Marmota marmota marmota (Alpine marmot): 107157936 Help Entry 107157936         CDS       T09644                                  Symbol Ryr2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma04020   Calcium signaling pathway mmma04024   cAMP signaling pathway mmma04260   Cardiac muscle contraction mmma04261   Adrenergic signaling in cardiomyocytes mmma04371   Apelin signaling pathway mmma04713   Circadian entrainment mmma04911   Insulin secretion mmma04921   Oxytocin signaling pathway mmma04972   Pancreatic secretion mmma05020   Prion disease mmma05022   Pathways of neurodegeneration - multiple diseases mmma05410   Hypertrophic cardiomyopathy mmma05412   Arrhythmogenic right ventricular cardiomyopathy mmma05414   Dilated cardiomyopathy mmma05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107157936 (Ryr2)    04020 Calcium signaling pathway     107157936 (Ryr2)    04024 cAMP signaling pathway     107157936 (Ryr2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     107157936 (Ryr2)    04921 Oxytocin signaling pathway     107157936 (Ryr2)   09153 Circulatory system    04260 Cardiac muscle contraction     107157936 (Ryr2)    04261 Adrenergic signaling in cardiomyocytes     107157936 (Ryr2)   09154 Digestive system    04972 Pancreatic secretion     107157936 (Ryr2)   09159 Environmental adaptation    04713 Circadian entrainment     107157936 (Ryr2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     107157936 (Ryr2)    05022 Pathways of neurodegeneration - multiple diseases     107157936 (Ryr2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     107157936 (Ryr2)    05412 Arrhythmogenic right ventricular cardiomyopathy     107157936 (Ryr2)    05414 Dilated cardiomyopathy     107157936 (Ryr2)    05415 Diabetic cardiomyopathy     107157936 (Ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mmma04040]     107157936 (Ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:mmma04990]     107157936 (Ryr2) Ion channels [BR:mmma04040]  Voltage-gated cation channels   Ryanodine receptor    107157936 (Ryr2) Domain-containing proteins not elsewhere classified [BR:mmma04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    107157936 (Ryr2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  107157936 NCBI-ProteinID:  XP_048656368 Ensembl:  ENSMMMG00000018364 LinkDB All DBs Position Unknown AA seq 5055 aa AA seqDB search METITFAKLEWKGIDDMFMFRGSVRLLLAWPAATTDGWKIEWGPTTCRYLQLKSVAALNG RPWPPGLWETPATRCEFLFLASYLDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLEST SNSKNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRT LLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEG EKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGD VLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWG QPFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTS EIKYGDSVCYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGLNLSRSQHEE SRTARVIRSTVFLFNRFIRGLDALSKKAKAPAVDLPIESVSLSLQDLIGYFHPPDEHLEH EDKQNRLRALKNRQNLFQEEGMISLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNS LYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEG HIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHV SSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEE WGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRING QPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKL KVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTTQIVLPPHLERIREKLAENIHEL WVMNKIELGWQYGPVRDDNKRQHPCLVEFCKLPEQERNYNLQMSLETLKTLLALGCHVGI ADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRI RQGWTYGIQQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQEHA ARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDE RAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAF KDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLS KRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSSTDIMFYRLSMPIECAE VFSKTVAGGLPGAGLFGPKNDLEDYDDSDFEVLMKTAHGHLVSDRGDKDKEATKPEFNNH KDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIF PGQEPANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESFAFDSLCGFGIKRS NCYMVCAGESMSPGQGRNNNGLEIGCVVDAATGLLTFIANGKELSTYYQVEPSTKLFPAV FAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQF LKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSA VCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNN EFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNEFYQYSPEFP LDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGVFHNEDLKHIL QLIEPSVFKEAVTPEEEGHTLEKELSAEDSKLEGAGDEGGKRPQEGLLQMKLPEPVKLQM CLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFR SPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIR GRLLSLVEKVTYLKKKQAEKPVESDSKKSSSLQQLISETMVRWAQESVIEDPELVRAMFV LLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGL GDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRI SRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVV RYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIR RPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLKTHESDTEEEEDDT IHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQ MPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAAS LDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSL TKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYY CLPGGWGSFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYM ESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGW IYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALY NRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELE SKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRF AYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLY FLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLD ARTVMKTGLEGVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVAL LPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAA FAGAFPVAFLETHLDKHNPYSIYNTKSSRERAALSLPASVEDVCPNIPSLERLMEEIVEL AESGIRYTQMPHVMEVVLPMLCSYMSRWWEHGPESNPERAETCCTALSSEHMNTLLGNIL KIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMVVSEEDHLK AEARGDMSEAELLVLDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAE VFIYWSKSHNFKREEQNFVVQNEINNMSFLIADTKSKMSKAAVSDQERKKMKRKGDRYSM QTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSLKDTEDEVRDIIRNNIHLQGKLED PAIRWQMALYKDLPNRAEDTSDPERTVERVLDIANVLFHLEQKSKSVGRRYYSLVEHPQR SKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLI EDLAKPGAEPPEEDDVAKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHD EEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGP MVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNK AEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIIS TVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQ SLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNG TIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAME SHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDISFNVAVLLTNLSEHMPNDT RLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFI FDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKEDSEKDRPEEQGPRM GFFSILTVRSALFALRYNVLSLMRMLSLKSLKKQMKKVKKMTVRDMVTAFFSSYCSVFLT LLHFVASVCRGFFRIVCSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGDGEEGEKKP LEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLGDLMSSPVPLP EVQEKFQEQKAKEEEKEEKEETKSEPEKAEGEDGEKEEKTKEEKGKQKLRQLHTHRYGEP EVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVAEGKEL PTRSSIENSKVTTSLDSSSHRITAVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYC LKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRK VMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGV VFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIE DPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICG IGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFF PAGDCFRKQYEDQLN NT seq 15168 nt NT seq  +upstreamnt  +downstreamnt atggagactattacttttgctaaactggagtggaaaggcatcgatgacatgtttatgttc agaggcagcgtgcgccttctgctggcctggccagctgccaccactgacggttggaaaatt gagtggggtcctacaacctgcagatacctgcagctaaaaagtgtggcagctcttaatggc aggccctggcctccagggttgtgggagacccccgcaactcgttgtgaatttctttttcta gcttcctatcttgatgatgaagtggttctgcagtgtaccgcaaccatccacaaagaacaa cagaaactgtgtttggcagcagaaggatttggcaacagactttgtttcttagagtccact tccaattccaagaatgtgcccccggacctgtccatctgcacctttgtgctggagcagtcc ctctcggtgcgggccctgcaggagatgctggctaacacggtggagaagtcggaagggcaa gttgatgtggaaaaatggaaattcatgatgaagactgctcaaggtggtggccacaggaca ctcctctatgggcatgccatcctgctgcgccattcctacagcggcatgtacctatgctgc ctctccacctcgcggtcttcaactgataagctggcttttgacgttggcctgcaggaggac accacaggtgaggcctgttggtggactatacatccagcctcgaagcagcgatcagaagga gaaaaagtacgggttggagatgacctcatcctagttagtgtgtcctctgagaggtacttg cacttgtcttacggcaacggcagcctgcatgtggatgcagccttccagcagaccctgtgg agtgtggcacccatcagctcaggaagtgaagcagcccaagggtatctgattggtggtgat gtcctcaggttgctgcacggacacatggacgaatgtctcactgtcccttcaggagaacac ggcgaggagcaacggagaactgttcactatgaaggtggtgctgtctctgttcacgcacgg tccctttggagactagagacgctaagagttgcgtggagtgggagtcacataagatggggc cagccgttccgactacgccacgtcacgacaggaaaatacttaagtctcatggaagacaaa agccttctactcatggacaaagaaaaggcagatgtaaaatcgactgcatttacctttcgg tcttccaaggaaaagcttgacgtgggggtgaggaaagaggttgatggcatgggaacatct gagataaaatacggtgactcagtatgctacatacaacacgtggacacgggcctgtggctt acctaccagtcagtggatgtgaaatccgtgagaatggggtccatacaacgtaaggctatt atgcaccatgaaggccacatggacgatggcttaaacttgtccagatctcagcatgaagaa tcacgcacagcccgagtcatccggagcactgtcttccttttcaatagatttataagaggc ctggatgctctcagcaagaaagcgaaggctcctgcggttgacctacccatcgagtctgtg agcctgagtctgcaggacctcattggctacttccacccgcccgatgagcacttggagcac gaggacaagcagaacaggctgcgtgccctgaagaatcggcagaacctcttccaggaagag ggaatgatcagccttgtgctggagtgcatcgaccgactgcacgtctatagcagtgccgca cactttgccgacgtcgctgggcgagaagctggggagtcctggaaatccatcctgaactct ctgtatgagttgctggcggctctaattagaggaaatcgtaaaaactgtgctcaattttct ggctccctcgactggctgatcagcagattggaaagactagaagcttcctcgggtattctt gaagttctacactgtgtgttagtggaaagtccagaagcgctaaatattattaaagaagga catattaaatccattatctcacttttagataagcatgggagaaatcataaagtcttggat gtcttgtgttcactctgtgtttgccatggggtcgctgtccggtctaaccagcatctcatc tgtgacaatctcctgccaggacgtgatcttttactgcagactcgtcttgtgaaccacgtt agcagcatgaggcccaacatcttcctgggcgtcagtgaagggtctgctcagtataagaag