Mus musculus (house mouse): 18127
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Entry
18127 CDS
T01002
Symbol
Nos3, 2310065A03Rik, Nos-3, eNOS, ecNOS
Name
(RefSeq) nitric oxide synthase 3, endothelial cell
KO
K13242
nitric-oxide synthase, endothelial [EC:
1.14.13.39
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu00220
Arginine biosynthesis
mmu00330
Arginine and proline metabolism
mmu01100
Metabolic pathways
mmu04020
Calcium signaling pathway
mmu04022
cGMP-PKG signaling pathway
mmu04066
HIF-1 signaling pathway
mmu04071
Sphingolipid signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04370
VEGF signaling pathway
mmu04371
Apelin signaling pathway
mmu04611
Platelet activation
mmu04915
Estrogen signaling pathway
mmu04921
Oxytocin signaling pathway
mmu04926
Relaxin signaling pathway
mmu04931
Insulin resistance
mmu04933
AGE-RAGE signaling pathway in diabetic complications
mmu05415
Diabetic cardiomyopathy
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09100 Metabolism
09105 Amino acid metabolism
00220 Arginine biosynthesis
18127 (Nos3)
00330 Arginine and proline metabolism
18127 (Nos3)
09130 Environmental Information Processing
09132 Signal transduction
04370 VEGF signaling pathway
18127 (Nos3)
04371 Apelin signaling pathway
18127 (Nos3)
04066 HIF-1 signaling pathway
18127 (Nos3)
04020 Calcium signaling pathway
18127 (Nos3)
04071 Sphingolipid signaling pathway
18127 (Nos3)
04022 cGMP-PKG signaling pathway
18127 (Nos3)
04151 PI3K-Akt signaling pathway
18127 (Nos3)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
18127 (Nos3)
09152 Endocrine system
04915 Estrogen signaling pathway
18127 (Nos3)
04921 Oxytocin signaling pathway
18127 (Nos3)
04926 Relaxin signaling pathway
18127 (Nos3)
09160 Human Diseases
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
18127 (Nos3)
05418 Fluid shear stress and atherosclerosis
18127 (Nos3)
05415 Diabetic cardiomyopathy
18127 (Nos3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
18127 (Nos3)
04933 AGE-RAGE signaling pathway in diabetic complications
18127 (Nos3)
Enzymes [BR:
mmu01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
1.14.13.39 nitric-oxide synthase (NADPH)
18127 (Nos3)
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Gene cluster
GFIT
Motif
Pfam:
NO_synthase
FAD_binding_1
Flavodoxin_1
NAD_binding_1
Motif
Other DBs
NCBI-GeneID:
18127
NCBI-ProteinID:
NP_032739
MGI:
97362
Ensembl:
ENSMUSG00000028978
UniProt:
P70313
Q8C5P3
LinkDB
All DBs
Position
5:24569772..24589472
Genome browser
AA seq
1202 aa
AA seq
DB search
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPAPPSPTRPAPDHSPPLTR
PPDGPRFPRVKNWEVGSITYDTLSAQAQQDGPCTSRRCLGSLVFPRKLQSRPTQGPSPTE
QLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVAATGTYQLRESELVFGAKQAWRNA
PRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRCPGRGDF
RIWNSQLIRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPE
LFTLPPEMVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSE
IGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTIVDHH
AATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWK
GSAAKGAGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRL
FRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSP
RPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFC
AFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAAR
DIFSPKRSWKRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSKSTRATILV
RLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPP
PGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYE
EWKWFSCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTIAVLA
YRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPF
RGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDP
GSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGGMELDE
AGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPGPEIP
GS
