Marmota marmota marmota (Alpine marmot): 107150868
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Entry
107150868 CDS
T09644
Symbol
Plcg2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
mmma
Marmota marmota marmota (Alpine marmot)
Pathway
mmma00562
Inositol phosphate metabolism
mmma01100
Metabolic pathways
mmma01521
EGFR tyrosine kinase inhibitor resistance
mmma04012
ErbB signaling pathway
mmma04014
Ras signaling pathway
mmma04020
Calcium signaling pathway
mmma04062
Chemokine signaling pathway
mmma04064
NF-kappa B signaling pathway
mmma04066
HIF-1 signaling pathway
mmma04070
Phosphatidylinositol signaling system
mmma04072
Phospholipase D signaling pathway
mmma04360
Axon guidance
mmma04370
VEGF signaling pathway
mmma04380
Osteoclast differentiation
mmma04611
Platelet activation
mmma04613
Neutrophil extracellular trap formation
mmma04625
C-type lectin receptor signaling pathway
mmma04650
Natural killer cell mediated cytotoxicity
mmma04662
B cell receptor signaling pathway
mmma04664
Fc epsilon RI signaling pathway
mmma04666
Fc gamma R-mediated phagocytosis
mmma04670
Leukocyte transendothelial migration
mmma04722
Neurotrophin signaling pathway
mmma04750
Inflammatory mediator regulation of TRP channels
mmma04919
Thyroid hormone signaling pathway
mmma04933
AGE-RAGE signaling pathway in diabetic complications
mmma04935
Growth hormone synthesis, secretion and action
mmma05167
Kaposi sarcoma-associated herpesvirus infection
mmma05169
Epstein-Barr virus infection
mmma05170
Human immunodeficiency virus 1 infection
mmma05171
Coronavirus disease - COVID-19
mmma05200
Pathways in cancer
mmma05205
Proteoglycans in cancer
mmma05206
MicroRNAs in cancer
mmma05214
Glioma
mmma05223
Non-small cell lung cancer
mmma05225
Hepatocellular carcinoma
Module
mmma_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
mmma00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
107150868 (Plcg2)
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
107150868 (Plcg2)
04064 NF-kappa B signaling pathway
107150868 (Plcg2)
04066 HIF-1 signaling pathway
107150868 (Plcg2)
04070 Phosphatidylinositol signaling system
107150868 (Plcg2)
04072 Phospholipase D signaling pathway
107150868 (Plcg2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
107150868 (Plcg2)
04613 Neutrophil extracellular trap formation
107150868 (Plcg2)
04650 Natural killer cell mediated cytotoxicity
107150868 (Plcg2)
04662 B cell receptor signaling pathway
107150868 (Plcg2)
04664 Fc epsilon RI signaling pathway
107150868 (Plcg2)
04666 Fc gamma R-mediated phagocytosis
107150868 (Plcg2)
04670 Leukocyte transendothelial migration
107150868 (Plcg2)
04062 Chemokine signaling pathway
107150868 (Plcg2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
107150868 (Plcg2)
04919 Thyroid hormone signaling pathway
107150868 (Plcg2)
09156 Nervous system
04722 Neurotrophin signaling pathway
107150868 (Plcg2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
107150868 (Plcg2)
09158 Development and regeneration
04360 Axon guidance
107150868 (Plcg2)
04380 Osteoclast differentiation
107150868 (Plcg2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
107150868 (Plcg2)
05206 MicroRNAs in cancer
107150868 (Plcg2)
05205 Proteoglycans in cancer
107150868 (Plcg2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
