KEGG   Marmota marmota marmota (Alpine marmot): 107145453
Entry
107145453         CDS       T09644                                 
Symbol
Plcb1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmma  Marmota marmota marmota (Alpine marmot)
Pathway
mmma00562  Inositol phosphate metabolism
mmma01100  Metabolic pathways
mmma04015  Rap1 signaling pathway
mmma04020  Calcium signaling pathway
mmma04022  cGMP-PKG signaling pathway
mmma04062  Chemokine signaling pathway
mmma04070  Phosphatidylinositol signaling system
mmma04071  Sphingolipid signaling pathway
mmma04072  Phospholipase D signaling pathway
mmma04081  Hormone signaling
mmma04082  Neuroactive ligand signaling
mmma04261  Adrenergic signaling in cardiomyocytes
mmma04270  Vascular smooth muscle contraction
mmma04310  Wnt signaling pathway
mmma04371  Apelin signaling pathway
mmma04540  Gap junction
mmma04611  Platelet activation
mmma04613  Neutrophil extracellular trap formation
mmma04621  NOD-like receptor signaling pathway
mmma04713  Circadian entrainment
mmma04720  Long-term potentiation
mmma04723  Retrograde endocannabinoid signaling
mmma04724  Glutamatergic synapse
mmma04725  Cholinergic synapse
mmma04726  Serotonergic synapse
mmma04728  Dopaminergic synapse
mmma04730  Long-term depression
mmma04742  Taste transduction
mmma04750  Inflammatory mediator regulation of TRP channels
mmma04911  Insulin secretion
mmma04912  GnRH signaling pathway
mmma04915  Estrogen signaling pathway
mmma04916  Melanogenesis
mmma04918  Thyroid hormone synthesis
mmma04919  Thyroid hormone signaling pathway
mmma04921  Oxytocin signaling pathway
mmma04922  Glucagon signaling pathway
mmma04924  Renin secretion
mmma04925  Aldosterone synthesis and secretion
mmma04926  Relaxin signaling pathway
mmma04927  Cortisol synthesis and secretion
mmma04928  Parathyroid hormone synthesis, secretion and action
mmma04929  GnRH secretion
mmma04933  AGE-RAGE signaling pathway in diabetic complications
mmma04934  Cushing syndrome
mmma04935  Growth hormone synthesis, secretion and action
mmma04961  Endocrine and other factor-regulated calcium reabsorption
mmma04970  Salivary secretion
mmma04971  Gastric acid secretion
mmma04972  Pancreatic secretion
mmma04973  Carbohydrate digestion and absorption
mmma05010  Alzheimer disease
mmma05016  Huntington disease
mmma05017  Spinocerebellar ataxia
mmma05022  Pathways of neurodegeneration - multiple diseases
mmma05142  Chagas disease
mmma05143  African trypanosomiasis
mmma05146  Amoebiasis
mmma05163  Human cytomegalovirus infection
mmma05200  Pathways in cancer
mmma05415  Diabetic cardiomyopathy
mmma05417  Lipid and atherosclerosis
Module
mmma_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmma00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    107145453 (Plcb1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    107145453 (Plcb1)
   04310 Wnt signaling pathway
    107145453 (Plcb1)
   04070 Phosphatidylinositol signaling system
    107145453 (Plcb1)
   04072 Phospholipase D signaling pathway
    107145453 (Plcb1)
   04071 Sphingolipid signaling pathway
    107145453 (Plcb1)
   04022 cGMP-PKG signaling pathway
    107145453 (Plcb1)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    107145453 (Plcb1)
   04081 Hormone signaling
    107145453 (Plcb1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    107145453 (Plcb1)
   04613 Neutrophil extracellular trap formation
    107145453 (Plcb1)
   04062 Chemokine signaling pathway
    107145453 (Plcb1)
  09152 Endocrine system
   04911 Insulin secretion
    107145453 (Plcb1)
   04922 Glucagon signaling pathway
    107145453 (Plcb1)
   04929 GnRH secretion
    107145453 (Plcb1)
   04915 Estrogen signaling pathway
    107145453 (Plcb1)
   04921 Oxytocin signaling pathway
    107145453 (Plcb1)
   04926 Relaxin signaling pathway
    107145453 (Plcb1)
   04935 Growth hormone synthesis, secretion and action
    107145453 (Plcb1)
   04918 Thyroid hormone synthesis
    107145453 (Plcb1)
   04919 Thyroid hormone signaling pathway
