Entry |
|
Symbol |
Itgam, CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a
|
Name |
(RefSeq) integrin alpha M
|
KO |
|
Organism |
mmu Mus musculus (house mouse)
|
Pathway |
mmu04610 | Complement and coagulation cascades |
mmu04613 | Neutrophil extracellular trap formation |
mmu04670 | Leukocyte transendothelial migration |
mmu04810 | Regulation of actin cytoskeleton |
mmu05150 | Staphylococcus aureus infection |
mmu05202 | Transcriptional misregulation in cancer |
|
Brite |
KEGG Orthology (KO) [BR:mmu00001]
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
16409 (Itgam)
09133 Signaling molecules and interaction
04514 Cell adhesion molecules
16409 (Itgam)
09140 Cellular Processes
09141 Transport and catabolism
04145 Phagosome
16409 (Itgam)
09142 Cell motility
04810 Regulation of actin cytoskeleton
16409 (Itgam)
09150 Organismal Systems
09151 Immune system
04640 Hematopoietic cell lineage
16409 (Itgam)
04610 Complement and coagulation cascades
16409 (Itgam)
04613 Neutrophil extracellular trap formation
16409 (Itgam)
04670 Leukocyte transendothelial migration
16409 (Itgam)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
16409 (Itgam)
09162 Cancer: specific types
05221 Acute myeloid leukemia
16409 (Itgam)
09171 Infectious disease: bacterial
05133 Pertussis
16409 (Itgam)
05134 Legionellosis
16409 (Itgam)
05150 Staphylococcus aureus infection
16409 (Itgam)
05152 Tuberculosis
16409 (Itgam)
09174 Infectious disease: parasitic
05146 Amoebiasis
16409 (Itgam)
05140 Leishmaniasis
16409 (Itgam)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mmu04131]
16409 (Itgam)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:mmu04147]
16409 (Itgam)
04515 Cell adhesion molecules [BR:mmu04515]
16409 (Itgam)
04090 CD molecules [BR:mmu04090]
16409 (Itgam)
00536 Glycosaminoglycan binding proteins [BR:mmu00536]
16409 (Itgam)
Membrane trafficking [BR:mmu04131]
Endocytosis
Phagocytosis
Integrins (complement receptors)
16409 (Itgam)
Exosome [BR:mmu04147]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
16409 (Itgam)
Cell adhesion molecules [BR:mmu04515]
Integrins
Integrin alpha subunits
16409 (Itgam)
CD molecules [BR:mmu04090]
Proteins
16409 (Itgam)
Glycosaminoglycan binding proteins [BR:mmu00536]
Heparan sulfate / Heparin
Adhesion molecules of cell surface
16409 (Itgam)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
7:127661812..127717663
|
AA seq |
1154 aa
MTLKALLVTALALCHGFNLDTEHPMTFQENAKGFGQSVVQLGGTSVVVAAPQEAKAVNQT
GALYQCDYSTSRCHPIPLQVPPEAVNMSLGLSLAVSTVPQQLLACGPTVHQNCKENTYVN
GLCYLFGSNLLRPPQQFPEALRECPQQESDIVFLIDGSGSINNIDFQKMKEFVSTVMEQF
KKSKTLFSLMQYSDEFRIHFTFNDFKRNPSPRSHVSPIKQLNGRTKTASGIRKVVRELFH
KTNGARENAAKILVVITDGEKFGDPLDYKDVIPEADRAGVIRYVIGVGNAFNKPQSRREL
DTIASKPAGEHVFQVDNFEALNTIQNQLQEKIFAIEGTQTGSTSSFEHEMSQEGFSASIT
SNGPLLGSVGSFDWAGGAFLYTSKDKVTFINTTRVDSDMNDAYLGYASAVILRNRVQSLV
LGAPRYQHIGLVVMFRENFGTWEPHTSIKGSQIGSYFGASLCSVDMDADGNTNLILIGAP
HYYEKTRGGQVSVCPLPRGQRARWQCEALLHGDQGHPWGRFGAALTVLGDVNGDKLTDVA
IGAPGEQENQGAVYIFYGASIASLSASHSQRIIGAHFSPGLQYFGQSLSGGKDLTMDGLM
DLAVGAQGHLLLLRAQPVLRLEATMEFSPKKVARSVFACQEQVLKNKDAGEVRVCLRVRK
NTKDRLREGDIQSTVTYDLALDPGRSRIRAFFDETKNNTRRRTQVFGLMQKCETLKLILP
DCVDDSVSPIILRLNYTLVGEPLRSFGNLRPVLAMDAQRFFTAMFPFEKNCGNDSICQDD
LSITMSAMGLDTLVVGGPQDFNMSVTLRNDGEDSYGTQVTVYYPSGLSYRKDSASQNPLT
KKPWFVKPAESSSSSEGHGALKSTTWNINHPIFPANSEVTFNVTFDVDSHASFGNKLLLK
AIVASENNMSRTHKTKFQLELPVKYAIYMIVTSDESSIRYLNFTASEMTSKVIQHQYQFN
NLGQRSLPVSVVFWIPVQINNVTVWDHPQVIFSQNLSSACHTEQKSPPHSNFRDQLERTP
VLNCSVAVCKRIQCDLPSFNTQEIFNVTLKGNLSFDWYIKTSHGHLLLVSSTEILFNDSA
FALLPGQESYVRSKTETKVEPYEVHNPVPLIVGSSIGGLVLLALITAGLYKLGFFKRQYK
DMMNEAAPQDAPPQ |
