Mus musculus (house mouse): 12675
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Entry
12675 CDS
T01002
Symbol
Chuk, Chuk1, Fbx24, Fbxo24, IKBKA, IKK_alpha, IKK1, Ikka, NFKBIKA
Name
(RefSeq) conserved helix-loop-helix ubiquitous kinase
KO
K04467
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:
2.7.11.10
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01523
Antifolate resistance
mmu04010
MAPK signaling pathway
mmu04014
Ras signaling pathway
mmu04062
Chemokine signaling pathway
mmu04064
NF-kappa B signaling pathway
mmu04068
FoxO signaling pathway
mmu04150
mTOR signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04210
Apoptosis
mmu04380
Osteoclast differentiation
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04623
Cytosolic DNA-sensing pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04658
Th1 and Th2 cell differentiation
mmu04659
Th17 cell differentiation
mmu04660
T cell receptor signaling pathway
mmu04662
B cell receptor signaling pathway
mmu04668
TNF signaling pathway
mmu04920
Adipocytokine signaling pathway
mmu04936
Alcoholic liver disease
mmu05010
Alzheimer disease
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05162
Measles
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05171
Coronavirus disease - COVID-19
mmu05200
Pathways in cancer
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05212
Pancreatic cancer
mmu05215
Prostate cancer
mmu05220
Chronic myeloid leukemia
mmu05221
Acute myeloid leukemia
mmu05222
Small cell lung cancer
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
12675 (Chuk)
04064 NF-kappa B signaling pathway
12675 (Chuk)
04668 TNF signaling pathway
12675 (Chuk)
04068 FoxO signaling pathway
12675 (Chuk)
04151 PI3K-Akt signaling pathway
12675 (Chuk)
04150 mTOR signaling pathway
12675 (Chuk)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
12675 (Chuk)
04660 T cell receptor signaling pathway
12675 (Chuk)
04658 Th1 and Th2 cell differentiation
12675 (Chuk)
04659 Th17 cell differentiation
12675 (Chuk)
04657 IL-17 signaling pathway
12675 (Chuk)
04662 B cell receptor signaling pathway
12675 (Chuk)
04062 Chemokine signaling pathway
12675 (Chuk)
09158 Development and regeneration
04380 Osteoclast differentiation
12675 (Chuk)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
12675 (Chuk)
05208 Chemical carcinogenesis - reactive oxygen species
12675 (Chuk)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
12675 (Chuk)
09162 Cancer: specific types
05212 Pancreatic cancer
12675 (Chuk)
05221 Acute myeloid leukemia
12675 (Chuk)
05220 Chronic myeloid leukemia
12675 (Chuk)
05215 Prostate cancer
12675 (Chuk)
05222 Small cell lung cancer
12675 (Chuk)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
12675 (Chuk)
05170 Human immunodeficiency virus 1 infection
12675 (Chuk)
05161 Hepatitis B
12675 (Chuk)
05160 Hepatitis C
12675 (Chuk)
05171 Coronavirus disease - COVID-19
12675 (Chuk)
05164 Influenza A
12675 (Chuk)
05162 Measles
12675 (Chuk)
05163 Human cytomegalovirus infection
12675 (Chuk)
05167 Kaposi sarcoma-associated herpesvirus infection
12675 (Chuk)
05169 Epstein-Barr virus infection
12675 (Chuk)
05165 Human papillomavirus infection
12675 (Chuk)
09171 Infectious disease: bacterial
05135 Yersinia infection
12675 (Chuk)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
12675 (Chuk)
05142 Chagas disease
12675 (Chuk)
09164 Neurodegenerative disease
05010 Alzheimer disease
12675 (Chuk)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