    107145453 (Plcb1)
   04928 Parathyroid hormone synthesis, secretion and action
    107145453 (Plcb1)
   04924 Renin secretion
    107145453 (Plcb1)
   04925 Aldosterone synthesis and secretion
    107145453 (Plcb1)
   04927 Cortisol synthesis and secretion
    107145453 (Plcb1)
  09154 Digestive system
   04970 Salivary secretion
    107145453 (Plcb1)
   04971 Gastric acid secretion
    107145453 (Plcb1)
   04972 Pancreatic secretion
    107145453 (Plcb1)
   04973 Carbohydrate digestion and absorption
    107145453 (Plcb1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    107145453 (Plcb1)
  09156 Nervous system
   04724 Glutamatergic synapse
    107145453 (Plcb1)
   04725 Cholinergic synapse
    107145453 (Plcb1)
   04728 Dopaminergic synapse
    107145453 (Plcb1)
   04726 Serotonergic synapse
    107145453 (Plcb1)
   04720 Long-term potentiation
    107145453 (Plcb1)
   04730 Long-term depression
    107145453 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    107145453 (Plcb1)
  09157 Sensory system
   04742 Taste transduction
    107145453 (Plcb1)
   04750 Inflammatory mediator regulation of TRP channels
    107145453 (Plcb1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    107145453 (Plcb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107145453 (Plcb1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    107145453 (Plcb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    107145453 (Plcb1)
   05142 Chagas disease
    107145453 (Plcb1)
   05143 African trypanosomiasis
    107145453 (Plcb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    107145453 (Plcb1)
   05016 Huntington disease
    107145453 (Plcb1)
   05017 Spinocerebellar ataxia
    107145453 (Plcb1)
   05022 Pathways of neurodegeneration - multiple diseases
    107145453 (Plcb1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    107145453 (Plcb1)
   05415 Diabetic cardiomyopathy
    107145453 (Plcb1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    107145453 (Plcb1)
   04934 Cushing syndrome
    107145453 (Plcb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmma04131]
    107145453 (Plcb1)
Enzymes [BR:mmma01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     107145453 (Plcb1)
Membrane trafficking [BR:mmma04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    107145453 (Plcb1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    107145453 (Plcb1)
SSDB
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like
Other DBs
NCBI-GeneID: 107145453
NCBI-ProteinID: XP_048667813
Ensembl: ENSMMMG00000000929
UniProt: A0AAJ8ALS1
LinkDB
Position
Unknown
AA seq 1290 aa
MEKSDGVLMVKGKLLQARVWNQIGAGQKSPKKYPLKKKRGALCNGRTGSGQGQPPGAQVV
ICQGGQQKAGGLRALLCPPGLELTSLLDLDSTIVTPIILRTDPQGFFFYWTDQNKETELL
DLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLVAFQE
EVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKR
VETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQ
MMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLSGEEN
GVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDC
WKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKM
AEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSE
QVSNTYSDSSSVFEPSSPGAGEAETESDDDDDDDDCKKSSMDEVGKDWVLQSRDEEHEKK
INIKQSILGSPKAASSTGSLIESFTFDFGLQQHKRNKSFEMSSFVETKGLEQLTKAPVEF
VEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKS
GYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPV
DTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQA
IRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQ
LAALTLEDEEEVKKEADPGETPTETPSETRTTPSENGVNHTTSLAPKPPSQALHSQPAPG
SVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIK
EHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLI
DLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKK
ELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQGKRQEKLLE
KHKEIRQQILDEKPKLQMELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPSL
ASDPGKVNHKPPSSEEVEGENPGKEFDTPL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggaaaagtctgatggagttctgatggtgaaggggaaactcctacaggccagagtgtgg