NT seq |
3465 nt +upstreamnt +downstreamnt
atgactcttaaagctcttctggtcacagccctagccttgtgtcatggcttcaatctggac
actgaacatcccatgaccttccaagagaatgcaaaaggctttggacagagtgtggtccag
cttggcggaaccagtgtggttgttgcagccccccaggaggcaaaggctgttaaccagaca
ggtgccctctaccagtgtgactacagcacaagccggtgtcaccccatccccctgcaagta
cctccagaggctgtgaatatgtccttgggcctgtccctggctgtttctactgtcccccag
cagctgctggcctgtggccccacggtgcaccaaaactgcaaggagaatacttatgtgaat
ggattgtgctatttgttcggctccaacctgctgaggccgccccagcagttcccagaggct
ctcagagaatgtcctcagcaggagagtgacattgtcttcttgattgatggctccggtagc
atcaacaacattgactttcagaagatgaaggagtttgtctcaactgtgatggagcagttc
aaaaagtctaaaaccttgttctctttgatgcagtactcggacgagttccggattcacttc
accttcaatgacttcaagagaaaccctagcccaagatcacatgtgagccccataaagcag
ctgaatgggaggacaaaaactgcctcagggatccggaaagtagtgagagaactgtttcac
aaaaccaatggggcccgggagaatgctgcgaagatcctagttgtcatcacagatggagaa
aaattcggtgatcccttggattataaggatgtcatccccgaggcagacagagcaggggtc
attcgctacgtaattggggtgggaaatgccttcaacaaaccacagtcccgcagagagctc
gacaccatcgcatctaagccagctggtgaacacgtgttccaagtggacaactttgaagcc
ctgaataccattcagaaccagcttcaggaaaagatctttgcaattgagggcacgcagaca
ggaagtaccagctcctttgagcatgagatgtctcaagaaggcttcagtgcttccattacc
tctaatggtcccttgctgggctctgtggggagctttgactgggcaggtggagccttcctg
tatacatcgaaggataaagtcaccttcatcaacacaaccagagtggattcagacatgaat
gatgcttacctgggttatgcttctgcagtcatcttgaggaaccgtgtccaaagcttggtt
ttaggagcacctcggtatcagcatattggcttggtggtgatgttcagggagaatttcggt
acctgggagccccacactagcatcaagggcagccagattggctcttattttggggcctcc
ctttgctctgtggacatggacgctgatggcaataccaacttgatcctcattggggcccct
cattactatgagaagacccgaggaggccaggtgtcagtgtgtcccttgcctcgagggcag
agggcacggtggcagtgtgaagctcttctccacggtgatcagggtcatccctggggtcgc
tttggggcagccctgacagtgctgggagacgtgaatggggacaaactgacagatgtggcc
attggggccccaggagagcaggagaatcagggcgctgtctacattttttatggagcatca
atagccagcctcagtgcctcccacagccagcggatcataggcgcccacttctcccctggg
ctccagtacttcgggcagtctctgagtgggggtaaggatctcacaatggatggcttgatg
gacctggctgttggggcgcaggggcatcttctgctgctcagagcccagccggtgctgaga
ctggaggcaaccatggaattcagccccaagaaagtagcaaggagtgtgtttgcatgtcaa
gaacaagtattaaaaaacaaggatgctggggaggtcagagtctgcctccgtgtccgcaag
aacaccaaggaccgtctgcgcgaaggagatatccagagcactgtcacttatgacctggct
ttagaccctggccgctcacgtatccgtgccttctttgatgagacaaagaacaacacacgc
aggcgcacccaggtctttggattgatgcagaaatgtgaaacactgaagctaattttaccg
gactgcgtggacgactcagtgagccccatcatcctgcgcctcaattatacactggttggg
gagcccttgaggtcctttgggaacctccgaccagttctggctatggatgctcagaggttc
ttcacagctatgtttccctttgagaaaaattgcggcaatgacagcatctgccaagacgat
ctcagcatcaccatgagtgccatgggcttggacactttggtggtgggaggcccccaggac
tttaacatgagtgtgactctgagaaatgacggtgaggattcctacgggacccaggttacc
gtctactacccatctggcttatcttaccggaaggattcagcaagccagaacccgctcacc
aagaagccttggtttgtaaagcctgctgagtccagctcttcttctgaagggcatggggct
ctgaagagtaccacctggaacataaaccatcccatctttcctgctaattctgaggtcaca
tttaatgtcacatttgatgtggactctcatgcctcctttgggaacaaactgctcctcaaa
gccattgtggccagtgagaacaacatgtccaggacccacaaaaccaagtttcagttggag
ctgcctgtgaagtacgccatctacatgattgtcaccagtgatgagagttctatcagatat
ctcaacttcacggcttcagagatgaccagtaaggtcatacagcatcagtaccagttcaac
aacctgggccagaggagcctccctgtcagtgtagtcttctggatccctgttcagatcaac
aatgtgaccgtatgggatcatccccaggtcatcttctcccagaacctctcaagtgcctgt
cacactgagcagaaatccccccctcactccaatttccgggatcagcttgaaaggacccca
gtgctgaactgctctgttgcagtctgtaagagaattcagtgtgaccttccatccttcaac
actcaggaaatattcaatgtcaccctcaagggcaacctatcatttgactggtacatcaag
acttctcatggtcacctcctgcttgtgagcagcactgagatcctgtttaatgactctgcg
tttgccctgcttccagggcaggagtcgtatgtgaggtctaagacagagaccaaagtggag
ccatatgaagttcacaatcctgtaccactcattgtgggcagctccattgggggcctggtg
ctcttggctctcatcactgctggcctatacaagcttggctttttcaagcggcagtacaag
gacatgatgaatgaagctgccccccaagacgccccacctcagtaa |