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
KO |
|
Organism |
mmma Marmota marmota marmota (Alpine marmot)
|
Pathway |
mmma04070 | Phosphatidylinositol signaling system |
mmma04261 | Adrenergic signaling in cardiomyocytes |
mmma04613 | Neutrophil extracellular trap formation |
mmma04621 | NOD-like receptor signaling pathway |
mmma04723 | Retrograde endocannabinoid signaling |
mmma04750 | Inflammatory mediator regulation of TRP channels |
mmma04925 | Aldosterone synthesis and secretion |
mmma04928 | Parathyroid hormone synthesis, secretion and action |
mmma04933 | AGE-RAGE signaling pathway in diabetic complications |
mmma04935 | Growth hormone synthesis, secretion and action |
mmma04961 | Endocrine and other factor-regulated calcium reabsorption |
mmma04973 | Carbohydrate digestion and absorption |
mmma05022 | Pathways of neurodegeneration - multiple diseases |
|
Module |
mmma_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
Brite |
KEGG Orthology (KO) [BR:mmma00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
107138232 (Plcb2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
107138232 (Plcb2)
04310 Wnt signaling pathway
107138232 (Plcb2)
04371 Apelin signaling pathway
107138232 (Plcb2)
04020 Calcium signaling pathway
107138232 (Plcb2)
04070 Phosphatidylinositol signaling system
107138232 (Plcb2)
04072 Phospholipase D signaling pathway
107138232 (Plcb2)
04071 Sphingolipid signaling pathway
107138232 (Plcb2)
04022 cGMP-PKG signaling pathway
107138232 (Plcb2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
107138232 (Plcb2)
04081 Hormone signaling
107138232 (Plcb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
107138232 (Plcb2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
107138232 (Plcb2)
04613 Neutrophil extracellular trap formation
107138232 (Plcb2)
04621 NOD-like receptor signaling pathway
107138232 (Plcb2)
04062 Chemokine signaling pathway
107138232 (Plcb2)
09152 Endocrine system
04911 Insulin secretion
107138232 (Plcb2)
04922 Glucagon signaling pathway
107138232 (Plcb2)
04929 GnRH secretion
107138232 (Plcb2)
04912 GnRH signaling pathway
107138232 (Plcb2)
04915 Estrogen signaling pathway
107138232 (Plcb2)
04921 Oxytocin signaling pathway
107138232 (Plcb2)
04926 Relaxin signaling pathway
107138232 (Plcb2)
04935 Growth hormone synthesis, secretion and action
107138232 (Plcb2)
04918 Thyroid hormone synthesis
107138232 (Plcb2)
04919 Thyroid hormone signaling pathway
107138232 (Plcb2)
04928 Parathyroid hormone synthesis, secretion and action
107138232 (Plcb2)
04916 Melanogenesis
107138232 (Plcb2)
04924 Renin secretion
107138232 (Plcb2)
04925 Aldosterone synthesis and secretion
107138232 (Plcb2)
04927 Cortisol synthesis and secretion
107138232 (Plcb2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
107138232 (Plcb2)
04270 Vascular smooth muscle contraction
107138232 (Plcb2)
09154 Digestive system
04970 Salivary secretion
107138232 (Plcb2)
04971 Gastric acid secretion
107138232 (Plcb2)
04972 Pancreatic secretion
107138232 (Plcb2)
04973 Carbohydrate digestion and absorption
107138232 (Plcb2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
107138232 (Plcb2)
09156 Nervous system
