Mus musculus (house mouse): 16451 Help Entry 16451             CDS       T01002                                  Symbol Jak1, BAP004, C130039L05Rik Name (RefSeq) Janus kinase 1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism mmu  Mus musculus (house mouse) Pathway mmu01521   EGFR tyrosine kinase inhibitor resistance mmu04151   PI3K-Akt signaling pathway mmu04217   Necroptosis mmu04380   Osteoclast differentiation mmu04550   Signaling pathways regulating pluripotency of stem cells mmu04621   NOD-like receptor signaling pathway mmu04630   JAK-STAT signaling pathway mmu04658   Th1 and Th2 cell differentiation mmu04659   Th17 cell differentiation mmu05140   Leishmaniasis mmu05145   Toxoplasmosis mmu05152   Tuberculosis mmu05160   Hepatitis C mmu05161   Hepatitis B mmu05162   Measles mmu05163   Human cytomegalovirus infection mmu05164   Influenza A mmu05165   Human papillomavirus infection mmu05166   Human T-cell leukemia virus 1 infection mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05168   Herpes simplex virus 1 infection mmu05169   Epstein-Barr virus infection mmu05171   Coronavirus disease - COVID-19 mmu05200   Pathways in cancer mmu05203   Viral carcinogenesis mmu05212   Pancreatic cancer mmu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     16451 (Jak1)    04151 PI3K-Akt signaling pathway     16451 (Jak1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     16451 (Jak1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     16451 (Jak1)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     16451 (Jak1)    04658 Th1 and Th2 cell differentiation     16451 (Jak1)    04659 Th17 cell differentiation     16451 (Jak1)   09158 Development and regeneration    04380 Osteoclast differentiation     16451 (Jak1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     16451 (Jak1)    05203 Viral carcinogenesis     16451 (Jak1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     16451 (Jak1)   09162 Cancer: specific types    05212 Pancreatic cancer     16451 (Jak1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     16451 (Jak1)    05161 Hepatitis B     16451 (Jak1)    05160 Hepatitis C     16451 (Jak1)    05171 Coronavirus disease - COVID-19     16451 (Jak1)    05164 Influenza A     16451 (Jak1)    05162 Measles     16451 (Jak1)    05168 Herpes simplex virus 1 infection     16451 (Jak1)    05163 Human cytomegalovirus infection     16451 (Jak1)    05167 Kaposi sarcoma-associated herpesvirus infection     16451 (Jak1)    05169 Epstein-Barr virus infection     16451 (Jak1)    05165 Human papillomavirus infection     16451 (Jak1)   09171 Infectious disease: bacterial    05152 Tuberculosis     16451 (Jak1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     16451 (Jak1)    05140 Leishmaniasis     16451 (Jak1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     16451 (Jak1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mmu01001]     16451 (Jak1) Enzymes [BR:mmu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      16451 (Jak1) Protein kinases [BR:mmu01001]  Non-receptor tyrosine kinases   JAK family [OT]    16451 (Jak1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 ABC1 RIO1 SH2 Motif Other DBs NCBI-GeneID:  16451 NCBI-ProteinID:  NP_038595 MGI:  96628 Ensembl:  ENSMUSG00000028530 LinkDB All DBs Position 4:complement(101009171..101122493) Genome browser AA seq 1052 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLDREPLRLGSGEYTAEEL CIRAAQECSISPLCHNLFALYDESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENELS RCHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLEYNKHKKDDERNKLR EEWNNFSYFPEITHIVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGT LLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSDIGPFIKLSDPGIPVSVLTRQDPDIVSEKQPTTEVDPTHFEKRFLKRIRDLG EGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKG ICMEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHR DLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIAS DVWSFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPD EVYQLMRKCWEFQPSNRTTFQNLIEGFEALLK NT seq 3159 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggcgttctgtgctaaaatgagg agcttcaagaagactgaggtgaagcaggtggtccctgagcctggagtggaggtgactttc tatctgttggacagggagcccctccgcctgggcagcggagagtatacagccgaggagctg tgcatcagggccgcccaggagtgcagtatctctcctctctgtcacaacctcttcgccctg tacgatgagagcaccaagctctggtacgctccgaaccgaatcatcactgtggatgacaaa acgtctctccggctccactaccgcatgaggttctactttaccaactggcacggaaccaat gacaacgaacagtctgtatggcgacattctccaaagaagcagaaaaacggctatgagaag aaaagggttccagaagcaaccccactccttgatgccagttcactggagtatctgtttgca cagggacagtatgatttgatcaaatgcctggctcccattcgggaccccaagacggagcaa gacggacatgatattgaaaatgagtgcctgggcatggcggtcctggccatctcccactat gccatgatgaagaagatgcagttgccggaacttcccaaagacatcagctacaagcgatat attccagaaacattgaataaatccatcagacagaggaaccttcttaccaggatgcgaata aataatgttttcaaggatttcttgaaggaatttaacaacaagaccatctgtgacagcagt gtgtctacacatgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggagctgaaatatttgagacttctatgctactgatttcatcagaaaatgaattgagt cgatgccattcgaatgacagtggcaatgttctctatgaggtcatggtgactggaaatctc gggatccagtggcggcagaaaccaaatgttgttcctgttgaaaaggaaaaaaataaactg aagcggaaaaaactggaatataataaacacaagaaggatgatgagagaaacaaactccgg gaagagtggaacaatttttcctatttccctgaaatcacccacattgtaataaaggagtct gtggtcagcattaacaaacaggacaacaaaaacatggaactcaagctctcttctcgagag gaagccttgtcctttgtgtccctggtggatggctacttccggctcactgcagatgcccac cattacctctgtactgatgtggctcccccactgattgtccacaatatacagaacggctgc cacggtccaatctgcacagaatatgccatcaataagctgcggcaggaagggagtgaagag gggatgtacgtgctgaggtggagctgcaccgactttgacaacattcttatgactgtcacc tgctttgaaaagtctgaggtattgggtggccagaagcagttcaagaactttcagattgag gtacagaagggccgctacagcctgcatggctctatggaccactttcccagcctgcgagac ctcatgaaccacctcaagaagcagatcctgcgcacggacaacataagctttgtgctgaaa cgatgctgtcagcctaagcctcgagaaatctccaatctgctcgtagccactaagaaagcc caggagtggcagcctgtctactccatgagccagctgagctttgatcggatccttaagaaa gatattatacaaggtgagcaccttggcagaggcacaagaacacatatctattctgggacc ctgctggactacaaggatgaggaaggaattgctgaagagaagaagataaaagtgatcctc aaagtcctagaccccagccaccgggacatctctctggccttctttgaggctgctagcatg atgagacaggtttcccacaaacatatagtgtacctctacggcgtgtgtgtccgagatgtg gaaaatatcatggtggaagagtttgtggagggggggccgttggatctcttcatgcaccgg aaaagtgatgcgcttactaccccctggaagttcaaggttgccaaacagctggccagtgcc ctgagttacttggaagataaagacctggttcatggaaatgtgtgcactaaaaacctcctt ctggcccgtgagggcattgacagtgacattggcccgttcatcaagcttagtgaccctggc atcccagtctctgtgctgaccaggcaagatccagacattgtttcagaaaagcagccaaca acagaggtggaccccactcactttgaaaagcggttcctgaagaggattcgtgacttggga gagggtcactttgggaaggttgagctctgcagatatgatcctgagggagacaacacaggg gagcaggtagctgtcaagtccctgaagcctgagagtggaggtaaccacatagctgatctg aagaaggagatagagatcttacggaacctctaccatgagaacattgtgaagtacaaagga atctgcatggaagacggaggcaatggtatcaagctcatcatggagtttctgccttcggga agcctaaaggagtatctgccaaagaataagaacaaaatcaacctcaaacagcagctaaaa tatgccatccagatttgtaaggggatggactacttgggttctcggcaatacgttcaccgg gacttagcagcaagaaatgtccttgttgagagtgagcatcaagtgaagatcggagacttt ggtttaaccaaagcaattgaaaccgataaggagtactacacagtcaaggacgaccgggac agcccagtgttctggtacgctccggaatgtttaatccagtgtaaattttatatcgcctct gatgtctggtcttttggagtgacactgcacgagctgctcacttactgtgactcagatttt agtcccatggccttgttcctgaaaatgataggcccaactcatggccagatgacagtgaca cggcttgtgaatactctgaaagaaggaaagcgtctgccatgtccacccaactgtcctgat gaggtttatcagcttatgagaaaatgctgggaattccaaccatctaaccggacaactttt cagaaccttattgaaggatttgaagcacttttaaaataa

