Mus musculus (house mouse): 18015 Help Entry 18015             CDS       T01002                                  Symbol Nf1, Dsk9, E030030H24Rik, Mhdadsk9, Nf-1 Name (RefSeq) neurofibromin 1   KO K08052   neurofibromin 1 Organism mmu  Mus musculus (house mouse) Pathway mmu01521   EGFR tyrosine kinase inhibitor resistance mmu04010   MAPK signaling pathway mmu04014   Ras signaling pathway Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     18015 (Nf1)    04014 Ras signaling pathway     18015 (Nf1)  09160 Human Diseases   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     18015 (Nf1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2 Motif Other DBs NCBI-GeneID:  18015 NCBI-ProteinID:  NP_035027 MGI:  97306 Ensembl:  ENSMUSG00000020716 UniProt:  Q04690 LinkDB All DBs Position 11:79223541..79472435 Genome browser AA seq 2841 aa AA seqDB search MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDESNINKKLFL DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK PTDLETRSYKCLLLSMVKLIHADPKLLLCNPRKQGPETQSSTAELITGLVQLVPQSHMPE VAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL REILICRNKFLLKNKQADRSSCHSLYLYGVGCEMSATGNTTQMSVDHDEFLRACTPGASL RKGRGNSSMDSTAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEAD IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNIEAWE DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI NMTGFLCALGGVCLQQRSSSGLATYSPPMGAVSERKGSMISVMSSEGNIDSPVSRFMDRL LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLSDSNT QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDIKCLTRDLDQASMEAVVS LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVIITSSDWQHVS FEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPSQLRSVCHCLYQATCHSLLN KATVKERKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG LKLMSKVLQSIANHVLFTKEEHMRPFNDFVKSNFDLARRFFLDIASDCPTSDAVNHSLSF ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA HLPYLFHVVTFLVATGPLSLRASTHGLLINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC LKGPDTYNSQVLIESTVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL EQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR KSLLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPAVGQTSPRA RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE METQRIPSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP TSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGLDKENVELSPTAGHCNSGRTRHGSA SQVQKQRSAGSFKRNSIKKIV NT seq 8526 nt NT seq  +upstreamnt  +downstreamnt atggccgcacacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag cttccaataaagacaggacagcagaacacacataccaaagtcagcaccgagcacaacaag gagtgtctgatcaacatttccaaatacaagttttctctggtcatcagtgggctcaccacc atcctaaagaatgttaacaatatgaggatatttggagaagctgctgaaaaaaatttgtat ctctctcagttgatcatattggatacactggaaaaatgtcttgctgggcaaccaaaggac acaatgagattagatgagacaatgctggtcaaacaattactaccagaaatctgccatttt cttcacacctgccgtgaaggaaaccaacatgcagccgaacttcggaattctgcctctggg gttttattttctctcagctgcaacaacttcaatgcagtctttagtcgcatttctacaagg ttacaggagttgactgtctgttcagaagataatgttgatgttcacgatatagaattgtta cagtatatcaatgtggattgtgcaaaattaaaacgacttctgaaggaaacagcatttaaa tttaaagccctgaagaaggttgcacagttggcagttataaatagcctagaaaaggctttt tggaactgggtagaaaattatccggatgaatttacaaagctataccaaattccacagaca gatatggctgaatgtgcagagaagctgtttgacttggtggatggttttgcagaaagcacc aaacgtaaagcagcagtgtggcccctacaaatcattctccttatcttgtgtccagaaata atccaggacatctccaaggatgtggtggacgagagcaacataaacaagaagctgtttctg gacagtttacggaaagcactcgctggccatggaggaagcaggcagctgactgagagtgct gccattgcttgtgtcaagttgtgtaaagcaagtacttacatcaactgggaagataattct gtcattttcctactggttcagtccatggtagttgatcttaagaacctgctttttaatcca agtaaaccattctctagaggcagtcagcctgcagatgtggacctcatgattgactgtctt gtctcttgctttcggataagccctcacaacaaccaacactttaagatctgcctggctcag aattcaccttctacatttcactatgtgttggtaaactcactgcaccgcatcatcaccaat