12675 (Chuk)
05418 Fluid shear stress and atherosclerosis
12675 (Chuk)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
12675 (Chuk)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
12675 (Chuk)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
12675 (Chuk)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
12675 (Chuk)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: Other
IKK family [OT]
12675 (Chuk)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IKBKB_SDD
Pkinase
PK_Tyr_Ser-Thr
Pkinase_fungal
Kdo
TBK1_ULD
YrbL-PhoP_reg
Motif
Other DBs
NCBI-GeneID:
12675
NCBI-ProteinID:
NP_001155882
MGI:
99484
Ensembl:
ENSMUSG00000025199
UniProt:
Q3TPN9
E9Q605
Q8CBT3
LinkDB
All DBs
Position
19:complement(44061773..44095940)
Genome browser
AA seq
719 aa
AA seq
DB search
MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCH
EIQIMKKLDHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKTIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDLTLKQPRC
FALMDHILNLKIVHILNMTSAKIISFLLPCDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPPDHLYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGYSLEGTVTPPVSAWLPPTLADREHPLTCVRDVSTNDRRKSELSWPFKYYYS
NT seq
2160 nt
NT seq
+upstream
nt +downstream
nt
atggagcggcccccggggctgcggccgggcgcgggcggcccctgggagatgcgggaacgg
cttggcaccggcggtttcgggaacgtcagtctgtaccagcaccgggaacttgatctcaaa
atagcaattaagtcttgtcgtttagagctaagttccaaaaacagagagcgatggtgccat
gaaatccagatcatgaaaaagttggaccatgcgaatgttgtaaaggcctgtgatgtccct
gaggaattgaactttttaattaacgatgtgcctcttctggcaatggagtactgttctgga
ggggacctccggaagctactcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactgagtgacataggatctgggatccgatatctgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaatatagttcttcaagatgttggtgggaagacaata
cataaaataattgatttgggttatgccaaagatgttgatcaaggaagtctctgtacatct
tttgtgggaacattgcagtatttggccccagagctctttgaaaataagccgtacacagcc
actgtggattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaagatccaaag
tgtatatttgcatgtgaagagatgactggagaagttcggtttagtagccatttacctcag
ccaaacagcctttgtagtttaatagtagagccaatggaaagctggctccaattgatgctg
aattgggacccacagcagagagggggacctattgatcttactttgaagcagccaagatgt
tttgcattaatggatcacattctcaatttaaagatagtgcacatcctaaatatgacttct
gcaaaaatcatttcttttctgttaccatgtgatgaaagtcttcattcactacagtctcga
attgagcgtgaaacaggaataaatacaggttctcaggagcttctgtcagagacagggatt
tctctggatcctcggaaaccagcctctcagtgtgttctagatggagttagaggctgtgat
agctacatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcatcc
agaagtttatctgattgtgtaaattatattgtacaagacagcaaaatacaactgccaatt
atacagctgcggaaagtatgggctgaagcagtgcactacgtatctgggctaaaggaagac
tacagcaggctcttccagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatctcagcatcacagcaactcaaagctaaattg
gagttttttcgaaaaagcattcagcttgacttggagagatatagtgagcagatgacttat
gggatatcttcagaaaaaatgttaaaagcatggaaagaaatggaagaaaaggccattcac
tattctgaggttggtgtcattggttatcttgaggatcaaattatgtctttgcacactgaa
atcatggagctgcagaagagcccctatggacgacgccagggagacttgatggagtctctg
gagcagcgtgccattgatctctataagcagctaaagcacagacctcctgatcacttgtac
agcgacagcacagagatggtgaagatcatcgtgcacaccgtgcagagtcaggaccgtgtt
ctcaaggagctgtttggtcacctgagcaagttgttgggctgcaagcagaagattattgat
ctactccccaaggtggaagtggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatttggcacctccttaaaattgcctgtacacag
agttctgcccgctctcttgtaggatacagtctagaaggcacagtaacccctccagtatca
gcatggctgccccctacattagcagaccgtgaacatcctctgacatgtgtgagagacgtt
agcacaaatgatagaagaaaatctgaactgtcttggccatttaagtactattattcgtga
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