04724 Glutamatergic synapse
107138232 (Plcb2)
04725 Cholinergic synapse
107138232 (Plcb2)
04728 Dopaminergic synapse
107138232 (Plcb2)
04726 Serotonergic synapse
107138232 (Plcb2)
04720 Long-term potentiation
107138232 (Plcb2)
04730 Long-term depression
107138232 (Plcb2)
04723 Retrograde endocannabinoid signaling
107138232 (Plcb2)
09157 Sensory system
04742 Taste transduction
107138232 (Plcb2)
04750 Inflammatory mediator regulation of TRP channels
107138232 (Plcb2)
09159 Environmental adaptation
04713 Circadian entrainment
107138232 (Plcb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
107138232 (Plcb2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
107138232 (Plcb2)
09174 Infectious disease: parasitic
05146 Amoebiasis
107138232 (Plcb2)
05142 Chagas disease
107138232 (Plcb2)
05143 African trypanosomiasis
107138232 (Plcb2)
09164 Neurodegenerative disease
05010 Alzheimer disease
107138232 (Plcb2)
05016 Huntington disease
107138232 (Plcb2)
05017 Spinocerebellar ataxia
107138232 (Plcb2)
05022 Pathways of neurodegeneration - multiple diseases
107138232 (Plcb2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
107138232 (Plcb2)
05415 Diabetic cardiomyopathy
107138232 (Plcb2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
107138232 (Plcb2)
04934 Cushing syndrome
107138232 (Plcb2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mmma04131]
107138232 (Plcb2)
Enzymes [BR:mmma01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
107138232 (Plcb2)
Membrane trafficking [BR:mmma04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
107138232 (Plcb2)
Endocytosis
Macropinocytosis
Phospholipase C
107138232 (Plcb2)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
Unknown
|
AA seq |
1182 aa
MSLLNPVLLPPKVKAYLSQGERFIKWDDETAVASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKIPKSQKLRDVFNMDFPDNHFLLKILTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPLTANAPRSTFLDKILVKLKMQLTPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPEQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRTMFGDMLLTEPLEKFPLKPGIPLPSPEDLRGKILIKNKKNQFSGSAAPSKEPSGE
AEGNGLPRAPVGEDTVWAGEEGSELEEEEVEVEEEEESGNLDEEEMKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYELLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEF
MRRLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSPNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFIFLEMKDYVPDTWADLTVALANPIKFFNAHDKKSMKLKEAMGGV
PEKPFSSISPVAHQVNGASSAPASNGSAAATARAREEAPKEAVEPQTTSPEELRELKGIV
KLQRRHEKELRELERRGARRWEELLQRGEAQLAELGLPSTCSKLRPGKGSRKKRTLPCEE
TGGAARGEGTEDADSRVRELKERLEQELQQQGEEQYLCILKRKEQHVAEQMAKMMELARE
KHAAELKTLKENSEIDTKEMKKKLEAKRLERIQAMTKASSDKMAQERLKREINNSHIQEV
VQTIKQMTDTLERHQEKLEEKQAACLEQIQDMEKRFQQEALAEYEARMKGLEAEVKESVR
ACLRACVPSEAEDKPERVCEASKEPCGQDPLTTMADIQESRL |
NT seq |
3549 nt +upstreamnt +downstreamnt
atgtctctgctgaaccctgtcctgctgccccccaaggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggacgatgaaactgcagtagcctccccagttatcctccgtgtg
gatcccaagggctattacttgtactggacctatcagagtaaggagatggagtttctggat
atcactagcatccgggacacccgctttgggaagtttgccaagattcccaagagccagaag
ctccgggatgtcttcaacatggactttccagataaccacttcctgctgaagatacttaca
gtggtgtccggccccgacatggtggacctcaccttccacaactttgtatcctacaaggag