107150868 (Plcg2)
05214 Glioma
107150868 (Plcg2)
05223 Non-small cell lung cancer
107150868 (Plcg2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
107150868 (Plcg2)
05171 Coronavirus disease - COVID-19
107150868 (Plcg2)
05167 Kaposi sarcoma-associated herpesvirus infection
107150868 (Plcg2)
05169 Epstein-Barr virus infection
107150868 (Plcg2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
107150868 (Plcg2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
107150868 (Plcg2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mmma04131
]
107150868 (Plcg2)
Enzymes [BR:
mmma01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
107150868 (Plcg2)
Membrane trafficking [BR:
mmma04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
107150868 (Plcg2)
Endocytosis
Macropinocytosis
Phospholipase C
107150868 (Plcg2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
SH3_9
PH
PH_12
EF-hand_PLCG1
SH2_1
SH3_2
PH_14
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
107150868
NCBI-ProteinID:
XP_015351508
Ensembl:
ENSMMMG00000012131
UniProt:
A0AAJ7AZS2
LinkDB
All DBs
Position
Unknown
AA seq
1267 aa
AA seq
DB search
MMPTMVNVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWTKTAD
KIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSREDA
MKWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKVSG
AKFLKDKLAEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSAVFILGNTDRPDAS
AVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTVRETAEPFLFVDEFLTYLFSREN
SIWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELD
CWDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVASSFPLILSIEEHCCVEQQRHMAK
VFKEVFGDQLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKEERKQQG
ELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEDELPQDTPPTELHFGEKWFHKKVER
RTSAEKLLQEYCAESGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTTEGGVLKY
YLTDNLTFDSIYALVQHYRESHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAEDM
LMRIPRDGAFLIRRRREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVN
YYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALY
DYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTVDVEELEKQ
IIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKKQGDPPVEFATDRVEELFE
WFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSF
VETKADSIVRQKPLDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPD
KYMQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGR
SIACPFVEVEVCGAEYDNSKFKTTVVNDNGLSPVWAASQEKVTFEIYDPNLAFLRFVVYE
EDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGHSEDIELASLLVFCEMRPVLESEEELYS
SCRQLRRRQEELNNQLFLYDTHQNLRSANRDALIKEFNVNENQLQLYQEKCNRRLREKRV
SNSKFYS
NT seq
3804 nt
NT seq
+upstream
nt +downstream
nt
atgatgcccaccatggtcaacgtggacgctcttccagaatacgagaagagtcagatcaag
agagccctggagctggggacagtgatgaccgtgttcagcttccgcaagtccactcctgag
cggaggacagtgcaggtgatcatggagacgcggcaggtggcctggaccaagactgccgac
aaaatcgagggcttcttggacatcatggagatcaaggagatccgcccggggaagaactcc
aaggatttcgagcgtgcgaaagcagtccgccagaaggaagactgctgcttcaccatcctg
tacggcacccagtttgtcctcagcacactcagtttggcagctgactctagggaggacgcc
atgaagtggctctctggcttgaagatcttgcaccaagaagcgatgagtgcgtccaccccc
accatcatcgagagttggctgaggaaacagatttattctgtagatcaaaccagaagaaac
agcatcagcctccgagagttgaaggccatcttacccctggtcaacttcaaagtaagcggt
gccaagttcctcaaagataagcttgcggaaattggtgcacataaagatgaactcagcttt
