Marmota marmota marmota (Alpine marmot): 107152144 Help Entry 107152144         CDS       T09644                                  Symbol Tlr4 Name (RefSeq) toll-like receptor 4 isoform X1   KO K10160   toll-like receptor 4 Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma04064   NF-kappa B signaling pathway mmma04066   HIF-1 signaling pathway mmma04145   Phagosome mmma04151   PI3K-Akt signaling pathway mmma04217   Necroptosis mmma04613   Neutrophil extracellular trap formation mmma04620   Toll-like receptor signaling pathway mmma04621   NOD-like receptor signaling pathway mmma04936   Alcoholic liver disease mmma05132   Salmonella infection mmma05133   Pertussis mmma05134   Legionellosis mmma05135   Yersinia infection mmma05140   Leishmaniasis mmma05142   Chagas disease mmma05144   Malaria mmma05145   Toxoplasmosis mmma05146   Amoebiasis mmma05152   Tuberculosis mmma05161   Hepatitis B mmma05162   Measles mmma05164   Influenza A mmma05170   Human immunodeficiency virus 1 infection mmma05171   Coronavirus disease - COVID-19 mmma05205   Proteoglycans in cancer mmma05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mmma05321   Inflammatory bowel disease mmma05323   Rheumatoid arthritis mmma05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     107152144 (Tlr4)    04066 HIF-1 signaling pathway     107152144 (Tlr4)    04151 PI3K-Akt signaling pathway     107152144 (Tlr4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     107152144 (Tlr4)   09143 Cell growth and death    04217 Necroptosis     107152144 (Tlr4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     107152144 (Tlr4)    04620 Toll-like receptor signaling pathway     107152144 (Tlr4)    04621 NOD-like receptor signaling pathway     107152144 (Tlr4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     107152144 (Tlr4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     107152144 (Tlr4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     107152144 (Tlr4)    05161 Hepatitis B     107152144 (Tlr4)    05171 Coronavirus disease - COVID-19     107152144 (Tlr4)    05164 Influenza A     107152144 (Tlr4)    05162 Measles     107152144 (Tlr4)   09171 Infectious disease: bacterial    05132 Salmonella infection     107152144 (Tlr4)    05135 Yersinia infection     107152144 (Tlr4)    05133 Pertussis     107152144 (Tlr4)    05134 Legionellosis     107152144 (Tlr4)    05152 Tuberculosis     107152144 (Tlr4)   09174 Infectious disease: parasitic    05146 Amoebiasis     107152144 (Tlr4)    05144 Malaria     107152144 (Tlr4)    05145 Toxoplasmosis     107152144 (Tlr4)    05140 Leishmaniasis     107152144 (Tlr4)    05142 Chagas disease     107152144 (Tlr4)   09163 Immune disease    05323 Rheumatoid arthritis     107152144 (Tlr4)    05321 Inflammatory bowel disease     107152144 (Tlr4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     107152144 (Tlr4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     107152144 (Tlr4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmma04131]     107152144 (Tlr4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:mmma04054]     107152144 (Tlr4)    04090 CD molecules [BR:mmma04090]     107152144 (Tlr4)    00536 Glycosaminoglycan binding proteins [BR:mmma00536]     107152144 (Tlr4) Membrane trafficking [BR:mmma04131]  Endocytosis   Phagocytosis    Toll-like receptors     107152144 (Tlr4) Pattern recognition receptors [BR:mmma04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    107152144 (Tlr4) CD molecules [BR:mmma04090]  Proteins   107152144 (Tlr4) Glycosaminoglycan binding proteins [BR:mmma00536]  Hyaluronan   Cell surface receptors    107152144 (Tlr4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  LRR_8 LRR_4 TIR TIR_2 LRR_6 LRR_9 LRR_NXF1-5 LRR_Zer-1 ThsB_TIR LRR_R13L1-DRL21 