KEGG   Marmota marmota marmota (Alpine marmot): 107146095
Entry
107146095         CDS       T09644                                 
Symbol
Egfr
Name
(RefSeq) epidermal growth factor receptor isoform X1
  KO
K04361  epidermal growth factor receptor [EC:2.7.10.1]
Organism
mmma  Marmota marmota marmota (Alpine marmot)
Pathway
mmma01521  EGFR tyrosine kinase inhibitor resistance
mmma01522  Endocrine resistance
mmma03272  Virion - Hepatitis viruses
mmma04010  MAPK signaling pathway
mmma04012  ErbB signaling pathway
mmma04014  Ras signaling pathway
mmma04015  Rap1 signaling pathway
mmma04020  Calcium signaling pathway
mmma04066  HIF-1 signaling pathway
mmma04068  FoxO signaling pathway
mmma04072  Phospholipase D signaling pathway
mmma04144  Endocytosis
mmma04151  PI3K-Akt signaling pathway
mmma04510  Focal adhesion
mmma04518  Integrin signaling
mmma04520  Adherens junction
mmma04540  Gap junction
mmma04630  JAK-STAT signaling pathway
mmma04810  Regulation of actin cytoskeleton
mmma04912  GnRH signaling pathway
mmma04915  Estrogen signaling pathway
mmma04921  Oxytocin signaling pathway
mmma04926  Relaxin signaling pathway
mmma04928  Parathyroid hormone synthesis, secretion and action
mmma04934  Cushing syndrome
mmma05160  Hepatitis C
mmma05163  Human cytomegalovirus infection
mmma05165  Human papillomavirus infection
mmma05171  Coronavirus disease - COVID-19
mmma05200  Pathways in cancer
mmma05205  Proteoglycans in cancer
mmma05206  MicroRNAs in cancer
mmma05207  Chemical carcinogenesis - receptor activation
mmma05208  Chemical carcinogenesis - reactive oxygen species
mmma05210  Colorectal cancer
mmma05212  Pancreatic cancer
mmma05213  Endometrial cancer
mmma05214  Glioma
mmma05215  Prostate cancer
mmma05218  Melanoma
mmma05219  Bladder cancer
mmma05223  Non-small cell lung cancer
mmma05224  Breast cancer
mmma05225  Hepatocellular carcinoma
mmma05226  Gastric cancer
mmma05230  Central carbon metabolism in cancer
mmma05231  Choline metabolism in cancer
mmma05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmma00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03272 Virion - Hepatitis viruses
    107146095 (Egfr)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    107146095 (Egfr)
   04012 ErbB signaling pathway
    107146095 (Egfr)
   04014 Ras signaling pathway
    107146095 (Egfr)
   04015 Rap1 signaling pathway
    107146095 (Egfr)
   04630 JAK-STAT signaling pathway
    107146095 (Egfr)
   04066 HIF-1 signaling pathway
    107146095 (Egfr)
   04068 FoxO signaling pathway
    107146095 (Egfr)
   04020 Calcium signaling pathway
    107146095 (Egfr)
   04072 Phospholipase D signaling pathway
    107146095 (Egfr)
   04151 PI3K-Akt signaling pathway
    107146095 (Egfr)
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    107146095 (Egfr)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    107146095 (Egfr)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    107146095 (Egfr)
   04520 Adherens junction
    107146095 (Egfr)
   04540 Gap junction
    107146095 (Egfr)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    107146095 (Egfr)
 09150 Organismal Systems
  09152 Endocrine system
   04912 GnRH signaling pathway
    107146095 (Egfr)
   04915 Estrogen signaling pathway
    107146095 (Egfr)
   04921 Oxytocin signaling pathway
    107146095 (Egfr)
   04926 Relaxin signaling pathway
    107146095 (Egfr)
   04928 Parathyroid hormone synthesis, secretion and action