tggtactatgagctcatggtggaccacactgagcccttcgtgactgcggaagcgactcac ctgagagtgggctgggcttccactgaggggtactcgccctaccccggagggggcgaagag tggggtggcaatggcgttggtgatgacctcttctcctatggatttgacggccttcatctc tggtcaggttgtattgcccgcactgtaagctcaccaaaccagcacctgctgagaactgat gatgtcatcagttgctgtttagatctaagtgcacccagcatctcattccgaattaatggt cagcctgttcaaggaatgtttgagaatttcaacattgatggcctcttctttccagttgtt agtttctctgcaggaataaaggttcgctttttgcttggggggcgacatggagaattcaaa ttccttcctccacccgggtatgctccttgttacgaagctgttctgcccaaggaaaagctg aaagtggagcacagcagggagtacaagcaggagaggacatacacgcgagacctgctgggc cccacggtgtccctgacacaagccgccttcacaccaatccccgtggacaccacccagatt gtgttgcctcctcacctggaaaggataagagaaaaactggcagagaatatccatgagctg tgggttatgaataaaatcgaacttggctggcagtatggtccggttagagatgacaataag agacagcacccgtgtctggtggagttctgcaagctgcctgaacaggagcgcaattacaac ttacagatgtcgctcgagaccctcaagactttgttggcactgggatgtcacgtgggtata gcggatgaacatgctgaagaaaaggtgaaaaaaatgaagctccccaagaattaccagctg acaagtggatacaagcctgccccgatggacctgagctttataaagctcaccccctctcag gaagcaatggtggacaagttggcggaaaatgctcacaatgtgtgggcccgggatagaatc cggcagggctggacttatggcatccagcaggatgtaaagaacagaagaaaccctcgcctc gtgccctacaccctcctggatgacagaaccaagaaatcaaacaaggacagcctgcgcgag gccgtgcgcacgctgctgggctacggctacaacctggaagccccggatcaagaacacgcg gccagagcagaggtgtgcagcggcaccggggaaaggttccgcatcttccgcgcggagaag acctacgcggtgaaggcgggccgctggtactttgaattcgaggcggtcactgcaggagac atgagggtcggctggagcaggccggggtgtcagcccgaccaggagctgggctcggatgag cgcgccttcgccttcgatggcttcaaggctcagcggtggcaccagggcaatgagcactat gggcgctcctggcaggcaggcgacgttgtgggttgcatggtcgacatgaacgaacacacc atgatgttcacgctgaatggtgaaatcttgctggacgattcaggttccgaactggctttc aaggacttcgatgttggtgatggattcatcccagtgtgtagccttggggtggctcaagtg ggcaggatgaacttcggaaaggatgtcagcaccttgaagtacttcaccatttgtggctta caagagggctacgaaccatttgctgttaatacaaacagggacattaccatgtggctgagc aagaggcttcctcagtttctccaggttccatcaaaccatgaacatattgaggtaaccaga atagatggcaccatagacagctccccgtgtctcaaggtcactcagaagtcctttggctcc cagaacagcagcaccgacatcatgttttaccgcttaagcatgcccatcgagtgtgccgag gtcttctccaagactgtggccggggggctcccgggtgctggcctctttgggcccaagaat gacttggaggactatgatgattctgactttgaggttctgatgaagacagctcatggccat ctggtttctgaccggggtgacaaagataaagaagctacaaagccggagtttaataaccac aaggactacgctcaggagaagccctctcgtctgaaacagagatttttgcttagaagaaca aagccagattacagcaccagccactccgcaaggctgacggaagatgtccttgctgatgac agggacgactatgacttcctgatgcagacttccacgtactattactcagtgagaatcttt cccggacaagaacctgctaacgtctgggtgggctggatcacgtcggatttccaccagtat gatacaggctttgacttggacagagttcgcacagtgacagtcactctaggagatgaaaaa ggaaaagtgcatgaaagctttgcctttgactcgctgtgtggctttggtatcaaacgtagc aactgttatatggtgtgtgcaggcgagagcatgagcccggggcaaggacgcaacaacaac gggctagagatcggctgcgtggtagacgctgccacagggctgctcacgttcattgccaac ggcaaggagctgagcacatactatcaggtggagccaagcacaaagctgtttcctgcagtg ttcgcacaagctacgagccccaatgtgttccagtttgaactgggaagaattaagaacgtg atgcctctctctgcgggattattcaagagtgagcacaagaaccctgtgccccagtgccca ccgcgtctccatgtgcagttcctgtcacatgtcctgtggagcaggatgcccaaccagttt ttgaaggtggacgtctcacggataagcgagcgccaaggctggctggtgcagtgtctggat cctctgcagttcatgtctctccacatccccgaggagaacaggtctgtggacatactggag ctgacagagcaggaggagctgctgaaatttcactaccacactctgcggctgtactctgct gtctgtgctcttggcaaccaccgggtggcccacgccctgtgcagccacgtggacgagcct cagctactctacgccatagagaacaagtacatgcccgggttgctgcgcgctggctactat gacctgctgatcgacattcacctgagctcctatgccacggccaggctcatgatgaacaac gagttcatcgtccccatgactgaggagacaaagagcatcactctcttccccgacgagaac