Mus musculus (house mouse): 18126
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Entry
18126 CDS
T01002
Symbol
Nos2, MAC-NOS, NOS-II, Nos-2, Nos2a, i-NOS, iNOS
Name
(RefSeq) nitric oxide synthase 2, inducible
KO
K13241
nitric-oxide synthase, inducible [EC:
1.14.13.39
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00220
Arginine biosynthesis
mmu00330
Arginine and proline metabolism
mmu01100
Metabolic pathways
mmu04020
Calcium signaling pathway
mmu04066
HIF-1 signaling pathway
mmu04146
Peroxisome
mmu04371
Apelin signaling pathway
mmu04926
Relaxin signaling pathway
mmu05010
Alzheimer disease
mmu05014
Amyotrophic lateral sclerosis
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05133
Pertussis
mmu05140
Leishmaniasis
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05146
Amoebiasis
mmu05152
Tuberculosis
mmu05200
Pathways in cancer
mmu05222
Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
18126 (Nos2)
00330 Arginine and proline metabolism
18126 (Nos2)
09130 Environmental Information Processing
09132 Signal transduction
04371 Apelin signaling pathway
18126 (Nos2)
04066 HIF-1 signaling pathway
18126 (Nos2)
04020 Calcium signaling pathway
18126 (Nos2)
09140 Cellular Processes
09141 Transport and catabolism
04146 Peroxisome
18126 (Nos2)
09150 Organismal Systems
09152 Endocrine system
04926 Relaxin signaling pathway
18126 (Nos2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
18126 (Nos2)
09162 Cancer: specific types
05222 Small cell lung cancer
18126 (Nos2)
09171 Infectious disease: bacterial
05133 Pertussis
18126 (Nos2)
05152 Tuberculosis
18126 (Nos2)
09174 Infectious disease: parasitic
05146 Amoebiasis
18126 (Nos2)
05145 Toxoplasmosis
18126 (Nos2)
05140 Leishmaniasis
18126 (Nos2)
05142 Chagas disease
18126 (Nos2)
09164 Neurodegenerative disease
05010 Alzheimer disease
18126 (Nos2)
05014 Amyotrophic lateral sclerosis
18126 (Nos2)
05022 Pathways of neurodegeneration - multiple diseases
18126 (Nos2)
Enzymes [BR:
mmu01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
18126 (Nos2)
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Ortholog
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
NAD_binding_6
KCTD11_21_C
Motif
Other DBs
NCBI-GeneID:
18126
NCBI-ProteinID:
NP_035057
MGI:
97361
Ensembl:
ENSMUSG00000020826
UniProt:
P29477
Structure
PDB
PDBj
LinkDB
All DBs
Position
11:78811613..78851052
Genome browser
AA seq
1144 aa
AA seq
DB search
MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQ
NVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLT
RGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDEL
IFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITV
FPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLP
LVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPA
CPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSF
QKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLS
PFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATE
TGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLK
KSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQE
DAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSS
IHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQG
ILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKL
ARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPR
YYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSG
FQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQ
EEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVR
MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPK
ATRL
NT seq
3435 nt
NT seq
+upstream
nt +downstream
