Mus musculus (house mouse): 18750 Help Entry 18750             CDS       T01002                                  Symbol Prkca, Pkca Name (RefSeq) protein kinase C, alpha   KO K02677   classical protein kinase C alpha type [EC:2.7.11.13] Organism mmu  Mus musculus (house mouse) Pathway mmu01521   EGFR tyrosine kinase inhibitor resistance mmu04010   MAPK signaling pathway mmu04012   ErbB signaling pathway mmu04014   Ras signaling pathway mmu04015   Rap1 signaling pathway mmu04020   Calcium signaling pathway mmu04066   HIF-1 signaling pathway mmu04070   Phosphatidylinositol signaling system mmu04071   Sphingolipid signaling pathway mmu04072   Phospholipase D signaling pathway mmu04150   mTOR signaling pathway mmu04151   PI3K-Akt signaling pathway mmu04261   Adrenergic signaling in cardiomyocytes mmu04270   Vascular smooth muscle contraction mmu04310   Wnt signaling pathway mmu04360   Axon guidance mmu04370   VEGF signaling pathway mmu04510   Focal adhesion mmu04540   Gap junction mmu04613   Neutrophil extracellular trap formation mmu04650   Natural killer cell mediated cytotoxicity mmu04664   Fc epsilon RI signaling pathway mmu04666   Fc gamma R-mediated phagocytosis mmu04670   Leukocyte transendothelial migration mmu04713   Circadian entrainment mmu04720   Long-term potentiation mmu04723   Retrograde endocannabinoid signaling mmu04724   Glutamatergic synapse mmu04725   Cholinergic synapse mmu04726   Serotonergic synapse mmu04727   GABAergic synapse mmu04728   Dopaminergic synapse mmu04730   Long-term depression mmu04750   Inflammatory mediator regulation of TRP channels mmu04911   Insulin secretion mmu04912   GnRH signaling pathway mmu04916   Melanogenesis mmu04918   Thyroid hormone synthesis mmu04919   Thyroid hormone signaling pathway mmu04921   Oxytocin signaling pathway mmu04925   Aldosterone synthesis and secretion mmu04926   Relaxin signaling pathway mmu04928   Parathyroid hormone synthesis, secretion and action mmu04929   GnRH secretion mmu04933   AGE-RAGE signaling pathway in diabetic complications mmu04935   Growth hormone synthesis, secretion and action mmu04960   Aldosterone-regulated sodium reabsorption mmu04961   Endocrine and other factor-regulated calcium reabsorption mmu04970   Salivary secretion mmu04971   Gastric acid secretion mmu04972   Pancreatic secretion mmu05017   Spinocerebellar ataxia mmu05022   Pathways of neurodegeneration - multiple diseases mmu05031   Amphetamine addiction mmu05032   Morphine addiction mmu05143   African trypanosomiasis mmu05146   Amoebiasis mmu05161   Hepatitis B mmu05163   Human cytomegalovirus infection mmu05164   Influenza A mmu05170   Human immunodeficiency virus 1 infection mmu05171   Coronavirus disease - COVID-19 mmu05200   Pathways in cancer mmu05205   Proteoglycans in cancer mmu05206   MicroRNAs in cancer mmu05207   Chemical carcinogenesis - receptor activation mmu05214   Glioma mmu05223   Non-small cell lung cancer mmu05225   Hepatocellular carcinoma mmu05231   Choline metabolism in cancer mmu05415   Diabetic cardiomyopathy mmu05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mmu00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     18750 (Prkca)    04012 ErbB signaling pathway     18750 (Prkca)    04014 Ras signaling pathway     18750 (Prkca)    04015 Rap1 signaling pathway     18750 (Prkca)    04310 Wnt signaling pathway     18750 (Prkca)    04370 VEGF signaling pathway     18750 (Prkca)    04066 HIF-1 signaling pathway     18750 (Prkca)    04020 Calcium signaling pathway     18750 (Prkca)    04070 Phosphatidylinositol signaling system     18750 (Prkca)    04072 Phospholipase D signaling pathway     18750 (Prkca)    04071 Sphingolipid signaling pathway     18750 (Prkca)    04151 PI3K-Akt signaling pathway     18750 (Prkca)    04150 mTOR signaling pathway     18750 (Prkca)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04510 Focal adhesion     18750 (Prkca)    04540 Gap junction     18750 (Prkca)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     18750 (Prkca)    04650 Natural killer cell mediated cytotoxicity     18750 (Prkca)    04664 Fc epsilon RI signaling pathway     18750 (Prkca)    04666 Fc gamma R-mediated phagocytosis     18750 (Prkca)    04670 Leukocyte transendothelial migration     18750 (Prkca)   09152 Endocrine system    04911 Insulin secretion     18750 (Prkca)    04929 GnRH secretion     18750 (Prkca)    04912 GnRH signaling pathway     18750 (Prkca)    04921 Oxytocin signaling pathway     18750 (Prkca)    04926 Relaxin signaling pathway     18750 (Prkca)    04935 Growth hormone synthesis, secretion and action     18750 (Prkca)    04918 Thyroid hormone synthesis     18750 (Prkca)    04919 Thyroid hormone signaling pathway     18750 (Prkca)    04928 Parathyroid hormone synthesis, secretion and action     18750 (Prkca)    04916 Melanogenesis     18750 (Prkca)    04925 Aldosterone synthesis and secretion     18750 (Prkca)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     18750 (Prkca)    04270 Vascular smooth muscle contraction     18750 (Prkca)   09154 Digestive system    04970 Salivary secretion     18750 (Prkca)    04971 Gastric acid secretion     18750 (Prkca)    04972 Pancreatic secretion     18750 (Prkca)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     18750 (Prkca)    04961 Endocrine and other factor-regulated calcium reabsorption     18750 (Prkca)   09156 Nervous system    04724 Glutamatergic synapse     18750 (Prkca)    04727 GABAergic synapse     18750 (Prkca)    04725 Cholinergic synapse     18750 (Prkca)    04728 Dopaminergic synapse     18750 (Prkca)    04726 Serotonergic synapse     18750 (Prkca)    04720 Long-term potentiation     18750 (Prkca)    04730 Long-term depression     18750 (Prkca)    04723 Retrograde endocannabinoid signaling     18750 (Prkca)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     18750 (Prkca)   09158 Development and regeneration    04360 Axon guidance     18750 (Prkca)   09159 Environmental adaptation    04713 Circadian entrainment     18750 (Prkca)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     18750 (Prkca)    05206 MicroRNAs in cancer     18750 (Prkca)    05205 Proteoglycans in cancer     18750 (Prkca)    05207 Chemical carcinogenesis - receptor activation     18750 (Prkca)    05231 Choline metabolism in cancer     18750 (Prkca)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     18750 (Prkca)    05214 Glioma     18750 (Prkca)    05223 Non-small cell lung cancer     18750 (Prkca)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     18750 (Prkca)    05161 Hepatitis B     18750 (Prkca)    05171 Coronavirus disease - COVID-19     18750 (Prkca)    05164 Influenza A     18750 (Prkca)    05163 Human cytomegalovirus infection     18750 (Prkca)   09174 Infectious disease: parasitic    05146 Amoebiasis     18750 (Prkca)    05143 African trypanosomiasis     18750 (Prkca)   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     18750 (Prkca)    05022 Pathways of neurodegeneration - multiple diseases     18750 (Prkca)   09165 