NT seq
3609 nt
NT seq
+upstream
nt +downstream
nt
atgggcaacttgaagagtgtgggccaggagcctgggccaccctgtggcctagggctcggg
ctgggtttagggctgtgcggcaagcagggcccagcctctccagcaccggagcctagccag
gcgccagcacccccgtccccaacccgaccagcaccagaccacagccccccgctaacccgg
cccccagacggacccaggtttcctcgagtaaagaattgggaagtgggcagcatcacctac
gacaccctcagtgcccaggctcagcaggatgggccctgtacctcaagacgctgcttggga
tccctggtgtttccaaggaagttacagagccggcccacccagggcccttcacccactgag
cagctattgggtcaagcccgggacttcatcaatcagtactataactccatcaaaaggagt
ggctcccaggctcatgagcagcggcttcaggaagtggaggctgaggtggcagccacaggc
acctaccagctccgggagagcgagctggtgtttggggccaagcaggcctggcgcaatgct
ccccgctgtgtgggccggatccagtggggaaagctgcaggtatttgatgctcgggactgc
aggactgcacaggaaatgttcacctacatctgtaaccacattaaatacgcaacaaataga
ggcaatcttcgttcagccatcacagtgttcccccagcgctgccctggccggggagacttc
cggatctggaacagccagctgatacgctatgcgggctataggcagcaggatggctccgtg
cgaggggaccccgccaacgtggagatcactgagctctgtatccaacatggctggacccca
ggaaatggccgctttgatgtgctgcccctgttactccaggctcctgatgagcccccagaa
ctcttcactctgcccccagagatggtcctcgaggtgcctctggagcaccccacgctcgag
tggtttgctgcccttggcctgcgctggtatgccctcccagctgtgtccaacatgctgcta
gaaatcgggggcctggagtttcctgctgcccctttcagcggctggtacatgagttcagag
attggcatgagggacctgtgtgaccctcaccgctacaacatacttgaggatgtggctgtg
tgcatggatctggacaccaggacaacctcatccctgtggaaagacaaggcagcggtggaa
attaatgtggccgtgttgcacagttaccagctggccaaagtgaccatagtggaccaccac
gccgccacagcctccttcatgaagcacctggaaaatgagcagaaggccagagggggctgc
cctgccgattgggcctggattgtgccccccatctcaggcagcctaactcctgtcttccat
caagagatggtcaactatttcctgtcccctgccttccgctaccagccagacccctggaag
ggaagtgcagcaaagggggcaggcatcaccaggaagaagacctttaaggaagtagccaat
gcagtgaagatctctgcctcactcatgggcacggtgatggcgaagcgtgtgaaggcaacc
attctgtatggctctgagactggccgggcccagagctacgcacagcagctgggaagactc
ttccggaaggcgtttgatccccgggtcctgtgcatggatgagtatgatgtggtgtcccta
gagcacgaggcactggtgttggtggtgaccagcacatttggcaatggggatcctccggag
aatggagagagctttgcagcagcgctcatggaaatgtcaggcccgtacaacagctcccct
aggcctgagcagcacaagagctacaaaatccgattcaacagtgtctcctgctcagaccca
ctggtatcctcttggcggcgcaagaggaaggagtctagcaacacagacagtgcaggagcc
ctgggcaccctcaggttctgtgtgtttgggctgggctcccgagcatacccccacttctgt
gcctttgctcgagcggtggacacaaggctggaggagctgggcggggagcgactactgcag
ctgggccaaggtgatgagctctgtggccaggaggaggctttccgaggctgggcccaggcc
gccttccaggctgcctgtgaaaccttctgtgtgggagaagatgccaaagctgctgcccga
gatatcttcagccccaaacgcagctggaagcgccagaggtaccggctgagtacccaggct
gagagcctgcaattactaccagggctgactcacgtgcacaggcggaagatgttccaggct
acaatcctctctgtggaaaacctacagagcagcaaatccacccgagccacgatcctggtg
cgtctggacaccggaggccaggagggactgcagtaccagccaggggaccacataggtgtg
tgcccacccaaccgtcctggcctagtggaggcactgctgagccgagtggaggaccctccg
ccatccacagaacctgtggctgtggaacaactggagaaaggcagccctggtggccctccc
cccggctgggtacgggacccccggctacccccatgtacgctgcggcaggctctcacctac
ttcctggacatcacttccccgcctagtcctcgcctccttcgactgctcagcaccctggca
gaagagtccagcgaacagcaggagctagaggctctcagccaggacccccggcgctacgaa
gaatggaagtggttcagctgccccacactgctagaggtgctggagcaatttccttcagtg
gcactgcctgccccgctgatcctcacccagctgcccttgctccagccccggtactactct
gtcagttcagcacccagcgcccacccaggagagatccacctcaccatagctgtgctggct
tacagaacccaggatgggctgggccctctgcactacggtgtctgctccacgtggatgagc
cagctcaaggcgggagatccagtgccctgcttcatcaggggggctccctccttccggctg
ccacctgatcctaacttgccctgcatcctggtgggcccagggactggcattgcacccttc
cggggattctggcaagacagactacacgacattgagatcaaagggctacaacctgccccc
atgactttggtgtttggctgccgatgctcccaactggaccatctctaccgggacgaggta
ctggacgcccagcagcgtggggtgtttggacaagtcctcaccgccttttccagggatcct
ggcagccccaagacctacgtgcaagacctcctgaggacagagctagccgcggaggttcac
cgtgtgctgtgccttgagcaaggacatatgtttgtctgcggcgatgtcactatggcaacc
agcgtcctgcaaaccgtgcagagaattctggcaacagagggcggcatggagctggatgaa
gccggtgacgtcatcggcgtgctgcgggatcagcaacgctaccacgaggacattttcgga
ctcacattgcgcacccaggaggtgacaagccgcatacgcacccagagcttttctttgcag
gagcgacagctgaggggcgcagtgccctggtcctttgacccgcctggcccagaaatacct
ggttcctga
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integrated database retrieval system
