Mus musculus (house mouse): 12039
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Entry
12039 CDS
T01002
Symbol
Bckdha, BCKAD, BCKDE1A, E1[a]
Name
(RefSeq) branched chain ketoacid dehydrogenase E1, alpha polypeptide
KO
K00166
2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:
1.2.4.4
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00280
Valine, leucine and isoleucine degradation
mmu00640
Propanoate metabolism
mmu00785
Lipoic acid metabolism
mmu01100
Metabolic pathways
mmu01210
2-Oxocarboxylic acid metabolism
Module
mmu_M00036
Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00640 Propanoate metabolism
12039 (Bckdha)
09105 Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
12039 (Bckdha)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
12039 (Bckdha)
Enzymes [BR:
mmu01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
12039 (Bckdha)
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Motif
Pfam:
E1_dh
TPP_enzyme_C
DXP_synthase_N
Motif
Other DBs
NCBI-GeneID:
12039
NCBI-ProteinID:
NP_001390439
MGI:
107701
Ensembl:
ENSMUSG00000060376
LinkDB
All DBs
Position
7:complement(25329371..25358178)
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AA seq
463 aa
AA seq
DB search
MAIVMSAAKIWRPSRGLRQAALLLLGRSGVRGLARSVAFSAGERAMDLAGARQHPSRQQQ
QQFPSLDDKPQFPGASAEFVDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPQEEV
LKFYRSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALERTDLVFGQYREAG
VLMYRDYPLELFMSQCYGNVNDPGKGRQMPVHYGCKERHFVTISSPLATQIPQAVGAAYA
AKRANANRIVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNNGYAISTPTSEQYRGD
GIAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQPFLIEAMTYRIGHHSTSDDS
SAYRSVDEVNYWDKQDHPISRLRQYLLNQGWWDEEQEKAWRKQSRKKVMEAFEQAERKLK
PNPSLLFSDVYQEMPAQLRRQQESLARHLQTYGEHYPLDHFDK
NT seq
1392 nt
NT seq
+upstream
nt +downstream
nt
atggcgatagtgatgtctgcggccaagatctggaggccgagccgtggcctgcgccaggct
gctcttctcctgttgggacgatctggggttcggggcttggctagatctgttgccttcagt
gctggggagagagccatggacctcgcgggtgctaggcagcaccccagcaggcagcagcaa
cagcagttcccatccctggacgacaagccccagttcccaggggcctctgcagagtttgta
gacaagcttgagttcatccagcccaatgtcatctccggcatccccatctaccgtgtcatg
gaccgccagggccagatcatcaaccccagtgaagatccccacctgccccaggaggaggtg
ctgaagttctaccggagcatgacgctgctcaacaccatggaccgcattctctatgagtcc
cagcggcagggccggatctccttctacatgaccaactatggcgaggaggggacacatgtg
ggcagtgccgctgccttggagcgcacagacctggtgtttggccagtaccgggaggcaggt
gtgctcatgtaccgggactacccgctggagctgttcatgtcccagtgctacggcaacgtg
aatgacccaggcaagggacgccagatgcctgttcactacggctgcaaggaacgccacttc
gtcaccatttcctctccactggccacgcagatccctcaggcggtaggggcagcctatgct
gccaagcgggccaatgccaaccggattgtgatctgttactttggcgagggggcagccagt
gaaggggatgcccacgccggtttcaatttcgctgccaccctggagtgtcccatcatcttc
ttctgccggaacaatggctatgccatctccacaccaacctctgagcagtaccgtggggat
ggcatagcggctcggggccctgggtacggcatcatgtcaatccgtgtggacggcaacgat
gtgtttgctgtgtacaatgccactaaggaggcccgacggcgggctgtggctgagaaccag
cccttcctcattgaggccatgacctacaggattggccaccacagcaccagtgacgacagc
tcagcgtaccgttcggtggacgaggtcaattactgggacaagcaggaccacccaatctcg
aggctgaggcagtacctgctgaaccagggttggtgggatgaggaacaggagaaggcctgg
cggaagcagtcacgaaagaaggtcatggaagcctttgagcaggctgagcggaagctaaag
ccgaacccaagcctcctcttctccgatgtgtaccaggagatgcccgcccagctccgcagg
cagcaggagtcgctggcacggcacctgcagacttacggggagcactaccccctggaccac
tttgacaagtga
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