    107146095 (Egfr)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    107146095 (Egfr)
   05206 MicroRNAs in cancer
    107146095 (Egfr)
   05205 Proteoglycans in cancer
    107146095 (Egfr)
   05207 Chemical carcinogenesis - receptor activation
    107146095 (Egfr)
   05208 Chemical carcinogenesis - reactive oxygen species
    107146095 (Egfr)
   05230 Central carbon metabolism in cancer
    107146095 (Egfr)
   05231 Choline metabolism in cancer
    107146095 (Egfr)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    107146095 (Egfr)
  09162 Cancer: specific types
   05210 Colorectal cancer
    107146095 (Egfr)
   05212 Pancreatic cancer
    107146095 (Egfr)
   05225 Hepatocellular carcinoma
    107146095 (Egfr)
   05226 Gastric cancer
    107146095 (Egfr)
   05214 Glioma
    107146095 (Egfr)
   05218 Melanoma
    107146095 (Egfr)
   05219 Bladder cancer
    107146095 (Egfr)
   05215 Prostate cancer
    107146095 (Egfr)
   05213 Endometrial cancer
    107146095 (Egfr)
   05224 Breast cancer
    107146095 (Egfr)
   05223 Non-small cell lung cancer
    107146095 (Egfr)
  09172 Infectious disease: viral
   05160 Hepatitis C
    107146095 (Egfr)
   05171 Coronavirus disease - COVID-19
    107146095 (Egfr)
   05163 Human cytomegalovirus infection
    107146095 (Egfr)
   05165 Human papillomavirus infection
    107146095 (Egfr)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    107146095 (Egfr)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    107146095 (Egfr)
   01522 Endocrine resistance
    107146095 (Egfr)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmma01001]
    107146095 (Egfr)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmma04147]
    107146095 (Egfr)
Enzymes [BR:mmma01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     107146095 (Egfr)
Protein kinases [BR:mmma01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   107146095 (Egfr)
Exosome [BR:mmma04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   107146095 (Egfr)
  Exosomal proteins of pancreatic cancer cells
   107146095 (Egfr)
  Exosomal proteins of bladder cancer cells
   107146095 (Egfr)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1
Other DBs
NCBI-GeneID: 107146095
NCBI-ProteinID: XP_048642599
Ensembl: ENSMMMG00000015895
LinkDB
Position
Unknown
AA seq 1209 aa
MRPSRTAGPALLVLLAALVWASCALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQKNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNVLYENTYALA
VLSNYGANKTGLRELPMRNLQEILHGAVRFSNNPVLCNVESIQWRDIVDNDFMSNMSMDL
QNRLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGSDSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKL
FGTSSQKTKIINNRDQKDCKNRGHFCNPLCSSEGCWGPEPRDCVSCQNVSRGKECVEKCN
ILEGEPREFGENYKCIQCLPECLLQSMNIICTVQGPDNCIKCAHYIDGPHCVKTCPAGIM
GENNTLVWKYADANRVCHLCHPNCTYGCAGPGLQGCTINGPKIPSIATGIVGGLFLLVIV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIVEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEDDMEDVVDADEYLIPQ
QGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGQSCPTKEDSFLQRYSSDPTGALTEDS
IDDTFLPAPEYINQSIPKRPAGSVQNPVYHNQPLHPAAGRDPHYQNPHSNAVGNPEYLNT
TQPICVNSAFDSSAHWAQKGNHQISLDNPDYQQDFLPKESKPNGIFKGPTAENAEYLRVA
PPSSEFIGA
NT seq 3630 nt   +upstreamnt  +downstreamnt
atgcgaccctccaggaccgccggacccgcgctgctggtgctactagctgcgctggtatgg
gcgagttgtgcgttggaggaaaagaaagtttgccaaggcacaagtaacaagctcacccag
ttgggcacttttgaagatcactttctgagcctccagaggatgttcaataactgtgaagtg
gtcctggggaacttggaaattacctacgtgcaaaagaattatgacctttccttcttaaag
accatccaggaagttgctggttatgtactcatcgccctcaacacagtggagaggattcct