aaccagattggagcagggcagaagtctccaaaaaaataccccttgaagaagaaaaggggc
gcgttatgcaatgggcgcactgggagcgggcaggggcagcctccgggcgcacaggttgtc
atctgccaaggcggacagcaaaaggctggaggcttacgcgcgctcctgtgtcctccaggt
ttagagttgacatccttgttggatctggactccactattgttactccaattattttgagg
actgaccctcagggatttttcttttactggacagatcaaaataaggagacggagctgtta
gatctcagccttgtcaaggatgccaggtgtgggaagcatgccaaagctcccaaggatcca
aaattacgtgaacttctggatgtggggaacattgggcgcttggagcatcggatgataaca
gtggtgtacgggccagacctagttaatatctcccatttgaatctcgtggctttccaagaa
gaagtagccaaggaatggacaaatgaggttttcagtctggcaacaaacctgttggcccaa
aacatgtccagggacgcatttctggaaaaagcctatactaaactcaagctacaagtcact
ccagaagggcgcattcctcttaaaaacatatatcgcttgttttcagcagaccggaaacga
gttgaaactgcattagaggcttgtagtcttccatcttcaaggaatgattctatacctcaa
gaggacttcactccagatgtgtacagagttttcctgaataatctttgccctcgacctgaa
attgataacatcttttcagaatttggtgccaaaagcaaaccataccttactgttgatcag
atgatggattttatcaacctgaagcagcgagatccccggctaaatgaaatactttaccca
cctctgaaacaagaacaagtgcaagtactgattgagaagtatgagcccaataacagcctt
gccaagaaaggacagatatcagtggatggatttatgcgctatctgagtggagaagaaaat
ggagtcgtttcacctgagaaactggatttgaatgaagacatgtctcagcccctgtctcac
tatttcattaattcctcgcacaacacctacctcacagctggccagctggctggaaactcc
tctgtggagatgtatcgccaagtgcttctgtctggttgtcgctgtgtggagctggactgc
tggaagggaaggactgcagaagaagaacccgtcatcacccacggattcaccatgacaacg
gaaatatccttcaaggaagtgatagaagcaatcgcagagtgtgcatttaagacctcacct
tttccaattcttctatcatttgagaaccacgtggattccccaaagcagcaagccaagatg
gcggagtactgccgactaatctttggtgatgcccttctcatggagccactggaaaaatac
ccactggaatccggagttcctcttcccagccctatggatttaatgtataaaatcttggtg
aaaaacaagaagaagtcacacaagtcatcagaaggaagtggcaagaagaagctctctgaa
caagtgtccaacacatacagtgattcctctagcgtgttcgagccctcatctcccggagca
ggggaagctgagaccgaaagtgatgatgatgacgatgatgatgactgtaaaaaatcttca
atggatgaggtgggtaaagactgggttctccagagtagggacgaagagcatgagaagaag
attaacattaaacagtccatacttggttctccaaaagctgctagttcaacaggcagctta
attgagagttttacctttgattttggtttgcaacaacacaaaagaaacaagagttttgaa
atgtcttcctttgtggaaaccaaaggactcgaacaacttacgaaggctccggtggaattt
gtggaatataacaaaatgcagctgagcagaatatatccaaaaggaacacgtgtggactca
tccaactacatgccccagctcttctggaatgcaggctgtcagatggtggcccttaacttc
cagaccgtggacctggcaatgcaaatcaacatgggcatgtatgaatacaatgggaagagt
ggctacaggttgaagccagagttcatgaggaggccggacaagcattttgatccctttacg
gaaggcatcgttgatgggatagtggccaacactttatctgtaaagattatttcaggtcag
tttctttctgataagaaagttgggacttatgttgaagtggatatgtttggtttgcctgtg
gacaccaggaggaaggcattcaagaccaagacttcccaagggaatgctgtaaatcctgtc
tgggaagaagagccaattgtgttcaaaaaggtggttcttccttctctggcctgtttgagg
atagcagtttatgaagaaggagggaaatttattggccaccggatcttgccagtacaagcc
attcggccaggctatcactacatctgtctgaggaatgaaaggaaccagcccctaatgctg
ccagctgtctttgtctacatagaagtgaaagactatgtgccagacacatatgcagatgtg
atcgaagctttgtcaaacccaatccgatatgtgaatctgatggagcagagagctaagcaa
ctggctgctttgacactggaggatgaagaagaagtaaagaaagaggctgatcctggggaa
acaccaacagagactccaagtgaaaccaggacgactccctcagaaaatggggtgaatcac
actacatccctggcacccaaaccaccttcccaggctctgcacagccaacctgctccaggt
tctgtcaaggctcctgccaaaacagaagatcttattcagagcgtcctaacagaagtggaa
gcacagacgattgaagagctaaagcaacagaaatcattcgtgaaacttcaaaagaagcac
tacaaagaaatgaaagacctggtgaagagacaccacaagaaaactactgacctgatcaaa
gaacacactacaaaatataatgagattcagaatgactacttgagaaggagggcagctctg
gagaagtcagccaaaaaggacagcaagaaaaaatcagagcccagcagccctgaccatggc
tcatcgacaattgagcaagatcttgctgccctggatgccgaaatgacccagaagttaata
gacctgaaggacaaacaacagcagcagctgcttaatcttcggcaagaacaatattacagt
gaaaaataccagaagcgagaacatattaaactgctcattcaaaagttgacagatgttgct
gaagagtgtcagaacaaccaattaaagaagctcaaagaaatctgtgagaaagagaagaaa
gaattaaagaaaaaaatggataaaaagaggcaggagaagataacagaagctaaatccaaa
gacaaaagccagatggaagaggagaagacagagatgatccggtcctacatccaggaggtg
gtgcagtatatcaaaaggttagaagaggcacaaggtaaacgacaagaaaaactcttggag
aaacacaaggaaatccgccagcagatactggacgagaagcccaagctacagatggagttg
gagcaagaataccaagacaagttcaaaagattgcccctggagattttggaatttgtgcag
gaagccatgaaagggaagatcagtgaagacagcaatcacagttctgcccctccctccttg
gcctctgaccctggaaaagtgaaccacaagcctccctccagtgaggaggtggaaggagag
aacccaggaaaagagtttgatactcctctgtga

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