Mus musculus (house mouse): 11652 Help Entry 11652             CDS       T01002                                  Symbol Akt2, 2410016A19Rik, PKB, PKBbeta Name (RefSeq) thymoma viral proto-oncogene 2   KO K04456   RAC serine/threonine-protein kinase [EC:2.7.11.1] Organism mmu  Mus musculus (house mouse) Pathway mmu01521   EGFR tyrosine kinase inhibitor resistance mmu01522   Endocrine resistance mmu01524   Platinum drug resistance mmu04010   MAPK signaling pathway mmu04012   ErbB signaling pathway mmu04014   Ras signaling pathway mmu04015   Rap1 signaling pathway mmu04022   cGMP-PKG signaling pathway mmu04024   cAMP signaling pathway mmu04062   Chemokine signaling pathway mmu04066   HIF-1 signaling pathway mmu04068   FoxO signaling pathway mmu04071   Sphingolipid signaling pathway mmu04072   Phospholipase D signaling pathway mmu04140   Autophagy - animal mmu04150   mTOR signaling pathway mmu04151   PI3K-Akt signaling pathway mmu04152   AMPK signaling pathway mmu04210   Apoptosis mmu04211   Longevity regulating pathway mmu04213   Longevity regulating pathway - multiple species mmu04218   Cellular senescence mmu04261   Adrenergic signaling in cardiomyocytes mmu04370   VEGF signaling pathway mmu04371   Apelin signaling pathway mmu04380   Osteoclast differentiation mmu04510   Focal adhesion mmu04517   IgSF CAM signaling mmu04550   Signaling pathways regulating pluripotency of stem cells mmu04611   Platelet activation mmu04613   Neutrophil extracellular trap formation mmu04620   Toll-like receptor signaling pathway mmu04625   C-type lectin receptor signaling pathway mmu04630   JAK-STAT signaling pathway mmu04660   T cell receptor signaling pathway mmu04662   B cell receptor signaling pathway mmu04664   Fc epsilon RI signaling pathway mmu04666   Fc gamma R-mediated phagocytosis mmu04668   TNF signaling pathway mmu04722   Neurotrophin signaling pathway mmu04725   Cholinergic synapse mmu04728   Dopaminergic synapse mmu04810   Regulation of actin cytoskeleton mmu04910   Insulin signaling pathway mmu04914   Progesterone-mediated oocyte maturation mmu04915   Estrogen signaling pathway mmu04917   Prolactin signaling pathway mmu04919   Thyroid hormone signaling pathway mmu04920   Adipocytokine signaling pathway mmu04922   Glucagon signaling pathway mmu04923   Regulation of lipolysis in adipocytes mmu04926   Relaxin signaling pathway mmu04929   GnRH secretion mmu04931   Insulin resistance mmu04932   Non-alcoholic fatty liver disease mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04935   Growth hormone synthesis, secretion and action mmu04936   Alcoholic liver disease mmu04973   Carbohydrate digestion and absorption mmu05010   Alzheimer disease mmu05017   Spinocerebellar ataxia mmu05132   Salmonella infection mmu05135   Yersinia infection mmu05142   Chagas disease mmu05145   Toxoplasmosis mmu05152   Tuberculosis mmu05160   Hepatitis C mmu05161   Hepatitis B mmu05162   Measles mmu05163   Human cytomegalovirus infection mmu05164   Influenza A mmu05165   Human papillomavirus infection mmu05166   Human T-cell leukemia virus 1 infection mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05168   Herpes simplex virus 1 infection mmu05169   Epstein-Barr virus infection mmu05170   Human immunodeficiency virus 1 infection mmu05200   Pathways in cancer mmu05205   Proteoglycans in cancer mmu05207   Chemical carcinogenesis - receptor activation mmu05208   Chemical carcinogenesis - reactive oxygen species mmu05210   Colorectal cancer mmu05211   Renal cell carcinoma mmu05212   Pancreatic cancer mmu05213   Endometrial cancer mmu05214   Glioma mmu05215   Prostate cancer mmu05218   Melanoma mmu05220   Chronic myeloid leukemia mmu05221   Acute myeloid leukemia mmu05222   Small cell lung cancer mmu05223   Non-small cell lung cancer mmu05224   Breast cancer mmu05225   Hepatocellular carcinoma mmu05226   Gastric cancer mmu05230   Central carbon metabolism in cancer mmu05231   Choline metabolism in cancer mmu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mmu05415   Diabetic cardiomyopathy mmu05417   Lipid and atherosclerosis mmu05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     