Marmota marmota marmota (Alpine marmot): 107143517 Help Entry 107143517         CDS       T09644                                  Symbol Sos2 Name (RefSeq) son of sevenless homolog 2   KO K03099   son of sevenless Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma01521   EGFR tyrosine kinase inhibitor resistance mmma01522   Endocrine resistance mmma04010   MAPK signaling pathway mmma04012   ErbB signaling pathway mmma04014   Ras signaling pathway mmma04062   Chemokine signaling pathway mmma04068   FoxO signaling pathway mmma04072   Phospholipase D signaling pathway mmma04150   mTOR signaling pathway mmma04151   PI3K-Akt signaling pathway mmma04510   Focal adhesion mmma04540   Gap junction mmma04630   JAK-STAT signaling pathway mmma04650   Natural killer cell mediated cytotoxicity mmma04660   T cell receptor signaling pathway mmma04662   B cell receptor signaling pathway mmma04664   Fc epsilon RI signaling pathway mmma04714   Thermogenesis mmma04722   Neurotrophin signaling pathway mmma04810   Regulation of actin cytoskeleton mmma04910   Insulin signaling pathway mmma04912   GnRH signaling pathway mmma04915   Estrogen signaling pathway mmma04917   Prolactin signaling pathway mmma04926   Relaxin signaling pathway mmma04935   Growth hormone synthesis, secretion and action mmma05034   Alcoholism mmma05160   Hepatitis C mmma05161   Hepatitis B mmma05163   Human cytomegalovirus infection mmma05165   Human papillomavirus infection mmma05200   Pathways in cancer mmma05205   Proteoglycans in cancer mmma05206   MicroRNAs in cancer mmma05207   Chemical carcinogenesis - receptor activation mmma05208   Chemical carcinogenesis - reactive oxygen species mmma05210   Colorectal cancer mmma05211   Renal cell carcinoma mmma05213   Endometrial cancer mmma05214   Glioma mmma05215   Prostate cancer mmma05220   Chronic myeloid leukemia mmma05221   Acute myeloid leukemia mmma05223   Non-small cell lung cancer mmma05224   Breast cancer mmma05225   Hepatocellular carcinoma mmma05226   Gastric cancer mmma05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     107143517 (Sos2)    04012 ErbB signaling pathway     107143517 (Sos2)    04014 Ras signaling pathway     107143517 (Sos2)    04630 JAK-STAT signaling pathway     107143517 (Sos2)    04068 FoxO signaling pathway     107143517 (Sos2)    04072 Phospholipase D signaling pathway     107143517 (Sos2)    04151 PI3K-Akt signaling pathway     107143517 (Sos2)    04150 mTOR signaling pathway     107143517 (Sos2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     107143517 (Sos2)    04540 Gap junction     107143517 (Sos2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     107143517 (Sos2)  09150 Organismal Systems   09151 Immune system    04650 Natural killer cell mediated cytotoxicity     107143517 (Sos2)    04660 T cell receptor signaling pathway     107143517 (Sos2)    04662 B cell receptor signaling pathway     107143517 (Sos2)    04664 Fc epsilon RI signaling pathway     107143517 (Sos2)    04062 Chemokine signaling pathway     107143517 (Sos2)   09152 Endocrine system    04910 Insulin signaling pathway     107143517 (Sos2)    04912 GnRH signaling pathway     107143517 (Sos2)    04915 Estrogen signaling pathway     107143517 (Sos2)    04917 Prolactin signaling pathway     107143517 (Sos2)    04926 Relaxin signaling pathway     107143517 (Sos2)    04935 Growth hormone synthesis, secretion and action     107143517 (Sos2)   09156 Nervous system    04722 Neurotrophin signaling pathway     107143517 (Sos2)   09159 Environmental adaptation    04714 Thermogenesis     107143517 (Sos2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     107143517 (Sos2)    05206 MicroRNAs in cancer     107143517 (Sos2)    05205 Proteoglycans in cancer     107143517 (Sos2)    05207 Chemical carcinogenesis - receptor activation     107143517 (Sos2)    05208 Chemical carcinogenesis - reactive oxygen species     107143517 (Sos2)    05231 Choline metabolism in cancer     107143517 (Sos2)   09162 Cancer: specific types    05210 Colorectal cancer     107143517 (Sos2)    05225 Hepatocellular carcinoma     107143517 (Sos2)    05226 Gastric cancer     107143517 (Sos2)    05214 Glioma     107143517 (Sos2)    05221 Acute myeloid leukemia     107143517 (Sos2)    05220 Chronic myeloid leukemia     107143517 (Sos2)    05211 Renal cell carcinoma     107143517 (Sos2)    05215 Prostate cancer     107143517 (Sos2)    05213 Endometrial cancer     107143517 (Sos2)    05224 Breast cancer     107143517 (Sos2)    05223 Non-small cell lung cancer     107143517 (Sos2)   09172 Infectious disease: viral    05161 Hepatitis B     107143517 (Sos2)    05160 Hepatitis C     107143517 (Sos2)    05163 Human cytomegalovirus infection     107143517 (Sos2)    05165 Human papillomavirus infection     107143517 (Sos2)   09165 Substance dependence    05034 Alcoholism     107143517 (Sos2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     107143517 (Sos2)    01522 Endocrine resistance     107143517 (Sos2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RasGEF RasGEF_N RhoGEF SOS1_NGEF_PH PH RHG20_PH PH_19 IQ_SEC7_PH PH_13 Motif Other DBs NCBI-GeneID:  107143517 NCBI-ProteinID:  XP_048654574 Ensembl:  ENSMMMG00000002005 LinkDB All DBs Position Unknown AA seq 1299 aa AA seqDB search MVQEQVHPNLSANEESLYYIEELIFQLLNKLCMAQPRTVQDVEERVQKTFPHPIDKWAIA DAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGYKVDYHVSLYIVAVLEYISADILKLAGNY VFNIRHYEISQQDIKVSMCADKVLMDMFDQDDIGLVSLCEDEPSSSGELNYYDLVRTEIA EERQYLRELNMIIKVFREAFLSDRKLFKPSDIEKIFSNISDIHELTVKLLGLIEDTVEMT DESSPHPLAGSCFEDLAEEQAFDPYETLSQDILSPEFNEHFSKLMARPAVALHFQSIADG FKEAVRYVLPRLMLVPVYHCWHYFELLKQLKACSEEQEDRECLNQAITALMNLQGSMDRI YKQYSPRRRPGDPVCPFYNRQLRSKHLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGPL TRIGAKHERHIFLFDGLMISCKPNHGQTRLPGYSSAEYRLKEKFVMRKVQICDKEDTCEC RHAFELVSKDENSIIFAAKSAEEKNNWMAALISLHYRSTLDRMLDSVLLKEENDQPLRLP SPDVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLTYHMYADPNFVRTFLTT YRSFCKPQELLSLLIERFEIPEPEPTEADKLAIEKGEQPISADLKRFRKEYVQPVQLRIL NVFRHWVEHHFYDFERDVELLKRLESFISSVRGKAMKKWVESIAKIIKRKKQAQANGISH NITFESPPPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWT KEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNG VLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLKSINPPCVPFF GIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPEMRRF FENLNPMGSSSEKEFTDYLFNKSLEIEPRNCKQPPRFARKSTYSLKSPGIRPNSGRHGST SGTLRGHPTPLEREPYKISFSRVAETELESTVSAPTSPNTPSTPPVSASSEHSVFSDMDL NSSCGSNSIFATVLLPHSKSIFSSCGSLNKPSEELLIPPPLPPRRKFDQDASNSKGTVKS DDDPPAIPPRQPPPPKIKPRVPVPTSAFDGLLHSPPPPPPRDPLPDTPPPVPLRPPEHFI NCPFNLQPPPLGHLHRDPDWLRDISTCPNSPSTPPSTPSPRVPRRCYHNSLAHPQAPPVP PRQNSSPHLPKLPPKTYKREFSHPPLYRLSMVENAETPQ NT seq 3900 nt NT seq  +upstreamnt  +downstreamnt atggttcaggagcaagtacatcccaatctatcagctaatgaagagtctctttattatatt gaagaactgatttttcagctgcttaataaattatgcatggcccaaccaaggactgttcaa gatgttgaggaacgagttcaaaagacctttcctcatccaattgacaaatgggctattgct gatgcacaatctgccatagagaaacgaaaacgaagaaatcctcttttactacctgtggac aaaattcatccttcattgaaggaagttttggggtataaagtggactaccatgtgtcccta tatattgtggctgtactagagtatatatcagcagatattttgaaattggctggtaattat gtttttaatatccgacattatgaaatatctcaacaggatattaaagtgtctatgtgtgca