Substance dependence    05031 Amphetamine addiction     18750 (Prkca)    05032 Morphine addiction     18750 (Prkca)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     18750 (Prkca)    05415 Diabetic cardiomyopathy     18750 (Prkca)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     18750 (Prkca)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     18750 (Prkca)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mmu01001]     18750 (Prkca)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:mmu04131]     18750 (Prkca) Enzymes [BR:mmu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.13  protein kinase C      18750 (Prkca) Protein kinases [BR:mmu01001]  Serine/threonine kinases: AGC group   PKC family [OT]    18750 (Prkca) Membrane trafficking [BR:mmu04131]  Endocytosis   Lipid raft mediated endocytosis    Caveolin-mediated endocytosis     18750 (Prkca) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr C1_1 C2 Pkinase_C C1_2 ABC1 DUF4656 Motif Other DBs NCBI-GeneID:  18750 NCBI-ProteinID:  NP_035231 MGI:  97595 Ensembl:  ENSMUSG00000050965 UniProt:  P20444 Q4VA93 Structure PDB LinkDB All DBs Position 11:complement(107824213..108237360) Genome browser AA seq 672 aa AA seqDB search MADVYPANDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDA KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN PQFVHPILQSAV NT seq 2019 nt NT seq  +upstreamnt  +downstreamnt atggctgacgtttacccggccaacgactccacggcgtctcaggacgtggccaaccgcttc gcccgcaaaggggcgctgaggcagaagaacgtgcatgaggtgaaagaccacaaattcatc gcccgcttcttcaagcaacccaccttctgcagccactgcaccgacttcatctgggggttt gggaaacaaggcttccagtgccaagtttgctgttttgtggttcataagaggtgccatgag ttcgttacgttctcttgtccgggtgcggataagggacctgacactgacgaccccaggagc aagcacaagttcaaaatccacacatacggaagccctaccttctgtgatcactgtgggtcc ctgctctatggacttatccaccaagggatgaaatgtgacacctgcgacatgaatgttcac aagcagtgtgtgatcaatgtccctagcctctgcggaatggatcacacagagaagaggggg cggatttatctgaaggctgaggtcactgatgaaaagctccacgtcacggtacgagatgca aaaaatctaatccctatggatccaaatgggctttcggatccttatgtgaagctgaaactt atccctgaccccaagaatgagagcaaacagaaaaccaaaaccatccgctccacactgaat cctcagtggaatgagtccttcacgttcaaattaaaaccttcagacaaagaccggcgactg tctgtagaaatctgggactgggatcggacgactcggaatgacttcatgggatccctttcc tttggtgtctcagagctaatgaagatgccggccagtggatggtataaactgctcaaccaa gaagagggcgaatactacaatgtgcccattccagaaggagatgaagaaggcaacatggaa ctcaggcagaagtttgagaaagccaagctaggccctgctggtaacaaagtcatcagccct tcagaagacagaaagcaaccatccaacaacctggacagagtgaaactcacagacttcaac ttcctcatggtgctggggaaggggagttttgggaaggtgatgcttgctgacaggaaggga acggaggaactgtacgccatcaagatcctgaagaaggacgtggtgatccaggacgacgac gtggagtgcaccatggtggagaagcgcgtgctggccctgctggacaagccgccatttctg acacagctgcactcctgcttccagacagtggaccggctgtacttcgtcatggaatacgtc aacggcggggacctcatgtaccacattcagcaagtcgggaaatttaaggagccacaagca gtattctacgcagccgagatctccatcggactgttcttccttcataaaagagggatcatt tacagggatctgaagctggacaatgtcatgctggactcagaagggcacatcaaaatcgcc gactttgggatgtgcaaggaacacatgatggatggagtcacgaccaggaccttctgtggg actccggactacattgccccagagataatcgcttaccagccgtacgggaagtctgtagat tggtgggcgtacggtgtgctgctgtacgagatgctagccgggcagcctccgtttgatggt gaagatgaagatgaactgtttcagtctataatggagcacaacgtgtcctaccccaaatcc ttgtccaaggaagccgtctctatctgcaaaggacttatgaccaaacaccctgccaagcgg ctgggctgcgggcccgagggagagagggatgtcagagagcatgccttcttcaggagaatc gactgggagaaactggagaacagggagatccaaccaccattcaagcccaaagtgtgtggc aaaggagcagaaaactttgacaagttcttcacgcgaggacagcctgtcttaacaccacca gatcagctggtcattgctaacatagaccaatctgattttgaagggttctcgtatgtcaac ccccagtttgtgcacccaatcttgcaaagtgcagtatga

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