aagaagcacggcctccctgggattggcctcagcacttccctccggccccggatgcagttc tcctccccaagttttgtgagcattagtaatgaattttaccagtacagtccagagttccca ctggacatcctgaaggccaaaaccatacagatgctgacggaagcggttaaagagggcagc ctgcatgctcgggacccggttggggggaccactgaattcctctttgtgcctctcatcaag ctgttctacaccctgctgatcatgggcgtcttccacaatgaggacctgaagcacatcttg cagctgattgagcccagtgtgttcaaagaagctgtcacgccagaggaggagggccacacc ttggagaaagagctcagtgcagaagactcaaagctggagggagcaggcgatgaagggggc aagagaccccaggaaggcctgctccaaatgaagctgcctgagcctgtcaaactgcagatg tgcctgttgctccagtacctctgtgactgccaggtccggcaccggatagaagccatcgta gccttttcagatgactttgtggctaagctccaagataatcagcgtttccgatataacgaa gtcatgcaagccttaaacatgtcggctgcactcacagccaggaaaaccaaggaatttaga tcaccacctcaagagcagatcaatatgcttctcaatttcaaggatgacaaaagtgaatgt ccttgtcctgaagaaattcgtgaccaactattggattttcatgaagatttgatgacacac tgtggaattgagctggatgaagatgggtctctggatggaaacagtgacttaaccattaga gggcgtctgctgtccctggtagaaaaggtgacatacctgaagaagaagcaagcagaaaag ccagtggagagtgactccaagaagtcctctagccttcagcagttgatatctgagaccatg gttcggtgggcccaggagtcggtcattgaggaccctgagctggtgagggccatgtttgtg ttgctgcatcgtcaatacgatggcatagggggtctggtccgggctctgccgaagacctac accatcaatggcgtctctgtggaggacaccatcaacctgctggcatctctcggtcagatt cgttctctgctgagtgtgcgaatgggaaaagaggaggagaagcttatgattcgtggattg ggggatatcatgaacaataaagtgttttaccagcacccgaatctcatgagggcccttggg atgcatgagacagtgatggaggtcatggtcaatgtccttggaggtggggaatccaaggag atcacctttcccaagatggtggccaactgttgtcgctttctctgttacttctgtcgaata agtcggcagaatcaaaaagccatgtttgatcatctcagttatttactggagaacagcagt gttggtcttgcctcaccggctatgagaggttcaacgccactggacgtggcggcagcctcg gtgatggataacaatgagcttgccctcgctctgcgggagccggatctggagaaggttgta cgctatttggctggctgtggtctgcagagctgccagatgctggtgtccaagggttatcca gacattgggtggaatccagtggagggggagagataccttgacttcctcagatttgctgtc ttctgtaatggggagagtgtggaagaaaatgcaaatgtcgtggtgagattgctcattagg aggcctgagtgcttcggtcctgctttgagaggggaaggtgggaatggtcttcttgcagct atggaagaagcaataaaaatagctgaggatccttcccgagatggcccctctccaacgagc ggatccagcaaaaccctgaaaacccatgaaagtgacacagaagaggaggaagatgacacc atccacatggggaacgccattatgaccttttatgcagccttgattgacctcctgggtcgc tgtgcccctgagatgcatttgattcatgctggtaagggagaagccatcagaatcagatct attctgagatccctgattcccctgggagacttggtgggagtcattagcatcgctttccag atgccgacaatcgccaaagatgggaatgtggtggaacctgacatgtctgcggggttttgc ccagatcacaaggcagccatggttttgttccttgacagggtctatgggattgaggtgcaa gatttcctcctccaccttctcgaggttggctttctgccagatctccgggctgctgcttct ctagacacggctgctctgagtgcaacagacatggccttggccctcaatcggtacctttgc acagctgtcttgcctttgctgacaaggtgtgctcccctctttgctgggacagagcaccac gcatccctcatcgactcattgctgcataccgtgtataggctctctaagggctgctcgctc accaaagctcagcgggactccatagaagtgtgcttgctctccatctgtggccagttgagg ccttctatgatgcagcacttgctgagaagattggtgttcgatgtccctttattaaatgaa catgcaaagatgcctctcaagctgctgaccaatcactacgagagatgctggaagtactac tgcttgcccgggggctggggcagctttggtgctgcctccgaagaggagcttcacttatca aggaagttgttctggggcatttttgatgccctgtctcaaaagaaatatgaacaagaactt ttcaagctggcactgccttgcctgagtgcagtcgcaggagctttacctccagactacatg gagtcaaactatgtcagtatgatggaaaaacagtcatccatggattctgaagggaacttt aacccacaacctgttgatacctccaatattacaattcctgagaagttggaatacttcatt aacaaatacgcagagcattcccacgacaaatggtcaatggacaagttggcaaatggatgg atttatggagaaatatattcggattcttctaaggtgcagccattgatgaagccatataaa ctcttatctgaaaaggaaaaagaaatttatcgatggccaatcaaagaatctttgaagact atgttggcttggggttggagaattgaaaggacccgggagggagacagtatggccctttac aaccggactcgtcgcatttctcagacaagccaggtttctgtagatgctgcccatggttac