Mus musculus (house mouse): 16452 Help Entry 16452             CDS       T01002                                  Symbol Jak2, Fd17 Name (RefSeq) Janus kinase 2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism mmu  Mus musculus (house mouse) Pathway mmu01521   EGFR tyrosine kinase inhibitor resistance mmu04062   Chemokine signaling pathway mmu04151   PI3K-Akt signaling pathway mmu04217   Necroptosis mmu04550   Signaling pathways regulating pluripotency of stem cells mmu04630   JAK-STAT signaling pathway mmu04658   Th1 and Th2 cell differentiation mmu04659   Th17 cell differentiation mmu04725   Cholinergic synapse mmu04917   Prolactin signaling pathway mmu04920   Adipocytokine signaling pathway mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04935   Growth hormone synthesis, secretion and action mmu05140   Leishmaniasis mmu05145   Toxoplasmosis mmu05152   Tuberculosis mmu05161   Hepatitis B mmu05164   Influenza A mmu05167   Kaposi sarcoma-associated herpesvirus infection mmu05168   Herpes simplex virus 1 infection mmu05200   Pathways in cancer mmu05207   Chemical carcinogenesis - receptor activation mmu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mmu05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     16452 (Jak2)    04151 PI3K-Akt signaling pathway     16452 (Jak2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     16452 (Jak2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     16452 (Jak2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     16452 (Jak2)    04659 Th17 cell differentiation     16452 (Jak2)    04062 Chemokine signaling pathway     16452 (Jak2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     16452 (Jak2)    04917 Prolactin signaling pathway     16452 (Jak2)    04935 Growth hormone synthesis, secretion and action     16452 (Jak2)   09156 Nervous system    04725 Cholinergic synapse     16452 (Jak2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     16452 (Jak2)    05207 Chemical carcinogenesis - receptor activation     16452 (Jak2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     16452 (Jak2)   09172 Infectious disease: viral    05161 Hepatitis B     16452 (Jak2)    05164 Influenza A     16452 (Jak2)    05168 Herpes simplex virus 1 infection     16452 (Jak2)    05167 Kaposi sarcoma-associated herpesvirus infection     16452 (Jak2)   09171 Infectious disease: bacterial    05152 Tuberculosis     16452 (Jak2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     16452 (Jak2)    05140 Leishmaniasis     16452 (Jak2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     16452 (Jak2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     16452 (Jak2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     16452 (Jak2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mmu01001]     16452 (Jak2) Enzymes [BR:mmu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      16452 (Jak2) Protein kinases [BR:mmu01001]  Non-receptor tyrosine kinases   JAK family [OT]    16452 (Jak2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 ABC1 RIO1 Kinase-like APH Motif Other DBs NCBI-GeneID:  16452 NCBI-ProteinID:  NP_001041642 MGI:  96629 Ensembl:  ENSMUSG00000024789 UniProt:  Q62120 Structure PDB LinkDB All DBs Position 19:29229006..29290495 Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEATSTSPVHQNGDIPGSANSVKQIEPVLQVYLYHSLGQAEGEYLKFPSG EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHDILYRIRFYF PHWYCSGSSRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKEKDQTPLAVYNSVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHKQDGKVLEIELSSLK EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKRNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQMVFHKI RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHKTEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA MHFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL ANLINNCMDYEPDFRPAFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE LLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSLRVDQIRDSIAA NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcctgccttacaatgacagaaatggaggcaacctccacatctcctgtacat cagaatggtgatattcctggaagtgctaattctgtgaagcagatagagccagtccttcaa gtgtatctgtaccattctcttgggcaagctgaaggagagtatctgaagtttccaagtgga gagtatgttgcagaagaaatttgtgtggctgcttctaaagcttgtggtattacgcctgtg tatcataatatgtttgcgttaatgagtgaaaccgaaaggatctggtacccacccaatcat gtcttccacatagacgagtcaaccaggcatgacatactctacaggataaggttctacttc cctcattggtactgtagtggcagcagcagaacctacagatacggagtgtcccgtggggct gaagctcctctgcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttgttcacggatggataaaagtacctgtgactcatgaaactcaggaagagtgtcttggg atggcggtgttagacatgatgagaatagctaaggagaaagaccagactccactggctgtc tataactctgtcagctacaagacattcttaccaaagtgcgttcgagcgaagatccaagac tatcacattttaacccggaagcgaatcaggtacagatttcgcagattcattcagcaattc agtcaatgtaaagccactgccaggaacctaaaacttaagtatcttataaacctggaaacc ctgcagtctgccttctacacagaacagtttgaagtaaaagaatctgcaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaggaaagtgagacactgacagaacaggacgtacagttatattgtgatttc cctgatattattgatgtcagtattaagcaagcaaaccaggaatgctcaaatgaaagtaga attgtaactgtccataaacaagatggtaaagttttggagatagaacttagctcattaaaa gaagccttgtcattcgtgtcattaattgacgggtattacagactaactgcggatgcgcac cattacctctgcaaagaggtggctcccccagctgtgctcgagaacatacacagcaactgc cacggcccaatatcaatggattttgccattagcaaactaaagaaggcgggtaaccagact ggactatatgtgctacgatgcagccctaaggacttcaacaaatactttctgacctttgct gttgagcgagaaaatgtcattgaatataaacactgtttgattacgaagaatgagaatgga gaatacaacctcagcgggactaagaggaacttcagtaaccttaaggaccttttgaattgc taccagatggaaactgtgcgctcagacagtatcatcttccagtttaccaaatgctgcccc ccaaagccaaaagataaatcaaaccttctcgtcttcagaacaaatggtatttctgatgtt cagatctcaccaacattacagaggcataataatgtgaatcaaatggtgtttcacaaaatc aggaatgaagatttaatatttaatgaaagtcttggccaaggtacttttacaaaaattttt aaaggtgtaagaagagaagttggagattatggtcaactgcacaaaacggaagttcttttg aaagtcctagataaagcacataggaactattcagagtctttcttcgaagcagcaagcatg atgagtcagctttctcacaagcatttggttttgaattatggtgtctgtgtctgtggagag gagaacattctggttcaagaatttgtaaaatttggatcactggatacatacctgaagaag aacaaaaattccataaatatattatggaaacttggagtggctaagcagttggcatgggcc atgcattttctagaagaaaaatcccttattcatgggaatgtgtgtgctaaaaatatcctg cttatcagagaagaagacaggagaacggggaacccacctttcatcaaacttagtgatcct ggcattagcattacagttctaccgaaggacattcttcaggagagaataccatgggtacct cctgaatgcattgagaatcctaaaaatctcaatctggcaacagacaagtggagcttcggg accactctgtgggagatctgcagtggaggagataagcccctgagtgctctggattctcaa agaaagctgcagttctatgaagataagcatcagcttcctgcacccaagtggacagagtta gcaaaccttataaataattgcatggactatgagccagatttcaggcctgctttcagagct gtcatccgtgatcttaacagcctgtttactccagattatgaactactaacagaaaatgac atgctaccaaacatgagaataggtgccctagggttttctggtgcttttgaagacagggac cctacacagtttgaagagagacacttgaagtttctacagcagcttggcaaaggtaacttc gggagtgtggagatgtgccgctatgacccgctgcaggacaacactggcgaggtggtcgct gtgaagaaactccagcacagcactgaagagcacctccgagactttgagagggagatcgag atcctgaaatccttgcagcatgacaacatcgtcaagtacaagggagtgtgctacagtgcg ggtcggcgcaacctaagattaattatggaatatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcacaaaaaacttcttcaatacacatctcagata tgcaagggcatggaatatcttggtacaaaaaggtatatccacagggacctggcaacaagg aacatattggtggaaaatgagaacagggttaaaataggagacttcggattaaccaaagtc ttgccgcaggacaaagaatactacaaagtaaaggagccaggggaaagccccatattctgg tacgcacctgaatccttgacggagagcaagttttctgtggcctcagatgtgtggagcttt ggagtggttctatacgaacttttcacatacatcgagaagagtaaaagtccacccgtggaa tttatgcgaatgattggcaatgataaacaagggcaaatgattgtgttccatttgatagag ctactgaagagcaacggaagattgccaaggccagaaggatgcccagatgagatttatgtg atcatgacagagtgctggaacaacaatgtgagccagcgtccctccttcagggacctttcc cttcgggtggatcaaatccgggacagtatagctgcgtga

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