Marmota marmota marmota (Alpine marmot): 107146721 Help Entry 107146721         CDS       T09644                                  Symbol Tsc2 Name (RefSeq) tuberin isoform X1   KO K07207   tuberous sclerosis 2 Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma04072   Phospholipase D signaling pathway mmma04115   p53 signaling pathway mmma04140   Autophagy - animal mmma04150   mTOR signaling pathway mmma04151   PI3K-Akt signaling pathway mmma04152   AMPK signaling pathway mmma04211   Longevity regulating pathway mmma04218   Cellular senescence mmma04714   Thermogenesis mmma04910   Insulin signaling pathway mmma04919   Thyroid hormone signaling pathway mmma05163   Human cytomegalovirus infection mmma05165   Human papillomavirus infection mmma05168   Herpes simplex virus 1 infection mmma05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     107146721 (Tsc2)    04151 PI3K-Akt signaling pathway     107146721 (Tsc2)    04152 AMPK signaling pathway     107146721 (Tsc2)    04150 mTOR signaling pathway     107146721 (Tsc2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     107146721 (Tsc2)   09143 Cell growth and death    04115 p53 signaling pathway     107146721 (Tsc2)    04218 Cellular senescence     107146721 (Tsc2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     107146721 (Tsc2)    04919 Thyroid hormone signaling pathway     107146721 (Tsc2)   09149 Aging    04211 Longevity regulating pathway     107146721 (Tsc2)   09159 Environmental adaptation    04714 Thermogenesis     107146721 (Tsc2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     107146721 (Tsc2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     107146721 (Tsc2)    05163 Human cytomegalovirus infection     107146721 (Tsc2)    05165 Human papillomavirus infection     107146721 (Tsc2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:mmma01009]     107146721 (Tsc2) Protein phosphatases and associated proteins [BR:mmma01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      107146721 (Tsc2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP Cnd1 Motif Other DBs NCBI-GeneID:  107146721 NCBI-ProteinID:  XP_015346395 Ensembl:  ENSMMMG00000009837 LinkDB All DBs Position Unknown AA seq 1838 aa AA seqDB search MAKPASKDSGLKEKFKILLGLGTPRPSPRSAEGKQTEFIITAEILRELSVECGLNNRIRV IGQICEVAKTKKFEEHAVEALWKTVADLLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGKHITYLEEELAEFVLQWMDVGLTSEFLLVL VNLVKFNSCYLDEYIASMVHMICLLCIRTVSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRKELQAVTWDI LLNIIERLLQQLQSLESPELRTIVHDLLTTVEELCDQNEFHGSQERYFQLVESCADQRPE SSLLNLISYRAQSIHPAKDGWIQNLQLLMERFFRNEPRSAVRIKVLDVLSFVLLINRQFY EEELINSVVISQLSHIPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARPLS LPPELEERDVAAYSASLEDVKTAVLGLLVILQTKLYTLPASHAMRVYEMLVSHIQLHYKH GYSLPIASSIRLQAFDFLLLLRADSLHRLGLPSKDGVVRFSPYCLCDCAEPEWGSEKKAS GPLSPPTGPPGTVPSGPTVRLGHLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYK VLIFTSPCSVDQLSSALCSMLSGPKTLERLRGTPEGFSRTDLHLAVVPVLTALVSYHSYL DKAKQAELGRPVPGCALPLLCGWPAILALPQKREMVYCLEQGLIYRCASQCVVALAICSV EMPDIIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISL PYTNPSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPYITKGLRSNVLLSFDDTPEKDSF RARSTSLNERPKSLRIARAPKQGSNNSPPVKELKESPAAEAFRCRSVSVSDHVVRSRIQT SLTSASLGSADENSMAQADDNLKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLA