| Entry |
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| Symbol |
Egfr
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| Name |
(RefSeq) epidermal growth factor receptor isoform X1
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| KO |
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| Organism |
mmma Marmota marmota marmota (Alpine marmot)
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| Pathway |
| mmma01521 | EGFR tyrosine kinase inhibitor resistance |
| mmma04928 | Parathyroid hormone synthesis, secretion and action |
| mmma05207 | Chemical carcinogenesis - receptor activation |
| mmma05208 | Chemical carcinogenesis - reactive oxygen species |
| mmma05230 | Central carbon metabolism in cancer |
| mmma05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Brite |
KEGG Orthology (KO) [BR:mmma00001]
09120 Genetic Information Processing
09125 Information processing in viruses
03272 Virion - Hepatitis viruses
107146095 (Egfr)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
107146095 (Egfr)
04012 ErbB signaling pathway
107146095 (Egfr)
04014 Ras signaling pathway
107146095 (Egfr)
04015 Rap1 signaling pathway
107146095 (Egfr)
04630 JAK-STAT signaling pathway
107146095 (Egfr)
04066 HIF-1 signaling pathway
107146095 (Egfr)
04068 FoxO signaling pathway
107146095 (Egfr)
04020 Calcium signaling pathway
107146095 (Egfr)
04072 Phospholipase D signaling pathway
107146095 (Egfr)
04151 PI3K-Akt signaling pathway
107146095 (Egfr)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
107146095 (Egfr)
09144 Cellular community - eukaryotes
04510 Focal adhesion
107146095 (Egfr)
04520 Adherens junction
107146095 (Egfr)
04540 Gap junction
107146095 (Egfr)
09142 Cell motility
04810 Regulation of actin cytoskeleton
107146095 (Egfr)
09150 Organismal Systems
09152 Endocrine system
04912 GnRH signaling pathway
107146095 (Egfr)
04915 Estrogen signaling pathway
107146095 (Egfr)
04921 Oxytocin signaling pathway
107146095 (Egfr)
04926 Relaxin signaling pathway
107146095 (Egfr)
04928 Parathyroid hormone synthesis, secretion and action
107146095 (Egfr)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
107146095 (Egfr)
05206 MicroRNAs in cancer
107146095 (Egfr)
05205 Proteoglycans in cancer
107146095 (Egfr)
05207 Chemical carcinogenesis - receptor activation
107146095 (Egfr)
05208 Chemical carcinogenesis - reactive oxygen species
107146095 (Egfr)
05230 Central carbon metabolism in cancer
107146095 (Egfr)
05231 Choline metabolism in cancer
107146095 (Egfr)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
107146095 (Egfr)
09162 Cancer: specific types
05210 Colorectal cancer
107146095 (Egfr)
05212 Pancreatic cancer
107146095 (Egfr)
05225 Hepatocellular carcinoma
107146095 (Egfr)
05226 Gastric cancer
107146095 (Egfr)
05214 Glioma
107146095 (Egfr)
05218 Melanoma
107146095 (Egfr)
05219 Bladder cancer
107146095 (Egfr)
05215 Prostate cancer
107146095 (Egfr)
05213 Endometrial cancer
107146095 (Egfr)
05224 Breast cancer
107146095 (Egfr)
05223 Non-small cell lung cancer
107146095 (Egfr)
09172 Infectious disease: viral
05160 Hepatitis C
107146095 (Egfr)
05171 Coronavirus disease - COVID-19
107146095 (Egfr)
05163 Human cytomegalovirus infection
107146095 (Egfr)
05165 Human papillomavirus infection
107146095 (Egfr)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
107146095 (Egfr)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
107146095 (Egfr)
01522 Endocrine resistance
107146095 (Egfr)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:mmma01001]
107146095 (Egfr)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:mmma04147]
107146095 (Egfr)
Enzymes [BR:mmma01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
107146095 (Egfr)
Protein kinases [BR:mmma01001]
Receptor tyrosine kinases (RTK)
EGFR family [OT]
107146095 (Egfr)
Exosome [BR:mmma04147]
Exosomal proteins
Exosomal proteins of colorectal cancer cells
107146095 (Egfr)
Exosomal proteins of pancreatic cancer cells
107146095 (Egfr)
Exosomal proteins of bladder cancer cells
107146095 (Egfr)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
1209 aa
MRPSRTAGPALLVLLAALVWASCALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQKNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNVLYENTYALA
VLSNYGANKTGLRELPMRNLQEILHGAVRFSNNPVLCNVESIQWRDIVDNDFMSNMSMDL
QNRLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGSDSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKL
FGTSSQKTKIINNRDQKDCKNRGHFCNPLCSSEGCWGPEPRDCVSCQNVSRGKECVEKCN
ILEGEPREFGENYKCIQCLPECLLQSMNIICTVQGPDNCIKCAHYIDGPHCVKTCPAGIM
GENNTLVWKYADANRVCHLCHPNCTYGCAGPGLQGCTINGPKIPSIATGIVGGLFLLVIV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIVEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEDDMEDVVDADEYLIPQ
QGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGQSCPTKEDSFLQRYSSDPTGALTEDS
IDDTFLPAPEYINQSIPKRPAGSVQNPVYHNQPLHPAAGRDPHYQNPHSNAVGNPEYLNT
TQPICVNSAFDSSAHWAQKGNHQISLDNPDYQQDFLPKESKPNGIFKGPTAENAEYLRVA
PPSSEFIGA |
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| NT seq |
3630 nt +upstreamnt +downstreamnt
atgcgaccctccaggaccgccggacccgcgctgctggtgctactagctgcgctggtatgg
gcgagttgtgcgttggaggaaaagaaagtttgccaaggcacaagtaacaagctcacccag
ttgggcacttttgaagatcactttctgagcctccagaggatgttcaataactgtgaagtg
gtcctggggaacttggaaattacctacgtgcaaaagaattatgacctttccttcttaaag
accatccaggaagttgctggttatgtactcatcgccctcaacacagtggagaggattcct
ttggaaaacctgcagatcatcagaggaaatgtgctctatgaaaatacttatgccttagca
gtcctgtctaactatggtgcaaataaaactggactaagggagctgcccatgagaaactta
caggaaatcctgcatggtgccgtgcggttcagcaataaccctgtcctctgcaacgtggaa
agcatccagtggcgcgatatcgtcgacaacgactttatgagcaatatgtcaatggacttg
cagaaccgcctgggcagctgccaaaagtgtgatccaagctgtcccaatggaagctgctgg
ggcgcaggagaggaaaactgccagaaattgaccaagatcatctgtgcccagcagtgttca
gggcgatgccgtggcaagtcccccagtgactgctgtcacaaccagtgtgcagctggctgc
acggggccccgggagagcgactgcctggtctgccgcaagttccgagatgaagcaacatgc
aaggacacctgtccaccacttatgctgtacaaccccaccacataccagatggatgtcaac
cccgaggggaagtatagcttcggtgccacctgtgtgaagaagtgtccccggaactatgtg
gtgacagatcatggctcctgtgtccgtgcctgtggttctgacagctatgaaatggaggag
gatggtgtccgcaagtgtaagaagtgtgaagggccgtgtcgcaaagtttgtaacggaata
ggaattggtgaatttaaagacacactttccataaatgctacaaacataaagcacttcaaa
aactgcacttctatcagtggagatcttcatatcctgccagtggcatttaggggggactcc
ttcacacgtactcctcctctagatccaaaggaactggatattctaaaaaccgtaaaggaa
ataacagggtttttgctgattcaagcttggcctgaaaacaggactgacctccatgctttt
gagaacctagaaatcatacgtggcaggacaaagcaacatggtcagttttctctagcagtt
gttggcctgaacataacatccttgggattacgctccctgaaggagataagtgatggagat
gtgataatttcaggaaaccgaaatttgtgctatgcaaacacaataaactggaaaaaacta
tttgggacttccagtcagaaaaccaaaattataaacaacagagatcaaaaagactgcaag
aacagagggcacttctgtaatcccttgtgctcatctgagggctgctggggccctgagccc
agagactgcgtctcctgccaaaatgtcagccgaggcaaggagtgtgtagagaagtgcaac
attctggagggggagcccagggagtttggggagaattataagtgcatccagtgccttcca
gaatgtctgctccagtccatgaacataatttgcacagtgcagggaccagacaactgcata
aagtgtgcccactacattgatggcccccactgtgtcaagacctgcccagctggaatcatg
ggagaaaacaacaccctggtctggaagtatgcagatgccaaccgtgtctgccacctatgc
catccaaactgcacttatggatgtgctggaccagggcttcaagggtgtacaataaatgga
cccaagatcccatccattgccactgggattgtgggtggcctcttcttgctggtgatagtg
gcccttgggattggccttttcatgagaaggcgccacattgtcaggaagcgcacgctgcgt
cgactgctgcaggagagagagcttgtggagcctctgacgcccagtggagaagcccccaac
caagctctcctgaggatcttaaaggaaacagaattcaaaaagataaaagtgctgggctca
ggagcattcggcactgtgtataagggactctggattccagaaggtgagaaagttaaaatt
ccggtagcaatcaaagaattaagagaagccacatctccaaaagccaacaaggaaattctt
gacgaagcctatgtgatggccagtgtggacaatcctcatgtgtgccgcctcttgggtatc
tgtctgacctccaccgtccagcttatcactcagctcatgccctttggttgcctcctggac
tatgtccgagaacacaaggacaacatcggttcccagtacctactcaactggtgtgtgcag
attgcaaagggcatgaactacctggaagaccggcgcttggtgcatcgtgacctggcagcc
aggaacgtcctagtgaagacaccacagcatgtcaagatcacagattttggactggccaaa
ctgcttggggctgaggagaaagaataccatgcagagggaggaaaggtgcctatcaagtgg
atggctttggaatcaattttacaccgaatttatacccaccaaagtgatgtctggagctat
ggagtcactgtttgggagttgatgacttttgggtccaagccttatgatggaatccctgca
agtgagatctcatccatcctagaaaaaggagagcgccttccgcagcctcccatctgcacc
attgatgtctacatgatcatggtcaagtgctggatgatagatgcagacagtcgcccaaag
ttccgggagttgatcgtggaattctccaaaatggctcgagatccccagcgctatcttgtc
atacagggggatgaaagaatgcatttgccaagccctacagactccaatttttatcgtgcc
ctgatggatgaagatgacatggaagatgtggtggatgctgatgagtacctcattccacag
cagggcttcttcaacagcccatctacatctcggactcccctcttaagttctctgagtgca
accagcaacaattccactgtggcttgcattaacagaaatgggcagagttgtcccacaaag
gaggacagcttcttgcagcggtacagctcagacccaactggcgccttgacagaggacagc
atagatgatacattcctcccagcacctgaatatataaaccagtctattcctaagaggcct
gcaggatctgtgcagaaccccgtctatcacaatcaacccttgcatccagcagctggcaga
gacccacactaccaaaatccccacagtaacgccgtgggcaaccctgaatatctcaacacc
acccagcctatttgtgtcaacagtgcatttgacagctctgcccactgggcccagaaaggc
aaccaccaaattagcctggacaaccctgactaccaacaggacttcttgcccaaggaatcc
aagccaaatggcatctttaagggtcccacagctgaaaatgcagaatacctacgagtagca
ccaccaagcagtgaatttattggagcatga |
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