tctgcgttggattggtggcctaagattgatgctgtatattgtcactcagttgaacttcgc aatatgtttggtgaaacacttcataaagcagtgcaaggctgtggagcgcacccagcaata cgaatggcaccaagtctcacctttaaagaaaaggtaacaagccttaaatttaaagaaaag cctacagacctagagacaaggagctacaaatgtcttcttttgtccatggtgaaactgatt catgcagacccaaagcttttgctttgtaatccaagaaaacagggccctgaaactcagagc agtacagcagaactaattacagggctcgtacaactggttcctcagtcacacatgccagag gtcgctcaggaggctatggaggctttgctggtccttcatcagttagatagcattgatctc tggaatcctgacgctcctgtagagacattctgggaaatcagctcacaaatgcttttttac atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaagtggtta cgggaaattctgatctgcagaaataaatttcttcttaaaaataagcaggcagatagaagc tcctgtcattctctctacctttatggagtaggatgtgaaatgtctgctactggaaatacc actcagatgtcagttgatcatgatgagttcctgcgtgcctgtactcctggagcatctctg cggaaaggaagagggaattcctccatggatagcacagcagggtgcagtggaaccccacct atatgccgacaagcccagaccaagctagaagtggccttatacatgtttctgtggaatcct gacactgaagctgttctggttgctatgtcctgtttccgccacctctgtgaagaagcagat attcgatgtggggtagatgaagtgtcagtacacaacttcttgcccaactataacacattc atggaatttgcctcagtcagcaatatgatgtcaacaggaagagcagcgcttcagaaaaga gtgatggccctgctaaggcgcattgagcaccctactgcaggaaacattgaggcctgggaa gatacacatgcaaagtgggaacaggctacaaaactaatccttaactacccaaaagccaaa atggaagatggccaggctgcagaaagtcttcataagaccattgttaagagacggatgtcc catgtcagtggaggaggctccatagacttgtctgacacagactccctgcaggagtggatc aacatgactggcttcctttgtgcccttggtggggtgtgcctgcaacagagaagcagctct ggcctagcgacatacagcccacctatgggcgctgtcagtgaacgcaaagggtctatgatt tctgtaatgtcttctgaagggaatattgattcacctgtcagcagatttatggaccggctt ctgtccttaatggtgtgtaaccacgagaaagtggggcttcagatacggaccaatgttaag gacctggtgggtctggagttgagtcctgctctgtatccaatgctgtttaacaaactgaag aataccatcagcaagttttttgactctcaaggacaggtattactaagtgacagcaatact cagtttgtagagcaaaccatagccataatgaaaaacctactggataatcatactgaaggc agctctgagcatctgggacaagcgagcattgagacaatgatgctaaatctggtcagatac gttcgtgttcttgggaatatggtccatgcaatacaaataaaaacaaaattgtgtcagtta gttgaagtcatgatggcaagaagagatgacctctcgttttgtcaagagatgaaatttagg aataagatggtagaatatctaacagactgggttatgggaacatcaaaccaagcagcagat gatgacataaaatgtcttacgagagatctggaccaagcaagcatggaagcagtagtttct ctcctcgctggtcttccactgcagcccgaagaaggagatggggtggagctgatggaggcc aaatcacagttattccttaagtacttcacattatttatgaaccttttgaatgactgtagt gaagttgaagatgaaaatgcacaaacgggtggcaggaaacgtggcatgtctcggaggctg gcatccctgaggcactgtacagtgcttgcaatgtcaaacttactcaatgctaatgtggac agtggactcatgcactccataggcttaggttatcacaaggatcttcagacaagagctacg tttatggaagttctgacaaaaatccttcaacaaggaacagaattcgatacacttgcggaa acggtgttggcagatcgatttgagagacttgtggaactggtcacaatgatgggagaccag ggagaactccctatagctatggctcttgccaatgtggtcccttgttctcagtgggatgag ctggctcgggttctggtcactctgtttgattcccggcatttactctaccagctgctctgg aacatgttttctaaggaggtagaattggcagactccatgcagactctctttcgaggcaac agcttggccagtaagataatgacattctgcttcaaggtgtatggtgctacttacctacaa aagctcttggaccctttattacgagtcatcatcacatcttcggattggcaacatgttagc tttgaagtggatcctaccaggttagaaccctctgagagccttgaggagaaccagaggaac ctccttcagatgacagagaagttcttccatgccatcatcagctcttcctcagaattcccc tcacagcttcgaagtgtctgccattgtttgtaccaggcaacttgccactccctactgaat aaagctacagtaaaagaaagaaaggaaaacaaaaaatcagtggttagccagcgcttccct cagaacagcatcggtgccgtaggaagtgccatgtttctcagattcatcaatcctgccatt gtctcgccgtatgaagcagggattttagataaaaagccaccacctagaattgaaaggggc ttgaagttaatgtcaaaggtacttcagagcattgccaatcatgtactgttcacaaaagaa gagcatatgagaccttttaatgattttgtgaaaagcaactttgacttggcacgaaggttt ttcctagatatagcatcagattgtcccacaagtgatgcagtaaaccatagtctttccttc atcagcgatggcaatgtgcttgctttacatcggctgctttggaacaatcaggagaaaatt ggccagtatctttccagtaacagggatcataaagctgttggaagacgaccttttgataag atggccacacttctcgcgtatctgggtcctccggagcacaagcctgtggcagatacacac tggtccagccttaaccttaccagttcaaagtttgaggaatttatgaccaggcaccaggta catgagaaagaagagttcaaggccttgaaaacgttaagcatcttctaccaagctggcacc tccaaagctgggaatcctattttttattatgttgcacggaggttcaaaactggccagatc aatggtgatctgctgatataccatgtcttgctgactttaaagccatattatgcaaagcca tatgaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacagacttc ctctctaagtggtttgttgtctttcctggctttgcctatgacaacgtctctgcagtctat atctataactgtaactcctgggtcagggagtataccaaataccatgagcggctgctgact ggcctcaagggcagcaaaaggctcattttcatcgactgtcctgggaagctggctgaacat atagagcatgagcaacagaaactccctgctgctaccttggctttggaagaagatctaaag gttttccacaatgctctcaagttagctcacaaggacaccaaagtttctattaaggttggt tctactgctgttcaggtaacttcagcagaaagaacaaaagttttggggcaatccgtcttt ttaaatgatatttactatgcttctgaaatcgaagagatctgcctagttgatgagaaccag ttcactctaaccattgcaaaccaaggcacaccactgaccttcatgcaccaagaatgtgaa gccattgttcagtctatcattcatatcaggacccgctgggagctgtcacaacctgactcc atccctcagcataccaagattcgaccaaaggatgtccctgggacactgcttaatattgcg ttactgaatttgggcagttcagaccctagtttacggtctgctgcctataatctcctgtgt gccttaacctgcacctttaatttaaagattgaaggtcagttgctagagacatcggggtta tgcatccctgccaacaacacactcttcattgtctctatcagtaagacgctcgcagccaat gagccacacctcaccttagagtttttggaagagtgtatttctggatttagcaaatctagt attgaattgaagcacctttgtttggaatatatgaccccatggctgtcaaatctagtccgt ttttgtaagcataatgatgatgccaaacgacaaagggttactgccatccttgataagcta ataacaatgactataaacgagaagcagatgtatccttctattcaagcaaaaatctggggg agccttgggcagatcacagacctgctggatgttgtgcttgacagtttcatcaagaccagt gcgacaggaggcttagggtctatcaaagctgaggtgatggcagacacagctgtggcttta gcttctggaaatgtgaaattggtgtcgagtaaggttattggaaggatgtgtaaaataatt gacaagacttgcttatccccaactccaactttagaacaacatcttatgtgggacgacatt gccattttagcccgctacatgctgatgctgtccttcaacaactccctcgatgtggcggct catctgccctatctcttccatgttgtcactttcttagtagccacaggtcccttgtccctc cgagcttccacacatgggctgctcatcaatatcattcactctctgtgtacttgttctcag cttcactttagtgaagagaccaagcaagttttgaggctcagtctaacagagttctcgtta cccaaattttacttactgtttggcattagcaaagtcaagtcggctgctgtcattgccttc cgttccagttaccgggaccgctccttctcccctggctcctatgagagggagacttttgct ttgacgtccctggaaacagtcacagaagctttgttggagatcatggaggcatgtatgaga gatattccaacatgcaagtggctggatcagtggacagaactagctcaaagatttgcgttt cagtataacccatcgctgcagccaagagctcttgtggtgtttggctgtattagcaaacga gtgtctcatgggcagataaagcagattatccgaattcttagcaaggcacttgaaagttgt ttaaaaggacctgacacttacaacagtcaagttctgatagaatctacggtgatagcacta acaaaattacagccgcttcttaataaggactcgcccctgcacaaagccctcttttgggtt gctgtggctgtgctgcagctggacgaagtcaacttgtattcagccggcactgcacttctg gaacaaaacctgcacaccttggacagtctccggatattcaatgacaagagtccggaagaa gtatttatggcgatccggaatcctctggaatggcactgcaagcagatggatcactttgtc ggactcaacttcaactctaactttaactttgcactagttggacacctcttaaaagggtac aggcatccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaact ctcgttaacaaacatagaaattgtgacaaatttgaggtgaatacacagagtgtggcttac ttagcagctctactcacagtgtctgaagaggttcgaagtcgctgtagcctcaagcatagg aagtcccttcttcttactgatatttcaatggaaaatgttcctatggatacatatcccatt catcacggtgaccccagctataggacactaaaggagacccagccatggtcctctcccaaa ggttcagaaggataccttgcagccacctacccagctgtaggccaaaccagtccccgagcc aggaaatccatgagcttggatatgggacagccttctcaggccaacacaaaaaaattgctt ggaacaagaaaaagttttgatcacttgatatctgacacaaaggctcctaaaagacaagaa atggaatcagggattacaacacccccgaaaatgagaagagtggcagagactgactatgaa atggaaacccaaaggattccctcctcgcagcagcacccacatttacggaaagtctcagtc tctgaatcaaatgttcttttggatgaagaagttcttaccgacccaaagatccaagcgctg cttcttactgttctggctacactggtaaaatatactacagatgaatttgatcaacggatt ctttatgaatatctagcagaggccagcgttgtgtttcccaaagtgtttcctgttgtgcac aatttgttggactctaagatcaataccctcttgtctttatgccaagatccaaatttgtta aatccaatccatggaattgtacagagtgtggtgtaccatgaggagtccccgccacagtac cagacatcttacctgcaaagttttggttttaatggcttatggcggtttgcaggacccttt tcaaagcaaacacaaatccctgactatgctgagctcattgttaaatttcttgatgccttg attgacacgtacttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc acatctccttaccctcctgcactgcagagccagcttagtatcactgccaaccttaacctc tctaattccatgacctcacttgcaacttcccagcattccccaggactcgacaaggagaac gttgaactctcccccaccgctggccactgtaacagtggacggactcgccatggatccgca agccaagtgcagaagcaaagaagtgctggcagtttcaaacgtaatagcattaagaagatc gtgtga

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