nt
atggcttgcccctggaagtttctcttcaaagtcaaatcctaccaaagtgacctgaaagag
gaaaaggacattaacaacaacgtgaagaaaaccccttgtgctgttctcagcccaacaata
caagatgaccctaagagtcaccaaaatggctccccgcagctcctcactgggacagcacag
aatgttccagaatccctggacaagctgcatgtgacatcgacccgtccacagtatgtgagg
atcaaaaactggggcagtggagagattttgcatgacactcttcaccacaaggccacatcg
gatttcacttgcaagtccaagtcttgcttggggtccatcatgaaccccaagagtttgacc
agaggacccagagacaagcctacccctctggaggagctcctgcctcatgccattgagttc
atcaaccagtattatggctcctttaaagaggcaaaaatagaggaacatctggccaggctg
gaagctgtaacaaaggaaatagaaacaacaggaacctaccagctcactctggatgagctc
atctttgccaccaagatggcctggaggaatgcccctcgctgcatcggcaggatccagtgg
tccaacctgcaggtctttgacgctcggaactgtagcacagcacaggaaatgtttcagcac
atctgcagacacatactttatgccaccaacaatggcaacatcaggtcggccatcactgtg
ttcccccagcggagtgacggcaaacatgacttcaggctctggaattcacagctcatccgg
tacgctggctaccagatgcccgatggcaccatcagaggggatgctgccaccttggagttc
acccagttgtgcatcgacctaggctggaagccccgctatggccgctttgatgtgctgcct
ctggtcttgcaagctgatggtcaagatccagaggtctttgaaatccctcctgatcttgtg
ttggaggtgaccatggagcatcccaagtacgagtggttccaggagctcgggttgaagtgg
tatgcactgcctgccgtggccaacatgctactggaggtgggtggcctcgaattcccagcc
tgccccttcaatggttggtacatgggcaccgagattggagttcgagacttctgtgacaca
cagcgctacaacatcctggaggaagtgggccgaaggatgggcctggagacccacacactg
gcctccctctggaaagaccgggctgtcacggagatcaatgtggctgtgctccatagtttc
cagaagcagaatgtgaccatcatggaccaccacacagcctcagagtccttcatgaagcac
atgcagaatgagtaccgggcccgtggaggctgcccggcagactggatttggctggtccct
ccagtgtctgggagcatcacccctgtgttccaccaggagatgttgaactatgtcctatct
ccattctactactaccagatcgagccctggaagacccacatctggcagaatgagaagctg
aggcccaggaggagagagatccgatttagagtcttggtgaaagtggtgttctttgcttcc
atgctaatgcgaaaggtcatggcttcacgggtcagagccacagtcctctttgctactgag
acagggaagtctgaagcactagccagggacctggccaccttgttcagctacgccttcaac
accaaggttgtctgcatggaccagtataaggcaagcaccttggaagaggagcaactactg
ctggtggtgacaagcacatttgggaatggagactgtcccagcaatgggcagactctgaag
aaatctctgttcatgcttagagaactcaaccacaccttcaggtatgctgtgtttggcctt
ggctccagcatgtaccctcagttctgcgcctttgctcatgacatcgaccagaagctgtcc
cacctgggagcctctcagcttgccccaacaggagaaggggacgaactcagtgggcaggag
gatgccttccgcagctgggctgtacaaaccttccgggcagcctgtgagacctttgatgtc
cgaagcaaacatcacattcagatcccgaaacgcttcacttccaatgcaacatgggagcca
cagcaatataggctcatccagagcccggagcctttagacctcaacagagccctcagcagc
atccatgcaaagaacgtgtttaccatgaggctgaaatcccagcagaatctgcagagtgaa
aagtccagccgcaccaccctcctcgttcagctcaccttcgagggcagccgagggcccagc
tacctgcctggggaacacctggggatcttcccaggcaaccagaccgccctggtgcaggga
atcttggagcgagttgtggattgtcctacaccacaccaaactgtgtgcctggaggttctg
gatgagagcggcagctactgggtcaaagacaagaggctgcccccctgctcactcagccaa
gccctcacctacttcctggacattacgacccctcccacccagctgcagctccacaagctg
gctcgctttgccacggacgagacggataggcagagattggaggccttgtgtcagccctca
gagtacaatgactggaagttcagcaacaaccccacgttcctggaggtgcttgaagagttc
ccttccttgcatgtgcccgctgccttcctgctgtcgcagctccctatcttgaagccccgc
tactactccatcagctcctcccaggaccacaccccctcggaggttcacctcactgtggcc
gtggtcacctaccgcacccgagatggtcagggtcccctgcaccatggtgtctgcagcact
tggatcaggaacctgaagccccaggacccagtgccctgctttgtgcgaagtgtcagtggc
ttccagctccctgaggacccctcccagccttgcatcctcattgggcctggtacgggcatt
gctcccttccgaagtttctggcagcagcggctccatgactcccagcacaaagggctcaaa
ggaggccgcatgagcttggtgtttgggtgccggcacccggaggaggaccacctctatcag
gaagaaatgcaggagatggtccgcaagagagtgctgttccaggtgcacacaggctactcc
cggctgcccggcaaacccaaggtctacgttcaggacatcctgcaaaagcagctggccaat
gaggtactcagcgtgctccacggggagcagggccacctctacatttgcggagatgtgcgc
atggctcgggatgtggctaccacattgaagaagctggtggccaccaagctgaacttgagc
gaggagcaggtggaagactatttcttccagctcaagagccagaaacgttatcatgaagat
atcttcggtgcagtcttttcctatggggcaaaaaagggcagcgccttggaggagcccaaa
gccacgaggctctga
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