ttggaaaacctgcagatcatcagaggaaatgtgctctatgaaaatacttatgccttagca
gtcctgtctaactatggtgcaaataaaactggactaagggagctgcccatgagaaactta
caggaaatcctgcatggtgccgtgcggttcagcaataaccctgtcctctgcaacgtggaa
agcatccagtggcgcgatatcgtcgacaacgactttatgagcaatatgtcaatggacttg
cagaaccgcctgggcagctgccaaaagtgtgatccaagctgtcccaatggaagctgctgg
ggcgcaggagaggaaaactgccagaaattgaccaagatcatctgtgcccagcagtgttca
gggcgatgccgtggcaagtcccccagtgactgctgtcacaaccagtgtgcagctggctgc
acggggccccgggagagcgactgcctggtctgccgcaagttccgagatgaagcaacatgc
aaggacacctgtccaccacttatgctgtacaaccccaccacataccagatggatgtcaac
cccgaggggaagtatagcttcggtgccacctgtgtgaagaagtgtccccggaactatgtg
gtgacagatcatggctcctgtgtccgtgcctgtggttctgacagctatgaaatggaggag
gatggtgtccgcaagtgtaagaagtgtgaagggccgtgtcgcaaagtttgtaacggaata
ggaattggtgaatttaaagacacactttccataaatgctacaaacataaagcacttcaaa
aactgcacttctatcagtggagatcttcatatcctgccagtggcatttaggggggactcc
ttcacacgtactcctcctctagatccaaaggaactggatattctaaaaaccgtaaaggaa
ataacagggtttttgctgattcaagcttggcctgaaaacaggactgacctccatgctttt
gagaacctagaaatcatacgtggcaggacaaagcaacatggtcagttttctctagcagtt
gttggcctgaacataacatccttgggattacgctccctgaaggagataagtgatggagat
gtgataatttcaggaaaccgaaatttgtgctatgcaaacacaataaactggaaaaaacta
tttgggacttccagtcagaaaaccaaaattataaacaacagagatcaaaaagactgcaag
aacagagggcacttctgtaatcccttgtgctcatctgagggctgctggggccctgagccc
agagactgcgtctcctgccaaaatgtcagccgaggcaaggagtgtgtagagaagtgcaac
attctggagggggagcccagggagtttggggagaattataagtgcatccagtgccttcca
gaatgtctgctccagtccatgaacataatttgcacagtgcagggaccagacaactgcata
aagtgtgcccactacattgatggcccccactgtgtcaagacctgcccagctggaatcatg
ggagaaaacaacaccctggtctggaagtatgcagatgccaaccgtgtctgccacctatgc
catccaaactgcacttatggatgtgctggaccagggcttcaagggtgtacaataaatgga
cccaagatcccatccattgccactgggattgtgggtggcctcttcttgctggtgatagtg
gcccttgggattggccttttcatgagaaggcgccacattgtcaggaagcgcacgctgcgt
cgactgctgcaggagagagagcttgtggagcctctgacgcccagtggagaagcccccaac
caagctctcctgaggatcttaaaggaaacagaattcaaaaagataaaagtgctgggctca
ggagcattcggcactgtgtataagggactctggattccagaaggtgagaaagttaaaatt
ccggtagcaatcaaagaattaagagaagccacatctccaaaagccaacaaggaaattctt
gacgaagcctatgtgatggccagtgtggacaatcctcatgtgtgccgcctcttgggtatc
tgtctgacctccaccgtccagcttatcactcagctcatgccctttggttgcctcctggac
tatgtccgagaacacaaggacaacatcggttcccagtacctactcaactggtgtgtgcag
attgcaaagggcatgaactacctggaagaccggcgcttggtgcatcgtgacctggcagcc
aggaacgtcctagtgaagacaccacagcatgtcaagatcacagattttggactggccaaa
ctgcttggggctgaggagaaagaataccatgcagagggaggaaaggtgcctatcaagtgg
atggctttggaatcaattttacaccgaatttatacccaccaaagtgatgtctggagctat
ggagtcactgtttgggagttgatgacttttgggtccaagccttatgatggaatccctgca
agtgagatctcatccatcctagaaaaaggagagcgccttccgcagcctcccatctgcacc
attgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccaaag
ttccgggagttgatcgtggaattctccaaaatggctcgagatccccagcgctatcttgtc
atacagggggatgaaagaatgcatttgccaagccctacagactccaatttttatcgtgcc
ctgatggatgaagatgacatggaagatgtggtggatgctgatgagtacctcattccacag
cagggcttcttcaacagcccatctacatctcggactcccctcttaagttctctgagtgca
accagcaacaattccactgtggcttgcattaacagaaatgggcagagttgtcccacaaag
gaggacagcttcttgcagcggtacagctcagacccaactggcgccttgacagaggacagc
atagatgatacattcctcccagcacctgaatatataaaccagtctattcctaagaggcct
gcaggatctgtgcagaaccccgtctatcacaatcaacccttgcatccagcagctggcaga
gacccacactaccaaaatccccacagtaacgccgtgggcaaccctgaatatctcaacacc
acccagcctatttgtgtcaacagtgcatttgacagctctgcccactgggcccagaaaggc
aaccaccaaattagcctggacaaccctgactaccaacaggacttcttgcccaaggaatcc
aagccaaatggcatctttaagggtcccacagctgaaaatgcagaatacctacgagtagca
ccaccaagcagtgaatttattggagcatga

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