Mus musculus (house mouse): 14450
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Entry
14450 CDS
T01002
Symbol
Gart, Gaps, Prgs
Name
(RefSeq) phosphoribosylglycinamide formyltransferase
KO
K11787
phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase [EC:
6.3.4.13
2.1.2.2
6.3.3.1
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00230
Purine metabolism
mmu00670
One carbon pool by folate
mmu01100
Metabolic pathways
mmu01523
Antifolate resistance
Module
mmu_M00048
De novo purine biosynthesis, PRPP + glutamine => IMP
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
14450 (Gart)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
14450 (Gart)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
14450 (Gart)
Enzymes [BR:
mmu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.2 Hydroxymethyl-, formyl- and related transferases
2.1.2.2 phosphoribosylglycinamide formyltransferase 1
14450 (Gart)
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.3 Cyclo-ligases
6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
14450 (Gart)
6.3.4 Other carbon-nitrogen ligases
6.3.4.13 phosphoribosylamine---glycine ligase
14450 (Gart)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GARS_A
Formyl_trans_N
AIRS_C
GARS_N
GARS_C
AIRS
ATP-grasp
CPSase_L_D2
ATP-grasp_3
ATP-grasp_4
ATP-grasp_2
Dala_Dala_lig_C
RimK
Sacchrp_dh_NADP
Motif
Other DBs
NCBI-GeneID:
14450
NCBI-ProteinID:
NP_034386
MGI:
95654
Ensembl:
ENSMUSG00000022962
UniProt:
Q64737
LinkDB
All DBs
Position
16:complement(91418283..91444505)
Genome browser
AA seq
1010 aa
AA seq
DB search
MAARVLVIGSGGREHTLAWKLAQSPQVKQVLVAPGNAGTACAGKISNAAVSVNDHSALAQ
FCKDEKIELVVVGPEAPLAAGIVGDLTSAGVRCFGPTAQAAQLESSKKFAKEFMDRHEIP
TAQWRAFTNPEDACSFITSANFPALVVKASGLAAGKGVIVAKSQAEACRAVQEIMQEKSF
GAAGETVVVEEFLEGEEVSCLCFTDGKTVAEMPPAQDHKRLLDGDEGPNTGGMGAYCPAP
QVSKDLLVKIKNTILQRAVDGMQQEGAPYTGILYAGIMLTKDGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVMQSTLDGLLSASLPVWLENHSAVTVVMASKGYPGAYTKGVEITGFPEA
QALGLQVFHAGTALKDGKVVTSGGRVLTVTAVQENLMSALAEARKGLAALKFEGAIYRKD
IGFRAVAFLQRPRGLTYKDSGVDIAAGNMLVKKIQPLAKATSRPGCSVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDSIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSTTEAVIAGIAAACQQAGCALLGGETAEMPNMYPPGEYDLAGFAVGAMERHQKLP
QLERITEGDAVIGVASSGLHSNGFSLVRKIVERSSLQYSSPAPGGCGDQTLGDLLLTPTR
IYSHSLLPIIRSGRVKAFAHITGGGLLENIPRVLPQKFGVDLDASTWRVPKVFSWLQQEG
ELSEEEMARTFNCGIGAALVVSKDQAEQVLHDVRRRQEEAWVIGSVVACPEDSPRVRVKN
LIETIQTNGSLVANGFLKSNFPVQQKKARVAVLISGTGSNLQALIDSTRDPKSSSHIVLV
ISNKAAVAGLDRAERAGIPTRVINHKLYKNRVEFDNAVDHVLEEFSVDIVCLAGFMRILS
GPFVRKWDGKMLNIHPSLLPSFKGSNAHEQVLEAGVTITGCTVHFVAEDVDAGQIILQEA
VPVRRGDTVATLSERVKVAEHKIFPAALQLVASGAVQLREDGKIHWAKEQ
NT seq
3033 nt
NT seq
+upstream
nt +downstream
nt
atggcagcccgagttcttgtcatcggtagcgggggaagggaacataccctggcctggaag
ctcgcacagtctcctcaggtcaagcaagtgttggttgccccaggaaacgcaggcactgcg
tgcgctgggaagatctccaatgctgctgtctctgtcaatgatcacagtgccctcgctcag
ttctgcaaggatgaaaagattgaactcgtagttgtcggaccagaggcccctctggctgca