Curto_V2 ANG-1 Motif Other DBs NCBI-GeneID:  107152144 NCBI-ProteinID:  XP_015353174 Ensembl:  ENSMMMG00000000105 UniProt:  A0A8C5YL38 LinkDB All DBs Position Unknown AA seq 840 aa AA seqDB search MIPPRSLAGTLIPAMAFLSCLRPESWEPCVEVEPNVTYQCMELNLSKIPNSIPSSAKNLD LSFNPLKCIDSHSFSSFPELEVLDLSRCEIQTIEDDAYEGLHNLSTLILTGNPIQSLGAG AFHGLSSLRTLVAVETKLTSLGNFPIEHLTNLEKLNVAHNLIHSFKLPEYFSNLPNLKHL DLSSNKIQNIFNVDLEALHKMPLLNLSLDLSLNPIDFIQPGAFKEIRLHELTLRSNFHSK NVMKTCIQGLAGLEVHRLVLGEFKNERNVEMVDKSVLEELCNLTIEEFRLAYIDNLARDV TDLLSCLANVSAMSLVSLNLNRVEEISTGFNWQSLELVKCQFEQFPKIVLPSLKRFTCIA NKDLDSFGELKAPRLEHLDLSGNDLSFKSCCSHYHFGTTSLKYLDLSFNGVITMTVNFMG LEQLEYLDFQYSTLKKINEFSVFLSLSKLHYLDISYTKIQVAFHGIFNGLVSLQILKMAG NSFEDNLLPDIFTNMRNLTYLDLSKCQLERVSEKAFDTLPELKFLNMSHNNLFLLDELAY KPLYSLEVLDCSFNSIKSSRGQELQHFPSNLTINLTQNVLACTCEHQHFLQWIKDQRRSL VEVEKLVCATPSDLQGMPALSFKNDTCQIKKTIISVSVLSALVVSVIVFLVYKFYFHLML FAGCKKYGRGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAA NIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSHAGIIFIVLQKVEKSLLR QQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALMDGKLWSPEATADAGNNQQEATTCI NT seq 2523 nt NT seq  +upstreamnt  +downstreamnt atgatacctccccggagcctggctgggactctgatcccagccatggcctttctctcctgc ctgagacccgagagctgggagccctgcgtggaggtggagcctaatgttacgtaccaatgc atggagctgaatctctccaaaatccccaacagcatcccttcctcagccaagaatctggac ctgagtttcaaccccttgaagtgcatagacagtcacagcttctccagtttcccagaactg gaggtgctggatttatccaggtgtgaaattcagactattgaagatgatgcatatgagggc ttacacaacctttctaccttgatattgacaggaaatcctatccagagtttaggcgcagga gcctttcatggactatcaagtttaaggacactggtggctgtggagacaaaattgacctct ctaggaaatttccctattgaacatctcacaaacttggagaagcttaatgtggctcacaat cttattcattccttcaagttacctgaatatttttctaacctgccaaacctgaagcacttg gacctctccagtaacaagattcaaaatattttcaatgtggacttggaggctctacacaaa atgcccttactcaatctctctttagacctgtctctgaacccaatagatttcatccaaccc ggtgcctttaaagaaattaggctccatgaactgactttgagaagcaattttcatagtaaa aatgtaatgaaaacatgtattcaaggtctggctggtttagaagtccatcgcttggttctg ggagaatttaaaaatgaaagaaatgtggaaatggttgataaatctgtcctggaagaacta tgcaatttgaccattgaggaattccggttagcatatatagataatttggcaagagatgtt actgacttattgagttgtttggcaaatgtttctgcaatgtctctggtaagcctgaatttg aatagggtagaagaaatttctacaggcttcaactggcaatctttagaactggtgaagtgt caatttgaacaatttcctaagatagtgctcccatctctcaaaagatttacttgcattgcc aacaaagatttagacagttttggagaacttaaagcgccaagacttgagcatctagatctc agtggaaacgacttgagctttaagagttgctgttctcattatcactttggaacaaccagt ctgaagtacttagatctgagcttcaatggggttattacaatgactgtaaacttcatgggt ttagaacaactggaatatctggattttcagtattccactttgaaaaagatcaacgagttt tcggtattcttgtcgctcagcaaactccattaccttgatatttcttacactaaaatccag gtggccttccatggcatcttcaatggcttggtcagtctccaaatcttaaaaatggctggc aattcttttgaggacaacctccttccagatatcttcacaaacatgagaaacttgacttac ctggatctttccaaatgtcaactggaacgggtgtctgagaaagcctttgacactctccct gaacttaagttcctaaatatgagtcacaacaacctgtttttgttggatgaacttgcttat aaacctctctactccctcgaggttctggactgcagttttaatagcattaaatcttccaga gggcaagaactacagcattttccaagtaatctcaccataaatcttactcagaacgtactt gcttgtacttgtgaacaccagcatttcctgcagtggataaaggaccagaggagatccttg gtggaggttgaaaaactggtgtgtgcaaccccttcagatctacagggcatgcctgctctg agttttaagaatgacacctgtcaaataaagaagaccattatcagcgtgtcggtattgagt gcgctggtggtatctgtgatagtgtttctggtctacaagttctattttcacttgatgctt tttgctggttgcaaaaagtatggcagaggtgaaagcacctatgatgcttttgtgatctac tcaagccaggatgaggactgggtgaggaatgaattggtaaagaatttagaagaaggggta cccccctttcagctctgcctccactacagagactttattcctggtgtggctattgcagcc aacatcatccaggaaggtttccataaaagccggaaggtcatagtggtggtctctcagcac ttcatccagagccgctggtgtatctttgaatatgagattgctcagacctggcagttcctg agcagccacgctggcatcattttcattgtcctgcagaaggtggagaagtccctgctccgg cagcaggtggagttgtaccgtctactcagcaggaacacttacctggaatgggaggacagt gtcctggggcgccacatcttctggagaagactcagaaaagccctgatggatggaaagcta tggagtccagaagcaacagcagatgcaggaaacaaccagcaggaagccacaacatgtata tga

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