GGRTKTWLVGNKLVTVTTSVGAGTRSLLGLDSGDLQASPESSSNPGLHVRQTKEAPAKLE SQTGQQVSRGVRDRVRSMSGGHGLRVAALDAPASHIPGGCTSAGPQNVPATKPEKASVGA QVLAPEKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQELSN ALMAAERFKEHRDTALYKSLSVPAAGTARPPPLPRSNTVASFSSLYQSSCQGQLHRSISW ADSAVVLEEGSPGETHVPGEPPELEDLEVMLSADRCCRRSEAYSRSSSASSQEEKPHTEE LAAGGIPIEAAVSSEGGRPSVDPSFQPSQTLSKSSSSPELQTLQDILGNPGDKADAGRLS PEAKARSQSGILDGESVAWAAPGEEGRGPAVPEGPLPSSCPRSPSGLRPRGYTISDSAPS RRGKRVERDTLKSRAAASSAEKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESFERSV QLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDK VYLGGLDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRHLGNDFVSIIYN DSGEDFKLGTIKGQFNFVHVIITPLDYECNLLSLQCRKDMEGLVDTSVAKIVSDRNLPFV ARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRHRIREEAHYSNPSLPLLQMQ STAHPRAQAQAPAEATATCEAGQRKRLISSVDDFTEFV NT seq 5517 nt NT seq  +upstreamnt  +downstreamnt atggccaagccagcaagcaaagattcaggcttgaaggaaaagttcaagattctgctggga ctgggaacaccaaggccaagccctagatccgcagaaggcaaacagacagagtttattatc acagcggaaatcctgagagaactgagtgttgaatgtggtctcaacaatcgcatcagagtg atagggcagatctgtgaagttgcaaaaactaagaagtttgaagagcatgcagtggaagca ctctggaagactgtcgcggacctgctgcagccagagcggccaccagaggctcgacacgcg gtgctggctctgctgaaggccattgtgcaggggcagggtgaccgtttgggggtcctcaga gccctcttctttaaggtcatcaaggattatccctccaatgaagacctccatgaaaggctg gaagttttcaaggccctcacagacaatgggaaacacatcacctacttggaagaagaactg gcggagtttgtcctgcagtggatggatgttggcttgacctcagaattccttctggtgctt gtgaacttggtcaaatttaacagctgttacctcgatgagtatattgcatcaatggttcac atgatctgtctgctctgcatccggactgtgtcctctgtggacatagaggtctccctgcag gtgctggatgctgtggtctgctataactgcctgccggctgaaagcctccccctgttcatc gtcactctttgtcgtactatcaacgtcaaggagctctgtgagccttgttggaagctgatg cgtaacctcctgggcacccacctgggccatagtgccatctacaacatgtgccgcatcatg gaagacagagcctatatggaagatgccccactgctgcgaggagctgtgttctttgtaggc atggctctctggggagcccaccgactctattctctcaagaattccccaacatctgtgttg ccatctttttatgaggccatgacctgtcccaatgaggtggtgtcctatgagatcgtgctg tccataaccagacttatcaagaagtacagaaaggagctacaggctgtgacgtgggacatc ctgctgaacatcatcgagcggctgcttcagcagctccagagcttggagagcccagagctc agaaccatcgtccatgacctgctgaccactgtggaggagctgtgtgaccagaatgagttc catggctcacaggagagatacttccagctggtggagagctgtgcagaccagaggcccgag tcctccctcttaaacctgatatcctatcgagctcagtccatccacccagcaaaggatggc tggatccagaatctgcagctgctgatggagaggttcttcaggaacgagccccgcagtgct gtgcgcatcaaggtgctggacgtgctgtcctttgtgctgcttatcaacaggcagttctat gaggaggagctgattaactcggtggtcatctcccaactttcccacatccctgaggataaa gatcaccaagtccgaaagctggctacccaattgctggtggacctggcggaaggctgccac acccaccacttcaacagcctgctggatatcatcgaaaaagtgatggcccgccccctttcc ctgcctccagagctggaagaaagggatgtggctgcctactcggcctccctggaggatgtg aagactgcagtcctggggcttctggtcattcttcagaccaagctgtataccttgcctgcc agccatgccatgcgtgtgtatgagatgcttgtcagccacatccagctccactacaagcat ggctactccctgcccattgccagtagcatccggctacaggccttcgacttcctgctgcta ctgcgggctgattcgctgcaccgcctcgggttgcccagcaaggatggggtcgtgcggttc agcccctactgcctctgtgactgcgcggagccagagtggggctctgagaagaaggccagc ggccccctttcacctcccacagggccacctggcactgtcccctctggccctaccgtgcgg cttggccacctgccctactccctgctcttccgtgtcctgctgcagtgtttgaagcaggag accgactggaaggtgttgaagctagtcctcagcaagctgcctgagtcgctgcgctacaag gtcctcatcttcacttccccatgcagtgttgaccaactgtcgtctgccctctgctccatg ctctcaggtccaaagaccctcgagcggctccgaggtacccccgaaggcttctccagaacc gacctccacttggccgtggtcccggtgctgacagctctggtctcttatcacagctactta