agcccccgagccatcgacatgagcaatgttacactgtctagagacctgcacgctatggca gaaatgatggctgaaaactaccataacatatgggcaaagaagaagaaaatggagttggag tccaaaggtggtggaaaccatcccctgctggtgccctatgataccctgacagcgaaggag aaagccaaggatcgagagaaggcacaggacatcctcaagttcctgcagatcaatggctat gctgtatccagagggttcaaggacctggaactggacacaccttccatcgagaaacgattt gcttacagtttcctccagcagctcattcgctatgtggacgaagcccatcagtatattctg gagtttgatggtggcagcagaagcaaaggagaacatttcccttatgaacaagaaatcaaa ttctttgccaaagtagttcttcctttaattgatcagtatttcaaaaaccaccgtttatac ttcttatctgcagcaagtcgacctctctgctccgggggacatgcatcaaacaaagagaag gagatggtgactagcctattctgcaaacttggagttcttgtcaggcataggatttcacta tttggaaatgatgcaacgtctatcgtcaactgtctccatattttgggtcagactttggat gcaaggactgtgatgaagaccggcctggagggtgtgaagagcgcgctcagggcctttctg gacaatgctgcagaggatctggagaagaccatggaaaatctgaaacagggccagttcacc cacacccggaaccagcccaaaggggttacgcagattatcaattacaccacagtggcactc ttgcccatgctgtcgtcattatttgaacacattggccagcatcagtttggagaagatcta atattggaagatgtgcaggtgtcttgttatagaattctaactagcttatatgctctggga accagcaagagtatttatgtggaaaggcagcgttctgccctgggagagtgcctggcggcc ttcgcaggtgcctttcctgttgcatttttggaaacacatcttgacaagcacaatccttac tccatctacaacaccaagtcttcccgagagagagcagcactcagtttgccagccagtgtg gaagacgtttgtccaaatatcccatctctagagagactcatggaagaaatcgtggagctg gccgagtctggcatccgctacacacagatgccccacgtgatggaggtggtgctgcccatg ctgtgcagctacatgtcgcgctggtgggagcatgggcctgagagcaaccccgagagggca gagacctgctgcacggccctgagctcggagcacatgaacacgctcctggggaacatcctg aagattatctataacaacctggggattgacgagggggcctggatgaagaggttagcagtg ttttcccagccgattatcaataaagtgaaacctcagctcttaaaaactcatttcttacca ctgatggagaaactcaagaaaaaggctgccatggtggtgtctgaggaagaccacctgaaa gctgaggccagaggggacatgtcggaggccgagcttctcgtcctagatgagttcaccaca ctggccagagacctctatgccttctaccctctcttgattagatttgtggactataacagg gccaagtggctgaaggagcccaacccagaagcagaggagcttttccgcatggtggccgaa gtcttcatctattggtccaagtcccataatttcaagagagaggagcagaacttcgttgtg cagaatgaaatcaacaacatgtcatttctcattgctgacaccaagtcaaagatgtccaag gcagctgtttctgaccaggaaaggaagaaaatgaagcgcaaaggagaccgctactctatg cagacttctctgattgtagcagctctgaagcggctcctgcccattgggttgaacatctgt gcccctggggaccaggagctcattgctctggccaaaaatcgatttagtctgaaagacaca gaggatgaagtacgagacataatccgcaataatattcatttacaaggcaagttagaagat cctgctattagatggcaaatggctctttacaaagacttgccaaacagagcagaagatacc tcagatccagagaggacggtggagagagttctggatatagcaaatgtgctttttcatctt gagcagaaatctaaaagtgttggccggagatattacagtctggtggagcatcctcagaga tctaaaaaggccgtgtggcataaactactctccaaacagaggaaaagggcagtggtggcc tgcttcaggatggctcccttgtataatctgccaaggcatcgggctgtcaatctctttctt cagggatatgaaaagtcttggattgaaacagaagaacattactttgaagataagctgatc gaagatttagcaaaacctggggctgaacctccagaagaagatgatgtcgctaaaagagtt gatcctctgcatcagttgatccttctgttcagtcgcacggctttaacagagaaatgcaaa ctggaggaagattttttatatatggcttatgcagatattatggcaaagagttgtcatgat gaggaagacgatgatggtgaagaagaagtgaagagtttcgaagtcacaggatcccaacgc agcaaggaaaaggagatggaaaagcagaagctgctctaccagcaagccaggctgcatgac cggggggccgcagagatggtgctgcagaccatcagtgccagcaaaggtgaaactggaccc atggtggctgctactttgaaacttggaattgctattttaaatggtgggaactctacagta cagcagaagatgctcgactacctcaaggagaagaaggacgtgggcttctttcagagcctg gcaggcctgatgcagtcctgcagtgtccttgacctgaatgcttttgagcgacaaaacaaa gctgaaggacttggaatggtgacagaggaaggatcaggagaaaaggttctgcaggatgac gagttcacctgtgacctcttccgattcctgcagctgctttgtgaggggcacaactcagat tttcaaaattatctgagaactcagactggcaacaatacaactgtcaacatcatcatctct actgtggactacctgctgagggttcaggaatcaattagtgatttctattggtattactct gggaaagatgttattgacgaacaaggacaacggaacttctccaaagctattcaagtcgca