ggaattgttggggacctgacctctgcaggagtacgatgctttggccccacagcacaagca
gctcaattagagtccagtaagaagtttgctaaagagtttatggaccgccatgaaatccca
actgcacagtggagagcattcaccaaccctgaagatgcctgcagctttattacaagcgcg
aactttcctgctttggttgtgaaggccagtggccttgcagcagggaagggagtgattgtg
gccaagagccaagcggaggcctgcagagctgtacaggagatcatgcaagaaaagtctttc
ggagcagctggtgaaacagttgttgtggaagagtttctggaaggggaagaagtgtcttgc
ctttgcttcactgacgggaagacggtggccgaaatgcccccagcacaagaccataagcga
ttgctggatggagacgaaggccccaacaccggggggatgggagcctactgcccagcacct
caggtttctaaggacttgttagtaaaaattaagaacactattcttcagagagcagtagac
ggcatgcagcaggagggtgcgccgtacacaggaattctttatgctggtataatgctgacc
aaagatggcccaaaagtgttggagtttaattgccgctttggtgatccggaatgccaggtc
atcctcccacttcttaaaagtgacctctatgaggtgatgcagtccaccttggatggcctg
ctgagcgcgtctctgcctgtttggctagaaaaccacagtgccgtaaccgtcgtcatggcg
agtaaagggtaccctggagcctacaccaaaggcgtggagattacagggtttcctgaggcc
caggctttaggactgcaggtattccatgcaggcactgctcttaaagatggcaaagtagtg
accagcgggggcagggtcctcaccgtgacagctgtccaggaaaatctcatgtcagccctt
gctgaggccaggaaaggactcgctgctctaaagtttgagggagccatctatagaaaggac
attggcttccgtgctgtggccttcctccagcggcccaggggcttgacttacaaggactcc
ggagtagacatcgcagctggaaatatgctggttaagaaaattcagcctttagcaaaagcc
acctccagaccaggctgcagtgttgaccttgggggctttgctggtctttttgatttgaaa
gcagctggtttcaaagatcctcttctggcctctggaacagatggtgtgggaactaaacta
aagattgcgcagctgtgcaataagcatgattccatcgggcaggatctggtggccatgtgt
gtgaacgacatcctcgcccagggagcagagcccctcttcttccttgactacttttcctgt
gggaagctcgacctcagtacaactgaagccgtcattgctggaattgctgcagcttgccag
caggctggctgtgccctgctgggtggggagacagcagagatgcccaacatgtaccctcct
ggagagtatgatcttgctgggtttgctgttggtgctatggagagacaccagaagctccct
cagctagaaaggatcaccgaaggggatgctgttattggagtggcttcatctggtcttcac
agcaatgggtttagccttgtgaggaaaatcgtggagaggtcttcgctccaatactcctcc
ccagcacctggtggttgtggagatcagaccttaggggacttacttctaactccaaccagg
atctacagccattcactgctgcccatcatacgttcaggacgtgtcaaagcttttgctcat
atcactggaggcgggttgctggaaaacatccccagagtcctccctcagaagtttggagta
gatttagatgccagcacctggagggtccccaaggtcttctcgtggctacagcaggaagga
gagctctctgaagaagaaatggccaggacattcaactgtgggattggagctgccctggtg
gtgtcaaaggaccaggccgagcaggttctgcatgacgttcggcggcggcaggaggaagcc
tgggtgataggcagtgtcgttgcgtgtcctgaagattcccctcgtgtcagagttaagaat
ctgattgaaaccatacaaacgaatgggtcattggtggcaaatggcttcctgaaaagtaat
ttccctgtgcaacaaaagaaggcaagagtggctgtcttgatatctggaacagggtcgaac
ctccaggcgctcatagatagcacccgggatcccaagagctcctcacatattgttcttgtc
atctccaacaaagccgccgtagccggcttagaccgagctgagcgagctggtattcccacc
agggtaattaatcacaaattatataaaaatcgtgttgagtttgacaatgcagttgaccac
gtcctggaagagttctctgtagacatcgtctgtcttgcagggttcatgaggatcctctct
gggcccttcgtcagaaaatgggacgggaaaatgctcaacatccacccatccttgctccct
tcctttaagggttcaaatgcccacgagcaagtcctggaagctggagtcacaatcactggg
tgtaccgtacactttgtcgctgaagatgtagatgccggacaaatcatcctgcaggaagct
gtccctgtgcggaggggtgacactgtggcaacgctgtctgaacgggtcaaagtggcagaa
cataagatctttcctgccgctcttcagctggtggccagcggggctgtgcagctgcgagaa
gatggcaagatccactgggccaaggagcagtga
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