Mus musculus (house mouse): 108147
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Entry
108147 CDS
T01002
Symbol
Atic, 2610509C24Rik
Name
(RefSeq) 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
KO
K00602
phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:
2.1.2.3
3.5.4.10
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00230
Purine metabolism
mmu00670
One carbon pool by folate
mmu01100
Metabolic pathways
mmu01523
Antifolate resistance
Module
mmu_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
108147 (Atic)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
108147 (Atic)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
108147 (Atic)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mmu04147
]
108147 (Atic)
Enzymes [BR:
mmu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.3 phosphoribosylaminoimidazolecarboxamide formyltransferase
108147 (Atic)
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.10 IMP cyclohydrolase
108147 (Atic)
Exosome [BR:
mmu04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
108147 (Atic)
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Gene cluster
GFIT
Motif
Pfam:
AICARFT_IMPCHas
MGS
Motif
Other DBs
NCBI-GeneID:
108147
NCBI-ProteinID:
NP_080471
MGI:
1351352
Ensembl:
ENSMUSG00000026192
UniProt:
Q9CWJ9
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Position
1:71596315..71618562
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AA seq
592 aa
AA seq
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MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFT
HTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINL
CDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLA
VAYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIV
ATVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKA
GVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDA
FFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
NT seq
1779 nt
NT seq
+upstream
nt +downstream
nt
atggctccgtctcagcttgccctgttcagtgtgtctgacaaaactggcctcgtggaattt
gccagaagtctcgcgtctcttggtttgagtctggtcgcttccggaggcacggcaaaagcg
atcagggatgctggcctggcagtcagagatgtgtctgagctaacagggttccctgaaatg
ttagggggacgcgtgaaaaccttgcaccctgcggtccatgctgggatcttggcacgcaac
attccagaagacgctgcagacatggccaggcttgatttcaaccttgtaagggttgtggtc
tgtaacctgtaccccttcgtgaagactgtggcttctccagatgtaactgttgaggcagct
gttgaacaaattgatattggtggcgtgacattactgagagctgcagccaaaaaccacgct
cgagtgacagtcgtctgtgaaccagaggactatgcgggggtagctgcagagatgcacggc
tctgatagtaaggacacctccctagagaccaggcgccacttggccttgaaggcattcact
cataccgctcaatacgatgaagcaatttcagattacttcaggaaacagtacagtaaggga
atttctcagatgcccttgcggtatgggatgaacccccatcagactcctgcccagttgtat
acgctgaagcccaaacttcccatcacagttctcaatggagccccaggattcataaacttg
tgtgacgctttgaacgcctggcagctggtgacagagctgagaggagcagtagacatccca
gcggctgcttctttcaagcacgtcagcccggcaggtgctgctgttggggttccactcagt
gaggacgaggccagagtctgcatggtctatgacctctacccgaccctcacgcccctggcc
gttgcatatgcaagagcaagaggagctgataggatgtcttcatttggtgattttgttgca
ttgtctgacatttgtgatgtcccaactgcaaaaattatctccagagaagtgtcggatggt
attgttgccccgggatatgaagaagaagccttgaaaatactttctaaaaagaaaaatgga
aactactgtgttcttcagatggaccagtcctacaaaccagatgaaaatgaagttcgaaca
ctctttggtcttcgtttaagccagaagagaaataatggtgtcgttgacaagtcattattt
agcaatattgtcaccaagaataaagatctgccggagtctgcactcagagacctcattgtc
gccaccgtcgctgtcaagtatactcagtctaattcggtgtgctatgccaaggatgggcag
gttattggcatcggagcaggacagcagtctcggatacactgcactcgccttgcaggtgat
aaggcaaactcttggtggcttcggcaccacccacgagtgctgtccatgaagtttaaagcc
ggggtgaagagagcagagatctccaatgcgattgatcagtatgtgaccggcactatcggt
gagggcgaagacctggtgaaatgggaagcactgttcgaagaggttcctgagttactcacg
gaggcggagaagaaggaatgggtggacaagctgagcggcgtgtctgtcagctccgacgcc
ttctttcctttcagggataatgtggaccgagctaaaaggagtggtgtggcctacattgtc
gctccatctggatctactgctgacaaggttgtgattgaggcgtgcgacgagctggggatt
gtcttggctcatacggatctccggctcttccaccactga
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