11652 (Akt2)    04012 ErbB signaling pathway     11652 (Akt2)    04014 Ras signaling pathway     11652 (Akt2)    04015 Rap1 signaling pathway     11652 (Akt2)    04370 VEGF signaling pathway     11652 (Akt2)    04371 Apelin signaling pathway     11652 (Akt2)    04630 JAK-STAT signaling pathway     11652 (Akt2)    04668 TNF signaling pathway     11652 (Akt2)    04066 HIF-1 signaling pathway     11652 (Akt2)    04068 FoxO signaling pathway     11652 (Akt2)    04072 Phospholipase D signaling pathway     11652 (Akt2)    04071 Sphingolipid signaling pathway     11652 (Akt2)    04024 cAMP signaling pathway     11652 (Akt2)    04022 cGMP-PKG signaling pathway     11652 (Akt2)    04151 PI3K-Akt signaling pathway     11652 (Akt2)    04152 AMPK signaling pathway     11652 (Akt2)    04150 mTOR signaling pathway     11652 (Akt2)   09133 Signaling molecules and interaction    04517 IgSF CAM signaling     11652 (Akt2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     11652 (Akt2)   09143 Cell growth and death    04210 Apoptosis     11652 (Akt2)    04218 Cellular senescence     11652 (Akt2)   09144 Cellular community - eukaryotes    04510 Focal adhesion     11652 (Akt2)    04550 Signaling pathways regulating pluripotency of stem cells     11652 (Akt2)   09142 Cell motility    04810 Regulation of actin cytoskeleton     11652 (Akt2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     11652 (Akt2)    04613 Neutrophil extracellular trap formation     11652 (Akt2)    04620 Toll-like receptor signaling pathway     11652 (Akt2)    04625 C-type lectin receptor signaling pathway     11652 (Akt2)    04660 T cell receptor signaling pathway     11652 (Akt2)    04662 B cell receptor signaling pathway     11652 (Akt2)    04664 Fc epsilon RI signaling pathway     11652 (Akt2)    04666 Fc gamma R-mediated phagocytosis     11652 (Akt2)    04062 Chemokine signaling pathway     11652 (Akt2)   09152 Endocrine system    04910 Insulin signaling pathway     11652 (Akt2)    04922 Glucagon signaling pathway     11652 (Akt2)    04923 Regulation of lipolysis in adipocytes     11652 (Akt2)    04920 Adipocytokine signaling pathway     11652 (Akt2)    04929 GnRH secretion     11652 (Akt2)    04915 Estrogen signaling pathway     11652 (Akt2)    04914 Progesterone-mediated oocyte maturation     11652 (Akt2)    04917 Prolactin signaling pathway     11652 (Akt2)    04926 Relaxin signaling pathway     11652 (Akt2)    04935 Growth hormone synthesis, secretion and action     11652 (Akt2)    04919 Thyroid hormone signaling pathway     11652 (Akt2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     11652 (Akt2)   09154 Digestive system    04973 Carbohydrate digestion and absorption     11652 (Akt2)   09156 Nervous system    04725 Cholinergic synapse     11652 (Akt2)    04728 Dopaminergic synapse     11652 (Akt2)    04722 Neurotrophin signaling pathway     11652 (Akt2)   09158 Development and regeneration    04380 Osteoclast differentiation     11652 (Akt2)   09149 Aging    04211 Longevity regulating pathway     11652 (Akt2)    04213 Longevity regulating pathway - multiple species     11652 (Akt2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     11652 (Akt2)    05205 Proteoglycans in cancer     11652 (Akt2)    05207 Chemical carcinogenesis - receptor activation     11652 (Akt2)    05208 Chemical carcinogenesis - reactive oxygen species     11652 (Akt2)    05230 Central carbon metabolism in cancer     11652 (Akt2)    05231 Choline metabolism in cancer     11652 (Akt2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     11652 (Akt2)   09162 Cancer: specific types    05210 Colorectal cancer     11652 (Akt2)    05212 Pancreatic cancer     11652 (Akt2)    05225 Hepatocellular carcinoma     11652 (Akt2)    05226 Gastric cancer     11652 (Akt2)    05214 Glioma     11652 (Akt2)    05221 Acute myeloid leukemia     11652 (Akt2)    05220 Chronic myeloid leukemia     11652 (Akt2)    05218 Melanoma     11652 (Akt2)    05211 Renal cell carcinoma     11652 (Akt2)    05215 Prostate cancer     11652 (Akt2)    05213 Endometrial cancer     11652 (Akt2)    05224 Breast