Mus musculus (house mouse): 14629
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Entry
14629 CDS
T01002
Symbol
Gclc, D9Wsu168e, GLCL-H, Ggcs-hs, Glclc
Name
(RefSeq) glutamate-cysteine ligase, catalytic subunit
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00270
Cysteine and methionine metabolism
mmu00480
Glutathione metabolism
mmu01100
Metabolic pathways
mmu01240
Biosynthesis of cofactors
mmu04216
Ferroptosis
Module
mmu_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
14629 (Gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
14629 (Gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
14629 (Gclc)
Enzymes [BR:
mmu01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
14629 (Gclc)
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GFIT
Motif
Pfam:
GCS
GCS2
Motif
Other DBs
NCBI-GeneID:
14629
NCBI-ProteinID:
NP_034425
MGI:
104990
Ensembl:
ENSMUSG00000032350
UniProt:
P97494
Q3TEF1
Q3UNA7
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All DBs
Position
9:77661817..77701771
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AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EANMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAI
NKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDAEASKASQPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNRFRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLE
EGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGNAVVDGCSKAQSSSEPAAEEYTLMSIDTIINGKEGVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYS
LIWKCNQIADELCECPELLGSGFRKAKYSGGKSDPSA
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccaaggctcgccactgagctgggaagagacccagcgccacgccgac
cacgtgcggaggcacggcatcctccagttcctgcacatctaccacgcagtcaaggaccgg
cacaaggacgtgctcaagtggggtgacgaggtggagtacatgttggtgtccttcgatcat
gaaaataggaaagtccagttgttactgaatggaggcgatgttcttgagactctgcaggag
aagggggagaggacaaaccccaaccatccgaccctctggagaccagagtatgggagttac
atgatcgaaggaacgcctggccagccctacggaggaacgatgtctgagttcaacactgtg
gaggccaatatgaggaaacgccggaaggaggctacttctgtactaggagagcatcaggct
ctctgcaccatcacttcattccccagactaggctgtcctggattcacactgccagaacac
agacccaacccagaggaaggaggcgcatcaaagtccctcttctttccagatgaagccata
aacaagcacccccgcttcggtactctaacaagaaacatccggcatcggagaggagaaaag
gttgtcatcaatgtgccaatattcaaggacaagaatacaccatctccatttgtagaaaca
tttccagaagatgcggaggcatcaaaggcttctcagccagaccatatctacatggatgcc
atgggattcgggatgggcaactgctgtctccaggtgacattccaagcctgcagcatatct
gaggcaagatacctttatgatcagctggccactatctgcccaattgttatggctttgagt
gctgcatctccattttaccgaggctacgtgtcagacattgattgtcgctggggagtgatt
tctgcctctgtagatgatagaacacgggaggagagaggcctggagcctctgaagaacaat
cgctttaggatcagtaagtctcggtatgactcaatagatagctacctgtctaagtgtggg
gagaagtacaatgacatcgacctgaccatcgataaggagatctacgagcagctcctggag
gaaggcatcgatcatcttctggcacagcacgttgctcatctctttattagagacccactc
accctttttgaagagaaaatacacctggatgatgccaacgagtctgaccattttgagaat
attcagtctacaaactggcagacaatgaggtttaagcctcctcctccaaactcagatatt
ggatggagagtagagttccgaccaatggaggtgcagttaacagactttgagaactctgcc
tatgtggtattcgtggtactgctcactagggtgatcctctcatacaaactagacttcctc
attccgctgtccaaggttgacgagaacatgaaagtggcccagaagcgagatgctgtcttg
caggggatgttttatttcaggaaagacatctgcaaaggcggcaacgctgtggtggacggg
tgcagcaaggcccagagcagctctgagccagctgcagaggagtacaccctgatgagcata
gacaccatcatcaatgggaaggaaggggtatttcctggactcatccccattctgaactcc
tatctggagaacatggaagttgatgtggacacccgatgcagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgactgttgccaggtggatgagagagttc
attgcaaaccatcctgactacaagcaagacagtgtaataactgatgaaatcaactatagc
ctcatttggaagtgcaaccaaattgcagatgagctgtgtgaatgtccagagttacttgga
tcaggatttagaaaagcgaagtacagtggaggtaaaagcgacccttcagcctag
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