gataaggttttgatggacatgtttgatcaggatgatataggtttggtttctctctgtgaa gatgaacctagttcttcaggtgaattaaactactatgatcttgtcagaactgaaattgca gaagaaagacagtatctgcgggaactaaatatgattataaaagtgtttcgagaagccttt ctttctgacagaaagttatttaaaccttctgatatcgaaaagattttcagtaacatttca gatatacatgaattgactgtgaaacttttaggtttaattgaagacacagttgaaatgaca gatgaaagcagtcctcatcctttagctggcagctgttttgaagatttggcagaagagcaa gcatttgatccttatgaaacattatcacaggacattctttcaccagagtttaatgaacat tttagtaagttgatggctagacctgcagttgctctacactttcagtccattgctgatggt tttaaagaagcagttcgttatgtccttcctcgccttatgctggtaccagtgtatcattgt tggcattattttgaattattaaagcaactgaaagcatgtagtgaagagcaagaagacaga gaatgtttgaaccaagctattactgctctcatgaatcttcaaggtagtatggaccgaatt tacaagcagtattcacctagacgccgacctggggatcctgtttgccctttttataatcgt caattaagaagcaagcacctggccatcaaaaaaatgaatgaaattcagaaaaacatagat ggatgggaaggcaaagatattggacagtgctgcaatgaatttataatggaaggaccgttg acaagaattggtgctaaacatgaacgacatatttttctctttgatggcttaatgatcagc tgtaaacctaatcatggccagacccggcttccaggttacagtagtgcagaatatagatta aaagaaaagtttgtcatgaggaaagtacaaatctgtgataaggaagatacttgtgagtgc agacatgcttttgaattagtatccaaagatgaaaacagcataatatttgctgctaagtct gcagaagagaaaaataattggatggcagcccttatttctcttcattatcgtagtactcta gatcgaatgctagattctgtattattgaaagaagaaaatgatcagccactgagattacca agtccagatgtgtatcgttttgtggtaaaagactctgaggaaaacattgtttttgaagac aacttgcaaagtagaagtggaatccccattattaaaggaggaactgtggtgaaattaatt gaaaggttaacatatcatatgtatgcagatcccaattttgttcgtacttttcttactaca tatcgttcattttgtaaaccacaggaattgctaagcttactgattgaacgatttgaaatt ccagagccagaacctactgaagcagacaaattggcaatagagaaaggcgagcagccaatc agtgcagaccttaaaagattccgaaaggaatacgtccaaccagtacaacttaggatttta aatgtatttcgccattgggttgaacaccatttttatgactttgaaagagatgtggaattg cttaaaagactggaatccttcatttcaagtgtaagagggaaagctatgaagaaatgggta gagtcaattgctaagatcatcaagaggaagaagcaagctcaggcaaacggaataagccat aatattacctttgaaagtccacctccaccaattgaatggcatatcagtaaaccagggcag tttgaaacatttgatcttatgacacttcatccaatagaaattgctcgtcagctaacactt ttggaatctgatctctacaggaaagtccagccttctgaacttgtagggagtgtgtggacc aaagaagataaagagataaattctccaaatttattaaaaatgattcgccataccacaaac ctcaccctgtggtttgaaaaatgcattgtggaagcagaaaattttgaagaacgggtggca gtactaagtagaattatagaaattctgcaagtttttcaagatttgaataatttcaatggc gtattggagatagtcagtgcagtaaattcagtgtcagtgtacagactagaccataccttt gaggcattacaggaaagaaaacggaaaattttagatgaagctgtggaattaagtcaagat cactttaaaaaatacctagtaaaactaaagtcaatcaatccaccttgtgtgccttttttt ggaatatatttaacaaatattctgaagactgaagaagggaataatgattttttaaaaaag aaagggaaagatttaatcaatttcagtaagaggagaaaagtggcagaaattactggagaa attcagcaatatcagaatcagccttattgtttacgaatagaaccagaaatgaggaggttc tttgaaaaccttaaccccatgggaagctcatctgaaaaagagtttacagattatttgttc aacaagtcactagaaatcgaaccccgaaactgcaaacagcctcctcgatttgctaggaaa tcaacctactccttaaaatctcctggaataaggcctaattcaggccggcatggctctacc tcaggcactttacgaggtcatccaacaccattagaaagagaaccttataagataagcttt agtcgggttgctgaaactgagctcgaatcaacagtgtcagcaccaacctctccaaataca ccatctactccaccagtgtctgcttcttcagaacatagtgtgttttcagatatggatctc aatagttcctgtggtagcaatagcatctttgctacagtgctcttgccacattcaaagtcc atcttcagttcgtgtggtagtttaaataaaccaagtgaagagctactgattcctcctcca cttcctcctcgaagaaagtttgaccaagatgcttcaaattcaaagggaactgtgaaatct gatgacgaccctcctgctattccaccaagacagcctcctccgccaaagataaaacctaga gttcctgttcctaccagtgcatttgatggacttctgcatagtccacctccacctccacca agagatcctcttcctgatacccctccaccagttccccttcgacctccagaacactttata aactgtccttttaatcttcagccacctccactgggacatcttcacagagatccagactgg ctcagagacattagtacatgtccaaattcaccaagcactcctcctagcacgccctctcca agggtaccacgtcgatgctatcacaacagtcttgctcatcctcaagctccccctgttcca ccaaggcagaattcaagccctcacctaccaaaacttccaccaaagacttacaagcgagag ttttcacatcccccattgtatagactgtctatggtagaaaatgcagaaactcctcaatga

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