cancer     11652 (Akt2)    05222 Small cell lung cancer     11652 (Akt2)    05223 Non-small cell lung cancer     11652 (Akt2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     11652 (Akt2)    05170 Human immunodeficiency virus 1 infection     11652 (Akt2)    05161 Hepatitis B     11652 (Akt2)    05160 Hepatitis C     11652 (Akt2)    05164 Influenza A     11652 (Akt2)    05162 Measles     11652 (Akt2)    05168 Herpes simplex virus 1 infection     11652 (Akt2)    05163 Human cytomegalovirus infection     11652 (Akt2)    05167 Kaposi sarcoma-associated herpesvirus infection     11652 (Akt2)    05169 Epstein-Barr virus infection     11652 (Akt2)    05165 Human papillomavirus infection     11652 (Akt2)   09171 Infectious disease: bacterial    05132 Salmonella infection     11652 (Akt2)    05135 Yersinia infection     11652 (Akt2)    05152 Tuberculosis     11652 (Akt2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     11652 (Akt2)    05142 Chagas disease     11652 (Akt2)   09164 Neurodegenerative disease    05010 Alzheimer disease     11652 (Akt2)    05017 Spinocerebellar ataxia     11652 (Akt2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     11652 (Akt2)    05418 Fluid shear stress and atherosclerosis     11652 (Akt2)    05415 Diabetic cardiomyopathy     11652 (Akt2)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     11652 (Akt2)    04932 Non-alcoholic fatty liver disease     11652 (Akt2)    04931 Insulin resistance     11652 (Akt2)    04933 AGE-RAGE signaling pathway in diabetic complications     11652 (Akt2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     11652 (Akt2)    01524 Platinum drug resistance     11652 (Akt2)    01522 Endocrine resistance     11652 (Akt2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mmu01001]     11652 (Akt2) Enzymes [BR:mmu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      11652 (Akt2) Protein kinases [BR:mmu01001]  Serine/threonine kinases: AGC group   AKT/PKB family    11652 (Akt2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Motif Other DBs NCBI-GeneID:  11652 NCBI-ProteinID:  NP_001103678 MGI:  104874 Ensembl:  ENSMUSG00000004056 UniProt:  Q60823 Q3TY95 Q8CE74 LinkDB All DBs Position 7:27290977..27340251 Genome browser AA seq 481 aa AA seqDB search MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDAM DYKCGSPSDSSTSEMMEVAVNKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH LSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE LILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLDPLELDQRTHFPQFSYSASIR E NT seq 1446 nt NT seq  +upstreamnt  +downstreamnt atgaatgaggtatctgtcatcaaagaaggctggctccacaaacgtggtgaatacatcaag acctggaggccacggtacttccttctgaagagtgatggatctttcattgggtataaggag aggcccgaggcccctgaccagaccttaccccccctgaacaatttctctgtagcagaatgc cagctgatgaagactgagaggccacgacccaacacctttgtcatacgctgcctgcagtgg accacagtcatcgagaggaccttccatgtagactctccagatgagagggaagagtggatg cgggctatccagatggtcgccaacagtctgaagcagcggggcccaggtgaggacgccatg gattacaagtgtggctcccccagtgactcttccacatctgagatgatggaggtagctgtc aacaaggcacgggccaaagtgaccatgaatgacttcgattatctcaaactcctcggcaag ggcaccttcggcaaggtcattctggttcgagagaaggccactggccgctattatgccatg aagatcctgcgcaaggaggtcatcattgcaaaggatgaagtcgcccacacagtcacagag agccgggttctgcagaataccaggcaccccttccttacagccctcaagtatgccttccag acccatgaccgcctatgctttgtgatggagtatgccaacgggggtgagctgtttttccac ctctctcgggagcgagtcttcacggaggatcgggcgcgcttttatggagcagagattgtg tcagctctggagtatttgcactcgagagatgtggtgtaccgtgacatcaagctggaaaac cttatgttggacaaagatggccacatcaagatcactgactttggcttgtgcaaagagggc atcagtgatggagccaccatgaaaaccttctgtggtaccccggagtacttggcgcctgag gtgctagaggacaatgactatgggcgagcagtggactggtgggggctgggtgtggtcatg tatgagatgatgtgtggccgcctgccattctacaaccaggaccacgagcgcctctttgag ctcattcttatggaggagatccgcttcccgcgcacactcgggccagaggccaagtccctg ctggctggactgctgaagaaggacccaaagcagaggctcggcggaggtcccagtgatgcg aaggaggtcatggagcatagattcttcctcagcatcaactggcaggacgtggtacagaaa aagctcctgccacccttcaaacctcaggtcacttcagaagtggacacaaggtactttgat gacgagttcaccgcccagtccatcacaatcacacccccagaccgatatgacagcctggac ccgctggaactggaccagcggacgcacttcccccagttctcctactcagccagcatccga gagtga

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