gacaaagccaagcaggctgagcttggcagacctgtcccaggatgtgctctgcccctcctg tgtggctggcctgccattctggcattaccccagaagcgtgagatggtttactgcctggag caaggcctcatctaccgctgtgccagccagtgtgtggtggccctagccatctgcagcgtg gagatgcccgacatcatcatcaaggcgctgcctgtcctggtggtgaagctgacacacatc tctgccacggccagcatggctgtgccgctcctggagttcctgtccactctggccaggctg ccccatctctacagaaactttgctgcagagcagtatgcaagtgtgtttgccatctccctg ccgtacactaacccctccaagttcaaccagtacatcgtgtgcctggcccatcatgttatt gccatgtggttcattaggtgtcgcctgcccttccggaaggattttgtcccttacatcact aagggcctgcgctctaacgtcctcctgtcctttgatgacacccccgagaaggacagtttc agagcacggagcaccagtctcaacgagaggcccaaaagtttgaggatagccagagccccc aaacaaggctcgaataactccccacctgtgaaagaactcaaggagagccctgcagccgag gccttccggtgccgcagcgtcagtgtgtctgatcatgtggtccgcagcagaatacagaca tccctcaccagtgccagcctggggtcagcagacgagaactccatggcccaggctgatgac aacttgaaaaatctccatctggagctcacagaaacgtgcctggatatgatggcccgatac gtgttctccaacttcacggcagtacccaagaggtctcccgtgggagaatttctcctggca ggcggcaggaccaaaacctggctggttgggaacaagcttgtcacagtgacgaccagtgtg ggagctgggacccgctcattgctgggcctggactctggggatctgcaggccagcccagag tcaagctccaaccctggcctgcacgtgagacagacaaaagaggcgcctgctaagctggaa tcccagactgggcagcaggtgtctcgcggggtccgggatcgggtgcgctccatgtcgggg ggacatggccttcgagttgctgccctggatgcaccagcttcccatatcccaggaggctgc acttctgcaggaccacagaatgtaccagctacaaagccggagaaggcctctgtgggtgcc caggttctagcaccagagaagacgaatctcgcagcctatgtacccctgctgacccagggc tgggccgagatcttggtccgaaggcccacagggaacaccagctggctgatgagccttgag aacccacttagtcccttctcctcggacatcaacaacatgcccctgcaagagctgtccaac gccctcatggctgctgagcgcttcaaggagcaccgtgacacggctctgtacaagtcactg tcagtgccggcagctggcacggccaggccccctcctctcccacgctctaatacagtggcc tctttctcctccctgtaccagtccagctgccaaggacagctgcacaggagcatttcctgg gcagactctgctgtggttctggaggaggggagtccaggcgagactcatgtaccaggggag ccccccgagttggaggatttggaggtaatgttaagtgcagacagatgttgccggcgctct gaggcttacagcaggtcatcctcggcctccagccaggaggagaagccccacactgaggag ctggctgcggggggcatcccaattgaggcagcagtctcctctgagggtggccggccctcc gtggacccctccttccagccatcacagaccctgagcaagtccagctcctcgcctgagctg caaacactgcaggacatccttgggaaccctggggacaaggctgatgctggccggctgagc cctgaggccaaggcccgatcccagtctgggatcctggatggggaaagtgtggcctgggca gccccaggtgaagagggccggggccccgccgtacccgagggtcctttgccatccagttgc ccccgctctcccagtggcctccggccccgaggctacaccatctccgattcagccccatcg cgcaggggcaagagggtggagagggacactttgaagagcagagctgcagcctccagtgct gagaaagtacccggcatcaaccccagcttcgtgttcctgcagctctaccactcgccgttc tttggtgatgagtccaacaagcccatccttttgcccaatgagtccttcgagcggtccgtg caactccttgaccagatcccttcgtatgacacacacaagattgctgtgctgtatgtgggc gaaggccagagcaacagcgagctggccatcctctccaatgagcacggctcctacaggtac acagagttcctgacagggcttggcaggctcatcgagctcaaggactgccagcccgacaag gtgtacctgggtggcctggacgtgtgtggcgaggatggccagttcacctactgttggcac gatgacatcatgcaagctgtcttccatattgctacgctgatgcccaccaaggatgtggac aagcaccgctgtgacaagaagcgacacctgggcaatgactttgtctccatcatctacaat gactctggggaggacttcaagctgggcaccatcaagggccagttcaactttgtccacgtg atcatcacacccctggactacgagtgcaacctgctgtcactgcagtgcaggaaagacatg gagggccttgtggacacgagcgtggccaagattgtgtctgaccgcaacttgccctttgtg gctcgccagatggccctgcacgcaaacatggcctcacaggtgcaccacagtcgctccaac cccaccgacatctacccctccaagtggatcgcccggctccgccatatcaagcggctccgc caccggatccgtgaggaagcccactactcgaaccccagcctgcctctgctacagatgcag tccacagcccaccccagagcccaggctcaggccccagctgaggccacagccacctgtgag gcaggccagcggaagcgcctcatctcctcagtggacgacttcaccgagtttgtgtga

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