aacgtgggcaaggactgggctgaagatgtactagctctggccaagcacccattgacggcc
aatgccccccgcagcaccttcctggacaagatcctggtgaagctcaagatgcaactgacc
cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagtgcctgtcacctggcaaaggggaagaatgatgctatcaatcct
gaggacttcccagaatctgtctacaagagttttctcatgagcctctgtcctcggccagaa
atagacgagatcttcacttcctaccatgctaaggccaaaccctacatgaccaaggagcac
ctgaccaaattcatcaaccagaaacagcgtgactctcggctcaactccttgctgttccca
ccagcgagacctgaacaggtgcagggcctcatcgacaaatatgaacccagtggcatcaac
gtgcagaggggccagctgtcacctgagggcatggtctggtttctctgtgggccagagaac
agtgtgctggcccaggacaagctgctgctccaccatgacatgacgcagcctctcaatcat
tacttcatcaactcctcacacaacacctacctgacagctggccagttctcaggcctttcc
tcggctgagatgtaccgccaggtgctgctgtctggctgccgctgtgtggagctggactgc
tggaaggggaagccccctgacgaggagcccattattacccatggcttcaccatgaccaca
gacatcttgttcaaggaagctattgaagcaattgcagaaagtgcctttaagacctctccc
tatcccgtcatcctgtcatttgaaaaccatgtggactcaccccgccaacaggctaagatg
gctgagtactgcaggacgatgtttggggatatgctgctcacagagcccttggaaaaattc
ccactgaaaccaggcatccctctgcccagtcctgaggacctccggggtaagatcctcatc
aagaataagaaaaaccagttttctggttcagcagcccccagcaaggagcctagtggggag
gctgagggcaatggcctgcccagggccccagtgggcgaggacacagtgtgggctggtgag
gaagggtctgagctggaggaggaggaggtggaagtggaagaggaagaggagtcgggaaac
ctggatgaagaagagatgaagaagatgcagtcggatgagggcaccgcaggcctggaggtg
acggcttatgaagagatgtccagcctagttaattacatccagcccaccaagttcatctct
ttcgagttctctgcccagaagaaccgaagttatgtcatctcctccttcacggagctcaag
gcttatgaactgctctccaaggcctccgtgcagtttgtggactacaacaagcgccagatg
agtcgcatttaccccaagggcactcgcatggactcctccaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacgatggacctgcccatgcag
cagaacatggcactgttcgagttcaacgggcagagcggctacctcctcaagcatgagttc
atgcgccgactggacaagcagttcaatcccttctcggtggaccgaattgatgtggtggta
gccaccactctttctattacggtcatctctgggcagttcctgtcagaacgcagtgtgcgc
acctatgtggaagtggaattgtttggtcttccaggggaccccaagaggcgctatcgcacc
aagctgtcacccagtcccaactccatcaatcctgtgtggaaagaggagccctttgttttt
gagaagatcttaatgcctgagctggcttccctcagggtggctgtgatggaggaaggcaat
aaatttctcggccaccgcatcatccccatcaacgctctgaattctggatatcatcatctg
tgcctgcacagtgagagcaacatgcccctcaccatgcctgcactgtttatcttcctggag
atgaaggactatgtacctgacacttgggcagatctcaccgttgcccttgccaaccccatc
aagttcttcaatgcccatgataagaagtctatgaagctcaaggaggccatgggaggtgtg
cctgagaagcccttctcatccataagtccagttgctcaccaagtaaatggagcatcatct
gccccagcaagcaacgggtcagcagcagccacggccagggccagggaggaggcccccaaa
gaagctgtggagccgcagaccactagcccggaggagctgcgcgagctgaagggcatcgtg
aagctgcagcggcggcacgagaaggagcttcgggagctggagcggcgaggcgcgcggcgt
tgggaggagctgctgcagcgcggtgaggcgcagctggccgagcttgggctgcccagcacc
tgcagcaagctccgcccgggaaagggctcccgcaagaagaggaccctgccctgcgaggag
actggtggggccgcccggggcgagggcactgaggacgcagactcacgtgtgcgggaactg
aaggaaaggctggagcaggaactacaacagcagggcgaggaacagtacctgtgcattctg
aaacgcaaggagcagcatgtggctgagcaaatggctaaaatgatggagctggccagagag
aaacacgctgcagagctgaagaccctcaaggagaactcagagattgacaccaaagagatg
aagaaaaagctggaggccaagaggctagagagaatccaggccatgaccaaagcttcctct
gacaagatggcccaggagaggctgaagagagagattaacaactcccacatccaggaagtg
gtgcagaccatcaagcagatgactgataccctggagcggcaccaggaaaagctggaggaa
aagcaggcagcctgcttggaacagatccaggacatggaaaagcggttccagcaagaggca
ttggcggagtatgaggccaggatgaagggcctggaggctgaggtgaaggagtcggtgagg
gcctgcctcagggcctgcgtcccctctgaggctgaggacaagcctgagagagtctgtgaa
gcctccaaggagccatgtggccaggacccactcacaaccatggcagacatccaggaaagc
cgcctctga |