gaacagttccacctcttctataaaaaacttatgtttgagcagcagaaatcgattcttgac
gaattcaagaaggactccgcggtgttcatcctgggcaacactgaccggccggatgcctct
gccgtctacctgcaggacttccagaggtttctcttacatgagcagcaggagctgtgggct
caggatctgaacaaggtccgggagcggatgaccaagttcatcgacgacacagtgagggaa
actgccgaacccttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaac
agcatctgggacgagaagtacgacgtggtggacatgcaggacatgaataaccccttgtcg
cactactggatctcctcgtcccacaacacgtacctcacaggtgaccagctgcgcagcgag
tcatccccggaagcgtacattcgctgcctgcgcatgggctgccgctgcatcgaattggac
tgctgggacgggcctgacgggaagcccatcatctaccacggctggacgcggaccaccaag
atcaagtttgatgacgtcgtccaggccatcaaagaccacgccttcgttgcctccagcttc
cctttgatcctgtccatcgaggagcactgctgcgtggagcagcagcgccacatggccaag
gtcttcaaggaggtgtttggcgaccagctgctgacaaagcccacggaggccagtgccgac
cagctgccgtcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggc
cctcgaggtgacgttgatgtcaatgtggaggacaagaaagaagagcgcaagcagcagggt
gaactgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccattgcg
gatgccaagctgtccttcagtgacgacattgaacagactgtggaggatgaactgccccag
gacacgccccccacggagctgcacttcggggagaaatggttccacaagaaggtggagaga
aggacgagcgccgagaagctgctgcaggagtactgcgccgagagcggcggcaaggacggc
accttcctggtgcgcgagagcgagaccttccccaacgactacaccctgtccttctggcgg
tcgggccgcgtgcagcactgccggatccgctccaccaccgagggcggggtcctcaagtac
tacctgaccgacaacctcaccttcgacagcatctacgcgctcgtccagcactaccgcgag
tcgcacctgcgctgcgccgagttcgagctgcggctcaccgaccccgtgcccaaccccaac
ccgcacgagtccaagccctggtactatgacaggctgagccgtggagaagcagaggacatg
ctgatgaggattccccgtgacggagccttcctcatccggagacggcgggaggggaccgac
tcctatgccatcaccttcagggccaggggcaaggtgaagcactgtcgcatcaaccgggac
ggccggcactttgtgctggggacctctgcctacttcgagagcctcgtggaacttgttaat
tactatgagaagcacgcgctgtaccggaagatgcgcctgcgctaccctgtgacccctgag
ctgctggagcgctacaacatggaaagagatataaattccctctacgatgtcagcaggatg
tacgtggacccaagtgaaatcaacccttctatgcctcagagaaccgtgaaagctctgtac
gactacaaagccaagcgaagtgacgagctgagcttctgccgtggggccctcatccacaac
gtctccaaggagcccgggggctggtggaagggagactatggcaccagaatccagcagtac
ttcccgtccaactacgtcgaggacatttcaacagttgatgttgaggaactggaaaagcag
attattgaagacaatcccttagggtctctttgcagaggaatcttggacctcaatacctac
aatgttgtgaaagccccccaggggaaaaaccagaagtcttttgtcttcatcctggagccc
aagaagcagggtgatcctcctgtggagtttgccacggacagggtggaggagctttttgag
tggtttcagagcatccgagagatcacctggaagatcgacaccaaggagaacaacatgaag
tactgggagaagaaccagtccatcgccatcgagctctcggacctggtcgtctactgcaag
cccaccagcaagaccaaggacaacttggaaaaccccgatttccgggaaatccgctctttc
gtggagacgaaggccgacagcatcgtcagacagaagccccttgatctcctgaggtataac
caaaagggcctgacccgcgtctacccgaagggacagagagttgactcttcaaactatgat
cccttccgcctgtggctgtgtggctcccagatggtggcactcaacttccagactccagac
aagtacatgcagatgaaccacgcgctgttctcgctcaacgggcggacgggctacgtccta
cagccggagagcatgcggacagagaagtacgacccgatgccaccagagtcgcagaggaag
atcctgatgactctcactgtcaaggttcttggtgcccgccatctccccaagcttgggcgc
agcatcgcttgtcccttcgtagaggtggaagtctgtggagccgagtatgacaacagcaag
tttaagacgacggtcgtgaatgacaatggcctcagccctgtctgggctgcatcgcaggag
aaggtgacatttgaaatttatgacccaaaccttgcattcctgcgctttgtggtttatgag
gaagacatgttcagcgaccccaacttcctggctcatgccacgtaccccattaaaggcatc
aaatcagggtttagatctgttcctctgaagaatgggcacagcgaggacatcgagctggct
tccctcctggttttctgtgagatgcggcctgtcctggagagtgaagaggaactttactcc
tcctgtcgccagctgcggaggcggcaagaagagctgaacaaccagctctttctgtacgac
acacaccagaacctgcgcagtgccaaccgtgatgccctcatcaaggagttcaatgtcaat
gagaaccagctccaactgtaccaggagaagtgcaaccggaggttgagagagaagagagtc
agtaacagcaagttttactcctag
DBGET
integrated database retrieval system