aaacaagtgtttaatactcttacagaatatatccagggcccttgcaccgggaaccagcag agcctggcacacagcaggctgtgggacgcagtggtgggtttcctgcacgtgtttgcccac atgcagatgaagctgtctcaggattccagtcaaattgagctactgaaggaattaatggat cttcagaaggatatggtggtcatgttgctgtccatgttggaaggtaatgtggtgaacgga accattggcaagcagatggtcgacatgctggtggaatcttccaacaacgtggagatgatt ctcaagtttttcgacatgttcctcaaactgaaggacttgacatcctcggacacatttaag gagtacgaccccgatggcaaaggtgtcatttccaaaagggacttccacaaagccatggag agccacaagcactacacccagtcggaaaccgagtttcttctgtcctgtgcagagaccgat gaaaacgaaacgctggattatgaggagtttgtcaaacggttccacgaaccggccaaggac attagcttcaatgtcgccgtcctcctgaccaacctctctgagcacatgcccaacgacacg cggctgcagaccttcctggagctggcagaaagcgtgctcaactacttccagcccttcctg ggccgcattgagatcatgggcagcgccaagcgcatcgagagggtgtacttcgagatcagc gagtcgagccgcacccagtgggagaagccgcaggtcaaggagtccaagaggcagttcata ttcgacgtggtcaacgagggaggggaaaaggagaagatggagctgttcgtcaacttctgc gaggacaccatctttgagatgcagctggcagcccagatctccgagtcggacctgaacgag cgctcagccaataaggaggacagcgagaaggacaggccagaggagcagggcccccgcatg ggcttcttttccatcctgacggtcaggtcggccctgtttgcgctcaggtacaatgtgctg agcctgatgcgcatgctcagtctcaagagcctcaagaagcagatgaagaaggtgaagaag atgacggtgagggacatggtcaccgccttcttctcctcctactgcagcgtcttcctgaca ctgctgcacttcgtggccagcgtctgcagaggcttcttccgtatcgtctgcagcctgctg ctcggaggaagcctcgtggaaggggccaaaaaaatcaaagtcgcggagcttctggccaac atgccggaccccactcaggatgaggtgcgaggagatggagaggagggggagaagaagccc ctggaagccgccctgccttccgaggatctgacggatctgaaggagctgacggaagaaagc gaccttctctcagacatctttggcctggatctgaagcgagaaggagggcagtacaagctc attccccacaaccccaatgccggcctcggggacctgatgagcagccccgtccccctccct gaggtgcaagagaagtttcaggaacagaaggcaaaagaagaagaaaaggaagagaaggaa gagaccaaatctgaacctgaaaaggccgagggagaagatggagagaaagaggagaaaacc aaagaagaaaagggcaaacagaagctcaggcagcttcacacacacagatatggagaaccc gaagttcccgagtcagcgttctggaagaagatcatagcctatcaacagaagcttctaaac tattttgcacgcaacttctacaacatgagaatgctggccttgtttgttgcgtttgccatc aatttcatcttgctcttttataaggtctccacttcctctgtggctgaagggaaggagctg cccactcgaagctccattgaaaattccaaagtcaccaccagcctggacagcagctcgcac aggatcactgctgtccactatgtgctggaggagagcagcggctacatggagcccacgctg cgcatcctcgccatcctccacacggtcatctctttcttctgcatcattggatactactgc ctgaaggtcccactggttatttttaaacgagaaaaggaagtagcacggaaattggaattt gatgggctttatattacagagcagccttcagaagatgatattaaaggccagtgggataga cttgtaatcaacacacagtcatttcccaacaactactgggataaatttgttaaaagaaag gttatggataaatatggcgagttctatggtcgagacaggatcagcgagttactaggcatg gacaaggctgcactggactttagtgacgccagagagaagaagaagccaaagaaagacagc tccctgtcagccgtactgaattccattgatgtgaagtatcagatgtggaaattgggagtt gtttttactgacaattctttcctctacctagcctggtatatgaccatgtctgttcttgga cactataacaactttttttttgctgctcatcttcttgatattgctatgggattcaagacc ttaagaaccatcttgtcatcagtaactcacaatggcaaacagctggtattaactgtggga ttattggctgttgtcgtatacctatatacagtggtggcattcaattttttccgaaaattc tacaataagagtgaagatggtgatacgccagatatgaaatgtgacgatatgctaacgtgc tacatgttccacatgtatgtgggggtccgtgctggagggggcattggagatgagattgaa gacccagcgggagatgagtatgagatctaccgtatcatcttcgacatcaccttcttcttt tttgtgatcgtcatcctcctggctatcatacaaggtttaattattgatgcttttggggaa ctgagagaccaacaggagcaagtcaaggaagacatggagaccaagtgcttcatctgtgga ataggcaatgactacttcgacacagtgccacatggctttgaaacccacactttgcaggag cacaatttggccaactacctgttttttctgatgtatctcataaacaaagatgaaacggaa cacacgggacaggaatcttatgtctggaagatgtatcaagagaggtgctgggaatttttc ccagcaggggattgcttccggaaacagtatgaagaccaactaaattaa

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